{"id":"https://openalex.org/W7204892760","doi":"https://doi.org/10.64898/2026.08.30.747939","title":"miR-34/449 miRNAs regulate choroid plexus ciliogenesis to control cerebrospinal fluid production","display_name":"miR-34/449 miRNAs regulate choroid plexus ciliogenesis to control cerebrospinal fluid production","publication_year":2026,"publication_date":"2026-09-01","ids":{"openalex":"https://openalex.org/W7204892760","doi":"https://doi.org/10.64898/2026.08.30.747939","pmid":"https://pubmed.ncbi.nlm.nih.gov/42922535","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13684506"},"language":"en","primary_location":{"id":"doi:10.64898/2026.08.30.747939","doi":"https://doi.org/10.64898/2026.08.30.747939","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.30.747939","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/01/2026.08.30.747939.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/01/2026.08.30.747939.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043123243","display_name":"Suifang Mao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Suifang Mao","raw_affiliation_strings":["Division of Cellular and Developmental Biology, MCB department, University of California at Berkeley, Berkeley, CA 94705, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cellular and Developmental Biology, MCB department, University of California at Berkeley, Berkeley, CA 94705, USA","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Rui Song","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rui Song","raw_affiliation_strings":["Division of Cellular and Developmental Biology, MCB department, University of California at Berkeley, Berkeley, CA 94705, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cellular and Developmental Biology, MCB department, University of California at Berkeley, Berkeley, CA 94705, USA","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101965712","display_name":"Aleksandra Jovanovi\u0107","orcid":"https://orcid.org/0000-0001-8809-8951","observed_orcids":["https://orcid.org/0000-0001-8809-8951"]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aleksandra Jovanovic","raw_affiliation_strings":["Division of Cellular and Developmental Biology, MCB department, University of California at Berkeley, Berkeley, CA 94705, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cellular and Developmental Biology, MCB department, University of California at Berkeley, Berkeley, CA 94705, USA","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008090688","display_name":"Shibo Jin","orcid":"https://orcid.org/0000-0003-3514-4605","observed_orcids":["https://orcid.org/0000-0003-3514-4605"]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shibo Jin","raw_affiliation_strings":["Division of Cellular and Developmental Biology, MCB department, University of California at Berkeley, Berkeley, CA 94705, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cellular and Developmental Biology, MCB department, University of California at Berkeley, Berkeley, CA 94705, USA","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046846079","display_name":"Song Pang","orcid":"https://orcid.org/0000-0002-7231-4151","observed_orcids":["https://orcid.org/0000-0002-7231-4151"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I195573530","display_name":"Janelia Research Campus","ror":"https://ror.org/013sk6x84","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410","https://openalex.org/I195573530"]},{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Song Pang","raw_affiliation_strings":["Department of Cellular & Molecular Physiology, Yale School of Medicine, New Haven, CT 06510, USA","Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cellular & Molecular Physiology, Yale School of Medicine, New Haven, CT 06510, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I195573530"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072470315","display_name":"Danielle M. Jorgens","orcid":"https://orcid.org/0000-0002-7143-0118","observed_orcids":["https://orcid.org/0000-0002-7143-0118"]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Danielle M Jorgens","raw_affiliation_strings":["Electron Microscope Laboratory, University of California, Berkeley, Berkeley, CA, 94720 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Electron Microscope Laboratory, University of California, Berkeley, Berkeley, CA, 94720 USA","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108477820","display_name":"Michael F. Wendland","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael F. Wendland","raw_affiliation_strings":["Division of Cellular and Developmental Biology, MCB department, University of California at Berkeley, Berkeley, CA 94705, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cellular and Developmental Biology, MCB department, University of California at Berkeley, Berkeley, CA 94705, USA","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148859015","display_name":"Adam Zimmerman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adam Zimmerman","raw_affiliation_strings":["Division of Cellular and Developmental Biology, MCB department, University of California at Berkeley, Berkeley, CA 94705, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cellular and Developmental Biology, MCB department, University of California at Berkeley, Berkeley, CA 94705, USA","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148878354","display_name":"David Lin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Lin","raw_affiliation_strings":["Division of Cellular and Developmental Biology, MCB department, University of California at Berkeley, Berkeley, CA 94705, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cellular and Developmental Biology, MCB department, University of California at Berkeley, Berkeley, CA 94705, USA","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031286769","display_name":"Zhenyu Xuan","orcid":"https://orcid.org/0000-0001-9344-8493","observed_orcids":["https://orcid.org/0000-0001-9344-8493"]},"institutions":[{"id":"https://openalex.org/I162577319","display_name":"The University of Texas at Dallas","ror":"https://ror.org/049emcs32","country_code":"US","type":"education","lineage":["https://openalex.org/I162577319"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhenyu Xuan","raw_affiliation_strings":["Department of Biological Sciences, Center for Systems Biology, University of Texas at Dallas, Richardson, TX 75080, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Center for Systems Biology, University of Texas at Dallas, Richardson, TX 75080, USA","institution_ids":["https://openalex.org/I162577319"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015279818","display_name":"C. Shan Xu","orcid":"https://orcid.org/0000-0002-8564-7836","observed_orcids":["https://orcid.org/0000-0002-8564-7836"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I195573530","display_name":"Janelia Research Campus","ror":"https://ror.org/013sk6x84","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410","https://openalex.org/I195573530"]},{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C Shan Xu","raw_affiliation_strings":["Department of Cellular & Molecular Physiology, Yale School of Medicine, New Haven, CT 06510, USA","Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cellular & Molecular Physiology, Yale School of Medicine, New Haven, CT 06510, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I195573530"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068937717","display_name":"Harald F. Hess","orcid":"https://orcid.org/0000-0003-3000-1533","observed_orcids":["https://orcid.org/0000-0003-3000-1533"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I195573530","display_name":"Janelia Research Campus","ror":"https://ror.org/013sk6x84","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410","https://openalex.org/I195573530"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Harald F. Hess","raw_affiliation_strings":["Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I195573530"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018755353","display_name":"Srigokul Upadhyayula","orcid":"https://orcid.org/0000-0001-6727-5883","observed_orcids":["https://orcid.org/0000-0001-6727-5883","https://orcid.org/0000-0002-6911-0270"]},"institutions":[{"id":"https://openalex.org/I148283060","display_name":"Lawrence Berkeley National Laboratory","ror":"https://ror.org/02jbv0t02","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I148283060","https://openalex.org/I39565521"]},{"id":"https://openalex.org/I4210100286","display_name":"Chan Zuckerberg Biohub San Francisco","ror":"https://ror.org/00knt4f32","country_code":"US","type":"facility","lineage":["https://openalex.org/I180670191","https://openalex.org/I4210100286","https://openalex.org/I4210121800","https://openalex.org/I95457486","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Srigokul Upadhyayula","raw_affiliation_strings":["Chan Zuckerberg Biohub, San Francisco, CA, USA","Division of Cellular and Developmental Biology, MCB department, University of California at Berkeley, Berkeley, CA 94705, USA","Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chan Zuckerberg Biohub, San Francisco, CA, USA","institution_ids":["https://openalex.org/I4210100286"]},{"raw_affiliation_string":"Division of Cellular and Developmental Biology, MCB department, University of California at Berkeley, Berkeley, CA 94705, USA","institution_ids":["https://openalex.org/I95457486"]},{"raw_affiliation_string":"Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA","institution_ids":["https://openalex.org/I148283060"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081064913","display_name":"Lin He","orcid":"https://orcid.org/0000-0001-5928-1263","observed_orcids":["https://orcid.org/0000-0001-5928-1263"]},"institutions":[{"id":"https://openalex.org/I4210100286","display_name":"Chan Zuckerberg Biohub San Francisco","ror":"https://ror.org/00knt4f32","country_code":"US","type":"facility","lineage":["https://openalex.org/I180670191","https://openalex.org/I4210100286","https://openalex.org/I4210121800","https://openalex.org/I95457486","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Lin He","raw_affiliation_strings":["Chan Zuckerberg Biohub, San Francisco, CA, USA","Division of Cellular and Developmental Biology, MCB department, University of California at Berkeley, Berkeley, CA 94705, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chan Zuckerberg Biohub, San Francisco, CA, USA","institution_ids":["https://openalex.org/I4210100286"]},{"raw_affiliation_string":"Division of Cellular and Developmental Biology, MCB department, University of California at Berkeley, Berkeley, CA 94705, USA","institution_ids":["https://openalex.org/I95457486"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5081064913"],"corresponding_institution_ids":["https://openalex.org/I4210100286","https://openalex.org/I95457486"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11412","display_name":"Genetic and Kidney Cyst Diseases","score":0.8598999977111816,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11412","display_name":"Genetic and Kidney Cyst Diseases","score":0.8598999977111816,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11406","display_name":"Cerebrospinal fluid and hydrocephalus","score":0.09709999710321426,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.020999999716877937,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/choroid-plexus","display_name":"choroid plexus","score":0.9929999709129333},{"id":"https://openalex.org/keywords/multiciliogenesis","display_name":"multiciliogenesis","score":0.9539999961853027},{"id":"https://openalex.org/keywords/cerebrospinal-fluid-production","display_name":"cerebrospinal fluid production","score":0.9900000095367432},{"id":"https://openalex.org/keywords/sonic-hedgehog-signaling","display_name":"Sonic hedgehog signaling","score":0.9539999961853027},{"id":"https://openalex.org/keywords/hydrocephalus","display_name":"hydrocephalus","score":0.7400000095367432},{"id":"https://openalex.org/keywords/microcephaly","display_name":"microcephaly","score":0.9990000128746033},{"id":"https://openalex.org/keywords/brain-development","display_name":"brain development","score":0.4819999933242798}],"concepts":[{"id":"https://openalex.org/C195267511","wikidata":"https://www.wikidata.org/wiki/Q5119969","display_name":"Ciliogenesis","level":3,"score":0.9710000157356262},{"id":"https://openalex.org/C2776538271","wikidata":"https://www.wikidata.org/wiki/Q926250","display_name":"Choroid plexus","level":3,"score":0.7860999703407288},{"id":"https://openalex.org/C2776637008","wikidata":"https://www.wikidata.org/wiki/Q14860072","display_name":"Sonic hedgehog","level":3,"score":0.6837999820709229},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.679099977016449},{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.6705999970436096},{"id":"https://openalex.org/C2779651940","wikidata":"https://www.wikidata.org/wiki/Q54196","display_name":"Cerebrospinal fluid","level":2,"score":0.666700005531311},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.623199999332428},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.5325000286102295},{"id":"https://openalex.org/C100094513","wikidata":"https://www.wikidata.org/wiki/Q180436","display_name":"Cilium","level":2,"score":0.506600022315979},{"id":"https://openalex.org/C186310378","wikidata":"https://www.wikidata.org/wiki/Q941796","display_name":"Psychological repression","level":4,"score":0.4424000084400177},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.42969998717308044},{"id":"https://openalex.org/C88498014","wikidata":"https://www.wikidata.org/wiki/Q14859918","display_name":"Hedgehog signaling pathway","level":3,"score":0.42340001463890076},{"id":"https://openalex.org/C2778024521","wikidata":"https://www.wikidata.org/wiki/Q55639806","display_name":"Basal (medicine)","level":3,"score":0.3946000039577484},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.36239999532699585},{"id":"https://openalex.org/C203635412","wikidata":"https://www.wikidata.org/wiki/Q17007432","display_name":"Compartment (ship)","level":2,"score":0.3497999906539917},{"id":"https://openalex.org/C164659718","wikidata":"https://www.wikidata.org/wiki/Q5159266","display_name":"Conditional gene knockout","level":4,"score":0.34540000557899475},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.34439998865127563},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.33730000257492065},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.3025999963283539},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.30090001225471497},{"id":"https://openalex.org/C131934819","wikidata":"https://www.wikidata.org/wiki/Q135390","display_name":"Biogenesis","level":3,"score":0.27390000224113464},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.2632000148296356},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.25609999895095825}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.64898/2026.08.30.747939","doi":"https://doi.org/10.64898/2026.08.30.747939","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.30.747939","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/01/2026.08.30.747939.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:13684506","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13684506/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13684506/pdf/nihpp-2026.08.30.747939v1.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv","raw_type":"Text"},{"id":"pmid:42922535","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42922535","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.64898/2026.08.30.747939","doi":"https://doi.org/10.64898/2026.08.30.747939","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.30.747939","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/01/2026.08.30.747939.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.46810001134872437}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204892760.pdf","grobid_xml":"https://content.openalex.org/works/W7204892760.grobid-xml"},"referenced_works_count":71,"referenced_works":["https://openalex.org/W1471053741","https://openalex.org/W1495762998","https://openalex.org/W1588994353","https://openalex.org/W1972714642","https://openalex.org/W1996906010","https://openalex.org/W2014946489","https://openalex.org/W2021772330","https://openalex.org/W2029532148","https://openalex.org/W2031598882","https://openalex.org/W2038167014","https://openalex.org/W2044098675","https://openalex.org/W2047678214","https://openalex.org/W2054141330","https://openalex.org/W2059848983","https://openalex.org/W2069207545","https://openalex.org/W2079891083","https://openalex.org/W2088019375","https://openalex.org/W2091684557","https://openalex.org/W2092193387","https://openalex.org/W2095864300","https://openalex.org/W2096049380","https://openalex.org/W2101266961","https://openalex.org/W2103344845","https://openalex.org/W2110894673","https://openalex.org/W2114104545","https://openalex.org/W2117391818","https://openalex.org/W2131959123","https://openalex.org/W2134629862","https://openalex.org/W2138069365","https://openalex.org/W2142218173","https://openalex.org/W2144102348","https://openalex.org/W2144154026","https://openalex.org/W2162674813","https://openalex.org/W2168186256","https://openalex.org/W2169304714","https://openalex.org/W2187684510","https://openalex.org/W2253906470","https://openalex.org/W2259282260","https://openalex.org/W2289824882","https://openalex.org/W2498494766","https://openalex.org/W2554199252","https://openalex.org/W2783495962","https://openalex.org/W2884109281","https://openalex.org/W2930900438","https://openalex.org/W2941156663","https://openalex.org/W2951555881","https://openalex.org/W2965263411","https://openalex.org/W2981030064","https://openalex.org/W2993347499","https://openalex.org/W3005603509","https://openalex.org/W3007240445","https://openalex.org/W3125308054","https://openalex.org/W3157931598","https://openalex.org/W3173593974","https://openalex.org/W3182939646","https://openalex.org/W3204294504","https://openalex.org/W4211114670","https://openalex.org/W4220864729","https://openalex.org/W4229040286","https://openalex.org/W4285092133","https://openalex.org/W4321019150","https://openalex.org/W4387996317","https://openalex.org/W4388698293","https://openalex.org/W4400235675","https://openalex.org/W4401174362","https://openalex.org/W4403278401","https://openalex.org/W4403826697","https://openalex.org/W4404535307","https://openalex.org/W4405848405","https://openalex.org/W4408258877","https://openalex.org/W4410831132"],"related_works":["https://openalex.org/W4406697521","https://openalex.org/W4408258877","https://openalex.org/W2029532148","https://openalex.org/W4399787746","https://openalex.org/W2061349122","https://openalex.org/W2022120773","https://openalex.org/W3169159462","https://openalex.org/W2012319310","https://openalex.org/W4367173947","https://openalex.org/W2904900791"],"abstract_inverted_index":{"Abstract":[0],"A":[1,19],"developmental":[2,116,186,200],"increase":[3],"in":[4,80,134],"cerebrospinal":[5],"fluid":[6],"(CSF)":[7],"production":[8,24,86],"during":[9,58],"development":[10],"is":[11,25],"essential":[12,73],"for":[13],"neuronal":[14],"growth":[15],"and":[16,46,63,87,97,113,127,140,144,166,183],"ventricular":[17],"expansion.":[18],"key":[20],"regulator":[21,158],"of":[22,30,75,92,101,115,137,159,180,188,202],"CSF":[23,52,65,85,95,146,203],"the":[26,31,185],"specialized":[27],"sensory":[28],"multicilia":[29,55,190],"choroid":[32],"plexus":[33],"(ChP),":[34],"which":[35],"mediate":[36],"non-canonical":[37],"Sonic":[38],"hedgehog":[39],"(Shh)":[40],"signaling":[41,62,197],"to":[42,89,129,161,194,199],"suppress":[43],"water":[44,138],"channel":[45,139],"ion":[47,141],"transporter":[48,142],"expression,":[49],"thereby":[50],"limiting":[51],"production.":[53,66,147,204],"ChP":[54,76,122,181,189],"progressively":[56],"shortens":[57],"development,":[59],"attenuating":[60],"Shh":[61,131,196],"promoting":[64],"Here,":[67],"we":[68],"identify":[69,174],"miR-34/449":[70,93,102,120,149,175],"miRNAs":[71,103,150,176],"as":[72,177,191],"regulators":[74,179],"multiciliogenesis.":[77],"Whereas":[78],"mutations":[79],"canonical":[81],"ciliogenesis":[82],"genes":[83],"elevate":[84],"contribute":[88],"hydrocephaly,":[90],"deletion":[91],"reduces":[94],"volume":[96],"causes":[98,104],"microcephaly.":[99],"Loss":[100],"excessive":[105],"basal":[106,110,163,168],"body":[107,111,164,169],"amplification,":[108],"defective":[109],"docking,":[112],"failure":[114],"multiciliary":[117],"shortening.":[118],"Consequently,":[119],"-deficient":[121],"cilia":[123],"remain":[124],"abnormally":[125],"long":[126],"fail":[128],"attenuate":[130],"signaling,":[132],"resulting":[133],"sustained":[135],"repression":[136],"expression":[143],"reduced":[145],"Mechanistically,":[148],"directly":[151],"target":[152],"Gmnc":[153],",":[154],"a":[155,192],"master":[156],"transcriptional":[157],"multiciliogenesis,":[160],"restrain":[162],"amplification":[165],"promote":[167],"docking.":[170],"Together,":[171],"our":[172],"findings":[173],"critical":[178],"multiciliogenesis":[182],"establish":[184],"remodeling":[187],"mechanism":[193],"couple":[195],"dynamics":[198],"control":[201]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-09-02T00:00:00"}