{"id":"https://openalex.org/W7204830447","doi":"https://doi.org/10.1016/j.jacc.2026.08.026","title":"Protocol-Based Implementation of Early Intensive Lipid Management After Acute Coronary Syndrome","display_name":"Protocol-Based Implementation of Early Intensive Lipid Management After Acute Coronary Syndrome","publication_year":2026,"publication_date":"2026-08-01","ids":{"openalex":"https://openalex.org/W7204830447","doi":"https://doi.org/10.1016/j.jacc.2026.08.026","pmid":"https://pubmed.ncbi.nlm.nih.gov/42671370"},"language":"en","primary_location":{"id":"doi:10.1016/j.jacc.2026.08.026","doi":"https://doi.org/10.1016/j.jacc.2026.08.026","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jacc.2026.08.026","pdf_url":null,"source":{"id":"https://openalex.org/S60865174","display_name":"Journal of the American College of Cardiology","issn_l":"0735-1097","issn":["0735-1097","1558-3597"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JACC","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.jacc.2026.08.026","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029237199","display_name":"Kazuma Oyama","orcid":"https://orcid.org/0000-0002-4001-7312","observed_orcids":["https://orcid.org/0000-0002-4001-7312"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuma Oyama","raw_affiliation_strings":["Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan"],"raw_orcid":"https://orcid.org/0000-0002-4001-7312","affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103642937","display_name":"J. T. Takahashi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Jun Takahashi","raw_affiliation_strings":["Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026075939","display_name":"Takahiro Funaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takahiro Funaki","raw_affiliation_strings":["Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088473705","display_name":"Shunsuke Oyamada","orcid":"https://orcid.org/0000-0002-8130-6815","observed_orcids":["https://orcid.org/0000-0002-8130-6815"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shunsuke Oyamada","raw_affiliation_strings":["Department of Biostatistics, JORTC Data Center, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, JORTC Data Center, Tokyo, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006093679","display_name":"Satoru Horiguchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210158758","display_name":"Hiraka General Hospital","ror":"https://ror.org/05mgn5w61","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210158758"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Satoru Horiguchi","raw_affiliation_strings":["Cardiovascular Division, Hiraka General Hospital, Yokote, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Division, Hiraka General Hospital, Yokote, Japan","institution_ids":["https://openalex.org/I4210158758"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5123204425","display_name":"Akihiro Nakamura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210090926","display_name":"Iwate Prefectural Central Hospital","ror":"https://ror.org/00g916n77","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210090926"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akihiro Nakamura","raw_affiliation_strings":["Department of Cardiology, Iwate Prefectural Central Hospital, Morioka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Iwate Prefectural Central Hospital, Morioka, Japan","institution_ids":["https://openalex.org/I4210090926"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065826771","display_name":"Takuya Yagi","orcid":"https://orcid.org/0000-0003-3822-9444","observed_orcids":["https://orcid.org/0000-0003-3822-9444"]},"institutions":[{"id":"https://openalex.org/I4405257215","display_name":"Iwate Prefectural Isawa Hospital","ror":"https://ror.org/051124b05","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4405257215"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takuya Yagi","raw_affiliation_strings":["Department of Cardiology, Iwate Prefectural Isawa Hospital, Oshu, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Iwate Prefectural Isawa Hospital, Oshu, Japan","institution_ids":["https://openalex.org/I4405257215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148786602","display_name":"Kazunori Ogata","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kazunori Ogata","raw_affiliation_strings":["Department of Cardiology, Kesennuma City Hospital, Kesennuma, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Kesennuma City Hospital, Kesennuma, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008762948","display_name":"Hirokazu Yahagi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405253358","display_name":"Kurihara Central Hospital","ror":"https://ror.org/00k4p0q25","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4405253358"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hirokazu Yahagi","raw_affiliation_strings":["Department of Cardiology, Kurihara Central Hospital, Kurihara, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Kurihara Central Hospital, Kurihara, Japan","institution_ids":["https://openalex.org/I4405253358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054895419","display_name":"Kaoru Iwabuchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210110954","display_name":"Osaki Citizen Hospital","ror":"https://ror.org/01paha414","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210110954"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kaoru Iwabuchi","raw_affiliation_strings":["Cardiovascular Division, Osaki Citizen Hospital, Osaki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Division, Osaki Citizen Hospital, Osaki, Japan","institution_ids":["https://openalex.org/I4210110954"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013837317","display_name":"Shigeto Namiuchi","orcid":"https://orcid.org/0000-0002-2368-9897","observed_orcids":["https://orcid.org/0000-0002-2368-9897"]},"institutions":[{"id":"https://openalex.org/I4210116024","display_name":"Sendai Medical Center","ror":"https://ror.org/02cq51909","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210116024","https://openalex.org/I4210137409"]},{"id":"https://openalex.org/I4405283872","display_name":"Sendai City Medical Center","ror":"https://ror.org/02ejx0c73","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4405283872"]},{"id":"https://openalex.org/I4405284367","display_name":"Sendai Open Hospital","ror":"https://ror.org/03e2hp829","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4405283872","https://openalex.org/I4405284367"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shigeto Namiuchi","raw_affiliation_strings":["Department of Cardiology, Sendai City Medical Center, Sendai Open Hospital, Sendai, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Sendai City Medical Center, Sendai Open Hospital, Sendai, Japan","institution_ids":["https://openalex.org/I4210116024","https://openalex.org/I4405283872","https://openalex.org/I4405284367"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073463915","display_name":"Tomoko Tomioka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405252889","display_name":"South Miyagi Medical Center","ror":"https://ror.org/003536y35","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4405252889"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomoko Tomioka","raw_affiliation_strings":["Cardiovascular Division, South Miyagi Medical Center, Ogawara, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Division, South Miyagi Medical Center, Ogawara, Japan","institution_ids":["https://openalex.org/I4405252889"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113823819","display_name":"Masafumi Sugi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405256039","display_name":"Iwaki City Medical Center","ror":"https://ror.org/03psq8c32","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4405256039"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masafumi Sugi","raw_affiliation_strings":["Cardiovascular Division, Iwaki City Medical Center, Iwaki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Division, Iwaki City Medical Center, Iwaki, Japan","institution_ids":["https://openalex.org/I4405256039"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101997263","display_name":"Satoshi Yasuda","orcid":"https://orcid.org/0000-0002-2856-8154","observed_orcids":["https://orcid.org/0000-0002-2856-8154"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Satoshi Yasuda","raw_affiliation_strings":["Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan. Electronic address: satoshi.yasuda.c8@tohoku.ac.jp"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan. Electronic address: satoshi.yasuda.c8@tohoku.ac.jp","institution_ids":["https://openalex.org/I201537933"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":11,"corresponding_author_ids":["https://openalex.org/A5101997263"],"corresponding_institution_ids":["https://openalex.org/I201537933"],"apc_list":{"value":7166,"currency":"USD","value_usd":7166},"apc_paid":{"value":7166,"currency":"USD","value_usd":7166},"fwci":3.501,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.86249202,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10292","display_name":"Acute Myocardial Infarction Research","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10193","display_name":"Coronary Interventions and Diagnostics","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-coronary-syndrome","display_name":"acute coronary syndrome","score":0.9779999852180481},{"id":"https://openalex.org/keywords/intensive-lipid-lowering-therapy","display_name":"intensive lipid-lowering therapy","score":0.9620000123977661},{"id":"https://openalex.org/keywords/ldl-cholesterol-targets","display_name":"LDL cholesterol targets","score":0.8270000219345093},{"id":"https://openalex.org/keywords/guideline-adherence","display_name":"guideline adherence","score":0.5649999976158142},{"id":"https://openalex.org/keywords/high-intensity-statins","display_name":"high-intensity statins","score":0.8970000147819519},{"id":"https://openalex.org/keywords/ezetimibe","display_name":"ezetimibe","score":0.9739999771118164},{"id":"https://openalex.org/keywords/pcsk9-inhibitors","display_name":"PCSK9 inhibitors","score":1.0},{"id":"https://openalex.org/keywords/treatment-intensification","display_name":"treatment intensification","score":0.628000020980835},{"id":"https://openalex.org/keywords/hospitalization","display_name":"hospitalization","score":0.3889999985694885},{"id":"https://openalex.org/keywords/secondary-prevention","display_name":"secondary prevention","score":0.5379999876022339},{"id":"https://openalex.org/keywords/cardiovascular-risk-reduction","display_name":"cardiovascular risk reduction","score":0.652999997138977},{"id":"https://openalex.org/keywords/quality-improvement-initiative","display_name":"quality improvement intervention","score":0.492000013589859}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9861000180244446},{"id":"https://openalex.org/C2777698277","wikidata":"https://www.wikidata.org/wiki/Q266018","display_name":"Acute coronary syndrome","level":3,"score":0.8342000246047974},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.5504999756813049},{"id":"https://openalex.org/C2987404301","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care","level":2,"score":0.5108000040054321},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4799000024795532},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.4027999937534332},{"id":"https://openalex.org/C3019550498","wikidata":"https://www.wikidata.org/wiki/Q28749","display_name":"Ldl cholesterol","level":3,"score":0.34369999170303345},{"id":"https://openalex.org/C3018906752","wikidata":"https://www.wikidata.org/wiki/Q844935","display_name":"Coronary heart disease","level":2,"score":0.2809999883174896},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.2700999975204468},{"id":"https://openalex.org/C2776104379","wikidata":"https://www.wikidata.org/wiki/Q21112670","display_name":"Lipoprotein(a)","level":4,"score":0.26660001277923584},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.26010000705718994},{"id":"https://openalex.org/C194828623","wikidata":"https://www.wikidata.org/wiki/Q2861470","display_name":"Emergency medicine","level":1,"score":0.25270000100135803}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1016/j.jacc.2026.08.026","doi":"https://doi.org/10.1016/j.jacc.2026.08.026","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jacc.2026.08.026","pdf_url":null,"source":{"id":"https://openalex.org/S60865174","display_name":"Journal of the American College of Cardiology","issn_l":"0735-1097","issn":["0735-1097","1558-3597"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JACC","raw_type":"journal-article"},{"id":"pmid:42671370","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42671370","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American College of Cardiology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.jacc.2026.08.026","doi":"https://doi.org/10.1016/j.jacc.2026.08.026","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jacc.2026.08.026","pdf_url":null,"source":{"id":"https://openalex.org/S60865174","display_name":"Journal of the American College of Cardiology","issn_l":"0735-1097","issn":["0735-1097","1558-3597"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JACC","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320318442","display_name":"Novartis Animal Health","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W1520609538","https://openalex.org/W2102330235","https://openalex.org/W2159449551","https://openalex.org/W2596179513","https://openalex.org/W2899997727","https://openalex.org/W2975025631","https://openalex.org/W3101397443","https://openalex.org/W3120916025","https://openalex.org/W3170272938","https://openalex.org/W3199787878","https://openalex.org/W3203317155","https://openalex.org/W4220918130","https://openalex.org/W4230914943","https://openalex.org/W4292114749","https://openalex.org/W4327640186","https://openalex.org/W4394920069","https://openalex.org/W4413804012","https://openalex.org/W7116751046","https://openalex.org/W7135214394","https://openalex.org/W7142532888"],"related_works":["https://openalex.org/W4406256379","https://openalex.org/W3040856067","https://openalex.org/W4401600297","https://openalex.org/W7196988722","https://openalex.org/W7164171418","https://openalex.org/W3211004208","https://openalex.org/W7127929135","https://openalex.org/W7143300349","https://openalex.org/W4410849752","https://openalex.org/W4408184708"],"abstract_inverted_index":{"BACKGROUND:":[0],"Although":[1],"guideline-recommended":[2,53,334,359],"intensive":[3,19,327],"lipid-lowering":[4],"therapy":[5],"(LLT)":[6],"reduces":[7],"recurrent":[8],"cardiovascular":[9],"events":[10],"after":[11,56,192,337],"acute":[12],"coronary":[13],"syndrome":[14],"(ACS),":[15],"timely":[16,50,349],"implementation":[17,47,323,357],"of":[18,23,38,52,131,163,307,332,353,358],"LLT":[20,84,101,328,354],"and":[21,103,110,157,167,178,185,224,311,351,355,367],"achievement":[22,51,162,331],"low-density":[24],"lipoprotein":[25],"cholesterol":[26],"(LDL-C)":[27],"target":[28,55,336],"remain":[29],"suboptimal":[30],"in":[31,152,240,274,316,362,372],"routine":[32,363],"clinical":[33,364],"practice.":[34,365],"OBJECTIVES:":[35],"The":[36,155,197,215],"purpose":[37],"this":[39],"study":[40,190],"was":[41,85,114,135,148,218,229,238,260,314],"to":[42,74,94,267,347],"determine":[43],"whether":[44],"a":[45,61,95,275,342],"protocol-based":[46,75,82,126,318,322],"strategy":[48,324],"improves":[49],"LDL-C":[54,104,113,129,145,164,207,227,235,284,335],"ACS.":[57,67,338],"METHODS:":[58],"We":[59],"conducted":[60],"cluster-randomized":[62],"trial":[63],"involving":[64],"patients":[65,182,187,203],"with":[66,119,204,374],"Ten":[68],"centers":[69],"were":[70,161,183,211,222,281],"randomly":[71],"assigned":[72],"1:1":[73],"or":[76,87],"standard":[77],"lipid":[78,360],"management.":[79],"In":[80,124],"the":[81,90,125,138,149,189,225,257,317,333],"group,":[83,127],"initiated":[86],"intensified":[88],"during":[89],"index":[91],"hospitalization":[92],"according":[93],"prespecified":[96],"algorithm":[97],"based":[98],"on":[99],"baseline":[100],"status":[102],"levels":[105],"using":[106],"high-intensity":[107,308],"statins,":[108,309],"ezetimibe,":[109,310],"PCSK9":[111,312],"inhibitors.":[112],"reassessed":[115],"at":[116,170],"4":[117],"weeks,":[118],"treatment":[120,150],"escalation":[121],"when":[122],"indicated.":[123],"an":[128],"level":[130,228],"approximately":[132],"55":[133],"mg/dL":[134,147,166,169,237,286],"used":[136],"as":[137],"protocol-specified":[139],"operational":[140],"threshold":[141],"for":[142,283,325],"intensification,":[143],"whereas":[144],"<70":[146,165,236],"goal":[151],"both":[153],"groups.":[154,214],"primary":[156,198],"key":[158],"secondary":[159],"endpoints":[160],"<55":[168,285],"6":[171,233,304],"months,":[172,234,305],"respectively.":[173],"RESULTS:":[174],"Between":[175],"November":[176],"2024":[177],"July":[179],"2025,":[180],"330":[181],"enrolled,":[184],"329":[186],"comprised":[188],"population":[191],"1":[193],"patient":[194],"withdrew":[195],"consent.":[196],"efficacy":[199],"analysis":[200],"included":[201],"315":[202],"complete":[205],"6-month":[206],"data.":[208],"Baseline":[209],"characteristics":[210],"balanced":[212],"between":[213],"mean":[216],"age":[217],"69":[219],"years,":[220],"18%":[221],"women,":[223],"median":[226],"110":[230],"mg/dL.":[231],"At":[232,303],"achieved":[239],"86.4%":[241],"vs":[242,288],"73.7%":[243],"(between-group":[244],"difference,":[245,291],"12.6":[246],"percentage":[247,252,262,269,293,298],"points":[248,263,294],"[95%":[249,295],"CI:":[250,265,296],"3.8-21.5":[251],"points];":[253,299],"P":[254,271,300],"=":[255,272],"0.005);":[256],"corresponding":[258],"difference":[259],"12.8":[261],"(95%":[264],"-2.0":[266],"27.6":[268],"points;":[270],"0.08)":[273],"hospital-level":[276],"sensitivity":[277],"analysis.":[278],"Similar":[279],"findings":[280,340],"observed":[282],"(60.8%":[287],"34.5%;":[289],"between-group":[290],"26.3":[292],"18.5-34.0":[297],"<":[301],"0.001).":[302],"use":[306],"inhibitors":[313],"higher":[315],"group.":[319],"CONCLUSIONS:":[320],"A":[321],"early":[326],"significantly":[329],"improved":[330],"These":[339],"support":[341],"structured,":[343],"algorithm-based":[344],"care":[345],"pathway":[346],"facilitate":[348],"initiation":[350],"intensification":[352],"improve":[356],"management":[361],"(Brief":[366],"Protocol-Based":[368],"Intensive":[369],"Lipid":[370],"Management":[371],"Patients":[373],"Acute":[375],"Coronary":[376],"Syndrome;":[377],"jRCT1020240029).":[378]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2026-09-01T00:00:00"}