{"id":"https://openalex.org/W7204882446","doi":"https://doi.org/10.1111/febs.70704","title":"Metabolic shifts driven by host\u2010microbial interactions","display_name":"Metabolic shifts driven by host\u2010microbial interactions","publication_year":2026,"publication_date":"2026-09-01","ids":{"openalex":"https://openalex.org/W7204882446","doi":"https://doi.org/10.1111/febs.70704","pmid":"https://pubmed.ncbi.nlm.nih.gov/42677452","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13561154"},"language":"en","primary_location":{"id":"doi:10.1111/febs.70704","doi":"https://doi.org/10.1111/febs.70704","is_oa":true,"landing_page_url":"https://doi.org/10.1111/febs.70704","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/febs.70704","source":{"id":"https://openalex.org/S37672443","display_name":"FEBS Journal","issn_l":"1742-464X","issn":["1742-464X","1742-4658"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FEBS Journal","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/febs.70704","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011496499","display_name":"Tripti Nair","orcid":"https://orcid.org/0000-0002-5380-4622","observed_orcids":["https://orcid.org/0000-0002-5380-4622"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tripti Nair","raw_affiliation_strings":["Leonard Davis School of Gerontology University of Southern California  Los Angeles USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leonard Davis School of Gerontology University of Southern California  Los Angeles USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086929085","display_name":"Nicole L. Stuhr","orcid":"https://orcid.org/0000-0003-2537-7114","observed_orcids":["https://orcid.org/0000-0003-2537-7114"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicole L. Stuhr","raw_affiliation_strings":["Leonard Davis School of Gerontology University of Southern California  Los Angeles USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leonard Davis School of Gerontology University of Southern California  Los Angeles USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010788546","display_name":"Brandy A. Weathers","orcid":"https://orcid.org/0000-0003-3972-0833","observed_orcids":["https://orcid.org/0000-0003-3972-0833"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brandy A. Weathers","raw_affiliation_strings":["Dornsife College of Letters, Arts, and Sciences University of Southern California  Los Angeles USA","Leonard Davis School of Gerontology University of Southern California  Los Angeles USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dornsife College of Letters, Arts, and Sciences University of Southern California  Los Angeles USA","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"Leonard Davis School of Gerontology University of Southern California  Los Angeles USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030553063","display_name":"Sean P. Curran","orcid":"https://orcid.org/0000-0001-7791-6453","observed_orcids":["https://orcid.org/0000-0001-7791-6453"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Sean P. Curran","raw_affiliation_strings":["Leonard Davis School of Gerontology University of Southern California  Los Angeles USA"],"raw_orcid":"https://orcid.org/0000-0001-7791-6453","affiliations":[{"raw_affiliation_string":"Leonard Davis School of Gerontology University of Southern California  Los Angeles USA","institution_ids":["https://openalex.org/I1174212"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5030553063"],"corresponding_institution_ids":["https://openalex.org/I1174212"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.36745286,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10152","display_name":"Animal Nutrition and Physiology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/host-microbiota-interactions","display_name":"host-microbiota interactions","score":0.8690000176429749},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.8270000219345093},{"id":"https://openalex.org/keywords/microbial-metabolism","display_name":"microbial metabolism","score":0.6840000152587891},{"id":"https://openalex.org/keywords/gut-microbiota-metabolites","display_name":"gut microbiota metabolites","score":0.8220000267028809},{"id":"https://openalex.org/keywords/short-chain-fatty-acids","display_name":"short-chain fatty acids","score":0.9020000100135803},{"id":"https://openalex.org/keywords/secondary-bile-acids","display_name":"secondary bile acids","score":0.9430000185966492},{"id":"https://openalex.org/keywords/sphingolipids","display_name":"sphingolipids","score":0.9990000128746033},{"id":"https://openalex.org/keywords/neuroimmune-interactions","display_name":"neuroimmune interactions","score":0.8009999990463257},{"id":"https://openalex.org/keywords/energy-homeostasis","display_name":"energy homeostasis","score":0.847000002861023},{"id":"https://openalex.org/keywords/immune-tolerance","display_name":"immune tolerance","score":0.9929999709129333},{"id":"https://openalex.org/keywords/immunometabolism","display_name":"immunometabolism","score":0.9380000233650208},{"id":"https://openalex.org/keywords/engineered-probiotics","display_name":"engineered probiotics","score":0.8130000233650208},{"id":"https://openalex.org/keywords/postbiotics","display_name":"postbiotics","score":0.9980000257492065},{"id":"https://openalex.org/keywords/dietary-intervention","display_name":"dietary intervention","score":0.8870000243186951},{"id":"https://openalex.org/keywords/metabolic-disorders","display_name":"metabolic disorders","score":0.5580000281333923},{"id":"https://openalex.org/keywords/inflammatory-diseases","display_name":"inflammatory diseases","score":0.9570000171661377}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.7893000245094299},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6636999845504761},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.6129000186920166},{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.6029000282287598},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.574999988079071},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.48089998960494995},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.44269999861717224},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.43619999289512634},{"id":"https://openalex.org/C2491326","wikidata":"https://www.wikidata.org/wiki/Q5377024","display_name":"Energy homeostasis","level":3,"score":0.4235999882221222},{"id":"https://openalex.org/C4733338","wikidata":"https://www.wikidata.org/wiki/Q2792936","display_name":"Lipid metabolism","level":2,"score":0.4083999991416931},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.3921999931335449},{"id":"https://openalex.org/C101014631","wikidata":"https://www.wikidata.org/wiki/Q4889568","display_name":"Microbial metabolism","level":3,"score":0.3862000107765198},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.375},{"id":"https://openalex.org/C126831891","wikidata":"https://www.wikidata.org/wiki/Q221673","display_name":"Host (biology)","level":2,"score":0.37369999289512634},{"id":"https://openalex.org/C193419808","wikidata":"https://www.wikidata.org/wiki/Q1645075","display_name":"Acquired immune system","level":3,"score":0.364300012588501},{"id":"https://openalex.org/C143121216","wikidata":"https://www.wikidata.org/wiki/Q1330402","display_name":"Microbiome","level":2,"score":0.3625999987125397},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3562999963760376},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3244999945163727},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.3131999969482422},{"id":"https://openalex.org/C2991704936","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Cell metabolism","level":3,"score":0.2872999906539917},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.27399998903274536},{"id":"https://openalex.org/C70818257","wikidata":"https://www.wikidata.org/wiki/Q502671","display_name":"Metabolic control analysis","level":3,"score":0.2687999904155731},{"id":"https://openalex.org/C177857423","wikidata":"https://www.wikidata.org/wiki/Q17077315","display_name":"Gut\u2013brain axis","level":3,"score":0.267300009727478},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.25769999623298645},{"id":"https://openalex.org/C2992479659","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut bacteria","level":3,"score":0.2556000053882599}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1111/febs.70704","doi":"https://doi.org/10.1111/febs.70704","is_oa":true,"landing_page_url":"https://doi.org/10.1111/febs.70704","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/febs.70704","source":{"id":"https://openalex.org/S37672443","display_name":"FEBS Journal","issn_l":"1742-464X","issn":["1742-464X","1742-4658"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FEBS Journal","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13561154","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13561154/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13561154/pdf/nihms-2203325.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS J","raw_type":"Text"},{"id":"pmid:42677452","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42677452","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FEBS journal","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1111/febs.70704","doi":"https://doi.org/10.1111/febs.70704","is_oa":true,"landing_page_url":"https://doi.org/10.1111/febs.70704","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/febs.70704","source":{"id":"https://openalex.org/S37672443","display_name":"FEBS Journal","issn_l":"1742-464X","issn":["1742-464X","1742-4658"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FEBS Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8199999928474426,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G624917217","display_name":null,"funder_award_id":"# AG052374","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000889950","display_name":"Multidisciplinary Research Training in Gerontology","funder_award_id":"T32AG000037","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000904475","display_name":"USC-Buck Geroscience Training in the Biology of Aging","funder_award_id":"T32AG052374","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204882446.pdf","grobid_xml":"https://content.openalex.org/works/W7204882446.grobid-xml"},"referenced_works_count":378,"referenced_works":["https://openalex.org/W207735856","https://openalex.org/W214549959","https://openalex.org/W958079127","https://openalex.org/W1013361806","https://openalex.org/W1496381585","https://openalex.org/W1515023627","https://openalex.org/W1527298303","https://openalex.org/W1560531583","https://openalex.org/W1569358416","https://openalex.org/W1887681162","https://openalex.org/W1892607853","https://openalex.org/W1918288286","https://openalex.org/W1932150911","https://openalex.org/W1942154378","https://openalex.org/W1969140399","https://openalex.org/W1969144895","https://openalex.org/W1970472465","https://openalex.org/W1970929490","https://openalex.org/W1972237932","https://openalex.org/W1974738011","https://openalex.org/W1977334935","https://openalex.org/W1977804070","https://openalex.org/W1978258044","https://openalex.org/W1980914602","https://openalex.org/W1981266729","https://openalex.org/W1988784113","https://openalex.org/W1989153933","https://openalex.org/W1989478912","https://openalex.org/W1991803083","https://openalex.org/W1993830991","https://openalex.org/W1997608252","https://openalex.org/W1999906527","https://openalex.org/W2003342633","https://openalex.org/W2006242918","https://openalex.org/W2012490955","https://openalex.org/W2015346570","https://openalex.org/W2015392958","https://openalex.org/W2019419945","https://openalex.org/W2022461628","https://openalex.org/W2023678020","https://openalex.org/W2025341515","https://openalex.org/W2032347125","https://openalex.org/W2032409964","https://openalex.org/W2033386838","https://openalex.org/W2034082915","https://openalex.org/W2035421462","https://openalex.org/W2039907390","https://openalex.org/W2042074642","https://openalex.org/W2044216294","https://openalex.org/W2045119680","https://openalex.org/W2046835799","https://openalex.org/W2048366349","https://openalex.org/W2048469790","https://openalex.org/W2049169935","https://openalex.org/W2049506766","https://openalex.org/W2050775091","https://openalex.org/W2051477844","https://openalex.org/W2052638070","https://openalex.org/W2053047691","https://openalex.org/W2053192064","https://openalex.org/W2054219549","https://openalex.org/W2057179832","https://openalex.org/W2057411492","https://openalex.org/W2060185417","https://openalex.org/W2071273298","https://openalex.org/W2072417345","https://openalex.org/W2073714219","https://openalex.org/W2076738925","https://openalex.org/W2077553363","https://openalex.org/W2078967065","https://openalex.org/W2082578477","https://openalex.org/W2084536789","https://openalex.org/W2087577664","https://openalex.org/W2089211646","https://openalex.org/W2091587044","https://openalex.org/W2096185853","https://openalex.org/W2096261918","https://openalex.org/W2096418655","https://openalex.org/W2097136349","https://openalex.org/W2097634036","https://openalex.org/W2097875133","https://openalex.org/W2099118557","https://openalex.org/W2102247752","https://openalex.org/W2103282960","https://openalex.org/W2103561589","https://openalex.org/W2104319202","https://openalex.org/W2104330483","https://openalex.org/W2106348916","https://openalex.org/W2109013909","https://openalex.org/W2110936821","https://openalex.org/W2112948254","https://openalex.org/W2114992666","https://openalex.org/W2115338196","https://openalex.org/W2117595393","https://openalex.org/W2120320533","https://openalex.org/W2122219120","https://openalex.org/W2127257837","https://openalex.org/W2128769815","https://openalex.org/W2131186249","https://openalex.org/W2132406938","https://openalex.org/W2140118176","https://openalex.org/W2143375187","https://openalex.org/W2145336165","https://openalex.org/W2150320991","https://openalex.org/W2151798187","https://openalex.org/W2152529866","https://openalex.org/W2155352361","https://openalex.org/W2155831195","https://openalex.org/W2156322705","https://openalex.org/W2158859130","https://openalex.org/W2160363801","https://openalex.org/W2160806376","https://openalex.org/W2162088497","https://openalex.org/W2162232168","https://openalex.org/W2164206394","https://openalex.org/W2165067288","https://openalex.org/W2167062509","https://openalex.org/W2170951108","https://openalex.org/W2175093233","https://openalex.org/W2176518920","https://openalex.org/W2192218028","https://openalex.org/W2226880851","https://openalex.org/W2254366662","https://openalex.org/W2274927794","https://openalex.org/W2292760617","https://openalex.org/W2398894736","https://openalex.org/W2403674481","https://openalex.org/W2409656339","https://openalex.org/W2417777372","https://openalex.org/W2464670218","https://openalex.org/W2468194934","https://openalex.org/W2469986620","https://openalex.org/W2470574011","https://openalex.org/W2471010858","https://openalex.org/W2538820375","https://openalex.org/W2539843576","https://openalex.org/W2548618596","https://openalex.org/W2550084345","https://openalex.org/W2554850339","https://openalex.org/W2559267012","https://openalex.org/W2560875835","https://openalex.org/W2580185958","https://openalex.org/W2581148273","https://openalex.org/W2608930323","https://openalex.org/W2611097527","https://openalex.org/W2613412247","https://openalex.org/W2614084593","https://openalex.org/W2625050143","https://openalex.org/W2627092521","https://openalex.org/W2734873447","https://openalex.org/W2735584664","https://openalex.org/W2737489098","https://openalex.org/W2738971267","https://openalex.org/W2743071411","https://openalex.org/W2753995352","https://openalex.org/W2755198076","https://openalex.org/W2761145411","https://openalex.org/W2761340437","https://openalex.org/W2762408398","https://openalex.org/W2768617092","https://openalex.org/W2769145826","https://openalex.org/W2782131523","https://openalex.org/W2793072766","https://openalex.org/W2793484970","https://openalex.org/W2799514384","https://openalex.org/W2807286371","https://openalex.org/W2807728333","https://openalex.org/W2807772034","https://openalex.org/W2810663189","https://openalex.org/W2863269164","https://openalex.org/W2886401819","https://openalex.org/W2886520863","https://openalex.org/W2887026479","https://openalex.org/W2892787249","https://openalex.org/W2896792752","https://openalex.org/W2897944860","https://openalex.org/W2898905022","https://openalex.org/W2903257997","https://openalex.org/W2910159017","https://openalex.org/W2911672024","https://openalex.org/W2914165558","https://openalex.org/W2917317910","https://openalex.org/W2944330168","https://openalex.org/W2946237477","https://openalex.org/W2946372752","https://openalex.org/W2951518977","https://openalex.org/W2956016709","https://openalex.org/W2965321915","https://openalex.org/W2972007077","https://openalex.org/W2981063663","https://openalex.org/W2981305867","https://openalex.org/W2982301513","https://openalex.org/W2987088324","https://openalex.org/W2990182987","https://openalex.org/W2995784855","https://openalex.org/W2996359250","https://openalex.org/W2996654920","https://openalex.org/W2997490540","https://openalex.org/W2999785229","https://openalex.org/W3003103558","https://openalex.org/W3004016955","https://openalex.org/W3006529931","https://openalex.org/W3013508607","https://openalex.org/W3017326172","https://openalex.org/W3024651515","https://openalex.org/W3026296114","https://openalex.org/W3030200736","https://openalex.org/W3032030481","https://openalex.org/W3032722136","https://openalex.org/W3034006506","https://openalex.org/W3035220713","https://openalex.org/W3043621662","https://openalex.org/W3044346819","https://openalex.org/W3045231380","https://openalex.org/W3083367387","https://openalex.org/W3092672783","https://openalex.org/W3093234803","https://openalex.org/W3094545640","https://openalex.org/W3096637732","https://openalex.org/W3097883702","https://openalex.org/W3106931136","https://openalex.org/W3129925389","https://openalex.org/W3133888684","https://openalex.org/W3137495763","https://openalex.org/W3137815362","https://openalex.org/W3142049344","https://openalex.org/W3148890734","https://openalex.org/W3156209056","https://openalex.org/W3158478727","https://openalex.org/W3159386017","https://openalex.org/W3159676560","https://openalex.org/W3163767088","https://openalex.org/W3175895832","https://openalex.org/W3179751498","https://openalex.org/W3182386283","https://openalex.org/W3183294185","https://openalex.org/W3184167136","https://openalex.org/W3186544027","https://openalex.org/W3194237546","https://openalex.org/W3194826249","https://openalex.org/W3198868321","https://openalex.org/W3209369260","https://openalex.org/W3212098597","https://openalex.org/W3212361944","https://openalex.org/W4200415894","https://openalex.org/W4200445285","https://openalex.org/W4200614723","https://openalex.org/W4205198488","https://openalex.org/W4205459581","https://openalex.org/W4206424915","https://openalex.org/W4210359159","https://openalex.org/W4214737882","https://openalex.org/W4220731595","https://openalex.org/W4220948032","https://openalex.org/W4220989159","https://openalex.org/W4221107992","https://openalex.org/W4224299692","https://openalex.org/W4225286465","https://openalex.org/W4243833541","https://openalex.org/W4280562538","https://openalex.org/W4283079580","https://openalex.org/W4283522546","https://openalex.org/W4285028377","https://openalex.org/W4289174576","https://openalex.org/W4294751349","https://openalex.org/W4296583494","https://openalex.org/W4297236086","https://openalex.org/W4306649929","https://openalex.org/W4308364988","https://openalex.org/W4309181475","https://openalex.org/W4310035855","https://openalex.org/W4313388973","https://openalex.org/W4313827666","https://openalex.org/W4315798036","https://openalex.org/W4318612256","https://openalex.org/W4318706875","https://openalex.org/W4320491888","https://openalex.org/W4322494072","https://openalex.org/W4323665971","https://openalex.org/W4323840370","https://openalex.org/W4324370098","https://openalex.org/W4360601048","https://openalex.org/W4361280489","https://openalex.org/W4362525665","https://openalex.org/W4362558806","https://openalex.org/W4362664359","https://openalex.org/W4367626460","https://openalex.org/W4367842138","https://openalex.org/W4375956143","https://openalex.org/W4378783345","https://openalex.org/W4381149534","https://openalex.org/W4382362242","https://openalex.org/W4383723770","https://openalex.org/W4385214200","https://openalex.org/W4385274104","https://openalex.org/W4385422699","https://openalex.org/W4385611625","https://openalex.org/W4385728373","https://openalex.org/W4385850796","https://openalex.org/W4386022570","https://openalex.org/W4386559278","https://openalex.org/W4386796062","https://openalex.org/W4387372674","https://openalex.org/W4387741623","https://openalex.org/W4387843737","https://openalex.org/W4387878132","https://openalex.org/W4388446531","https://openalex.org/W4388894204","https://openalex.org/W4390238800","https://openalex.org/W4390665451","https://openalex.org/W4391430149","https://openalex.org/W4391873493","https://openalex.org/W4392401747","https://openalex.org/W4392795087","https://openalex.org/W4392964402","https://openalex.org/W4393053214","https://openalex.org/W4393398521","https://openalex.org/W4393934910","https://openalex.org/W4395445997","https://openalex.org/W4395669807","https://openalex.org/W4399290063","https://openalex.org/W4400411818","https://openalex.org/W4401057212","https://openalex.org/W4401345144","https://openalex.org/W4401471986","https://openalex.org/W4401537623","https://openalex.org/W4401544042","https://openalex.org/W4402197596","https://openalex.org/W4402580845","https://openalex.org/W4402849815","https://openalex.org/W4403548941","https://openalex.org/W4403809065","https://openalex.org/W4403901992","https://openalex.org/W4403925894","https://openalex.org/W4403990587","https://openalex.org/W4404054835","https://openalex.org/W4404107464","https://openalex.org/W4404218131","https://openalex.org/W4407003518","https://openalex.org/W4407084052","https://openalex.org/W4407229971","https://openalex.org/W4407609697","https://openalex.org/W4408694322","https://openalex.org/W4408991883","https://openalex.org/W4409081038","https://openalex.org/W4409205434","https://openalex.org/W4409414699","https://openalex.org/W4409449234","https://openalex.org/W4409637340","https://openalex.org/W4409639782","https://openalex.org/W4409688818","https://openalex.org/W4409966908","https://openalex.org/W4410219709","https://openalex.org/W4410252354","https://openalex.org/W4410362948","https://openalex.org/W4410550085","https://openalex.org/W4410885073","https://openalex.org/W4411661336","https://openalex.org/W4412438332","https://openalex.org/W4412570114","https://openalex.org/W4412698727","https://openalex.org/W4412741143","https://openalex.org/W4412817464","https://openalex.org/W4413298453","https://openalex.org/W4413471081","https://openalex.org/W4413612218","https://openalex.org/W4413799646","https://openalex.org/W4414137838","https://openalex.org/W4414919622","https://openalex.org/W4415024924","https://openalex.org/W4415947693","https://openalex.org/W4416733524","https://openalex.org/W4417230997","https://openalex.org/W7117298112","https://openalex.org/W7117555590","https://openalex.org/W7122809279","https://openalex.org/W7125584977","https://openalex.org/W7126438967"],"related_works":["https://openalex.org/W2946826655","https://openalex.org/W4225670271","https://openalex.org/W4414299144","https://openalex.org/W7165473143","https://openalex.org/W3017930057","https://openalex.org/W1033375108","https://openalex.org/W3173501502","https://openalex.org/W4318542633","https://openalex.org/W3097540286","https://openalex.org/W4411516732"],"abstract_inverted_index":{"Host-microbe":[0],"interactions":[1],"within":[2],"the":[3,10,31,42],"gut":[4,36,142],"have":[5],"been":[6],"extensively":[7],"reviewed":[8],"in":[9,39],"context":[11],"of":[12,49,62,73,99],"host":[13,43,133],"immune":[14,24,83,139,145],"response.":[15],"Emerging":[16],"evidence,":[17],"however,":[18],"highlights":[19],"that":[20,52,76,156],"these":[21],"inflammatory":[22,185],"and":[23,55,79,85,114,127,147,166,180,184],"outcomes":[25],"are":[26],"often":[27],"deeply":[28],"intertwined":[29],"with":[30,41],"microbiome-derived":[32],"secondary":[33,108],"metabolites.":[34],"The":[35],"microbiota":[37],"functions":[38,140],"concert":[40],"by":[44],"providing":[45],"an":[46],"extensive":[47],"repertoire":[48],"metabolic":[50,159,183],"enzymes":[51],"enhance":[53],"digestion":[54],"capacity":[56],"to":[57,131],"assimilate":[58],"a":[59,70,95,173],"broad":[60],"spectrum":[61],"ingested":[63],"food":[64],"sources.":[65],"This":[66],"symbiotic":[67],"metabolism":[68,93,171],"generates":[69],"diverse":[71],"array":[72],"bioactive":[74],"metabolites":[75],"shape":[77],"local":[78],"systemic":[80],"physiology,":[81],"adaptive":[82],"responses,":[84],"neuroimmune":[86,148],"responses.":[87],"Here,":[88],"we":[89,151],"focus":[90],"on":[91],"microbial":[92,158,170],"as":[94,172],"central":[96],"organizing":[97],"principle":[98],"host-microbiota":[100],"symbiosis.":[101],"Microbiota-derived":[102],"metabolites,":[103],"including":[104],"short-chain":[105],"fatty":[106],"acids,":[107,110],"bile":[109],"tryptophan-derived":[111],"indoles,":[112],"sphingolipids,":[113],"gaseous":[115],"byproducts,":[116],"signal":[117],"through":[118],"downstream":[119],"molecular":[120],"partners":[121],"like":[122,141],"nuclear":[123],"receptors,":[124],"transcriptional":[125],"regulators,":[126],"redox-sensitive":[128],"homeostatic":[129],"pathways":[130],"regulate":[132],"energy":[134],"homeostasis,":[135],"but":[136],"also":[137],"alter":[138],"epithelial":[143],"integrity,":[144],"tolerance,":[146],"crosstalk.":[149],"Finally,":[150],"discuss":[152],"emerging":[153],"therapeutic":[154],"strategies":[155],"target":[157],"functions-including":[160],"dietary":[161],"interventions,":[162],"engineered":[163],"probiotics,":[164],"postbiotics,":[165],"receptor-directed":[167],"approaches-that":[168],"position":[169],"tractable":[174],"axis":[175],"for":[176],"modulating":[177],"immunometabolism":[178],"homeostasis":[179],"potentially":[181],"mitigating":[182],"diseases.":[186]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2026-09-02T00:00:00"}