{"id":"https://openalex.org/W7204880982","doi":"https://doi.org/10.5339/avi.2026.12","title":"Hepatic protection of resveratrol in mice injected with a virulent strain of Brucella melitensis","display_name":"Hepatic protection of resveratrol in mice injected with a virulent strain of Brucella melitensis","publication_year":2026,"publication_date":"2026-01-01","ids":{"openalex":"https://openalex.org/W7204880982","doi":"https://doi.org/10.5339/avi.2026.12"},"language":"en","primary_location":{"id":"doi:10.5339/avi.2026.12","doi":"https://doi.org/10.5339/avi.2026.12","is_oa":true,"landing_page_url":"https://doi.org/10.5339/avi.2026.12","pdf_url":null,"source":{"id":"https://openalex.org/S4210214206","display_name":"Avicenna","issn_l":"2220-2749","issn":["2220-2749"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","dongbi-c","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310320064","host_organization_name":"HBKU Press","host_organization_lineage":["https://openalex.org/P4310320064"],"host_organization_lineage_names":["HBKU Press"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Avicenna","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.5339/avi.2026.12","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073810591","display_name":"K.J. Awni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115078","display_name":"Middle Technical University","ror":"https://ror.org/02fvkg758","country_code":"IQ","type":"education","lineage":["https://openalex.org/I4210115078"]}],"countries":["IQ"],"is_corresponding":false,"raw_author_name":"K. J. Awni","raw_affiliation_strings":["Department of Medical Laboratory, Middle Technical University, Balad Technical Institute, Balad, Iraq"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Laboratory, Middle Technical University, Balad Technical Institute, Balad, Iraq","institution_ids":["https://openalex.org/I4210115078"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078388508","display_name":"Ali Reyadh Medhat","orcid":"https://orcid.org/0009-0006-0965-9911","observed_orcids":["https://orcid.org/0009-0006-0965-9911"]},"institutions":[{"id":"https://openalex.org/I4210115078","display_name":"Middle Technical University","ror":"https://ror.org/02fvkg758","country_code":"IQ","type":"education","lineage":["https://openalex.org/I4210115078"]}],"countries":["IQ"],"is_corresponding":false,"raw_author_name":"Ali Reyadh Medhat","raw_affiliation_strings":["Department of Medical Laboratory, Middle Technical University, Balad Technical Institute, Balad, Iraq"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Laboratory, Middle Technical University, Balad Technical Institute, Balad, Iraq","institution_ids":["https://openalex.org/I4210115078"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049145042","display_name":"Mustafa T. ALbaldawy","orcid":"https://orcid.org/0000-0002-6337-7345","observed_orcids":["https://orcid.org/0000-0002-6337-7345"]},"institutions":[{"id":"https://openalex.org/I4210115078","display_name":"Middle Technical University","ror":"https://ror.org/02fvkg758","country_code":"IQ","type":"education","lineage":["https://openalex.org/I4210115078"]}],"countries":["IQ"],"is_corresponding":false,"raw_author_name":"Mustafa T. ALbaldawy","raw_affiliation_strings":["Department of Medical Laboratory, Middle Technical University, Balad Technical Institute, Balad, Iraq"],"raw_orcid":"https://orcid.org/0000-0002-6337-7345","affiliations":[{"raw_affiliation_string":"Department of Medical Laboratory, Middle Technical University, Balad Technical Institute, Balad, Iraq","institution_ids":["https://openalex.org/I4210115078"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210115078"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"2026","issue":"2","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11899","display_name":"Brucella: diagnosis, epidemiology, treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11899","display_name":"Brucella: diagnosis, epidemiology, treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11051","display_name":"Sirtuins and Resveratrol in Medicine","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/resveratrol","display_name":"resveratrol","score":1.0},{"id":"https://openalex.org/keywords/brucella-melitensis","display_name":"Brucella melitensis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/brucellosis","display_name":"brucellosis","score":0.9950000047683716},{"id":"https://openalex.org/keywords/hepatoprotective-effect","display_name":"hepatoprotection","score":0.8560000061988831},{"id":"https://openalex.org/keywords/liver-enzymes","display_name":"liver enzymes","score":0.8199999928474426},{"id":"https://openalex.org/keywords/liver-histopathology","display_name":"liver histopathology","score":0.8009999990463257},{"id":"https://openalex.org/keywords/liver-abscess","display_name":"liver abscess","score":0.7649999856948853},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.5759999752044678},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.9110000133514404},{"id":"https://openalex.org/keywords/polyphenols","display_name":"polyphenols","score":0.6050000190734863}],"concepts":[{"id":"https://openalex.org/C2777692091","wikidata":"https://www.wikidata.org/wiki/Q3512031","display_name":"Brucella melitensis","level":4,"score":0.8349999785423279},{"id":"https://openalex.org/C2776816829","wikidata":"https://www.wikidata.org/wiki/Q407329","display_name":"Resveratrol","level":2,"score":0.7684000134468079},{"id":"https://openalex.org/C2779679107","wikidata":"https://www.wikidata.org/wiki/Q412474","display_name":"Aspartate transaminase","level":4,"score":0.5600000023841858},{"id":"https://openalex.org/C2778606649","wikidata":"https://www.wikidata.org/wiki/Q305481","display_name":"Alanine transaminase","level":2,"score":0.5365999937057495},{"id":"https://openalex.org/C2776877979","wikidata":"https://www.wikidata.org/wiki/Q424288","display_name":"Transaminase","level":3,"score":0.5309000015258789},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.5304999947547913},{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.49720001220703125},{"id":"https://openalex.org/C2781429187","wikidata":"https://www.wikidata.org/wiki/Q156050","display_name":"Brucellosis","level":2,"score":0.4959000051021576},{"id":"https://openalex.org/C160160445","wikidata":"https://www.wikidata.org/wiki/Q24769688","display_name":"Alkaline phosphatase","level":3,"score":0.47909998893737793},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.4487999975681305},{"id":"https://openalex.org/C2778022156","wikidata":"https://www.wikidata.org/wiki/Q576145","display_name":"Strain (injury)","level":2,"score":0.44600000977516174},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39239999651908875},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3781999945640564},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.36570000648498535},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3537999987602234},{"id":"https://openalex.org/C28212737","wikidata":"https://www.wikidata.org/wiki/Q5381543","display_name":"Enzyme assay","level":3,"score":0.33469998836517334},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3215999901294708},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3091999888420105},{"id":"https://openalex.org/C178666793","wikidata":"https://www.wikidata.org/wiki/Q422476","display_name":"Phosphatase","level":3,"score":0.30790001153945923},{"id":"https://openalex.org/C2992872382","wikidata":"https://www.wikidata.org/wiki/Q305481","display_name":"Alanine aminotransferase","level":2,"score":0.3025999963283539},{"id":"https://openalex.org/C3020359197","wikidata":"https://www.wikidata.org/wiki/Q1359801","display_name":"Liver enzyme","level":2,"score":0.2842999994754791},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.28369998931884766},{"id":"https://openalex.org/C119795356","wikidata":"https://www.wikidata.org/wiki/Q407801","display_name":"Isozyme","level":3,"score":0.2777000069618225},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2606000006198883},{"id":"https://openalex.org/C2777397205","wikidata":"https://www.wikidata.org/wiki/Q275792","display_name":"Saline","level":2,"score":0.2556000053882599}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.5339/avi.2026.12","doi":"https://doi.org/10.5339/avi.2026.12","is_oa":true,"landing_page_url":"https://doi.org/10.5339/avi.2026.12","pdf_url":null,"source":{"id":"https://openalex.org/S4210214206","display_name":"Avicenna","issn_l":"2220-2749","issn":["2220-2749"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","dongbi-c","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310320064","host_organization_name":"HBKU Press","host_organization_lineage":["https://openalex.org/P4310320064"],"host_organization_lineage_names":["HBKU Press"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Avicenna","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.5339/avi.2026.12","doi":"https://doi.org/10.5339/avi.2026.12","is_oa":true,"landing_page_url":"https://doi.org/10.5339/avi.2026.12","pdf_url":null,"source":{"id":"https://openalex.org/S4210214206","display_name":"Avicenna","issn_l":"2220-2749","issn":["2220-2749"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","dongbi-c","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310320064","host_organization_name":"HBKU Press","host_organization_lineage":["https://openalex.org/P4310320064"],"host_organization_lineage_names":["HBKU Press"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Avicenna","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W1967234985","https://openalex.org/W1972852504","https://openalex.org/W2000851115","https://openalex.org/W2007406202","https://openalex.org/W2017821807","https://openalex.org/W2027333823","https://openalex.org/W2052656267","https://openalex.org/W2083265739","https://openalex.org/W2109809365","https://openalex.org/W2161109243","https://openalex.org/W2793020488","https://openalex.org/W2903589122","https://openalex.org/W3028522915","https://openalex.org/W3047012230","https://openalex.org/W3142316465","https://openalex.org/W4225625518","https://openalex.org/W4282970276","https://openalex.org/W4316804698","https://openalex.org/W4385759346","https://openalex.org/W4390745023"],"related_works":["https://openalex.org/W2366083051","https://openalex.org/W2971124185","https://openalex.org/W3128791953","https://openalex.org/W2948868272","https://openalex.org/W2373426305","https://openalex.org/W2344856396","https://openalex.org/W7071185776","https://openalex.org/W2418851761","https://openalex.org/W2076495242","https://openalex.org/W4234857323"],"abstract_inverted_index":{"ABSTRACT":[0],"Introduction:":[1],"Resveratrol,":[2],"a":[3,95,109,124],"natural":[4],"polyphenolic":[5],"compound":[6],"of":[7,35,61,102,132,181,259,275,289,299],"the":[8,28,36,44,54,59,178,182,253,257,273,281,287],"stilbene":[9],"group,":[10],"has":[11],"various":[12],"biochemical":[13],"and":[14,23,46,66,164,186,211,232,246,266,272,294,318],"physiological":[15],"effects":[16],"such":[17,255],"as":[18,94,123,256,314],"anti-inflammatory,":[19,317],"antioxidative,":[20],"anticarcinogenic,":[21],"antiproliferative,":[22],"chemopreventive":[24],"effects.":[25],"Brucellosis":[26],"is":[27,39,53],"most":[29,55],"important":[30],"zoonosis":[31],"in":[32,63,84,227,252,280],"several":[33],"parts":[34,195],"world.":[37],"It":[38],"still":[40],"endemic,":[41],"affecting":[42],"both":[43,64],"financial":[45],"public":[47],"health":[48],"sectors.":[49],"Brucella":[50],"melitensis":[51,82,112,150,158,310],"species":[52],"pathogenic,":[56],"responsible":[57],"for":[58,196,201],"abortion":[60],"pregnancy":[62],"animals":[65],"humans.":[67],"Methods:":[68],"The":[69,223,297],"present":[70],"study":[71,301],"was":[72,134,154],"designed":[73],"to":[74,136,191,217,229],"improve":[75],"liver":[76,194,219,241],"enzymes":[77],"by":[78,312],"resveratrol":[79,133,142,166,304],"against":[80],"B.":[81,111,149,157,309],"injected":[83],"mice.":[85],"Fifty":[86],"mice":[87,171],"were":[88,175,215],"split":[89],"equally":[90],"into":[91],"five":[92],"groups:":[93],"control,":[96],"Group":[97,106,137,139,152],"1":[98],"administered":[99],"0.3":[100],"mL":[101],"normal":[103],"saline":[104],"orally.":[105],"2":[107,237],"received":[108,141],"virulent":[110],"strain":[113],"(1":[114,159],"\u00d7":[115,160],"10":[116,128,161],"8":[117,162],")":[118,163],"CFU/mL":[119],"I/P":[120],"infection,":[121],"acting":[122,313],"control":[125],"positive.":[126],"A":[127],"mg/kg":[129,144,168],"B.W.":[130],"dose":[131],"given":[135,165],"3.":[138],"4":[140],"(10":[143,167],"B.W.)":[145],"treatment":[146],"after":[147,270],"contracting":[148],".":[151],"5":[153],"infected":[155],"with":[156,234,262,284,286],"B.W.).":[169],"Five":[170],"from":[172,308],"each":[173],"group":[174,236],"killed":[176],"at":[177,244],"halfway":[179],"point":[180],"trial,":[183],"on":[184],"30":[185,245],"60":[187,247],"days.":[188],"In":[189],"addition":[190],"processing":[192],"small":[193],"histopathology,":[197],"blood":[198],"enzyme":[199,220],"tests":[200],"alanine":[202],"transaminase":[203,206],"(ALT),":[204],"aspartate":[205],"(AST),":[207],"alkaline":[208],"phosphatase":[209],"(ALP),":[210],"gamma-glutamyl":[212],"transpeptidase":[213],"(GGT)":[214],"performed":[216],"determine":[218],"levels.":[221],"Results:":[222],"findings":[224,298],"revealed":[225],"that,":[226],"comparison":[228],"groups":[230],"(G1":[231],"G3":[233],"G5),":[235],"(G2)":[238],"had":[239],"higher":[240],"enzymatic":[242],"levels":[243],"days,":[248],"severe":[249],"pathological":[250],"consequences":[251],"liver,":[254],"development":[258],"an":[260,315],"abscess":[261,283],"hepatic":[263],"injury,":[264],"damage,":[265],"necrosis":[267],"thirty":[268],"days":[269],"infection":[271,311],"occurrence":[274],"inflammatory":[276,290],"cells,":[277,291],"particularly":[278,292],"neutrophils,":[279],"micro":[282],"pyogranuloma":[285],"infiltration":[288],"lymphocytes":[293],"macrophages.":[295],"Conclusion:":[296],"this":[300],"indicate":[302],"that":[303],"protects":[305],"mice\u2019s":[306],"livers":[307],"antioxidant,":[316],"anti-cancer":[319],"agent.":[320]},"counts_by_year":[],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2026-09-02T00:00:00"}
