{"id":"https://openalex.org/W7204847769","doi":"https://doi.org/10.2174/0113862073450412260807073516","title":"Therapeutic Mechanism of Huayu Zhitong Plaster in Acute Soft Tissue Injury Rats via the PI3K/Akt/NF-\u03baB Signaling Pathway","display_name":"Therapeutic Mechanism of Huayu Zhitong Plaster in Acute Soft Tissue Injury Rats via the PI3K/Akt/NF-\u03baB Signaling Pathway","publication_year":2026,"publication_date":"2026-08-31","ids":{"openalex":"https://openalex.org/W7204847769","doi":"https://doi.org/10.2174/0113862073450412260807073516","pmid":"https://pubmed.ncbi.nlm.nih.gov/42708303"},"language":"en","primary_location":{"id":"doi:10.2174/0113862073450412260807073516","doi":"https://doi.org/10.2174/0113862073450412260807073516","is_oa":false,"landing_page_url":"https://doi.org/10.2174/0113862073450412260807073516","pdf_url":null,"source":{"id":"https://openalex.org/S50933791","display_name":"Combinatorial Chemistry & High Throughput Screening","issn_l":"1386-2073","issn":["1386-2073","1875-5402"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Combinatorial Chemistry &amp; High Throughput Screening","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100375363","display_name":"Xiaohui Liu","orcid":"https://orcid.org/0000-0002-4413-8509","observed_orcids":["https://orcid.org/0000-0002-4413-8509"]},"institutions":[{"id":"https://openalex.org/I14992734","display_name":"Hunan University of Traditional Chinese Medicine","ror":"https://ror.org/05qfq0x09","country_code":"CN","type":"education","lineage":["https://openalex.org/I14992734"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liu Xiaohui","raw_affiliation_strings":["Hunan Provincial Key Laboratory of Quality Evaluation of Hunan Bulk Medicinal Materials, Changsha 410208,Hunan, China","School of Pharmacy, Hunan University of Traditional Chinese Medicine, Changsha 410208, Hunan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hunan Provincial Key Laboratory of Quality Evaluation of Hunan Bulk Medicinal Materials, Changsha 410208,Hunan, China","institution_ids":[]},{"raw_affiliation_string":"School of Pharmacy, Hunan University of Traditional Chinese Medicine, Changsha 410208, Hunan, China","institution_ids":["https://openalex.org/I14992734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000358902","display_name":"Yajin Feng","orcid":"https://orcid.org/0009-0008-7776-3985","observed_orcids":["https://orcid.org/0009-0008-7776-3985"]},"institutions":[{"id":"https://openalex.org/I14992734","display_name":"Hunan University of Traditional Chinese Medicine","ror":"https://ror.org/05qfq0x09","country_code":"CN","type":"education","lineage":["https://openalex.org/I14992734"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Feng Yanting","raw_affiliation_strings":["Hunan Provincial Key Laboratory of Quality Evaluation of Hunan Bulk Medicinal Materials, Changsha 410208,Hunan, China","School of Pharmacy, Hunan University of Traditional Chinese Medicine, Changsha 410208, Hunan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hunan Provincial Key Laboratory of Quality Evaluation of Hunan Bulk Medicinal Materials, Changsha 410208,Hunan, China","institution_ids":[]},{"raw_affiliation_string":"School of Pharmacy, Hunan University of Traditional Chinese Medicine, Changsha 410208, Hunan, China","institution_ids":["https://openalex.org/I14992734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046817775","display_name":"Lixin Peng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I14992734","display_name":"Hunan University of Traditional Chinese Medicine","ror":"https://ror.org/05qfq0x09","country_code":"CN","type":"education","lineage":["https://openalex.org/I14992734"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Peng Lanchun","raw_affiliation_strings":["Hunan Provincial Key Laboratory of Quality Evaluation of Hunan Bulk Medicinal Materials, Changsha 410208,Hunan, China","School of Pharmacy, Hunan University of Traditional Chinese Medicine, Changsha 410208, Hunan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hunan Provincial Key Laboratory of Quality Evaluation of Hunan Bulk Medicinal Materials, Changsha 410208,Hunan, China","institution_ids":[]},{"raw_affiliation_string":"School of Pharmacy, Hunan University of Traditional Chinese Medicine, Changsha 410208, Hunan, China","institution_ids":["https://openalex.org/I14992734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148823646","display_name":"Zheng Qingzhu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I14992734","display_name":"Hunan University of Traditional Chinese Medicine","ror":"https://ror.org/05qfq0x09","country_code":"CN","type":"education","lineage":["https://openalex.org/I14992734"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zheng Qingzhu","raw_affiliation_strings":["Hunan Provincial Key Laboratory of Quality Evaluation of Hunan Bulk Medicinal Materials, Changsha 410208,Hunan, China","School of Pharmacy, Hunan University of Traditional Chinese Medicine, Changsha 410208, Hunan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hunan Provincial Key Laboratory of Quality Evaluation of Hunan Bulk Medicinal Materials, Changsha 410208,Hunan, China","institution_ids":[]},{"raw_affiliation_string":"School of Pharmacy, Hunan University of Traditional Chinese Medicine, Changsha 410208, Hunan, China","institution_ids":["https://openalex.org/I14992734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148760039","display_name":"Peng Jiangli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I14992734","display_name":"Hunan University of Traditional Chinese Medicine","ror":"https://ror.org/05qfq0x09","country_code":"CN","type":"education","lineage":["https://openalex.org/I14992734"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Peng Jiangli","raw_affiliation_strings":["School of Pharmacy, Hunan University of Traditional Chinese Medicine, Changsha 410208, Hunan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, Hunan University of Traditional Chinese Medicine, Changsha 410208, Hunan, China","institution_ids":["https://openalex.org/I14992734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148812381","display_name":"Wang Shi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210135807","display_name":"Second Affiliated Hospital of Hunan University of Traditional Chinese Medicine","ror":"https://ror.org/03jwxc595","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210135807"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Wang Shi","raw_affiliation_strings":["Department of Pharmacy, The Second Affiliated Hospital of Hunan University of Traditional ChineseMedicine, Changsha 410005, Hunan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, The Second Affiliated Hospital of Hunan University of Traditional ChineseMedicine, Changsha 410005, Hunan, China","institution_ids":["https://openalex.org/I4210135807"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5123929193","display_name":"Qiuxian Peng","orcid":"https://orcid.org/0000-0002-8916-0523","observed_orcids":["https://orcid.org/0000-0002-8916-0523"]},"institutions":[{"id":"https://openalex.org/I14992734","display_name":"Hunan University of Traditional Chinese Medicine","ror":"https://ror.org/05qfq0x09","country_code":"CN","type":"education","lineage":["https://openalex.org/I14992734"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Peng Qiuxian","raw_affiliation_strings":["Hunan Provincial Key Laboratory of Quality Evaluation of Hunan Bulk Medicinal Materials, Changsha 410208,Hunan, China","School of Pharmacy, Hunan University of Traditional Chinese Medicine, Changsha 410208, Hunan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hunan Provincial Key Laboratory of Quality Evaluation of Hunan Bulk Medicinal Materials, Changsha 410208,Hunan, China","institution_ids":[]},{"raw_affiliation_string":"School of Pharmacy, Hunan University of Traditional Chinese Medicine, Changsha 410208, Hunan, China","institution_ids":["https://openalex.org/I14992734"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5123929193","https://openalex.org/A5148812381"],"corresponding_institution_ids":["https://openalex.org/I14992734","https://openalex.org/I4210135807"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.6868431,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"29","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11709","display_name":"Traditional Chinese Medicine Analysis","score":0.6137999892234802,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11709","display_name":"Traditional Chinese Medicine Analysis","score":0.6137999892234802,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13026","display_name":"Natural Compounds in Disease Treatment","score":0.11620000004768372,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.06650000065565109,"subfield":{"id":"https://openalex.org/subfields/2742","display_name":"Rehabilitation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-soft-tissue-injury","display_name":"acute soft tissue injury","score":0.9929999709129333},{"id":"https://openalex.org/keywords/pi3k-akt-signaling","display_name":"PI3K/Akt signaling","score":0.8140000104904175},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.9860000014305115},{"id":"https://openalex.org/keywords/traditional-chinese-medicine","display_name":"traditional Chinese medicine","score":0.6549999713897705},{"id":"https://openalex.org/keywords/topical-plaster","display_name":"topical plaster","score":0.7730000019073486},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.8130000233650208},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.9760000109672546},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9850000143051147},{"id":"https://openalex.org/keywords/pro-inflammatory-mediators","display_name":"pro-inflammatory mediators","score":0.781000018119812},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.8690000176429749},{"id":"https://openalex.org/keywords/prostaglandin-e2","display_name":"prostaglandin E2","score":0.9020000100135803},{"id":"https://openalex.org/keywords/superoxide-dismutase","display_name":"superoxide dismutase","score":0.7760000228881836},{"id":"https://openalex.org/keywords/mda","display_name":"MDA","score":0.8709999918937683},{"id":"https://openalex.org/keywords/myeloperoxidase","display_name":"myeloperoxidase","score":0.7860000133514404},{"id":"https://openalex.org/keywords/flavonoids","display_name":"flavonoids","score":0.7789999842643738},{"id":"https://openalex.org/keywords/alkaloids","display_name":"alkaloids","score":0.8209999799728394},{"id":"https://openalex.org/keywords/terpenes","display_name":"terpenes","score":0.6890000104904175},{"id":"https://openalex.org/keywords/phenolic-acids","display_name":"phenolic acids","score":0.8370000123977661},{"id":"https://openalex.org/keywords/chemical-constituents","display_name":"chemical constituents","score":0.5929999947547913},{"id":"https://openalex.org/keywords/network-pharmacology","display_name":"network pharmacology","score":0.8500000238418579}],"concepts":[{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.670199990272522},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.6416000127792358},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.5467000007629395},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.5011000037193298},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4553000032901764},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.44449999928474426},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.42750000953674316},{"id":"https://openalex.org/C102652120","wikidata":"https://www.wikidata.org/wiki/Q2419430","display_name":"Therapeutic effect","level":2,"score":0.41620001196861267},{"id":"https://openalex.org/C153400128","wikidata":"https://www.wikidata.org/wiki/Q3150731","display_name":"Infiltration (HVAC)","level":2,"score":0.3783999979496002},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.37070000171661377},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.36500000953674316},{"id":"https://openalex.org/C2779703632","wikidata":"https://www.wikidata.org/wiki/Q581996","display_name":"Anti-inflammatory","level":2,"score":0.3352999985218048},{"id":"https://openalex.org/C2780348253","wikidata":"https://www.wikidata.org/wiki/Q7554047","display_name":"Soft tissue injury","level":3,"score":0.32839998602867126},{"id":"https://openalex.org/C3018449070","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signalling pathways","level":3,"score":0.3215000033378601},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.30169999599456787},{"id":"https://openalex.org/C2776120743","wikidata":"https://www.wikidata.org/wiki/Q3271540","display_name":"Mechanism of action","level":3,"score":0.29159998893737793},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.290800005197525},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.27219998836517334},{"id":"https://openalex.org/C136948725","wikidata":"https://www.wikidata.org/wiki/Q1458306","display_name":"Soft tissue","level":2,"score":0.2687999904155731},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.2676999866962433},{"id":"https://openalex.org/C2778236600","wikidata":"https://www.wikidata.org/wiki/Q592324","display_name":"Immunofluorescence","level":3,"score":0.251800000667572}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.2174/0113862073450412260807073516","doi":"https://doi.org/10.2174/0113862073450412260807073516","is_oa":false,"landing_page_url":"https://doi.org/10.2174/0113862073450412260807073516","pdf_url":null,"source":{"id":"https://openalex.org/S50933791","display_name":"Combinatorial Chemistry & High Throughput Screening","issn_l":"1386-2073","issn":["1386-2073","1875-5402"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Combinatorial Chemistry &amp; High Throughput Screening","raw_type":"journal-article"},{"id":"pmid:42708303","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42708303","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Combinatorial chemistry & high throughput screening","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4200633256","https://openalex.org/W245936995","https://openalex.org/W3040116434","https://openalex.org/W2358421759","https://openalex.org/W2572938657","https://openalex.org/W2362646066","https://openalex.org/W1978571745","https://openalex.org/W4389462253","https://openalex.org/W2377562901","https://openalex.org/W7124484528"],"abstract_inverted_index":{"INTRODUCTION:":[0],"To":[1],"explore":[2],"the":[3,60,94,127,151,156,166,169,175,212,218,221,244],"therapeutic":[4,46],"efficacy":[5,214],"of":[6,9,96,158,168,177,215,224],"external":[7],"use":[8],"Huayu":[10],"Zhitong":[11],"Plaster":[12],"(HZP)":[13],"in":[14,25,103,254],"treating":[15],"Acute":[16],"Soft":[17],"Tissue":[18],"Injury":[19],"(ASTI)":[20],"and":[21,38,65,82,88,112,129,135,147,162,164,179,181,186,197,229,251,260],"its":[22,45,231],"underlying":[23],"mechanism":[24,95],"a":[26,236],"rat":[27,52],"model.":[28],"METHODS:":[29],"UPLC-Q-TOF-MS/MS":[30,99],"was":[31,41,54,75],"used":[32],"to":[33,43,59,92,233],"analyze":[34],"HZP's":[35],"chemical":[36],"constituents,":[37],"network":[39],"pharmacology":[40,116],"applied":[42],"predict":[44],"targets":[47],"against":[48],"ASTI.":[49],"An":[50],"ASTI":[51,73,201],"model":[53],"established":[55],"by":[56,71,86],"blunt":[57],"trauma":[58],"gastrocnemius":[61],"muscle.":[62],"Inflammatory":[63],"mediators":[64,160],"oxidative":[66,170],"stress":[67],"indicators":[68],"were":[69,84,123],"quantified":[70],"ELISA;":[72],"severity":[74],"evaluated":[76],"via":[77,132],"H&E":[78],"staining;":[79],"protein":[80],"localization":[81],"expression":[83],"assessed":[85],"immunofluorescence":[87],"Western":[89],"blotting,":[90],"respectively,":[91],"investigate":[93],"action.":[97],"RESULTS:":[98],"identified":[100],"86":[101],"components":[102],"HZP,":[104,216],"mainly":[105],"flavonoids,":[106],"alkaloids,":[107],"cyclic":[108],"enol":[109],"ether":[110],"terpenes,":[111],"phenolic":[113],"acids.":[114],"Network":[115],"analysis":[117],"showed":[118],"that":[119,140,195],"ASTI-":[120],"related":[121],"genes":[122],"primarily":[124],"associated":[125],"with":[126],"PI3K-Akt":[128],"NF-\u03baB":[130],"pathways":[131],"PI3K":[133],"subunit":[134],"AKT1.":[136],"Animal":[137],"experiments":[138],"confirmed":[139],"HZP":[141,247],"significantly":[142],"inhibited":[143],"p-PI3K,":[144],"p-":[145],"AKT,":[146],"p-NF-\u03baB":[148],"expression,":[149],"blocking":[150],"PI3K/Akt/NF-\u03baB":[152,245],"pathway.":[153],"It":[154],"reduced":[155],"levels":[157],"proinflammatory":[159],"IL-6":[161],"PGE2,":[163],"increased":[165],"activity":[167],"stressrelated":[171],"enzyme":[172],"SOD,":[173],"decreased":[174],"level":[176],"MDA":[178],"MPO,":[180],"alleviated":[182],"tissue":[183,258],"damage,":[184],"edema,":[185],"inflammatory":[187],"infiltration":[188],"(H":[189],"&":[190],"E":[191],"staining).":[192],"DISCUSSION:":[193],"Given":[194],"effective":[196],"well-tolerated":[198],"treatments":[199],"for":[200,211,220],"are":[202],"highly":[203],"desirable,":[204],"our":[205],"experimental":[206],"data":[207],"offer":[208],"compelling":[209],"support":[210],"curative":[213],"paving":[217],"path":[219],"scientific":[222],"standardization":[223],"this":[225],"intricate":[226],"TCM":[227],"preparation":[228],"affirming":[230],"potential":[232],"serve":[234],"as":[235],"valuable":[237],"topical":[238],"treatment":[239],"agent.":[240],"CONCLUSION:":[241],"By":[242],"suppressing":[243],"pathway,":[246],"exerts":[248],"potent":[249],"antiinflammatory":[250],"antioxidant":[252],"effects":[253],"ASTI,":[255],"thereby":[256],"mitigating":[257],"damage":[259],"facilitating":[261],"repair.":[262]},"counts_by_year":[],"updated_date":"2026-09-24T07:57:37.273135","created_date":"2026-09-01T00:00:00"}
