{"id":"https://openalex.org/W7204900481","doi":"https://doi.org/10.64898/2026.08.31.746736","title":"3D ultrasound fascicle tractography for objective muscle architecture analysis","display_name":"3D ultrasound fascicle tractography for objective muscle architecture analysis","publication_year":2026,"publication_date":"2026-09-01","ids":{"openalex":"https://openalex.org/W7204900481","doi":"https://doi.org/10.64898/2026.08.31.746736"},"language":"en","primary_location":{"id":"doi:10.64898/2026.08.31.746736","doi":"https://doi.org/10.64898/2026.08.31.746736","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.31.746736","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/01/2026.08.31.746736.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/01/2026.08.31.746736.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049482244","display_name":"Paolo Tecchio","orcid":"https://orcid.org/0000-0003-0371-8475","observed_orcids":["https://orcid.org/0000-0003-0371-8475"]},"institutions":[{"id":"https://openalex.org/I904495901","display_name":"Ruhr University Bochum","ror":"https://ror.org/04tsk2644","country_code":"DE","type":"education","lineage":["https://openalex.org/I904495901"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Paolo Tecchio","raw_affiliation_strings":["Human Movement Science, Faculty of Sport Science, Ruhr University Bochum, Bochum, Germany"],"raw_orcid":"https://orcid.org/0000-0003-0371-8475","affiliations":[{"raw_affiliation_string":"Human Movement Science, Faculty of Sport Science, Ruhr University Bochum, Bochum, Germany","institution_ids":["https://openalex.org/I904495901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072504243","display_name":"Lara Schlaffke","orcid":"https://orcid.org/0000-0002-0716-3780","observed_orcids":["https://orcid.org/0000-0002-0716-3780"]},"institutions":[{"id":"https://openalex.org/I159743108","display_name":"Dortmund University of Applied Sciences and Arts","ror":"https://ror.org/03dv91853","country_code":"DE","type":"education","lineage":["https://openalex.org/I159743108"]},{"id":"https://openalex.org/I4210138993","display_name":"St. Josef-Hospital","ror":"https://ror.org/046vare28","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2799784675","https://openalex.org/I4210138993","https://openalex.org/I4210153564"]},{"id":"https://openalex.org/I904495901","display_name":"Ruhr University Bochum","ror":"https://ror.org/04tsk2644","country_code":"DE","type":"education","lineage":["https://openalex.org/I904495901"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Lara Schlaffke","raw_affiliation_strings":["Department of Information Technology, University of Applied Sciences and Arts Dortmund, Germany","Ruhr-University Bochum, St. Josef-Hospital, University Hospital of Pediatrics and Adolescent Medicine, Department of Neuropediatrics and Social Pediatrics"],"raw_orcid":"https://orcid.org/0000-0002-0716-3780","affiliations":[{"raw_affiliation_string":"Department of Information Technology, University of Applied Sciences and Arts Dortmund, Germany","institution_ids":["https://openalex.org/I159743108"]},{"raw_affiliation_string":"Ruhr-University Bochum, St. Josef-Hospital, University Hospital of Pediatrics and Adolescent Medicine, Department of Neuropediatrics and Social Pediatrics","institution_ids":["https://openalex.org/I4210138993","https://openalex.org/I904495901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072259355","display_name":"Bart Bolsterlee","orcid":"https://orcid.org/0000-0001-8277-5026","observed_orcids":["https://orcid.org/0000-0001-8277-5026"]},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]},{"id":"https://openalex.org/I83657090","display_name":"Neuroscience Research Australia","ror":"https://ror.org/01g7s6g79","country_code":"AU","type":"facility","lineage":["https://openalex.org/I83657090"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Bart Bolsterlee","raw_affiliation_strings":["Graduate School of Biomedical Engineering, University of New South Wales, Sydney, New South Wales, Australia","Neuroscience Research Australia (NeuRA), Sydney, new South Wales, Australia"],"raw_orcid":"https://orcid.org/0000-0001-8277-5026","affiliations":[{"raw_affiliation_string":"Graduate School of Biomedical Engineering, University of New South Wales, Sydney, New South Wales, Australia","institution_ids":["https://openalex.org/I31746571"]},{"raw_affiliation_string":"Neuroscience Research Australia (NeuRA), Sydney, new South Wales, Australia","institution_ids":["https://openalex.org/I83657090"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076947455","display_name":"Daniel Hahn","orcid":"https://orcid.org/0000-0002-9401-5478","observed_orcids":["https://orcid.org/0000-0002-9401-5478"]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]},{"id":"https://openalex.org/I904495901","display_name":"Ruhr University Bochum","ror":"https://ror.org/04tsk2644","country_code":"DE","type":"education","lineage":["https://openalex.org/I904495901"]}],"countries":["AU","DE"],"is_corresponding":false,"raw_author_name":"Daniel Hahn","raw_affiliation_strings":["Human Movement Science, Faculty of Sport Science, Ruhr University Bochum, Bochum, Germany","School of Human Movement and Nutrition Sciences, University of Queensland, Brisbane, Australia"],"raw_orcid":"https://orcid.org/0000-0002-9401-5478","affiliations":[{"raw_affiliation_string":"Human Movement Science, Faculty of Sport Science, Ruhr University Bochum, Bochum, Germany","institution_ids":["https://openalex.org/I904495901"]},{"raw_affiliation_string":"School of Human Movement and Nutrition Sciences, University of Queensland, Brisbane, Australia","institution_ids":["https://openalex.org/I165143802"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025770293","display_name":"Brent J. Raiteri","orcid":"https://orcid.org/0000-0002-2078-9075","observed_orcids":["https://orcid.org/0000-0002-2078-9075"]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]},{"id":"https://openalex.org/I904495901","display_name":"Ruhr University Bochum","ror":"https://ror.org/04tsk2644","country_code":"DE","type":"education","lineage":["https://openalex.org/I904495901"]}],"countries":["AU","DE"],"is_corresponding":false,"raw_author_name":"Brent J. Raiteri","raw_affiliation_strings":["Human Movement Science, Faculty of Sport Science, Ruhr University Bochum, Bochum, Germany","School of Human Movement and Nutrition Sciences, University of Queensland, Brisbane, Australia"],"raw_orcid":"https://orcid.org/0000-0002-2078-9075","affiliations":[{"raw_affiliation_string":"Human Movement Science, Faculty of Sport Science, Ruhr University Bochum, Bochum, Germany","institution_ids":["https://openalex.org/I904495901"]},{"raw_affiliation_string":"School of Human Movement and Nutrition Sciences, University of Queensland, Brisbane, Australia","institution_ids":["https://openalex.org/I165143802"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5049482244"],"corresponding_institution_ids":["https://openalex.org/I904495901"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":0.4982999861240387,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":0.4982999861240387,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10052","display_name":"Medical Image Segmentation Techniques","score":0.22789999842643738,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10727","display_name":"Ultrasound Imaging and Elastography","score":0.15479999780654907,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/muscle-architecture","display_name":"muscle architecture","score":0.7549999952316284},{"id":"https://openalex.org/keywords/3d-ultrasound","display_name":"3D ultrasound","score":0.9120000004768372},{"id":"https://openalex.org/keywords/fascicle-length","display_name":"fascicle length","score":0.9330000281333923},{"id":"https://openalex.org/keywords/tibialis-anterior","display_name":"tibialis anterior","score":0.972000002861023}],"concepts":[{"id":"https://openalex.org/C110537703","wikidata":"https://www.wikidata.org/wiki/Q5436639","display_name":"Fascicle","level":2,"score":0.978600025177002},{"id":"https://openalex.org/C2777001087","wikidata":"https://www.wikidata.org/wiki/Q6940306","display_name":"Muscle architecture","level":2,"score":0.8252000212669373},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5494999885559082},{"id":"https://openalex.org/C149550507","wikidata":"https://www.wikidata.org/wiki/Q899360","display_name":"Diffusion MRI","level":3,"score":0.532800018787384},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.5073999762535095},{"id":"https://openalex.org/C84787856","wikidata":"https://www.wikidata.org/wiki/Q3076659","display_name":"Tractography","level":4,"score":0.4666999876499176},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.46149998903274536},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.38510000705718994},{"id":"https://openalex.org/C143753070","wikidata":"https://www.wikidata.org/wiki/Q162564","display_name":"Ultrasound","level":2,"score":0.3831999897956848},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32910001277923584},{"id":"https://openalex.org/C89600930","wikidata":"https://www.wikidata.org/wiki/Q1423946","display_name":"Segmentation","level":2,"score":0.31189998984336853},{"id":"https://openalex.org/C2993909470","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Human muscle","level":3,"score":0.30730000138282776},{"id":"https://openalex.org/C2780170424","wikidata":"https://www.wikidata.org/wiki/Q229399","display_name":"3D ultrasound","level":3,"score":0.2957000136375427},{"id":"https://openalex.org/C2989316616","wikidata":"https://www.wikidata.org/wiki/Q6027402","display_name":"Lower limb","level":2,"score":0.27410000562667847},{"id":"https://openalex.org/C3019493240","wikidata":"https://www.wikidata.org/wiki/Q94701573","display_name":"3d scanning","level":2,"score":0.26660001277923584},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.2644999921321869},{"id":"https://openalex.org/C155281189","wikidata":"https://www.wikidata.org/wiki/Q3518150","display_name":"Tensor (intrinsic definition)","level":2,"score":0.25589999556541443},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.2558000087738037},{"id":"https://openalex.org/C29331040","wikidata":"https://www.wikidata.org/wiki/Q7239554","display_name":"Preclinical imaging","level":3,"score":0.2508000135421753}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.08.31.746736","doi":"https://doi.org/10.64898/2026.08.31.746736","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.31.746736","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/01/2026.08.31.746736.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.08.31.746736","doi":"https://doi.org/10.64898/2026.08.31.746736","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.31.746736","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/01/2026.08.31.746736.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204900481.pdf","grobid_xml":"https://content.openalex.org/works/W7204900481.grobid-xml"},"referenced_works_count":64,"referenced_works":["https://openalex.org/W1573424285","https://openalex.org/W1947967821","https://openalex.org/W1968786458","https://openalex.org/W1977075267","https://openalex.org/W1988957355","https://openalex.org/W2001607678","https://openalex.org/W2031438724","https://openalex.org/W2032560731","https://openalex.org/W2039165928","https://openalex.org/W2057170734","https://openalex.org/W2068322251","https://openalex.org/W2075502685","https://openalex.org/W2080486721","https://openalex.org/W2088775701","https://openalex.org/W2089461082","https://openalex.org/W2100229028","https://openalex.org/W2121498459","https://openalex.org/W2136434211","https://openalex.org/W2136627380","https://openalex.org/W2143870509","https://openalex.org/W2143904278","https://openalex.org/W2161020449","https://openalex.org/W2314841059","https://openalex.org/W2399286426","https://openalex.org/W2441969638","https://openalex.org/W2502118862","https://openalex.org/W2566341674","https://openalex.org/W2572046692","https://openalex.org/W2888810182","https://openalex.org/W2905645667","https://openalex.org/W2913529208","https://openalex.org/W2946145189","https://openalex.org/W2952462886","https://openalex.org/W2995230769","https://openalex.org/W3008375286","https://openalex.org/W3120107701","https://openalex.org/W3121360065","https://openalex.org/W3165781198","https://openalex.org/W3200305254","https://openalex.org/W4205172069","https://openalex.org/W4210493710","https://openalex.org/W4292834480","https://openalex.org/W4293089552","https://openalex.org/W4311356992","https://openalex.org/W4321366356","https://openalex.org/W4323920706","https://openalex.org/W4361283172","https://openalex.org/W4376956710","https://openalex.org/W4385851595","https://openalex.org/W4387333206","https://openalex.org/W4388998272","https://openalex.org/W4390749930","https://openalex.org/W4393183447","https://openalex.org/W4400359433","https://openalex.org/W4403135297","https://openalex.org/W4403667498","https://openalex.org/W4404730225","https://openalex.org/W4406804936","https://openalex.org/W4408282191","https://openalex.org/W4409961622","https://openalex.org/W4410296816","https://openalex.org/W4412934292","https://openalex.org/W4414148609","https://openalex.org/W4416897331"],"related_works":["https://openalex.org/W2057170734","https://openalex.org/W580437020","https://openalex.org/W4361283172","https://openalex.org/W4393183447","https://openalex.org/W4387333206","https://openalex.org/W2258785509","https://openalex.org/W3174131338","https://openalex.org/W4387956302","https://openalex.org/W2083599033","https://openalex.org/W2048239457"],"abstract_inverted_index":{"Abstract":[0],"Muscle":[1],"architecture":[2,19,137],"shapes":[3],"muscle":[4,18,40,121,136,151],"function":[5],"and":[6,12,82,90,131,149],"changes":[7],"with":[8,42,64,76,86],"age,":[9],"growth,":[10],"training":[11],"disease,":[13],"yet":[14],"quantifying":[15],"three-dimensional":[16],"(3D)":[17],"in":[20,103,138,147],"vivo":[21,94,139],"remains":[22],"challenging.":[23],"We":[24],"introduce":[25],"a":[26,73,109,142],"hybrid":[27,58],"fascicle":[28,62,70,80,101],"tractography":[29],"approach":[30,59,97],"for":[31,145],"freehand":[32],"3D":[33,39,135],"ultrasound":[34],"data":[35],"that":[36],"accurately":[37],"reconstructs":[38],"fascicles":[41],"respect":[43],"to":[44,67],"an":[45],"objective,":[46],"anatomically":[47,128],"relevant":[48],"coordinate":[49],"system":[50],"defined":[51],"by":[52],"the":[53,96,104,119],"muscle\u2019s":[54],"central":[55],"aponeurosis.":[56],"The":[57,124],"combines":[60],"Hessian-based":[61],"detection":[63],"wavelet-based":[65],"refinement":[66],"generate":[68],"volumetric":[69],"orientations.":[71],"In":[72,93],"synthetic":[74],"dataset":[75],"known":[77],"ground":[78],"truth,":[79],"orientations":[81],"lengths":[83],"were":[84],"estimated":[85],"errors":[87],"of":[88,118,134],"\u22642\u00b0":[89],"\u223c1.5%,":[91],"respectively.":[92],",":[95,140],"detected":[98],"physiologically":[99],"plausible":[100],"lengthening":[102],"human":[105],"tibialis":[106],"anterior":[107],"following":[108],"passive":[110],"plantar":[111],"flexion":[112],"rotation,":[113],"whereas":[114],"diffusion":[115],"tensor":[116],"imaging":[117],"same":[120],"did":[122],"not.":[123],"proposed":[125],"method":[126],"enables":[127],"relevant,":[129],"objective":[130],"non-invasive":[132],"quantification":[133],"providing":[141],"practical":[143],"framework":[144],"applications":[146],"clinical":[148],"applied":[150],"physiology.":[152]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-09-02T00:00:00"}
