{"id":"https://openalex.org/W7204842206","doi":"https://doi.org/10.1016/j.apsb.2026.08.023","title":"Conditionally active antibody\u2012drug conjugates","display_name":"Conditionally active antibody\u2012drug conjugates","publication_year":2026,"publication_date":"2026-09-01","ids":{"openalex":"https://openalex.org/W7204842206","doi":"https://doi.org/10.1016/j.apsb.2026.08.023","pmid":"https://pubmed.ncbi.nlm.nih.gov/42979125","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13729715"},"language":"en","primary_location":{"id":"doi:10.1016/j.apsb.2026.08.023","doi":"https://doi.org/10.1016/j.apsb.2026.08.023","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.apsb.2026.08.023","pdf_url":"https://www.sciencedirect.com/science/article/pii/S221138352600554X/pdf","source":{"id":"https://openalex.org/S2736993989","display_name":"Acta Pharmaceutica Sinica B","issn_l":"2211-3835","issn":["2211-3835","2211-3843"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-140"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Pharmaceutica Sinica B","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.sciencedirect.com/science/article/pii/S221138352600554X/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057109853","display_name":"Cuiyu Guo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I2800091995","display_name":"West China Medical Center of Sichuan University","ror":"https://ror.org/040nggs60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I24185976","https://openalex.org/I2800091995"]},{"id":"https://openalex.org/I4210089761","display_name":"West China Hospital of Sichuan University","ror":"https://ror.org/007mrxy13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089761"]},{"id":"https://openalex.org/I4391768003","display_name":"State Key Laboratory of Biotherapy","ror":"https://ror.org/00x43yy22","country_code":"CN","type":"facility","lineage":["https://openalex.org/I24185976","https://openalex.org/I4391768003"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Cuiyu Guo","raw_affiliation_strings":["Department of Pulmonary and Critical Care Medicine, Targeted Tracer Research and Development Laboratory, Institute of Respiratory Health; State Key Laboratory of Respiratory Health and Multimorbidity; West China Hospital, Sichuan University, Chengdu 610041, China","State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pulmonary and Critical Care Medicine, Targeted Tracer Research and Development Laboratory, Institute of Respiratory Health; State Key Laboratory of Respiratory Health and Multimorbidity; West China Hospital, Sichuan University, Chengdu 610041, China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I2800091995","https://openalex.org/I4210089761"]},{"raw_affiliation_string":"State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I2800091995","https://openalex.org/I4391768003"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148783062","display_name":"Yaqin He","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I2800091995","display_name":"West China Medical Center of Sichuan University","ror":"https://ror.org/040nggs60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I24185976","https://openalex.org/I2800091995"]},{"id":"https://openalex.org/I4210089761","display_name":"West China Hospital of Sichuan University","ror":"https://ror.org/007mrxy13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089761"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yaqin He","raw_affiliation_strings":["Department of Pulmonary and Critical Care Medicine, Targeted Tracer Research and Development Laboratory, Institute of Respiratory Health; State Key Laboratory of Respiratory Health and Multimorbidity; West China Hospital, Sichuan University, Chengdu 610041, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pulmonary and Critical Care Medicine, Targeted Tracer Research and Development Laboratory, Institute of Respiratory Health; State Key Laboratory of Respiratory Health and Multimorbidity; West China Hospital, Sichuan University, Chengdu 610041, China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I2800091995","https://openalex.org/I4210089761"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5143806276","display_name":"Ying Lu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I2800091995","display_name":"West China Medical Center of Sichuan University","ror":"https://ror.org/040nggs60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I24185976","https://openalex.org/I2800091995"]},{"id":"https://openalex.org/I4210089761","display_name":"West China Hospital of Sichuan University","ror":"https://ror.org/007mrxy13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089761"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ying Lu","raw_affiliation_strings":["Department of Pulmonary and Critical Care Medicine, Targeted Tracer Research and Development Laboratory, Institute of Respiratory Health; State Key Laboratory of Respiratory Health and Multimorbidity; West China Hospital, Sichuan University, Chengdu 610041, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pulmonary and Critical Care Medicine, Targeted Tracer Research and Development Laboratory, Institute of Respiratory Health; State Key Laboratory of Respiratory Health and Multimorbidity; West China Hospital, Sichuan University, Chengdu 610041, China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I2800091995","https://openalex.org/I4210089761"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148805361","display_name":"Qilin Dun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I2800091995","display_name":"West China Medical Center of Sichuan University","ror":"https://ror.org/040nggs60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I24185976","https://openalex.org/I2800091995"]},{"id":"https://openalex.org/I4210089761","display_name":"West China Hospital of Sichuan University","ror":"https://ror.org/007mrxy13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089761"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qilin Dun","raw_affiliation_strings":["Department of Pulmonary and Critical Care Medicine, Targeted Tracer Research and Development Laboratory, Institute of Respiratory Health; State Key Laboratory of Respiratory Health and Multimorbidity; West China Hospital, Sichuan University, Chengdu 610041, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pulmonary and Critical Care Medicine, Targeted Tracer Research and Development Laboratory, Institute of Respiratory Health; State Key Laboratory of Respiratory Health and Multimorbidity; West China Hospital, Sichuan University, Chengdu 610041, China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I2800091995","https://openalex.org/I4210089761"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031166800","display_name":"Jinliang Yang","orcid":"https://orcid.org/0000-0002-6152-6394","observed_orcids":["https://orcid.org/0000-0002-6152-6394"]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I2800091995","display_name":"West China Medical Center of Sichuan University","ror":"https://ror.org/040nggs60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I24185976","https://openalex.org/I2800091995"]},{"id":"https://openalex.org/I4391768003","display_name":"State Key Laboratory of Biotherapy","ror":"https://ror.org/00x43yy22","country_code":"CN","type":"facility","lineage":["https://openalex.org/I24185976","https://openalex.org/I4391768003"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jinliang Yang","raw_affiliation_strings":["State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I2800091995","https://openalex.org/I4391768003"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5143831537","display_name":"Yuxi Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I2800091995","display_name":"West China Medical Center of Sichuan University","ror":"https://ror.org/040nggs60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I24185976","https://openalex.org/I2800091995"]},{"id":"https://openalex.org/I4210089761","display_name":"West China Hospital of Sichuan University","ror":"https://ror.org/007mrxy13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089761"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yuxi Wang","raw_affiliation_strings":["Department of Pulmonary and Critical Care Medicine, Targeted Tracer Research and Development Laboratory, Institute of Respiratory Health; State Key Laboratory of Respiratory Health and Multimorbidity; West China Hospital, Sichuan University, Chengdu 610041, China","Frontiers Medical Center, Tianfu Jincheng Laboratory, Chengdu 610212, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pulmonary and Critical Care Medicine, Targeted Tracer Research and Development Laboratory, Institute of Respiratory Health; State Key Laboratory of Respiratory Health and Multimorbidity; West China Hospital, Sichuan University, Chengdu 610041, China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I2800091995","https://openalex.org/I4210089761"]},{"raw_affiliation_string":"Frontiers Medical Center, Tianfu Jincheng Laboratory, Chengdu 610212, China","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5031166800","https://openalex.org/A5143831537"],"corresponding_institution_ids":["https://openalex.org/I24185976","https://openalex.org/I2800091995","https://openalex.org/I4210089761","https://openalex.org/I4391768003"],"apc_list":{"value":2600,"currency":"USD","value_usd":2600},"apc_paid":{"value":2600,"currency":"USD","value_usd":2600},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.34362629,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"16","issue":"11","first_page":"7276","last_page":"7290"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9603999853134155,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9603999853134155,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12477","display_name":"Toxin Mechanisms and Immunotoxins","score":0.010300000198185444,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.008799999952316284,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antibody-engineering","display_name":"antibody engineering","score":0.6460000276565552},{"id":"https://openalex.org/keywords/steric-shielding","display_name":"steric shielding","score":0.7689999938011169},{"id":"https://openalex.org/keywords/site-specific-conjugation","display_name":"site-specific conjugation","score":0.9819999933242798},{"id":"https://openalex.org/keywords/bioorthogonal-chemistry","display_name":"bioorthogonal chemistry","score":0.9629999995231628},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.8130000233650208},{"id":"https://openalex.org/keywords/tumor-selectivity","display_name":"tumor selectivity","score":0.7979999780654907},{"id":"https://openalex.org/keywords/on-target-off-tumor-toxicity","display_name":"on-target off-tumor toxicity","score":0.902999997138977},{"id":"https://openalex.org/keywords/ror2","display_name":"ROR2","score":0.9430000185966492},{"id":"https://openalex.org/keywords/axl","display_name":"AXL","score":0.9990000128746033},{"id":"https://openalex.org/keywords/transferrin-receptor","display_name":"transferrin receptor","score":1.0}],"concepts":[{"id":"https://openalex.org/C12713177","wikidata":"https://www.wikidata.org/wiki/Q1900281","display_name":"Perspective (graphical)","level":2,"score":0.71670001745224},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.520799994468689},{"id":"https://openalex.org/C197336794","wikidata":"https://www.wikidata.org/wiki/Q5161150","display_name":"Conjugate","level":2,"score":0.49729999899864197},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.41130000352859497},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.313400000333786},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.30480000376701355},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.250900000333786},{"id":"https://openalex.org/C2776359362","wikidata":"https://www.wikidata.org/wiki/Q2145286","display_name":"Representation (politics)","level":3,"score":0.24629999697208405},{"id":"https://openalex.org/C188147891","wikidata":"https://www.wikidata.org/wiki/Q147638","display_name":"Cognitive science","level":1,"score":0.21699999272823334},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.2094999998807907}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1016/j.apsb.2026.08.023","doi":"https://doi.org/10.1016/j.apsb.2026.08.023","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.apsb.2026.08.023","pdf_url":"https://www.sciencedirect.com/science/article/pii/S221138352600554X/pdf","source":{"id":"https://openalex.org/S2736993989","display_name":"Acta Pharmaceutica Sinica B","issn_l":"2211-3835","issn":["2211-3835","2211-3843"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-140"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Pharmaceutica Sinica B","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13729715","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13729715/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13729715/pdf/main.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Pharm Sin B","raw_type":"Text"},{"id":"pmid:42979125","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42979125","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta pharmaceutica Sinica. B","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:e04ea04c86934507bdbb8e13c99cc8b6","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/e04ea04c86934507bdbb8e13c99cc8b6","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Acta Pharmaceutica Sinica B, Vol 16, Iss 11, Pp 7276-7290 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.apsb.2026.08.023","doi":"https://doi.org/10.1016/j.apsb.2026.08.023","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.apsb.2026.08.023","pdf_url":"https://www.sciencedirect.com/science/article/pii/S221138352600554X/pdf","source":{"id":"https://openalex.org/S2736993989","display_name":"Acta Pharmaceutica Sinica B","issn_l":"2211-3835","issn":["2211-3835","2211-3843"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-140"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Pharmaceutica Sinica B","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2229441123","display_name":null,"funder_award_id":"2024HXBH054","funder_id":"https://openalex.org/F4320322990","funder_display_name":"Sichuan University"},{"id":"https://openalex.org/G3844492606","display_name":null,"funder_award_id":"2024HXBH054","funder_id":"https://openalex.org/F4320336042","funder_display_name":"West China Hospital, Sichuan University"},{"id":"https://openalex.org/G5109005966","display_name":null,"funder_award_id":"2024ZYD0130","funder_id":"https://openalex.org/F4320321655","funder_display_name":"Science and Technology Development Fund"},{"id":"https://openalex.org/G5563064227","display_name":null,"funder_award_id":"82473782","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5908701641","display_name":null,"funder_award_id":"2024ZYD0130","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7504430546","display_name":null,"funder_award_id":"2025ZNSFSC1869","funder_id":"https://openalex.org/F4320329861","funder_display_name":"Natural Science Foundation of Sichuan Province"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321655","display_name":"Science and Technology Development Fund","ror":"https://ror.org/044vr6g03"},{"id":"https://openalex.org/F4320322990","display_name":"Sichuan University","ror":"https://ror.org/011ashp19"},{"id":"https://openalex.org/F4320329861","display_name":"Natural Science Foundation of Sichuan Province","ror":null},{"id":"https://openalex.org/F4320336042","display_name":"West China Hospital, Sichuan University","ror":"https://ror.org/007mrxy13"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204842206.pdf","grobid_xml":"https://content.openalex.org/works/W7204842206.grobid-xml"},"referenced_works_count":75,"referenced_works":["https://openalex.org/W1524815067","https://openalex.org/W1969524738","https://openalex.org/W2106071154","https://openalex.org/W2115749410","https://openalex.org/W2171368669","https://openalex.org/W2301551230","https://openalex.org/W2596256932","https://openalex.org/W2945262398","https://openalex.org/W2950892708","https://openalex.org/W2965243738","https://openalex.org/W2979540828","https://openalex.org/W2981635494","https://openalex.org/W2990699742","https://openalex.org/W3003593776","https://openalex.org/W3003913151","https://openalex.org/W3037526087","https://openalex.org/W3042785515","https://openalex.org/W3130964486","https://openalex.org/W3135311043","https://openalex.org/W3158787141","https://openalex.org/W3164185366","https://openalex.org/W3181419443","https://openalex.org/W3203960170","https://openalex.org/W4212946280","https://openalex.org/W4213336207","https://openalex.org/W4226173540","https://openalex.org/W4245096217","https://openalex.org/W4282917798","https://openalex.org/W4297453807","https://openalex.org/W4309047379","https://openalex.org/W4316813126","https://openalex.org/W4362459740","https://openalex.org/W4362592996","https://openalex.org/W4379282369","https://openalex.org/W4379986466","https://openalex.org/W4380320004","https://openalex.org/W4387183962","https://openalex.org/W4387497256","https://openalex.org/W4387907207","https://openalex.org/W4388336450","https://openalex.org/W4388771441","https://openalex.org/W4389914356","https://openalex.org/W4390673654","https://openalex.org/W4391054049","https://openalex.org/W4391616985","https://openalex.org/W4391929296","https://openalex.org/W4393072098","https://openalex.org/W4393100568","https://openalex.org/W4393388265","https://openalex.org/W4394762088","https://openalex.org/W4400265207","https://openalex.org/W4400330445","https://openalex.org/W4400452547","https://openalex.org/W4400605991","https://openalex.org/W4401793712","https://openalex.org/W4402617448","https://openalex.org/W4405208180","https://openalex.org/W4405727835","https://openalex.org/W4406822106","https://openalex.org/W4408413512","https://openalex.org/W4408578288","https://openalex.org/W4409290957","https://openalex.org/W4409334897","https://openalex.org/W4409628474","https://openalex.org/W4409630934","https://openalex.org/W4409631465","https://openalex.org/W4409631804","https://openalex.org/W4410804949","https://openalex.org/W4410814596","https://openalex.org/W4410816381","https://openalex.org/W4411057799","https://openalex.org/W4411867602","https://openalex.org/W4414084536","https://openalex.org/W4414407560","https://openalex.org/W4415685423"],"related_works":["https://openalex.org/W4206264022","https://openalex.org/W2921589168","https://openalex.org/W3128485166","https://openalex.org/W3150595399","https://openalex.org/W2001438931","https://openalex.org/W7203645040","https://openalex.org/W7148570981","https://openalex.org/W2970782214","https://openalex.org/W7162306295","https://openalex.org/W4414498343"],"abstract_inverted_index":{"Conditionally":[0],"active":[1,101,131],"antibody\u2012drug":[2],"conjugates":[3],"(ADCs)":[4],"can":[5,38],"be":[6,39],"achieved":[7],"through":[8,60],"antibody":[9,120],"engineering":[10,121],"and/or":[11],"linker-payload":[12,123],"design":[13,124],"to":[14,50,79,137],"achieve":[15],"context-dependent":[16],"activation,":[17],"addressing":[18],"the":[19,80,89,117],"limitations":[20],"of":[21,99,129],"conventional":[22],"ADCs":[23,102],"such":[24,63],"as":[25,64],"premature":[26],"payload":[27],"release,":[28],"inefficient":[29],"tumor":[30,81,139],"penetration,":[31],"and":[32,92,106,112,122,126,133,141],"on-target,":[33],"off-tumor":[34],"toxicities.":[35],"Antibody":[36],"surfaces":[37],"modified":[40],"with":[41],"steric":[42],"shields,":[43],"site-specific":[44],"conjugation,":[45],"or":[46,66,71],"reversible":[47],"masking":[48],"groups":[49],"further":[51],"limit":[52],"off-target":[53],"binding.":[54],"Linker-payloads":[55],"are":[56],"masked":[57],"in":[58],"circulation":[59],"prodrug":[61],"strategies,":[62,125],"multi-step":[65],"logic-gated":[67],"linkers,":[68],"releasable":[69],"caps,":[70],"bioorthogonal":[72],"chemistries.":[73],"These":[74],"strategies":[75],"confine":[76],"cytotoxic":[77],"drugs":[78],"microenvironment":[82],"(TME),":[83],"enhancing":[84],"intratumoral":[85],"drug":[86],"concentration,":[87],"expanding":[88],"therapeutic":[90,142],"window,":[91],"reducing":[93],"systemic":[94],"toxicity.":[95],"Early":[96],"clinical":[97,127],"studies":[98],"conditionally":[100,130],"targeting":[103],"ROR2,":[104],"AXL,":[105],"CD71":[107],"have":[108],"demonstrated":[109],"promising":[110],"safety":[111],"efficacy.":[113],"This":[114],"review":[115],"discusses":[116],"underlying":[118],"mechanisms,":[119],"progress":[128],"ADCs,":[132],"considers":[134],"future":[135],"avenues":[136],"improve":[138],"selectivity":[140],"performance.":[143]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2026-09-01T00:00:00"}