{"id":"https://openalex.org/W7204906329","doi":"https://doi.org/10.64898/2026.08.27.747386","title":"Abundant Glomerular Neutrophil Extracellular Traps in C3 Glomerulopathy","display_name":"Abundant Glomerular Neutrophil Extracellular Traps in C3 Glomerulopathy","publication_year":2026,"publication_date":"2026-09-01","ids":{"openalex":"https://openalex.org/W7204906329","doi":"https://doi.org/10.64898/2026.08.27.747386"},"language":"en","primary_location":{"id":"doi:10.64898/2026.08.27.747386","doi":"https://doi.org/10.64898/2026.08.27.747386","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.27.747386","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/01/2026.08.27.747386.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/01/2026.08.27.747386.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043305850","display_name":"Kim Maree O\u2019Sullivan","orcid":"https://orcid.org/0000-0002-3098-7948","observed_orcids":["https://orcid.org/0000-0002-3098-7948"]},"institutions":[{"id":"https://openalex.org/I2801350665","display_name":"Monash Medical Centre","ror":"https://ror.org/036s9kg65","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2801350665","https://openalex.org/I4210121067"]},{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Kim M. O\u2019Sullivan","raw_affiliation_strings":["Centre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre, Clayton, Victoria, Australia"],"raw_orcid":"https://orcid.org/0000-0002-3098-7948","affiliations":[{"raw_affiliation_string":"Centre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre, Clayton, Victoria, Australia","institution_ids":["https://openalex.org/I2801350665","https://openalex.org/I56590836"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006232198","display_name":"Priyanka Khandelwal","orcid":"https://orcid.org/0000-0002-8753-1837","observed_orcids":["https://orcid.org/0000-0002-8753-1837"]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2801317318","display_name":"Hospital for Sick Children","ror":"https://ror.org/057q4rt57","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801317318"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Priyanka Khandelwal","raw_affiliation_strings":["Department of Paediatrics, University of Toronto, Toronto, ON, Canada","Division of Nephrology, The Hospital for Sick Children, Toronto, ON, Canada"],"raw_orcid":"https://orcid.org/0000-0002-8753-1837","affiliations":[{"raw_affiliation_string":"Department of Paediatrics, University of Toronto, Toronto, ON, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Division of Nephrology, The Hospital for Sick Children, Toronto, ON, Canada","institution_ids":["https://openalex.org/I2801317318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112014471","display_name":"Patrick D. Walker","orcid":"https://orcid.org/0000-0002-1347-9765","observed_orcids":["https://orcid.org/0000-0002-1347-9765"]},"institutions":[{"id":"https://openalex.org/I4210088875","display_name":"Arkana Laboratories","ror":"https://ror.org/0053hg536","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210088875"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patrick D. Walker","raw_affiliation_strings":["Arkana Laboratories, Little Rock, Arkansas, USA"],"raw_orcid":"https://orcid.org/0000-0002-1347-9765","affiliations":[{"raw_affiliation_string":"Arkana Laboratories, Little Rock, Arkansas, USA","institution_ids":["https://openalex.org/I4210088875"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040346731","display_name":"Michael J. Hickey","orcid":"https://orcid.org/0000-0003-2354-357X","observed_orcids":["https://orcid.org/0000-0003-2354-357X"]},"institutions":[{"id":"https://openalex.org/I2801350665","display_name":"Monash Medical Centre","ror":"https://ror.org/036s9kg65","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2801350665","https://openalex.org/I4210121067"]},{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Michael J. Hickey","raw_affiliation_strings":["Centre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre, Clayton, Victoria, Australia"],"raw_orcid":"https://orcid.org/0000-0003-2354-357X","affiliations":[{"raw_affiliation_string":"Centre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre, Clayton, Victoria, Australia","institution_ids":["https://openalex.org/I2801350665","https://openalex.org/I56590836"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082634620","display_name":"Christoph P. B. Licht","orcid":"https://orcid.org/0000-0003-4168-3277","observed_orcids":["https://orcid.org/0000-0003-4168-3277"]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2801317318","display_name":"Hospital for Sick Children","ror":"https://ror.org/057q4rt57","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801317318"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Christoph Licht","raw_affiliation_strings":["Cell and Systems Biology Program, Research Institute, The Hospital for Sick Children, Toronto, ON, Canada","Department of Paediatrics, University of Toronto, Toronto, ON, Canada","Division of Nephrology, The Hospital for Sick Children, Toronto, ON, Canada"],"raw_orcid":"https://orcid.org/0000-0003-4168-3277","affiliations":[{"raw_affiliation_string":"Cell and Systems Biology Program, Research Institute, The Hospital for Sick Children, Toronto, ON, Canada","institution_ids":["https://openalex.org/I2801317318"]},{"raw_affiliation_string":"Department of Paediatrics, University of Toronto, Toronto, ON, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Division of Nephrology, The Hospital for Sick Children, Toronto, ON, Canada","institution_ids":["https://openalex.org/I2801317318"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5082634620"],"corresponding_institution_ids":["https://openalex.org/I185261750","https://openalex.org/I2801317318"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.7426999807357788,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.7426999807357788,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.09290000051259995,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.09049999713897705,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/c3-glomerulopathy","display_name":"C3 glomerulopathy","score":0.9800000190734863},{"id":"https://openalex.org/keywords/neutrophil-extracellular-traps","display_name":"neutrophil extracellular traps","score":0.996999979019165},{"id":"https://openalex.org/keywords/alternative-complement-pathway","display_name":"alternative complement pathway","score":0.8169999718666077},{"id":"https://openalex.org/keywords/dense-deposit-disease","display_name":"dense deposit disease","score":0.9929999709129333},{"id":"https://openalex.org/keywords/c3-glomerulonephritis","display_name":"C3 glomerulonephritis","score":0.9900000095367432},{"id":"https://openalex.org/keywords/glomerular-injury","display_name":"glomerular injury","score":0.7419999837875366},{"id":"https://openalex.org/keywords/renal-function","display_name":"renal function","score":0.6919999718666077},{"id":"https://openalex.org/keywords/estimated-glomerular-filtration-rate","display_name":"estimated glomerular filtration rate","score":0.8539999723434448},{"id":"https://openalex.org/keywords/myeloperoxidase","display_name":"myeloperoxidase","score":0.8399999737739563},{"id":"https://openalex.org/keywords/citrullinated-histone-h3","display_name":"citrullinated histone H3","score":0.8880000114440918},{"id":"https://openalex.org/keywords/complement-inhibitors","display_name":"complement inhibitors","score":0.48899999260902405}],"concepts":[{"id":"https://openalex.org/C2780199430","wikidata":"https://www.wikidata.org/wiki/Q3347169","display_name":"Glomerulopathy","level":4,"score":0.78329998254776},{"id":"https://openalex.org/C134897094","wikidata":"https://www.wikidata.org/wiki/Q7003141","display_name":"Neutrophil extracellular traps","level":3,"score":0.7127000093460083},{"id":"https://openalex.org/C2780368995","wikidata":"https://www.wikidata.org/wiki/Q605006","display_name":"Glomerulonephritis","level":3,"score":0.6984000205993652},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.5949000120162964},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.5853999853134155},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.5408999919891357},{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.5252000093460083},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5120999813079834},{"id":"https://openalex.org/C2781087799","wikidata":"https://www.wikidata.org/wiki/Q7312483","display_name":"Renal biopsy","level":3,"score":0.4957999885082245},{"id":"https://openalex.org/C2781184683","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Nephropathy","level":3,"score":0.41830000281333923},{"id":"https://openalex.org/C2778236600","wikidata":"https://www.wikidata.org/wiki/Q592324","display_name":"Immunofluorescence","level":3,"score":0.40849998593330383},{"id":"https://openalex.org/C2910856063","wikidata":"https://www.wikidata.org/wiki/Q909882","display_name":"Kidney Glomerulus","level":4,"score":0.39430001378059387},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3808000087738037},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3686999976634979},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3452000021934509},{"id":"https://openalex.org/C111684460","wikidata":"https://www.wikidata.org/wiki/Q334848","display_name":"Complement system","level":3,"score":0.3427000045776367},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.3334999978542328},{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.33309999108314514},{"id":"https://openalex.org/C2779912601","wikidata":"https://www.wikidata.org/wiki/Q1621830","display_name":"Lupus nephritis","level":3,"score":0.32749998569488525},{"id":"https://openalex.org/C3018920779","wikidata":"https://www.wikidata.org/wiki/Q909882","display_name":"Renal glomerulus","level":4,"score":0.3172000050544739},{"id":"https://openalex.org/C24040308","wikidata":"https://www.wikidata.org/wiki/Q574727","display_name":"Anti-neutrophil cytoplasmic antibody","level":4,"score":0.3149000108242035},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.31279999017715454},{"id":"https://openalex.org/C74864618","wikidata":"https://www.wikidata.org/wiki/Q2332446","display_name":"Staining","level":2,"score":0.3070000112056732},{"id":"https://openalex.org/C2777747828","wikidata":"https://www.wikidata.org/wiki/Q1323002","display_name":"Minimal change disease","level":5,"score":0.2962999939918518},{"id":"https://openalex.org/C2779561371","wikidata":"https://www.wikidata.org/wiki/Q570197","display_name":"Proteinuria","level":3,"score":0.29269999265670776},{"id":"https://openalex.org/C2777146197","wikidata":"https://www.wikidata.org/wiki/Q138912","display_name":"Podocyte","level":4,"score":0.29030001163482666},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2872999906539917},{"id":"https://openalex.org/C54847362","wikidata":"https://www.wikidata.org/wiki/Q177635","display_name":"Nephrology","level":2,"score":0.2842000126838684},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2818000018596649},{"id":"https://openalex.org/C2777058396","wikidata":"https://www.wikidata.org/wiki/Q401402","display_name":"Nephritis","level":2,"score":0.2734000086784363},{"id":"https://openalex.org/C153400128","wikidata":"https://www.wikidata.org/wiki/Q3150731","display_name":"Infiltration (HVAC)","level":2,"score":0.26589998602867126},{"id":"https://openalex.org/C2777390665","wikidata":"https://www.wikidata.org/wiki/Q5571239","display_name":"Glomerulosclerosis","level":4,"score":0.26460000872612},{"id":"https://openalex.org/C2780688133","wikidata":"https://www.wikidata.org/wiki/Q3772406","display_name":"Mesangial proliferative glomerulonephritis","level":4,"score":0.26330000162124634},{"id":"https://openalex.org/C163764329","wikidata":"https://www.wikidata.org/wiki/Q785022","display_name":"Autoantibody","level":3,"score":0.25450000166893005}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.08.27.747386","doi":"https://doi.org/10.64898/2026.08.27.747386","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.27.747386","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/01/2026.08.27.747386.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.08.27.747386","doi":"https://doi.org/10.64898/2026.08.27.747386","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.27.747386","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/01/2026.08.27.747386.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204906329.pdf","grobid_xml":"https://content.openalex.org/works/W7204906329.grobid-xml"},"referenced_works_count":1,"referenced_works":["https://openalex.org/W3035854813"],"related_works":["https://openalex.org/W3155094325","https://openalex.org/W7117312354","https://openalex.org/W7132954070","https://openalex.org/W4397025375","https://openalex.org/W2763402200","https://openalex.org/W1977818941","https://openalex.org/W4240509789","https://openalex.org/W2747145552","https://openalex.org/W2145795429","https://openalex.org/W4229054587"],"abstract_inverted_index":{"ABSTRACT":[0],"Introduction":[1],"C3":[2,61,261],"glomerulopathy":[3],"(C3G)":[4],"is":[5,241],"driven":[6],"by":[7],"fluid-phase":[8],"alternative":[9],"complement":[10,254,348],"pathway":[11],"dysregulation,":[12],"with":[13,50,53,60,66,119,145,183,225,314],"emerging":[14],"evidence":[15],"linking":[16],"glomerular":[17,111,188,247,309,317,334],"neutrophil":[18,159,287,294],"infiltration":[19,288],"to":[20,109,347],"disease":[21,56,78],"severity.":[22],"Neutrophil":[23],"extracellular":[24,295],"traps":[25,296],"(NETs)":[26,297],"are":[27,214,223],"implicated":[28],"in":[29,37,80,136,141,167,220,239,249,306,336,345,350],"other":[30],"forms":[31],"of":[32,40,124,139,153,177,246,283,293,330,333,342],"glomerulonephritis.":[33],"However,":[34],"their":[35],"participation":[36],"the":[38,115,137,234,269,331,340],"pathogenesis":[39,332],"C3G":[41,51,142,147,202,221,284,337,351],"remains":[42],"undefined.":[43],"Methods":[44],"Kidney":[45],"biopsies":[46,74,282],"from":[47],"33":[48],"patients":[49,285],"(15":[52],"dense":[54],"deposit":[55],"[DDD]":[57],"and":[58,87,102,114,134,169,193,204,217,222,268,291,298,338],"18":[59],"glomerulonephritis":[62],"[C3GN])":[63],"were":[64,89,117,132,303],"compared":[65],"15":[67],"anti-neutrophil":[68],"cytoplasmic":[69],"antibody":[70],"associated":[71,182,224,313],"vasculitis":[72],"(AAV)":[73],"as":[75,326],"a":[76,149,174,215,242,327],"neutrophil-rich":[77],"control":[79],"this":[81,194],"retrospective":[82],"cross-sectional":[83],"study.":[84],"Glomerular":[85],"neutrophils":[86,154],"NETs":[88,131,180,213,325],"identified":[90],"using":[91,126],"immunofluorescence,":[92],"staining":[93],"for":[94,200,260,286],"myeloperoxidase,":[95],"citrullinated":[96],"histone":[97],"H3,":[98],"peptidyl":[99],"arginine":[100],"deiminase-4,":[101],"DNA.":[103],"Supervised":[104],"machine":[105],"learning":[106],"was":[107,165,181,312],"used":[108],"quantify":[110],"NET":[112,163,237,310],"formation,":[113],"data":[116],"correlated":[118],"kidney":[120,185,227],"function":[121,186,228],"at":[122,191,229,320],"time":[123],"biopsy":[125],"linear":[127],"regression.":[128],"Results":[129],"Intraglomerular":[130],"abundant":[133,305],"detected":[135],"majority":[138],"glomeruli":[140,178,240],"biopsies.":[143],"Compared":[144],"AAV,":[146],"showed":[148],"significantly":[150],"higher":[151],"fraction":[152],"forming":[155],"NETs,":[156],"despite":[157],"similar":[158,166],"counts":[160],"per":[161],"glomerulus.":[162],"abundance":[164],"DDD":[168],"C3GN.":[170],"In":[171],"exploratory":[172],"analyses,":[173],"greater":[175],"proportion":[176],"containing":[179],"lower":[184,315],"(estimated":[187],"filtration":[189,318],"rate)":[190],"biopsy,":[192],"association":[195],"remained":[196],"significant":[197],"after":[198],"adjustment":[199],"age,":[201],"subtype,":[203],"interstitial":[205],"fibrosis.":[206],"Conclusions":[207],"These":[208,231],"observations":[209,323],"demonstrate":[210],"that":[211,236,300],"intraglomerular":[212],"common":[216],"prominent":[218],"observation":[219],"reduced":[226],"biopsy.":[230,321],"findings":[232],"raise":[233],"possibility":[235],"deposition":[238],"previously":[243],"unrecognized":[244],"driver":[245],"injury":[248,275],"C3G.":[250],"TRANSLATIONAL":[251],"STATEMENT":[252],"Targeted":[253],"inhibitors":[255],"have":[256],"expanded":[257],"treatment":[258,264],"options":[259],"glomerulopathy,":[262],"but":[263],"responses":[265],"remain":[266,276],"incomplete":[267],"cellular":[270],"processes":[271],"accompanying":[272],"active":[273],"intrarenal":[274],"incompletely":[277],"defined.":[278],"We":[279],"examined":[280],"renal":[281],"/":[289],"recruitment":[290],"release":[292],"found":[299],"these":[301],"structures":[302],"highly":[304],"glomeruli.":[307],"Greater":[308],"burden":[311],"estimated":[316],"rate":[319],"Our":[322],"identify":[324],"candidate":[328],"component":[329],"pathology":[335],"support":[339],"investigation":[341],"NET-targeting":[343],"interventions":[344],"addition":[346],"inhibition":[349],"patients.":[352]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-09-02T00:00:00"}
