{"id":"https://openalex.org/W7204893635","doi":"https://doi.org/10.1158/1078-0432.33402714","title":"Figure S4 from Phase I Trial of Intravenous VCN-01 Oncolytic Adenovirus and Durvalumab in Patients with Head and Neck Metastatic Squamous Cell Carcinoma Refractory to Immunotherapy","display_name":"Figure S4 from Phase I Trial of Intravenous VCN-01 Oncolytic Adenovirus and Durvalumab in Patients with Head and Neck Metastatic Squamous Cell Carcinoma Refractory to Immunotherapy","publication_year":2026,"publication_date":"2026-09-01","ids":{"openalex":"https://openalex.org/W7204893635","doi":"https://doi.org/10.1158/1078-0432.33402714"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.33402714","doi":"https://doi.org/10.1158/1078-0432.33402714","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.33402714","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1078-0432.33402714","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089518617","display_name":"Maria Jov\u00e9","orcid":"https://orcid.org/0000-0003-1462-9021","observed_orcids":["https://orcid.org/0000-0003-1462-9021"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maria Jove","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1462-9021","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079422406","display_name":"Irene Bra\u00f1a","orcid":"https://orcid.org/0000-0002-1068-9601","observed_orcids":["https://orcid.org/0000-0002-1068-9601"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Irene Bra\u00f1a","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1068-9601","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054682698","display_name":"Marc Oliva","orcid":"https://orcid.org/0000-0001-5352-8130","observed_orcids":["https://orcid.org/0000-0001-5352-8130"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marc Oliva","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5352-8130","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013892733","display_name":"Alberto Hernando\u2010Calvo","orcid":"https://orcid.org/0000-0002-1692-1125","observed_orcids":["https://orcid.org/0000-0002-1692-1125"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alberto Hernando-Calvo","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1692-1125","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5138197980","display_name":"Carlos Erasun","orcid":"https://orcid.org/0000-0002-6743-2903","observed_orcids":["https://orcid.org/0000-0002-6743-2903"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carlos Erasun","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6743-2903","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046300715","display_name":"Ana Mato-Berciano","orcid":"https://orcid.org/0009-0005-0811-3581","observed_orcids":["https://orcid.org/0009-0005-0811-3581"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ana Mato-Berciano","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0005-0811-3581","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026232524","display_name":"Mar\u00eda Victoria Maliandi","orcid":"https://orcid.org/0000-0001-5447-2343","observed_orcids":["https://orcid.org/0000-0001-5447-2343"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maria Victoria Maliandi","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5447-2343","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022276874","display_name":"Silvia Torres-Manjon","orcid":"https://orcid.org/0009-0008-9378-1067","observed_orcids":["https://orcid.org/0009-0008-9378-1067"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Silvia Torres-Manjon","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0008-9378-1067","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067346260","display_name":"Luis Alfonso Rojas","orcid":"https://orcid.org/0000-0001-9218-4086","observed_orcids":["https://orcid.org/0000-0001-9218-4086"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Luis A. Rojas","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9218-4086","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048270390","display_name":"Sheila Connelly","orcid":"https://orcid.org/0000-0003-0951-3593","observed_orcids":["https://orcid.org/0000-0003-0951-3593"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sheila Connelly","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0951-3593","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023223057","display_name":"Miriam Baz\u00e1n\u2010Peregrino","orcid":"https://orcid.org/0000-0001-7367-8304","observed_orcids":["https://orcid.org/0000-0001-7367-8304"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Miriam Bazan-Peregrino","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7367-8304","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070513666","display_name":"Rafael Moreno","orcid":"https://orcid.org/0000-0001-9957-3105","observed_orcids":["https://orcid.org/0000-0001-9957-3105"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rafael Moreno","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9957-3105","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087380508","display_name":"Jaime Mart\u00ednez de Villarreal","orcid":"https://orcid.org/0000-0002-3003-7766","observed_orcids":["https://orcid.org/0000-0002-3003-7766"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jaime Mart\u00ednez de Villarreal","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3003-7766","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060086359","display_name":"Francisco X. Real","orcid":"https://orcid.org/0000-0001-9501-498X","observed_orcids":["https://orcid.org/0000-0001-9501-498X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Francisco X. Real","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9501-498X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148899805","display_name":"Charles Le","orcid":"https://orcid.org/0009-0007-5110-1185","observed_orcids":["https://orcid.org/0009-0007-5110-1185"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Charles Le","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0007-5110-1185","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081259888","display_name":"Paolo Giovanni Nuciforo","orcid":"https://orcid.org/0000-0003-1380-0990","observed_orcids":["https://orcid.org/0000-0003-1380-0990"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paolo Nuciforo","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1380-0990","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084444653","display_name":"Ram\u00f3n Alemany","orcid":"https://orcid.org/0000-0001-8660-550X","observed_orcids":["https://orcid.org/0000-0001-8660-550X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ramon Alemany","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8660-550X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036172060","display_name":"Gabriel Capell\u00e1","orcid":"https://orcid.org/0000-0002-4669-7320","observed_orcids":["https://orcid.org/0000-0002-4669-7320"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gabriel Capell\u00e0","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4669-7320","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148902686","display_name":"Carmen Blasco","orcid":"https://orcid.org/0009-0003-2565-9995","observed_orcids":["https://orcid.org/0009-0003-2565-9995"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carmen Blasco","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0003-2565-9995","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035766272","display_name":"Manel Cascall\u00f3","orcid":"https://orcid.org/0009-0002-3260-600X","observed_orcids":["https://orcid.org/0009-0002-3260-600X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Manel Cascall\u00f3","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0002-3260-600X","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5037339388","display_name":"Ricard Mes\u00eda","orcid":"https://orcid.org/0000-0002-3785-3563","observed_orcids":["https://orcid.org/0000-0002-3785-3563"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ricard Mes\u00eda","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3785-3563","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9613999724388123,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9613999724388123,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.0142000000923872,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.01209999993443489,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oncolytic-adenovirus","display_name":"oncolytic adenovirus","score":0.9959999918937683},{"id":"https://openalex.org/keywords/durvalumab","display_name":"durvalumab","score":0.9929999709129333},{"id":"https://openalex.org/keywords/head-and-neck-squamous-cell-carcinoma","display_name":"head and neck squamous cell carcinoma","score":0.9739999771118164},{"id":"https://openalex.org/keywords/metastatic-cancer","display_name":"metastatic cancer","score":0.8799999952316284},{"id":"https://openalex.org/keywords/viral-load-quantification","display_name":"viral load quantification","score":0.8100000023841858},{"id":"https://openalex.org/keywords/sputum","display_name":"sputum","score":0.9929999709129333},{"id":"https://openalex.org/keywords/feces","display_name":"feces","score":0.8889999985694885}],"concepts":[{"id":"https://openalex.org/C2777742743","wikidata":"https://www.wikidata.org/wiki/Q19904005","display_name":"Durvalumab","level":5,"score":0.9150999784469604},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8824999928474426},{"id":"https://openalex.org/C82210918","wikidata":"https://www.wikidata.org/wiki/Q1560099","display_name":"Oncolytic virus","level":3,"score":0.6747000217437744},{"id":"https://openalex.org/C142424586","wikidata":"https://www.wikidata.org/wiki/Q7307572","display_name":"Refractory (planetary science)","level":2,"score":0.6672999858856201},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.6323000192642212},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5615000128746033},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5134999752044678},{"id":"https://openalex.org/C2776833033","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck squamous-cell carcinoma","level":4,"score":0.4814000129699707},{"id":"https://openalex.org/C3018411727","wikidata":"https://www.wikidata.org/wiki/Q3867488","display_name":"Head and neck","level":2,"score":0.4668999910354614},{"id":"https://openalex.org/C2776301714","wikidata":"https://www.wikidata.org/wiki/Q259346","display_name":"Sputum","level":3,"score":0.453000009059906},{"id":"https://openalex.org/C2777283488","wikidata":"https://www.wikidata.org/wiki/Q7095181","display_name":"Oncolytic adenovirus","level":4,"score":0.40470001101493835},{"id":"https://openalex.org/C3019992690","wikidata":"https://www.wikidata.org/wiki/Q92767510","display_name":"Basal cell","level":2,"score":0.36890000104904175},{"id":"https://openalex.org/C31760486","wikidata":"https://www.wikidata.org/wiki/Q7180990","display_name":"Phases of clinical research","level":3,"score":0.3643999993801117},{"id":"https://openalex.org/C3019814559","wikidata":"https://www.wikidata.org/wiki/Q681817","display_name":"Squamous cell cancer","level":3,"score":0.35519999265670776},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.3522000014781952},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.34369999170303345},{"id":"https://openalex.org/C2781447300","wikidata":"https://www.wikidata.org/wiki/Q374418","display_name":"Glottis","level":3,"score":0.30559998750686646},{"id":"https://openalex.org/C2780474809","wikidata":"https://www.wikidata.org/wiki/Q9637","display_name":"Larynx","level":2,"score":0.2930999994277954},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.29280000925064087},{"id":"https://openalex.org/C2994460389","wikidata":"https://www.wikidata.org/wiki/Q681817","display_name":"Epidermoid carcinoma","level":3,"score":0.27810001373291016},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2712000012397766},{"id":"https://openalex.org/C2775949291","wikidata":"https://www.wikidata.org/wiki/Q20707748","display_name":"Atezolizumab","level":5,"score":0.2572000026702881},{"id":"https://openalex.org/C2780030458","wikidata":"https://www.wikidata.org/wiki/Q7041828","display_name":"Nivolumab","level":4,"score":0.2558000087738037},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.2556000053882599},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.2551000118255615},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2517000138759613},{"id":"https://openalex.org/C2781053074","wikidata":"https://www.wikidata.org/wiki/Q21100639","display_name":"PD-L1","level":4,"score":0.2515999972820282},{"id":"https://openalex.org/C2993769353","wikidata":"https://www.wikidata.org/wiki/Q7598360","display_name":"Standard of care","level":2,"score":0.250900000333786}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1078-0432.33402714","doi":"https://doi.org/10.1158/1078-0432.33402714","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.33402714","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.33402714","doi":"https://doi.org/10.1158/1078-0432.33402714","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.33402714","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7204952477","https://openalex.org/W7204906281","https://openalex.org/W7204879641","https://openalex.org/W7204906029","https://openalex.org/W7204942154","https://openalex.org/W7204894420","https://openalex.org/W7204896621","https://openalex.org/W7204958179","https://openalex.org/W7204926008","https://openalex.org/W7204886930"],"abstract_inverted_index":{"Quantification":[0],"of":[1],"VCN-01":[2],"in":[3],"sputum":[4],"and":[5],"stool":[6]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2026-09-02T00:00:00"}