{"id":"https://openalex.org/W7204913437","doi":"https://doi.org/10.1016/j.gastha.2026.101111","title":"CYP2D6 Metabolizer Status Does Not Predict Response or Tolerability of Low-Dose Nortriptyline for Irritable Bowel Syndrome With Diarrhea","display_name":"CYP2D6 Metabolizer Status Does Not Predict Response or Tolerability of Low-Dose Nortriptyline for Irritable Bowel Syndrome With Diarrhea","publication_year":2026,"publication_date":"2026-01-01","ids":{"openalex":"https://openalex.org/W7204913437","doi":"https://doi.org/10.1016/j.gastha.2026.101111","pmid":"https://pubmed.ncbi.nlm.nih.gov/42831162","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13634428"},"language":"en","primary_location":{"id":"doi:10.1016/j.gastha.2026.101111","doi":"https://doi.org/10.1016/j.gastha.2026.101111","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.gastha.2026.101111","pdf_url":"https://www.ghadvances.org/article/S2772-5723(26)00232-3/pdf","source":{"id":"https://openalex.org/S4220651355","display_name":"Gastro Hep Advances","issn_l":"2772-5723","issn":["2772-5723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gastro Hep Advances","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.ghadvances.org/article/S2772-5723(26)00232-3/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084146359","display_name":"Kyle D. Staller","orcid":"https://orcid.org/0000-0003-4925-4290","observed_orcids":["https://orcid.org/0000-0003-4925-4290"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kyle Staller","raw_affiliation_strings":["Division of Gastroenterology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts","Harvard Medical School, Boston, Massachusetts"],"raw_orcid":"https://orcid.org/0000-0003-4925-4290","affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092415599","display_name":"Jenna Clukey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jenna Clukey","raw_affiliation_strings":["Division of Gastroenterology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts","Harvard Medical School, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045312320","display_name":"Elizabeth N. Madva","orcid":"https://orcid.org/0000-0003-2194-2032","observed_orcids":["https://orcid.org/0000-0003-2194-2032"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth N. Madva","raw_affiliation_strings":["Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts","Harvard Medical School, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043858638","display_name":"Brian C. Healy","orcid":"https://orcid.org/0000-0001-5272-2425","observed_orcids":["https://orcid.org/0000-0001-5272-2425"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian C. Healy","raw_affiliation_strings":["Biostatistics Center, Massachusetts General Hospital, Boston, Massachusetts","Department of Neurology, Harvard Medical School, Boston, Massachusetts","Harvard Medical School, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biostatistics Center, Massachusetts General Hospital, Boston, Massachusetts","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Department of Neurology, Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075981151","display_name":"Minyi Lee","orcid":"https://orcid.org/0000-0003-3814-9890","observed_orcids":["https://orcid.org/0000-0003-3814-9890"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Minyi Lee","raw_affiliation_strings":["Division of Gastroenterology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts","Harvard Medical School, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083672487","display_name":"Manish K. Gala","orcid":"https://orcid.org/0000-0002-3126-0783","observed_orcids":["https://orcid.org/0000-0002-3126-0783"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Manish K. Gala","raw_affiliation_strings":["Division of Gastroenterology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts","Harvard Medical School, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5084146359"],"corresponding_institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"],"apc_list":{"value":2000,"currency":"USD","value_usd":2000},"apc_paid":{"value":2000,"currency":"USD","value_usd":2000},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.58564384,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"5","issue":"12","first_page":"101111","last_page":"101111"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9711999893188477,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9711999893188477,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.017799999564886093,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12187","display_name":"Glutathione Transferases and Polymorphisms","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cyp2d6","display_name":"CYP2D6","score":0.8429999947547913},{"id":"https://openalex.org/keywords/nortriptyline","display_name":"nortriptyline","score":0.9739999771118164},{"id":"https://openalex.org/keywords/irritable-bowel-syndrome-with-diarrhea","display_name":"irritable bowel syndrome with diarrhea","score":0.8970000147819519},{"id":"https://openalex.org/keywords/antidepressant-response","display_name":"antidepressant response","score":0.6029999852180481},{"id":"https://openalex.org/keywords/drug-tolerability","display_name":"drug tolerability","score":0.8989999890327454},{"id":"https://openalex.org/keywords/pharmacogenetics","display_name":"pharmacogenetics","score":0.7129999995231628}],"concepts":[{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.6686000227928162},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6111000180244446},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5479999780654907},{"id":"https://openalex.org/C2780779033","wikidata":"https://www.wikidata.org/wiki/Q61387","display_name":"Nortriptyline","level":3,"score":0.5425000190734863},{"id":"https://openalex.org/C33664856","wikidata":"https://www.wikidata.org/wiki/Q3271142","display_name":"CYP2D6","level":4,"score":0.49939998984336853},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3059000074863434},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.2992999851703644},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.2964000105857849},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.28929999470710754},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.2603999972343445},{"id":"https://openalex.org/C2779831137","wikidata":"https://www.wikidata.org/wiki/Q425120","display_name":"Disopyramide","level":2,"score":0.2500999867916107}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1016/j.gastha.2026.101111","doi":"https://doi.org/10.1016/j.gastha.2026.101111","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.gastha.2026.101111","pdf_url":"https://www.ghadvances.org/article/S2772-5723(26)00232-3/pdf","source":{"id":"https://openalex.org/S4220651355","display_name":"Gastro Hep Advances","issn_l":"2772-5723","issn":["2772-5723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gastro Hep Advances","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13634428","doi":null,"is_oa":true,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42831162/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13634428/pdf/main.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gastro Hep Adv","raw_type":"Text"},{"id":"pmid:42831162","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42831162","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gastro hep advances","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.gastha.2026.101111","doi":"https://doi.org/10.1016/j.gastha.2026.101111","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.gastha.2026.101111","pdf_url":"https://www.ghadvances.org/article/S2772-5723(26)00232-3/pdf","source":{"id":"https://openalex.org/S4220651355","display_name":"Gastro Hep Advances","issn_l":"2772-5723","issn":["2772-5723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gastro Hep Advances","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G822889909","display_name":"The Role of Fiber in the Etiopathogenesis of Fecal Incontinence","funder_award_id":"K23DK120945","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000871278","display_name":"Pathogenic Germline Mutations in Barrett's Esophagus","funder_award_id":"R01DK137971","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204913437.pdf","grobid_xml":"https://content.openalex.org/works/W7204913437.grobid-xml"},"referenced_works_count":10,"referenced_works":["https://openalex.org/W2072359419","https://openalex.org/W2146589073","https://openalex.org/W2170297038","https://openalex.org/W2561831579","https://openalex.org/W2889182023","https://openalex.org/W3107703675","https://openalex.org/W4220688830","https://openalex.org/W4283157307","https://openalex.org/W4375955758","https://openalex.org/W7126034115"],"related_works":["https://openalex.org/W2101264455","https://openalex.org/W7160068402","https://openalex.org/W7098524463","https://openalex.org/W3139026092","https://openalex.org/W1974670279","https://openalex.org/W2335687005","https://openalex.org/W2004557299","https://openalex.org/W7126034115","https://openalex.org/W1999720233","https://openalex.org/W1991424018"],"abstract_inverted_index":{"Neuromodulators,":[0],"including":[1],"tricyclic":[2],"antidepressants":[3],"(TCAs),":[4],"have":[5],"long":[6],"been":[7],"used":[8,51],"to":[9,20,26,41],"treat":[10],"irritable":[11],"bowel":[12],"syndrome":[13],"with":[14],"diarrhea":[15],"(IBS-D),1,2":[16],"but":[17],"clinical":[18],"response":[19],"TCAs":[21],"is":[22,54],"not":[23],"clearly":[24],"related":[25],"dosage.3":[27],"Interindividual":[28],"variations":[29],"in":[30,43,52],"adverse":[31],"events":[32],"and":[33],"efficacy":[34],"may":[35],"be":[36],"at":[37],"least":[38],"partially":[39],"attributed":[40],"variability":[42],"drug":[44],"plasma":[45],"concentrations.4":[46],"Nortriptyline,":[47],"a":[48],"TCA":[49],"commonly":[50],"IBS-D,":[53],"primarily":[55],"metabolized":[56],"by":[57],"CYP2D6.":[58],"Genotype-inferred":[59],"phenotype":[60],"of":[61],"CYP2D6":[62],"can":[63],"classify":[64],"patients":[65],"into":[66],"different":[67],"metabolizer":[68],"classes.":[69]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2026-09-02T00:00:00"}