{"id":"https://openalex.org/W7204843685","doi":"https://doi.org/10.3389/fimmu.2026.1848350","title":"Potential hazard assessment of 6PPD-quinone in the context of ulcerative colitis: network toxicology, machine learning, transcriptomic analysis, and preliminary In vivo validation","display_name":"Potential hazard assessment of 6PPD-quinone in the context of ulcerative colitis: network toxicology, machine learning, transcriptomic analysis, and preliminary In vivo validation","publication_year":2026,"publication_date":"2026-08-31","ids":{"openalex":"https://openalex.org/W7204843685","doi":"https://doi.org/10.3389/fimmu.2026.1848350","pmid":"https://pubmed.ncbi.nlm.nih.gov/42741553","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13572913"},"language":"en","primary_location":{"id":"doi:10.3389/fimmu.2026.1848350","doi":"https://doi.org/10.3389/fimmu.2026.1848350","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1848350","pdf_url":null,"source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3389/fimmu.2026.1848350","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100399433","display_name":"Jingyi Li","orcid":"https://orcid.org/0000-0002-3126-7889","observed_orcids":["https://orcid.org/0000-0002-3126-7889","https://orcid.org/0000-0001-9968-9933"]},"institutions":[{"id":"https://openalex.org/I4210137355","display_name":"Northern Jiangsu People's Hospital","ror":"https://ror.org/04gz17b59","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210137355"]},{"id":"https://openalex.org/I78978612","display_name":"Yangzhou University","ror":"https://ror.org/03tqb8s11","country_code":"CN","type":"education","lineage":["https://openalex.org/I78978612"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jingyi Li","raw_affiliation_strings":["Department of Gastroenterology, Northern Jiangsu People\u2019s Hospital Affiliated to Yangzhou University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Northern Jiangsu People\u2019s Hospital Affiliated to Yangzhou University","institution_ids":["https://openalex.org/I4210137355","https://openalex.org/I78978612"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104281851","display_name":"Xizhuang Gao","orcid":"https://orcid.org/0009-0008-4658-0641","observed_orcids":["https://orcid.org/0009-0008-4658-0641"]},"institutions":[{"id":"https://openalex.org/I4210097338","display_name":"Zaozhuang Municipal Hospital","ror":"https://ror.org/01nvdh647","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097338"]},{"id":"https://openalex.org/I51185872","display_name":"Jining Medical University","ror":"https://ror.org/03zn9gq54","country_code":"CN","type":"education","lineage":["https://openalex.org/I51185872"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xizhuang Gao","raw_affiliation_strings":["Department of Functional Examination, Zaozhuang Municipal Hospital, Jining Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Functional Examination, Zaozhuang Municipal Hospital, Jining Medical University","institution_ids":["https://openalex.org/I4210097338","https://openalex.org/I51185872"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060968038","display_name":"Yemin Xu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137355","display_name":"Northern Jiangsu People's Hospital","ror":"https://ror.org/04gz17b59","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210137355"]},{"id":"https://openalex.org/I78978612","display_name":"Yangzhou University","ror":"https://ror.org/03tqb8s11","country_code":"CN","type":"education","lineage":["https://openalex.org/I78978612"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yemin Xu","raw_affiliation_strings":["Department of Gastroenterology, Northern Jiangsu People\u2019s Hospital Affiliated to Yangzhou University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Northern Jiangsu People\u2019s Hospital Affiliated to Yangzhou University","institution_ids":["https://openalex.org/I4210137355","https://openalex.org/I78978612"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115602087","display_name":"Lu Wang","orcid":"https://orcid.org/0000-0003-1535-8411","observed_orcids":["https://orcid.org/0000-0003-1535-8411"]},"institutions":[{"id":"https://openalex.org/I4210137355","display_name":"Northern Jiangsu People's Hospital","ror":"https://ror.org/04gz17b59","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210137355"]},{"id":"https://openalex.org/I78978612","display_name":"Yangzhou University","ror":"https://ror.org/03tqb8s11","country_code":"CN","type":"education","lineage":["https://openalex.org/I78978612"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lu Wang","raw_affiliation_strings":["Department of Gastroenterology, Northern Jiangsu People\u2019s Hospital Affiliated to Yangzhou University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Northern Jiangsu People\u2019s Hospital Affiliated to Yangzhou University","institution_ids":["https://openalex.org/I4210137355","https://openalex.org/I78978612"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148780641","display_name":"Ying Zhu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137355","display_name":"Northern Jiangsu People's Hospital","ror":"https://ror.org/04gz17b59","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210137355"]},{"id":"https://openalex.org/I78978612","display_name":"Yangzhou University","ror":"https://ror.org/03tqb8s11","country_code":"CN","type":"education","lineage":["https://openalex.org/I78978612"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ying Zhu","raw_affiliation_strings":["Department of Gastroenterology, Northern Jiangsu People\u2019s Hospital Affiliated to Yangzhou University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Northern Jiangsu People\u2019s Hospital Affiliated to Yangzhou University","institution_ids":["https://openalex.org/I4210137355","https://openalex.org/I78978612"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5159836742","display_name":"Bin Deng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137355","display_name":"Northern Jiangsu People's Hospital","ror":"https://ror.org/04gz17b59","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210137355"]},{"id":"https://openalex.org/I78978612","display_name":"Yangzhou University","ror":"https://ror.org/03tqb8s11","country_code":"CN","type":"education","lineage":["https://openalex.org/I78978612"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Bin Deng","raw_affiliation_strings":["Department of Gastroenterology, Northern Jiangsu People\u2019s Hospital Affiliated to Yangzhou University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Northern Jiangsu People\u2019s Hospital Affiliated to Yangzhou University","institution_ids":["https://openalex.org/I4210137355","https://openalex.org/I78978612"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5159836742"],"corresponding_institution_ids":["https://openalex.org/I4210137355","https://openalex.org/I78978612"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":null,"first_page":"1848350","last_page":"1848350"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.6615999937057495,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.6615999937057495,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.1225999966263771,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10122","display_name":"Toxic Organic Pollutants Impact","score":0.03739999979734421,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/6ppd-quinone","display_name":"6PPD-quinone","score":0.9459999799728394},{"id":"https://openalex.org/keywords/ulcerative-colitis","display_name":"ulcerative colitis","score":0.8939999938011169},{"id":"https://openalex.org/keywords/dss-induced-colitis","display_name":"DSS-induced colitis","score":0.9670000076293945},{"id":"https://openalex.org/keywords/network-toxicology","display_name":"network toxicology","score":0.9139999747276306},{"id":"https://openalex.org/keywords/adverse-outcome-pathways","display_name":"adverse outcome pathways","score":0.718999981880188},{"id":"https://openalex.org/keywords/mapkapk2","display_name":"MAPKAPK2","score":0.9330000281333923},{"id":"https://openalex.org/keywords/annexin-v","display_name":"annexin V","score":0.9549999833106995},{"id":"https://openalex.org/keywords/cfb","display_name":"CFB","score":0.8799999952316284},{"id":"https://openalex.org/keywords/farnesoid-x-receptor","display_name":"farnesoid X receptor","score":0.972000002861023},{"id":"https://openalex.org/keywords/plin2","display_name":"PLIN2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tight-junction-proteins","display_name":"tight junction proteins","score":0.902999997138977},{"id":"https://openalex.org/keywords/colonic-injury","display_name":"colonic injury","score":0.5299999713897705}],"concepts":[{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6924999952316284},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6614999771118164},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.6141999959945679},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.5719000101089478},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.45899999141693115},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42329999804496765},{"id":"https://openalex.org/C93231420","wikidata":"https://www.wikidata.org/wiki/Q841450","display_name":"Toxicogenomics","level":4,"score":0.4187000095844269},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.400299996137619},{"id":"https://openalex.org/C3019646584","wikidata":"https://www.wikidata.org/wiki/Q2311855","display_name":"Molecular biomarkers","level":2,"score":0.3433000147342682},{"id":"https://openalex.org/C2775862500","wikidata":"https://www.wikidata.org/wiki/Q2453464","display_name":"Colitis","level":2,"score":0.3264999985694885},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.29429998993873596},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2919999957084656},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.287200003862381},{"id":"https://openalex.org/C7952369","wikidata":"https://www.wikidata.org/wiki/Q844116","display_name":"Phenome","level":4,"score":0.28600001335144043},{"id":"https://openalex.org/C41685203","wikidata":"https://www.wikidata.org/wiki/Q1974042","display_name":"Docking (animal)","level":2,"score":0.27869999408721924},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2653999924659729},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.2606000006198883},{"id":"https://openalex.org/C2780479503","wikidata":"https://www.wikidata.org/wiki/Q1477","display_name":"Ulcerative colitis","level":3,"score":0.2572000026702881},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.2558000087738037}],"mesh":[{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003093","descriptor_name":"Colitis, Ulcerative","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D003093","descriptor_name":"Colitis, Ulcerative","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003093","descriptor_name":"Colitis, Ulcerative","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003093","descriptor_name":"Colitis, Ulcerative","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D003106","descriptor_name":"Colon","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003106","descriptor_name":"Colon","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003106","descriptor_name":"Colon","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010655","descriptor_name":"Phenylenediamines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016227","descriptor_name":"Benzoquinones","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016264","descriptor_name":"Dextran Sulfate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.3389/fimmu.2026.1848350","doi":"https://doi.org/10.3389/fimmu.2026.1848350","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1848350","pdf_url":null,"source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13572913","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13572913/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13572913/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Immunol","raw_type":"Text"},{"id":"pmid:42741553","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42741553","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in immunology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:3960d7df16dd402cbbcf1961870a4253","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/3960d7df16dd402cbbcf1961870a4253","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Immunology, Vol 17 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fimmu.2026.1848350","doi":"https://doi.org/10.3389/fimmu.2026.1848350","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1848350","pdf_url":null,"source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1384922612","display_name":null,"funder_award_id":"82400623","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321605","display_name":"Government of Jiangsu Province","ror":"https://ror.org/004svx814"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204843685.pdf","grobid_xml":"https://content.openalex.org/works/W7204843685.grobid-xml"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W2002177463","https://openalex.org/W2064272233","https://openalex.org/W2069164518","https://openalex.org/W2086968599","https://openalex.org/W2996019346","https://openalex.org/W4220681267","https://openalex.org/W4284889530","https://openalex.org/W4318320622","https://openalex.org/W4360825607","https://openalex.org/W4391486692","https://openalex.org/W4391529551","https://openalex.org/W4392583308","https://openalex.org/W4395480107","https://openalex.org/W4399042990","https://openalex.org/W4400497912","https://openalex.org/W4401031069","https://openalex.org/W4402717613","https://openalex.org/W4403338917","https://openalex.org/W4405183955","https://openalex.org/W4405950219","https://openalex.org/W4406870499","https://openalex.org/W4408769703","https://openalex.org/W4410483342","https://openalex.org/W4411075435","https://openalex.org/W4412711518","https://openalex.org/W4415230450","https://openalex.org/W7125479832"],"related_works":["https://openalex.org/W7212381372","https://openalex.org/W7203995029","https://openalex.org/W7171532499","https://openalex.org/W4391529551","https://openalex.org/W4410483342","https://openalex.org/W7171466440","https://openalex.org/W7171734865","https://openalex.org/W4411096087","https://openalex.org/W4413270568","https://openalex.org/W4410523014"],"abstract_inverted_index":{"Background":[0],"The":[1],"ubiquitous":[2],"tire-derived":[3],"pollutant":[4],"6PPD-quinone":[5],"(6PPD-Q)":[6],"poses":[7],"potential":[8,294],"systemic":[9],"health":[10],"risks,":[11],"yet":[12],"its":[13],"toxicological":[14,333],"impact":[15],"on":[16,253],"the":[17,22,177,183,238,245,249,293,314],"intestinal":[18,276,295,325],"tract,":[19],"particularly":[20],"in":[21,72,92,237,308],"context":[23],"of":[24,223,233,297],"ulcerative":[25],"colitis":[26,40,97],"(UC),":[27],"remains":[28],"largely":[29],"unknown.":[30],"This":[31,284],"study":[32,285,315],"aimed":[33],"to":[34,42,86,110,323],"investigate":[35],"whether":[36],"6PPD-Q":[37,159,175,199,241,266,298],"aggravates":[38],"DSS-induced":[39,96,203],"and":[41,50,64,70,79,104,115,153,160,166,176,188,208,228,230,235,279,311,327],"identify":[43],"candidate":[44,269,317],"molecular":[45,68,80,162,167,270,318],"events":[46,319],"using":[47,124],"integrative":[48,55,288],"computational":[49,304],"experimental":[51],"approaches.":[52],"Methods":[53],"An":[54],"strategy":[56],"combining":[57],"network":[58],"toxicology,":[59],"machine":[60],"learning,":[61],"public":[62],"bulk-":[63],"single-cell":[65],"transcriptomic":[66],"analyses,":[67],"simulations,":[69],"preliminary":[71],"vivo":[73,93,195,309],"validation":[74],"was":[75,100,263],"applied.":[76],"Molecular":[77,164],"docking":[78,165,186],"dynamics":[81,168],"(MD)":[82],"simulations":[83,169],"were":[84,108,122],"conducted":[85,123],"evaluate":[87,111],"protein-ligand":[88],"binding":[89],"stability.":[90],"For":[91],"validation,":[94],"a":[95,189,256],"mouse":[98],"model":[99],"utilized.":[101],"Furthermore,":[102],"qRT-PCR":[103],"Western":[105],"blot":[106],"analyses":[107,121],"performed":[109],"colonic":[112,204,220,281],"transcriptional":[113,312],"alterations":[114],"tight-junction":[116],"protein":[117],"expression,":[118],"respectively.":[119],"Statistical":[120],"Student\u2019s":[125],"t-test":[126],"or":[127],"one-way":[128],"ANOVA,":[129],"with":[130,158,180,244,268,307],"P":[131],"<":[132],"0.05":[133],"considered":[134],"statistically":[135],"significant.":[136],"Results":[137],"Through":[138],"multidimensional":[139],"screening,":[140],"we":[141],"identified":[142],"five":[143],"core":[144],"regulatory":[145],"genes":[146],"(":[147],"MAPKAPK2,":[148],"ANXA5,":[149],"CFB,":[150],"NR1H4":[151],",":[152,225,227],"PLIN2":[154],")":[155],"potentially":[156],"associated":[157],"UC-related":[161],"alterations.":[163],"supported":[170],"plausible":[171],"predicted":[172,247],"interactions":[173],"between":[174],"prioritized":[178],"proteins,":[179],"MAPKAPK2":[181],"showing":[182],"most":[184],"favorable":[185],"score":[187],"relatively":[190],"stable":[191],"simulated":[192],"trajectory.":[193],"In":[194],"experiments":[196],"demonstrated":[197],"that":[198,320],"exposure":[200,267],"significantly":[201],"exacerbated":[202],"shortening,":[205],"macroscopic":[206],"lesions,":[207],"histopathological":[209],"damage.":[210],"Quantitative":[211],"real-time":[212],"polymerase":[213],"chain":[214],"reaction":[215],"(qRT-PCR)":[216],"analysis":[217],"showed":[218],"increased":[219],"mRNA":[221],"expression":[222,232],"Mapkapk2":[224],"Anxa5":[226],"Cfb":[229],"decreased":[231],"Nr1h4":[234],"Plin2":[236],"DSS":[239],"plus":[240],"group,":[242],"consistent":[243],"directions":[246],"by":[248],"bioinformatics":[250],"analyses.":[251],"Based":[252],"these":[254],"findings,":[255],"proposed":[257],"Adverse":[258],"Outcome":[259],"Pathway":[260],"(AOP)":[261],"framework":[262,290],"constructed,":[264],"linking":[265],"targets,":[271],"putative":[272],"PI3K-Akt/MAPK":[273],"signaling":[274],"perturbations,":[275],"immune":[277],"dysregulation,":[278],"aggravated":[280],"injury.":[282],"Conclusions":[283],"provides":[286,328],"an":[287],"mechanistic":[289],"for":[291,331],"investigating":[292],"effects":[296],"under":[299],"inflammatory":[300],"conditions.":[301],"By":[302],"integrating":[303],"target":[305],"prioritization":[306],"phenotypic":[310],"evidence,":[313],"identifies":[316],"may":[321],"contribute":[322],"6PPD-Q-exacerbated":[324],"inflammation":[326],"testable":[329],"hypotheses":[330],"subsequent":[332],"investigation.":[334]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-09-01T00:00:00"}