{"id":"https://openalex.org/W7204865657","doi":"https://doi.org/10.1007/978-1-0716-5292-3_22","title":"Targeted Degradation of Mouse Embryo Proteins Using Trim-Away","display_name":"Targeted Degradation of Mouse Embryo Proteins Using Trim-Away","publication_year":2026,"publication_date":"2026-01-01","ids":{"openalex":"https://openalex.org/W7204865657","doi":"https://doi.org/10.1007/978-1-0716-5292-3_22","pmid":"https://pubmed.ncbi.nlm.nih.gov/42681395"},"language":"en","primary_location":{"id":"doi:10.1007/978-1-0716-5292-3_22","doi":"https://doi.org/10.1007/978-1-0716-5292-3_22","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-0716-5292-3_22","pdf_url":null,"source":{"id":"https://openalex.org/S4210172139","display_name":"Methods in molecular biology","issn_l":"1064-3745","issn":["1064-3745","1940-6029"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Methods in Molecular Biology","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W7204970340","display_name":"The Preimplantation Embryo"},"type":"book-chapter","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111069871","display_name":"Thomas Nolte","orcid":"https://orcid.org/0000-0002-6566-0240","observed_orcids":["https://orcid.org/0000-0002-6566-0240"]},"institutions":[{"id":"https://openalex.org/I4210152666","display_name":"Max Planck Institute for Molecular Biomedicine","ror":"https://ror.org/040djv263","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210152666"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Thomas Nolte","raw_affiliation_strings":["Max Planck Institute for Molecular Biomedicine, Muenster, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max Planck Institute for Molecular Biomedicine, Muenster, Germany","institution_ids":["https://openalex.org/I4210152666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060257265","display_name":"Steffen Israel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210152666","display_name":"Max Planck Institute for Molecular Biomedicine","ror":"https://ror.org/040djv263","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210152666"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Steffen Israel","raw_affiliation_strings":["Max Planck Institute for Molecular Biomedicine, Muenster, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max Planck Institute for Molecular Biomedicine, Muenster, Germany","institution_ids":["https://openalex.org/I4210152666"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050130710","display_name":"Michele Boiani","orcid":"https://orcid.org/0000-0003-2765-2781","observed_orcids":["https://orcid.org/0000-0003-2765-2781"]},"institutions":[{"id":"https://openalex.org/I4210152666","display_name":"Max Planck Institute for Molecular Biomedicine","ror":"https://ror.org/040djv263","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210152666"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Michele Boiani","raw_affiliation_strings":["Max Planck Institute for Molecular Biomedicine, Muenster, Germany. mboiani@mpi-muenster.mpg.de"],"raw_orcid":"https://orcid.org/0000-0003-2765-2781","affiliations":[{"raw_affiliation_string":"Max Planck Institute for Molecular Biomedicine, Muenster, Germany. mboiani@mpi-muenster.mpg.de","institution_ids":["https://openalex.org/I4210152666"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5050130710"],"corresponding_institution_ids":["https://openalex.org/I4210152666"],"apc_list":null,"apc_paid":null,"fwci":15.7936,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.98896435,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"3038","issue":null,"first_page":"399","last_page":"423"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12534","display_name":"Protein Degradation and Inhibitors","score":0.3799000084400177,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12534","display_name":"Protein Degradation and Inhibitors","score":0.3799000084400177,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":0.18790000677108765,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.14560000598430634,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mouse-embryo","display_name":"mouse embryo","score":0.7670000195503235},{"id":"https://openalex.org/keywords/zygote","display_name":"zygote","score":0.734000027179718},{"id":"https://openalex.org/keywords/microinjection","display_name":"microinjection","score":0.9700000286102295},{"id":"https://openalex.org/keywords/e-cadherin","display_name":"E-cadherin","score":0.8790000081062317},{"id":"https://openalex.org/keywords/experimental-control","display_name":"experimental control","score":0.5740000009536743},{"id":"https://openalex.org/keywords/protein-function","display_name":"protein function","score":0.6230000257492065}],"concepts":[{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5827000141143799},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.5343999862670898},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5139999985694885},{"id":"https://openalex.org/C2779679103","wikidata":"https://www.wikidata.org/wiki/Q5251805","display_name":"Degradation (telecommunications)","level":2,"score":0.41589999198913574},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36570000648498535},{"id":"https://openalex.org/C87073359","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryogenesis","level":3,"score":0.33970001339912415},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3131999969482422},{"id":"https://openalex.org/C2992195973","wikidata":"https://www.wikidata.org/wiki/Q33123","display_name":"Protein degradation","level":2,"score":0.29269999265670776},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.29179999232292175},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.28369998931884766},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.28060001134872437},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.26420000195503235},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.25519999861717224},{"id":"https://openalex.org/C174510640","wikidata":"https://www.wikidata.org/wiki/Q489618","display_name":"HEK 293 cells","level":3,"score":0.25440001487731934},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.2529999911785126}],"mesh":[{"descriptor_ui":"D000099207","descriptor_name":"SS-A Antigen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000099208","descriptor_name":"TRIM21 Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004622","descriptor_name":"Embryo, Mammalian","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008845","descriptor_name":"Microinjections","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009865","descriptor_name":"Oocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012261","descriptor_name":"Ribonucleoproteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012261","descriptor_name":"Ribonucleoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015820","descriptor_name":"Cadherins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059748","descriptor_name":"Proteolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1007/978-1-0716-5292-3_22","doi":"https://doi.org/10.1007/978-1-0716-5292-3_22","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-0716-5292-3_22","pdf_url":null,"source":{"id":"https://openalex.org/S4210172139","display_name":"Methods in molecular biology","issn_l":"1064-3745","issn":["1064-3745","1940-6029"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Methods in Molecular Biology","raw_type":"book-chapter"},{"id":"pmid:42681395","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42681395","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Methods in molecular biology (Clifton, N.J.)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W1936618403","https://openalex.org/W1950598818","https://openalex.org/W1967761542","https://openalex.org/W1979780600","https://openalex.org/W1985213868","https://openalex.org/W1985512165","https://openalex.org/W1996419268","https://openalex.org/W2021848169","https://openalex.org/W2022205071","https://openalex.org/W2030522563","https://openalex.org/W2038358949","https://openalex.org/W2045233723","https://openalex.org/W2052172534","https://openalex.org/W2079346360","https://openalex.org/W2140471823","https://openalex.org/W2177743576","https://openalex.org/W2327864955","https://openalex.org/W2472151583","https://openalex.org/W2735720719","https://openalex.org/W2769995426","https://openalex.org/W2806543441","https://openalex.org/W2893792887","https://openalex.org/W2981861857","https://openalex.org/W3088405549","https://openalex.org/W3092216297","https://openalex.org/W3093053585","https://openalex.org/W3108929519","https://openalex.org/W3130816211","https://openalex.org/W3150355302","https://openalex.org/W3160292978","https://openalex.org/W3182968854","https://openalex.org/W3206027303","https://openalex.org/W4225472167","https://openalex.org/W4225898999","https://openalex.org/W4288080898","https://openalex.org/W4316664764","https://openalex.org/W4321378358","https://openalex.org/W4388423020","https://openalex.org/W4398140546","https://openalex.org/W4404007819","https://openalex.org/W4408649459"],"related_works":["https://openalex.org/W2893792887","https://openalex.org/W7006392123","https://openalex.org/W2769995426","https://openalex.org/W2981861857","https://openalex.org/W2783053152","https://openalex.org/W4404007819","https://openalex.org/W4408649459","https://openalex.org/W7172554958","https://openalex.org/W4404827632","https://openalex.org/W3206027303"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2026-09-02T00:00:00"}