{"id":"https://openalex.org/W7204836854","doi":"https://doi.org/10.1002/efd2.70203","title":"Sinensetin From Citrus Peel Alleviates LPS\u2010Induced Acute Pneumonia by Regulating HIF\u20101\u03b1 Signaling Pathway in Mice","display_name":"Sinensetin From Citrus Peel Alleviates LPS\u2010Induced Acute Pneumonia by Regulating HIF\u20101\u03b1 Signaling Pathway in Mice","publication_year":2026,"publication_date":"2026-08-31","ids":{"openalex":"https://openalex.org/W7204836854","doi":"https://doi.org/10.1002/efd2.70203"},"language":"en","primary_location":{"id":"doi:10.1002/efd2.70203","doi":"https://doi.org/10.1002/efd2.70203","is_oa":true,"landing_page_url":"https://doi.org/10.1002/efd2.70203","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/efd2.70203","source":{"id":"https://openalex.org/S4210185879","display_name":"eFood","issn_l":"2666-3066","issn":["2666-3066"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","oarl"],"host_organization":"https://openalex.org/P4310315540","host_organization_name":"Atlantis Press","host_organization_lineage":["https://openalex.org/P4310315540"],"host_organization_lineage_names":["Atlantis Press"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eFood","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/efd2.70203","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004586593","display_name":"Zuomin Hu","orcid":"https://orcid.org/0000-0001-8110-292X","observed_orcids":["https://orcid.org/0000-0001-8110-292X"]},"institutions":[{"id":"https://openalex.org/I119273862","display_name":"Central South University of Forestry and Technology","ror":"https://ror.org/02czw2k81","country_code":"CN","type":"education","lineage":["https://openalex.org/I119273862"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zuomin Hu","raw_affiliation_strings":["Hunan Key Laboratory of Deeply Processing and Quality Control of Cereals and Oils, State Key Laboratory of Utilization of Woody Oil Resource, Hunan Key Laboratory of Forestry Edible Resources Safety and Processing Central South University of Forestry and Technology Changsha Hunan China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hunan Key Laboratory of Deeply Processing and Quality Control of Cereals and Oils, State Key Laboratory of Utilization of Woody Oil Resource, Hunan Key Laboratory of Forestry Edible Resources Safety and Processing Central South University of Forestry and Technology Changsha Hunan China","institution_ids":["https://openalex.org/I119273862"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077469650","display_name":"Yuchi Wu","orcid":"https://orcid.org/0000-0003-4974-0758","observed_orcids":["https://orcid.org/0000-0003-4974-0758"]},"institutions":[{"id":"https://openalex.org/I119273862","display_name":"Central South University of Forestry and Technology","ror":"https://ror.org/02czw2k81","country_code":"CN","type":"education","lineage":["https://openalex.org/I119273862"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuchi Wu","raw_affiliation_strings":["Hunan Key Laboratory of Deeply Processing and Quality Control of Cereals and Oils, State Key Laboratory of Utilization of Woody Oil Resource, Hunan Key Laboratory of Forestry Edible Resources Safety and Processing Central South University of Forestry and Technology Changsha Hunan China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hunan Key Laboratory of Deeply Processing and Quality Control of Cereals and Oils, State Key Laboratory of Utilization of Woody Oil Resource, Hunan Key Laboratory of Forestry Edible Resources Safety and Processing Central South University of Forestry and Technology Changsha Hunan China","institution_ids":["https://openalex.org/I119273862"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002229333","display_name":"Feijun Luo","orcid":"https://orcid.org/0000-0001-7489-544X","observed_orcids":["https://orcid.org/0000-0001-7489-544X"]},"institutions":[{"id":"https://openalex.org/I119273862","display_name":"Central South University of Forestry and Technology","ror":"https://ror.org/02czw2k81","country_code":"CN","type":"education","lineage":["https://openalex.org/I119273862"]},{"id":"https://openalex.org/I4210091706","display_name":"Henan Academy of Sciences","ror":"https://ror.org/00hy87220","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210091706"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Feijun Luo","raw_affiliation_strings":["Hunan Key Laboratory of Deeply Processing and Quality Control of Cereals and Oils, State Key Laboratory of Utilization of Woody Oil Resource, Hunan Key Laboratory of Forestry Edible Resources Safety and Processing Central South University of Forestry and Technology Changsha Hunan China","Pindingshan Industrial Technology Research Institute Henan Academy of Sciences Zhengzhou Henan China"],"raw_orcid":"https://orcid.org/0000-0001-7489-544X","affiliations":[{"raw_affiliation_string":"Hunan Key Laboratory of Deeply Processing and Quality Control of Cereals and Oils, State Key Laboratory of Utilization of Woody Oil Resource, Hunan Key Laboratory of Forestry Edible Resources Safety and Processing Central South University of Forestry and Technology Changsha Hunan China","institution_ids":["https://openalex.org/I119273862"]},{"raw_affiliation_string":"Pindingshan Industrial Technology Research Institute Henan Academy of Sciences Zhengzhou Henan China","institution_ids":["https://openalex.org/I4210091706"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102546155","display_name":"Zhongxing Chu","orcid":"https://orcid.org/0009-0009-7078-2267","observed_orcids":["https://orcid.org/0009-0009-7078-2267"]},"institutions":[{"id":"https://openalex.org/I119273862","display_name":"Central South University of Forestry and Technology","ror":"https://ror.org/02czw2k81","country_code":"CN","type":"education","lineage":["https://openalex.org/I119273862"]},{"id":"https://openalex.org/I4210091706","display_name":"Henan Academy of Sciences","ror":"https://ror.org/00hy87220","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210091706"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhongxing Chu","raw_affiliation_strings":["Hunan Key Laboratory of Deeply Processing and Quality Control of Cereals and Oils, State Key Laboratory of Utilization of Woody Oil Resource, Hunan Key Laboratory of Forestry Edible Resources Safety and Processing Central South University of Forestry and Technology Changsha Hunan China","Pindingshan Industrial Technology Research Institute Henan Academy of Sciences Zhengzhou Henan China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hunan Key Laboratory of Deeply Processing and Quality Control of Cereals and Oils, State Key Laboratory of Utilization of Woody Oil Resource, Hunan Key Laboratory of Forestry Edible Resources Safety and Processing Central South University of Forestry and Technology Changsha Hunan China","institution_ids":["https://openalex.org/I119273862"]},{"raw_affiliation_string":"Pindingshan Industrial Technology Research Institute Henan Academy of Sciences Zhengzhou Henan China","institution_ids":["https://openalex.org/I4210091706"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001801491","display_name":"Yongpan Huang","orcid":"https://orcid.org/0000-0002-0346-6266","observed_orcids":["https://orcid.org/0000-0002-0346-6266"]},"institutions":[{"id":"https://openalex.org/I4405280378","display_name":"Changsha Social Work College","ror":"https://ror.org/02vvpkg11","country_code":"CN","type":"education","lineage":["https://openalex.org/I4405280378"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yongpan Huang","raw_affiliation_strings":["School of Medicine Changsha Social Work College Changsha Hunan China"],"raw_orcid":"https://orcid.org/0000-0002-0346-6266","affiliations":[{"raw_affiliation_string":"School of Medicine Changsha Social Work College Changsha Hunan China","institution_ids":["https://openalex.org/I4405280378"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148785578","display_name":"Jiali Ren","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I119273862","display_name":"Central South University of Forestry and Technology","ror":"https://ror.org/02czw2k81","country_code":"CN","type":"education","lineage":["https://openalex.org/I119273862"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiali Ren","raw_affiliation_strings":["Hunan Key Laboratory of Deeply Processing and Quality Control of Cereals and Oils, State Key Laboratory of Utilization of Woody Oil Resource, Hunan Key Laboratory of Forestry Edible Resources Safety and Processing Central South University of Forestry and Technology Changsha Hunan China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hunan Key Laboratory of Deeply Processing and Quality Control of Cereals and Oils, State Key Laboratory of Utilization of Woody Oil Resource, Hunan Key Laboratory of Forestry Edible Resources Safety and Processing Central South University of Forestry and Technology Changsha Hunan China","institution_ids":["https://openalex.org/I119273862"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Zhengwen Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I119273862","display_name":"Central South University of Forestry and Technology","ror":"https://ror.org/02czw2k81","country_code":"CN","type":"education","lineage":["https://openalex.org/I119273862"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhengwen Li","raw_affiliation_strings":["Hunan Key Laboratory of Deeply Processing and Quality Control of Cereals and Oils, State Key Laboratory of Utilization of Woody Oil Resource, Hunan Key Laboratory of Forestry Edible Resources Safety and Processing Central South University of Forestry and Technology Changsha Hunan China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hunan Key Laboratory of Deeply Processing and Quality Control of Cereals and Oils, State Key Laboratory of Utilization of Woody Oil Resource, Hunan Key Laboratory of Forestry Edible Resources Safety and Processing Central South University of Forestry and Technology Changsha Hunan China","institution_ids":["https://openalex.org/I119273862"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068601995","display_name":"Dandan Qin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210110723","display_name":"Hunan Academy of Agricultural Sciences","ror":"https://ror.org/01fj5gf64","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210110723"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dandan Qin","raw_affiliation_strings":["Hunan Institute of Agricultural Product Processing and Quality Safety Hunan Academy of Agricultural Sciences Changsha Hunan China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hunan Institute of Agricultural Product Processing and Quality Safety Hunan Academy of Agricultural Sciences Changsha Hunan China","institution_ids":["https://openalex.org/I4210110723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102626398","display_name":"Yiping Tang","orcid":"https://orcid.org/0000-0001-6180-4801","observed_orcids":["https://orcid.org/0000-0001-6180-4801"]},"institutions":[{"id":"https://openalex.org/I119273862","display_name":"Central South University of Forestry and Technology","ror":"https://ror.org/02czw2k81","country_code":"CN","type":"education","lineage":["https://openalex.org/I119273862"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yiping Tang","raw_affiliation_strings":["Hunan Key Laboratory of Deeply Processing and Quality Control of Cereals and Oils, State Key Laboratory of Utilization of Woody Oil Resource, Hunan Key Laboratory of Forestry Edible Resources Safety and Processing Central South University of Forestry and Technology Changsha Hunan China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hunan Key Laboratory of Deeply Processing and Quality Control of Cereals and Oils, State Key Laboratory of Utilization of Woody Oil Resource, Hunan Key Laboratory of Forestry Edible Resources Safety and Processing Central South University of Forestry and Technology Changsha Hunan China","institution_ids":["https://openalex.org/I119273862"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5148809383","display_name":"Yaping Zhou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I119273862","display_name":"Central South University of Forestry and Technology","ror":"https://ror.org/02czw2k81","country_code":"CN","type":"education","lineage":["https://openalex.org/I119273862"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yaping Zhou","raw_affiliation_strings":["Hunan Key Laboratory of Deeply Processing and Quality Control of Cereals and Oils, State Key Laboratory of Utilization of Woody Oil Resource, Hunan Key Laboratory of Forestry Edible Resources Safety and Processing Central South University of Forestry and Technology Changsha Hunan China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hunan Key Laboratory of Deeply Processing and Quality Control of Cereals and Oils, State Key Laboratory of Utilization of Woody Oil Resource, Hunan Key Laboratory of Forestry Edible Resources Safety and Processing Central South University of Forestry and Technology Changsha Hunan China","institution_ids":["https://openalex.org/I119273862"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5001801491","https://openalex.org/A5002229333"],"corresponding_institution_ids":["https://openalex.org/I119273862","https://openalex.org/I4210091706","https://openalex.org/I4405280378"],"apc_list":{"value":2500,"currency":"USD","value_usd":2500},"apc_paid":{"value":2500,"currency":"USD","value_usd":2500},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"7","issue":"5","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T14194","display_name":"Bioactive Compounds in Plants","score":0.9667999744415283,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T14194","display_name":"Bioactive Compounds in Plants","score":0.9667999744415283,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12582","display_name":"Flavonoids in Medical Research","score":0.01600000075995922,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13919","display_name":"Medicinal plant effects and applications","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sinensetin","display_name":"sinensetin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/citrus-peel","display_name":"citrus peel","score":0.9570000171661377},{"id":"https://openalex.org/keywords/acute-pneumonia","display_name":"acute pneumonia","score":0.9890000224113464},{"id":"https://openalex.org/keywords/lps-induced-lung-injury","display_name":"lipopolysaccharide-induced lung injury","score":0.9599999785423279},{"id":"https://openalex.org/keywords/hif-1alpha-signaling-pathway","display_name":"HIF-1\u03b1 signaling pathway","score":0.8849999904632568},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.902999997138977},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.824999988079071},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.9559999704360962},{"id":"https://openalex.org/keywords/ap-1","display_name":"AP-1","score":0.8759999871253967},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.6570000052452087},{"id":"https://openalex.org/keywords/beas-2b-cells","display_name":"BEAS-2B cells","score":0.9190000295639038},{"id":"https://openalex.org/keywords/pulmonary-inflammation","display_name":"lung inflammation","score":0.3149999976158142}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5769000053405762},{"id":"https://openalex.org/C2778754761","wikidata":"https://www.wikidata.org/wiki/Q421804","display_name":"Lipopolysaccharide","level":2,"score":0.5755000114440918},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5184000134468079},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.45339998602867126},{"id":"https://openalex.org/C2777914695","wikidata":"https://www.wikidata.org/wiki/Q12192","display_name":"Pneumonia","level":2,"score":0.447299987077713},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3952000141143799},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.3589000105857849},{"id":"https://openalex.org/C85265743","wikidata":"https://www.wikidata.org/wiki/Q885458","display_name":"Blot","level":3,"score":0.30000001192092896},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.27950000762939453},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.26330000162124634}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1002/efd2.70203","doi":"https://doi.org/10.1002/efd2.70203","is_oa":true,"landing_page_url":"https://doi.org/10.1002/efd2.70203","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/efd2.70203","source":{"id":"https://openalex.org/S4210185879","display_name":"eFood","issn_l":"2666-3066","issn":["2666-3066"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","oarl"],"host_organization":"https://openalex.org/P4310315540","host_organization_name":"Atlantis Press","host_organization_lineage":["https://openalex.org/P4310315540"],"host_organization_lineage_names":["Atlantis Press"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eFood","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1002/efd2.70203","doi":"https://doi.org/10.1002/efd2.70203","is_oa":true,"landing_page_url":"https://doi.org/10.1002/efd2.70203","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/efd2.70203","source":{"id":"https://openalex.org/S4210185879","display_name":"eFood","issn_l":"2666-3066","issn":["2666-3066"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","oarl"],"host_organization":"https://openalex.org/P4310315540","host_organization_name":"Atlantis Press","host_organization_lineage":["https://openalex.org/P4310315540"],"host_organization_lineage_names":["Atlantis Press"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eFood","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.979200005531311,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1492397941","display_name":"\u57fa\u4e8elnc PSR/HIF-1\u03b1\u4fe1\u53f7\u63a2\u8ba8\u9ec4\u82aa\u7532\u82f7\u7eb3\u7c73\u7c92\u8c03\u63a7\u8840\u7ba1\u5e73\u6ed1\u808c\u7ec6\u80de\u8868\u578b\u8f6c\u6362\u7f13\u89e3\u9ad8\u8840\u538b\u8840\u7ba1\u91cd\u6784\u7684\u4f5c\u7528\u7814\u7a76","funder_award_id":"2026JJ80933","funder_id":"https://openalex.org/F4320322843","funder_display_name":"Natural Science Foundation of\u00a0Hunan Province"},{"id":"https://openalex.org/G2989080986","display_name":null,"funder_award_id":"2022YFF1100200","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4654628995","display_name":null,"funder_award_id":"U24A20466","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6643716303","display_name":null,"funder_award_id":"2023JJ60262","funder_id":"https://openalex.org/F4320322843","funder_display_name":"Natural Science Foundation of\u00a0Hunan Province"},{"id":"https://openalex.org/G967412921","display_name":null,"funder_award_id":"2019TP1029","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322843","display_name":"Natural Science Foundation of\u00a0Hunan Province","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204836854.pdf","grobid_xml":"https://content.openalex.org/works/W7204836854.grobid-xml"},"referenced_works_count":73,"referenced_works":["https://openalex.org/W1950762031","https://openalex.org/W1976869962","https://openalex.org/W1988201936","https://openalex.org/W1994004792","https://openalex.org/W2018905034","https://openalex.org/W2057842963","https://openalex.org/W2082414447","https://openalex.org/W2088297255","https://openalex.org/W2136444966","https://openalex.org/W2161173413","https://openalex.org/W2303251554","https://openalex.org/W2581431829","https://openalex.org/W2748179843","https://openalex.org/W2766575516","https://openalex.org/W2799451889","https://openalex.org/W2883562274","https://openalex.org/W2899389460","https://openalex.org/W2947997528","https://openalex.org/W2969180417","https://openalex.org/W2991791362","https://openalex.org/W3009852336","https://openalex.org/W3021862750","https://openalex.org/W3037568755","https://openalex.org/W3041960835","https://openalex.org/W3080981445","https://openalex.org/W3099361166","https://openalex.org/W3109009890","https://openalex.org/W3118826478","https://openalex.org/W3119952098","https://openalex.org/W3121844326","https://openalex.org/W3127569267","https://openalex.org/W3135771899","https://openalex.org/W3147174124","https://openalex.org/W3174334345","https://openalex.org/W3183591165","https://openalex.org/W3203803079","https://openalex.org/W3205472580","https://openalex.org/W3207633237","https://openalex.org/W3213949905","https://openalex.org/W4205480269","https://openalex.org/W4210624950","https://openalex.org/W4225711424","https://openalex.org/W4280610117","https://openalex.org/W4281668344","https://openalex.org/W4281683632","https://openalex.org/W4289527430","https://openalex.org/W4291177959","https://openalex.org/W4294767986","https://openalex.org/W4307122187","https://openalex.org/W4309170646","https://openalex.org/W4312093943","https://openalex.org/W4312121347","https://openalex.org/W4312141027","https://openalex.org/W4321495943","https://openalex.org/W4362601294","https://openalex.org/W4385185728","https://openalex.org/W4386519858","https://openalex.org/W4389639223","https://openalex.org/W4392160095","https://openalex.org/W4394580130","https://openalex.org/W4394932505","https://openalex.org/W4399703009","https://openalex.org/W4400133442","https://openalex.org/W4401896953","https://openalex.org/W4402302003","https://openalex.org/W4402680220","https://openalex.org/W4404122022","https://openalex.org/W4404621273","https://openalex.org/W4406570109","https://openalex.org/W4407242269","https://openalex.org/W4408245646","https://openalex.org/W7127636481","https://openalex.org/W7128903233"],"related_works":["https://openalex.org/W4406570109","https://openalex.org/W4400133442","https://openalex.org/W3179192103","https://openalex.org/W3217428668","https://openalex.org/W1973311207","https://openalex.org/W2131359503","https://openalex.org/W2993964876","https://openalex.org/W1994004792","https://openalex.org/W4386519858","https://openalex.org/W2766301090"],"abstract_inverted_index":{"ABSTRACT":[0],"Sinensetin,":[1],"a":[2],"key":[3],"bioactive":[4],"constituent":[5],"of":[6,81,131],"citrus":[7],"peel,":[8],"exhibits":[9],"potent":[10],"anti\u2010inflammatory":[11],"properties.":[12],"However,":[13],"the":[14,67,108,128,150],"mechanism":[15],"by":[16,65,148],"which":[17],"SIN":[18],"alleviates":[19,145],"acute":[20,29,45,63,146],"pneumonia":[21,30,46,64,147],"remains":[22],"unclear.":[23],"This":[24],"study":[25],"established":[26],"lipopolysaccharide":[27],"(LPS)\u2010induced":[28],"models":[31],"in":[32,35,47,86],"vivo":[33],"and":[34,54,79,97,103,121,136],"vitro.":[36],"Sinensetin":[37],"administration":[38],"for":[39],"3":[40],"days":[41],"significantly":[42],"attenuated":[43],"LPS\u2010induced":[44],"mice,":[48],"reducing":[49],"lung":[50,87],"injury,":[51],"oxidative":[52],"stress,":[53],"inflammation.":[55],"Transcriptomic":[56],"analysis":[57],"implicated":[58],"that":[59,74,143],"sinensetin":[60,75,93,111,132,144],"might":[61],"improve":[62],"modulating":[66],"HIF\u20101":[68],"signaling":[69],"pathway.":[70,152],"Western":[71],"blotting":[72],"revealed":[73],"suppressed":[76],"HIF\u20101\u03b1":[77,119,125,151],"expression":[78],"phosphorylation":[80],"MAPK":[82,122,137],"(p38,":[83],"ERK1/2,":[84],"JNK)":[85],"tissue.":[88],"In":[89],"LPS\u2010stimulated":[90],"BEAS\u20102B":[91],"cells,":[92],"mitigated":[94],"morphological":[95],"damage":[96],"ROS":[98],"accumulation":[99],"while":[100],"inhibiting":[101],"NF\u2010\u03baB":[102],"AP\u20101":[104],"transcriptional":[105],"activity.":[106],"At":[107],"protein":[109],"level,":[110],"reduced":[112],"inflammatory":[113,134],"factor":[114],"expression,":[115],"correlating":[116],"with":[117],"diminished":[118],"levels":[120],"phosphorylation.":[123],"Crucially,":[124],"overexpression":[126],"reversed":[127],"inhibitory":[129],"effects":[130],"on":[133],"factors":[135],"signaling.":[138],"Collectively,":[139],"these":[140],"findings":[141],"demonstrate":[142],"regulating":[149]},"counts_by_year":[],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2026-09-01T00:00:00"}