{"id":"https://openalex.org/W7204837334","doi":"https://doi.org/10.64898/2026.08.25.26361366","title":"Trans auricular vagus nerve stimulation for aneurysmal sub arachnoid haemorrhage (VNS-SAH): a pilot randomised controlled trial","display_name":"Trans auricular vagus nerve stimulation for aneurysmal sub arachnoid haemorrhage (VNS-SAH): a pilot randomised controlled trial","publication_year":2026,"publication_date":"2026-08-31","ids":{"openalex":"https://openalex.org/W7204837334","doi":"https://doi.org/10.64898/2026.08.25.26361366"},"language":"en","primary_location":{"id":"doi:10.64898/2026.08.25.26361366","doi":"https://doi.org/10.64898/2026.08.25.26361366","is_oa":false,"landing_page_url":"https://doi.org/10.64898/2026.08.25.26361366","pdf_url":null,"source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101468597","display_name":"Matthew Myers","orcid":"https://orcid.org/0000-0002-5051-1904","observed_orcids":["https://orcid.org/0000-0002-5051-1904"]},"institutions":[{"id":"https://openalex.org/I4210102902","display_name":"Sheffield Teaching Hospitals NHS Foundation Trust","ror":"https://ror.org/018hjpz25","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210102902"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Matthew Myers","raw_affiliation_strings":["Department of Neurosurgery, Sheffield Teaching Hospitals, NHS Foundation Trust, Sheffield, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Sheffield Teaching Hospitals, NHS Foundation Trust, Sheffield, UK","institution_ids":["https://openalex.org/I4210102902"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148806111","display_name":"Finlay Robson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I191240316","display_name":"University of Hull","ror":"https://ror.org/04nkhwh30","country_code":"GB","type":"education","lineage":["https://openalex.org/I191240316"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Finlay Robson","raw_affiliation_strings":["Medical Student, Hull Medical School, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Student, Hull Medical School, UK","institution_ids":["https://openalex.org/I191240316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093042103","display_name":"Dr Sheharyar Baig","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Sheharyar Baig","raw_affiliation_strings":["Department of Neurosciences, School of Medicine and Population Health, University of Sheffield, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosciences, School of Medicine and Population Health, University of Sheffield, UK","institution_ids":["https://openalex.org/I91136226"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002774987","display_name":"Saminderjit Kular","orcid":"https://orcid.org/0000-0003-3437-0918","observed_orcids":["https://orcid.org/0000-0003-3437-0918"]},"institutions":[{"id":"https://openalex.org/I4210102902","display_name":"Sheffield Teaching Hospitals NHS Foundation Trust","ror":"https://ror.org/018hjpz25","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210102902"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Saminderjit Kular","raw_affiliation_strings":["Department of Neuroradiology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroradiology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK","institution_ids":["https://openalex.org/I4210102902"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5135019814","display_name":"Mudasar Aziz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210102902","display_name":"Sheffield Teaching Hospitals NHS Foundation Trust","ror":"https://ror.org/018hjpz25","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210102902"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Mudasar Aziz","raw_affiliation_strings":["Department of Neurosciences, Sheffield Teaching Hospitals, NHS Foundation Trust, Sheffield, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosciences, Sheffield Teaching Hospitals, NHS Foundation Trust, Sheffield, UK","institution_ids":["https://openalex.org/I4210102902"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039576650","display_name":"Elisabetta Burchi","orcid":"https://orcid.org/0000-0002-7596-0212","observed_orcids":["https://orcid.org/0000-0002-7596-0212"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elisabetta Burchi","raw_affiliation_strings":["Research Lead, Parasym, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Lead, Parasym, London, UK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148793142","display_name":"Debapriya Battacharyya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210102902","display_name":"Sheffield Teaching Hospitals NHS Foundation Trust","ror":"https://ror.org/018hjpz25","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210102902"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Debapriya Bhattacharyya","raw_affiliation_strings":["Department of Neurosurgery, Sheffield Teaching Hospitals, NHS Foundation Trust, Sheffield, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Sheffield Teaching Hospitals, NHS Foundation Trust, Sheffield, UK","institution_ids":["https://openalex.org/I4210102902"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148777827","display_name":"Su Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Li Su","raw_affiliation_strings":["Department of Neurosciences, School of Medicine and Population Health, University of Sheffield, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosciences, School of Medicine and Population Health, University of Sheffield, UK","institution_ids":["https://openalex.org/I91136226"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046576242","display_name":"Arshad Majid","orcid":"https://orcid.org/0000-0002-1144-039X","observed_orcids":["https://orcid.org/0000-0002-1144-039X"]},"institutions":[{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Arshad Majid","raw_affiliation_strings":["Department of Neurosciences, School of Medicine and Population Health, University of Sheffield, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosciences, School of Medicine and Population Health, University of Sheffield, UK","institution_ids":["https://openalex.org/I91136226"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100418011","display_name":"Ali Ali","orcid":"https://orcid.org/0000-0001-6339-4076","observed_orcids":["https://orcid.org/0000-0001-6339-4076"]},"institutions":[{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ali N Ali","raw_affiliation_strings":["Department of Neurosciences, School of Medicine and Population Health, University of Sheffield, UK"],"raw_orcid":"https://orcid.org/0000-0001-6339-4076","affiliations":[{"raw_affiliation_string":"Department of Neurosciences, School of Medicine and Population Health, University of Sheffield, UK","institution_ids":["https://openalex.org/I91136226"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12580","display_name":"Vagus Nerve Stimulation Research","score":0.5746999979019165,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12580","display_name":"Vagus Nerve Stimulation Research","score":0.5746999979019165,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10420","display_name":"Intracranial Aneurysms: Treatment and Complications","score":0.3732999861240387,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10498","display_name":"Migraine and Headache Studies","score":0.007699999958276749,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aneurysmal-subarachnoid-hemorrhage","display_name":"aneurysmal subarachnoid hemorrhage","score":0.996999979019165},{"id":"https://openalex.org/keywords/delayed-cerebral-ischemia","display_name":"delayed cerebral ischemia","score":0.9990000128746033},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.6520000100135803},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9179999828338623},{"id":"https://openalex.org/keywords/interleukin-1","display_name":"interleukin-1","score":0.8080000281333923},{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":0.9520000219345093},{"id":"https://openalex.org/keywords/inflammatory-markers","display_name":"inflammatory markers","score":0.878000020980835},{"id":"https://openalex.org/keywords/neurocritical-care","display_name":"neurocritical care","score":0.7620000243186951},{"id":"https://openalex.org/keywords/sham-stimulation","display_name":"sham stimulation","score":0.6489999890327454},{"id":"https://openalex.org/keywords/secondary-brain-injury","display_name":"secondary brain injury","score":0.574999988079071}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9447000026702881},{"id":"https://openalex.org/C2780087125","wikidata":"https://www.wikidata.org/wiki/Q2062293","display_name":"Vagus nerve stimulation","level":4,"score":0.8726000189781189},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.6711999773979187},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.6419000029563904},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.5975000262260437},{"id":"https://openalex.org/C2994577977","wikidata":"https://www.wikidata.org/wiki/Q1203526","display_name":"Pilot trial","level":3,"score":0.5180000066757202},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.51419997215271},{"id":"https://openalex.org/C2992083352","wikidata":"https://www.wikidata.org/wiki/Q693442","display_name":"Subarachnoid haemorrhage","level":3,"score":0.508400022983551},{"id":"https://openalex.org/C2777736543","wikidata":"https://www.wikidata.org/wiki/Q693442","display_name":"Subarachnoid hemorrhage","level":2,"score":0.47450000047683716},{"id":"https://openalex.org/C2781404750","wikidata":"https://www.wikidata.org/wiki/Q190140","display_name":"Vagus nerve","level":3,"score":0.415800005197525},{"id":"https://openalex.org/C165455791","wikidata":"https://www.wikidata.org/wiki/Q7002299","display_name":"Neurointensive care","level":2,"score":0.4092999994754791},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.35929998755455017},{"id":"https://openalex.org/C133828647","wikidata":"https://www.wikidata.org/wiki/Q6159778","display_name":"Vasoactive","level":2,"score":0.31929999589920044},{"id":"https://openalex.org/C2780375056","wikidata":"https://www.wikidata.org/wiki/Q905905","display_name":"Neuromodulation","level":3,"score":0.3167000114917755},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.31279999017715454},{"id":"https://openalex.org/C16568411","wikidata":"https://www.wikidata.org/wiki/Q83042","display_name":"Neurology","level":2,"score":0.2919999957084656},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.2824999988079071},{"id":"https://openalex.org/C46762472","wikidata":"https://www.wikidata.org/wiki/Q178648","display_name":"Peripheral","level":2,"score":0.27810001373291016},{"id":"https://openalex.org/C2779951463","wikidata":"https://www.wikidata.org/wiki/Q7268788","display_name":"Quality of life (healthcare)","level":2,"score":0.2750999927520752},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.26019999384880066},{"id":"https://openalex.org/C2985799443","wikidata":"https://www.wikidata.org/wiki/Q4955838","display_name":"Brain stimulation","level":3,"score":0.2515999972820282}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.08.25.26361366","doi":"https://doi.org/10.64898/2026.08.25.26361366","is_oa":false,"landing_page_url":"https://doi.org/10.64898/2026.08.25.26361366","pdf_url":null,"source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W2028584578","https://openalex.org/W2043175847","https://openalex.org/W2082494913","https://openalex.org/W2131290020","https://openalex.org/W2168925567","https://openalex.org/W2784034563","https://openalex.org/W2789307087","https://openalex.org/W2902943717","https://openalex.org/W2981100201","https://openalex.org/W3028253383","https://openalex.org/W3037872343","https://openalex.org/W3044854238","https://openalex.org/W3090705660","https://openalex.org/W3186548700","https://openalex.org/W4306730655","https://openalex.org/W4308464152","https://openalex.org/W4323035237","https://openalex.org/W4379093303","https://openalex.org/W4394934840","https://openalex.org/W4406787251","https://openalex.org/W7116678898"],"related_works":["https://openalex.org/W4396590538","https://openalex.org/W4406787251","https://openalex.org/W4401806875","https://openalex.org/W4385398430","https://openalex.org/W7116678898","https://openalex.org/W4376875371","https://openalex.org/W4408216135","https://openalex.org/W4401753908","https://openalex.org/W7117386784","https://openalex.org/W4393945427"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Aneurysmal":[2],"subarachnoid":[3],"haemorrhage":[4],"(aSAH)":[5],"is":[6,203],"frequently":[7],"complicated":[8],"by":[9],"delayed":[10],"cerebral":[11],"ischaemia":[12],"(DCI),":[13],"for":[14,62,83],"which":[15],"current":[16],"therapies":[17],"incompletely":[18],"target":[19],"the":[20,133,209],"underlying":[21],"multifactorial":[22],"pathophysiology.":[23],"Transauricular":[24],"vagus":[25],"nerve":[26],"stimulation":[27],"(taVNS)":[28],"modulates":[29],"inflammatory,":[30],"vasoactive":[31],"and":[32,35,100,110,147,149,166,172,182,206,213],"autonomic":[33],"pathways":[34],"may":[36],"attenuate":[37],"secondary":[38,102],"brain":[39],"injury":[40],"after":[41,201],"aSAH.":[42,64],"Methods":[43],"We":[44],"conducted":[45],"a":[46,79],"prospective,":[47],"single-centre,":[48],"single-blind,":[49],"randomised,":[50],"sham-controlled":[51],"pilot":[52],"trial":[53],"in":[54,132,161,170,208,220],"adults":[55],"within":[56],"5":[57,89],"days":[58],"of":[59,152],"aneurysm":[60],"securing":[61],"non-traumatic":[63],"Participants":[65],"were":[66,93,119,144,155,191],"allocated":[67],"1:1":[68],"to":[69,113],"active":[70],"taVNS":[71,134,200],"(left":[72,76],"tragus)":[73],"or":[74],"sham":[75],"earlobe)":[77],"using":[78],"portable":[80],"device":[81],"delivered":[82],"45":[84],"minutes":[85],"twice":[86],"daily":[87],"over":[88,150],"days.":[90],"Primary":[91],"outcomes":[92,103,112,190],"safety":[94],"(taVNS-related":[95],"serious":[96,138],"adverse":[97,139],"events),":[98],"acceptability,":[99],"compliance;":[101],"included":[104],"inflammatory":[105],"biomarkers,":[106],"DCI,":[107],"in-hospital":[108],"complications,":[109],"functional":[111,189],"1":[114,196],"month.":[115,197],"Results":[116],"Thirty":[117],"patients":[118],"randomised":[120],"(16":[121],"taVNS,":[122],"14":[123],"sham),":[124],"with":[125,174],"numerically":[126,175],"more":[127],"severe":[128],"aSAH":[129,202],"at":[130,195],"baseline":[131],"arm.":[135],"No":[136],"taVNS-related":[137],"events":[140,178],"occurred;":[141],"side":[142],"effects":[143],"generally":[145],"mild":[146],"transient,":[148],"80%":[151],"planned":[153],"sessions":[154],"completed.":[156],"TaVNS":[157],"produced":[158],"greater":[159],"reductions":[160,169],"serum":[162],"tumour":[163],"necrosis":[164],"factor-\u03b1":[165],"trends":[167],"towards":[168],"interleukin-1\u03b2":[171],"interleukin-10,":[173],"fewer":[176],"DCI":[177],"(6.6%":[179],"vs":[180,186],"35.7%)":[181],"neurological":[183],"impairments":[184],"(16.7%":[185],"53.8%),":[187],"although":[188],"not":[192],"statistically":[193],"different":[194],"Conclusions":[198],"Early":[199],"safe,":[204],"acceptable,":[205],"feasible":[207],"neurocritical":[210],"care":[211],"setting":[212],"shows":[214],"biologically":[215],"plausible":[216],"signals":[217],"warranting":[218],"evaluation":[219],"larger":[221],"multicentre":[222],"trials.":[223]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2026-09-01T00:00:00"}