{"id":"https://openalex.org/W7204830019","doi":"https://doi.org/10.64898/2026.08.28.747625","title":"TNIK maintains a MYC-driven partial EMT state that supports proliferation and evasion of senescence in lung squamous cell carcinoma","display_name":"TNIK maintains a MYC-driven partial EMT state that supports proliferation and evasion of senescence in lung squamous cell carcinoma","publication_year":2026,"publication_date":"2026-08-31","ids":{"openalex":"https://openalex.org/W7204830019","doi":"https://doi.org/10.64898/2026.08.28.747625","pmid":"https://pubmed.ncbi.nlm.nih.gov/42800942","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13613121"},"language":"en","primary_location":{"id":"doi:10.64898/2026.08.28.747625","doi":"https://doi.org/10.64898/2026.08.28.747625","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.28.747625","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/08/31/2026.08.28.747625.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/08/31/2026.08.28.747625.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018709545","display_name":"Mohaddase Hamidi","orcid":"https://orcid.org/0000-0002-0431-0677","observed_orcids":["https://orcid.org/0000-0002-0431-0677"]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]},{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mohaddase Hamidi","raw_affiliation_strings":["Cancer Signaling and Microenvironment Program, Fox Chase Cancer Center, Philadelphia, PA, USA","Department of Cancer and Cellular Biology, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA"],"raw_orcid":"https://orcid.org/0000-0002-0431-0677","affiliations":[{"raw_affiliation_string":"Cancer Signaling and Microenvironment Program, Fox Chase Cancer Center, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I1289437631"]},{"raw_affiliation_string":"Department of Cancer and Cellular Biology, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047825816","display_name":"Kenneth Achola Omolo","orcid":"https://orcid.org/0009-0007-8511-6123","observed_orcids":["https://orcid.org/0009-0007-8511-6123"]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]},{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenneth O Omolo","raw_affiliation_strings":["Biomedical Sciences Graduate Program, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA","Cancer Signaling and Microenvironment Program, Fox Chase Cancer Center, Philadelphia, PA, USA","Department of Cancer and Cellular Biology, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA"],"raw_orcid":"https://orcid.org/0009-0007-8511-6123","affiliations":[{"raw_affiliation_string":"Biomedical Sciences Graduate Program, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I84392919"]},{"raw_affiliation_string":"Cancer Signaling and Microenvironment Program, Fox Chase Cancer Center, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I1289437631"]},{"raw_affiliation_string":"Department of Cancer and Cellular Biology, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5132835627","display_name":"Korrey W. Hart","orcid":"https://orcid.org/0009-0004-6124-484X","observed_orcids":["https://orcid.org/0009-0004-6124-484X"]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]},{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Korrey W Hart","raw_affiliation_strings":["Cancer Signaling and Microenvironment Program, Fox Chase Cancer Center, Philadelphia, PA, USA","Department of Cancer and Cellular Biology, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA"],"raw_orcid":"https://orcid.org/0009-0004-6124-484X","affiliations":[{"raw_affiliation_string":"Cancer Signaling and Microenvironment Program, Fox Chase Cancer Center, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I1289437631"]},{"raw_affiliation_string":"Department of Cancer and Cellular Biology, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5132914806","display_name":"Shrey Sitaram","orcid":"https://orcid.org/0009-0003-0171-7791","observed_orcids":["https://orcid.org/0009-0003-0171-7791"]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]},{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shrey Sitaram","raw_affiliation_strings":["Cancer Signaling and Microenvironment Program, Fox Chase Cancer Center, Philadelphia, PA, USA","Department of Cancer and Cellular Biology, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA"],"raw_orcid":"https://orcid.org/0009-0003-0171-7791","affiliations":[{"raw_affiliation_string":"Cancer Signaling and Microenvironment Program, Fox Chase Cancer Center, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I1289437631"]},{"raw_affiliation_string":"Department of Cancer and Cellular Biology, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5149298642","display_name":"Yan Zhou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]},{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yan Zhou","raw_affiliation_strings":["Biostatistics and Bioinformatics Core Facility, Fox Chase Cancer Center, Temple University, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biostatistics and Bioinformatics Core Facility, Fox Chase Cancer Center, Temple University, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I1289437631","https://openalex.org/I84392919"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088111017","display_name":"Pedro Torres\u2010Ayuso","orcid":"https://orcid.org/0000-0003-2213-9014","observed_orcids":["https://orcid.org/0000-0003-2213-9014"]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]},{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Pedro Torres-Ayuso","raw_affiliation_strings":["Cancer Signaling and Microenvironment Program, Fox Chase Cancer Center, Philadelphia, PA, USA","Department of Cancer and Cellular Biology, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA"],"raw_orcid":"https://orcid.org/0000-0003-2213-9014","affiliations":[{"raw_affiliation_string":"Cancer Signaling and Microenvironment Program, Fox Chase Cancer Center, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I1289437631"]},{"raw_affiliation_string":"Department of Cancer and Cellular Biology, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I84392919"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5088111017"],"corresponding_institution_ids":["https://openalex.org/I1289437631","https://openalex.org/I84392919"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.8324999809265137,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.8324999809265137,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.03620000183582306,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.02889999933540821,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tnik","display_name":"TNIK","score":0.9639999866485596},{"id":"https://openalex.org/keywords/lung-squamous-cell-carcinoma","display_name":"lung squamous cell carcinoma","score":0.9779999852180481},{"id":"https://openalex.org/keywords/c-myc","display_name":"c-Myc","score":0.9079999923706055},{"id":"https://openalex.org/keywords/partial-epithelial-mesenchymal-transition","display_name":"partial epithelial-mesenchymal transition","score":0.9470000267028809},{"id":"https://openalex.org/keywords/cellular-plasticity","display_name":"cellular plasticity","score":0.7910000085830688},{"id":"https://openalex.org/keywords/senescence-evasion","display_name":"senescence evasion","score":0.9750000238418579},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.9229999780654907},{"id":"https://openalex.org/keywords/ezh2","display_name":"EZH2","score":0.9369999766349792},{"id":"https://openalex.org/keywords/histone-methyltransferase","display_name":"histone methyltransferase","score":0.8889999985694885},{"id":"https://openalex.org/keywords/radiosensitization","display_name":"radiosensitization","score":0.7269999980926514},{"id":"https://openalex.org/keywords/tumor-cell-migration-and-invasion","display_name":"tumor cell migration and invasion","score":0.550000011920929}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6934000253677368},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5320000052452087},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.49149999022483826},{"id":"https://openalex.org/C522857546","wikidata":"https://www.wikidata.org/wiki/Q2070979","display_name":"Senescence","level":2,"score":0.47769999504089355},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4668999910354614},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.4250999987125397},{"id":"https://openalex.org/C50171091","wikidata":"https://www.wikidata.org/wiki/Q17917770","display_name":"EZH2","level":4,"score":0.36970001459121704},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.36419999599456787},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.33230000734329224},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.33149999380111694},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.3231000006198883},{"id":"https://openalex.org/C97037327","wikidata":"https://www.wikidata.org/wiki/Q5334291","display_name":"Ectopic expression","level":3,"score":0.32019999623298645},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.2953000068664551},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.2896000146865845},{"id":"https://openalex.org/C81729549","wikidata":"https://www.wikidata.org/wiki/Q4649475","display_name":"A549 cell","level":3,"score":0.2847000062465668},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.2809000015258789},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.27390000224113464},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.2718999981880188},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.2705000042915344},{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.263700008392334}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.64898/2026.08.28.747625","doi":"https://doi.org/10.64898/2026.08.28.747625","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.28.747625","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/08/31/2026.08.28.747625.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:42800942","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42800942","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13613121","doi":null,"is_oa":true,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42800942/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.64898/2026.08.28.747625","doi":"https://doi.org/10.64898/2026.08.28.747625","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.28.747625","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/08/31/2026.08.28.747625.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G661345454","display_name":"\"Role of Amplified Protein Kinases in Head and Neck Squamous Cell Carcinoma Progression and Therapy Resistance.\"","funder_award_id":"R03DE033064","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337365","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204830019.pdf","grobid_xml":"https://content.openalex.org/works/W7204830019.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4393075627","https://openalex.org/W3121865115","https://openalex.org/W4282961179","https://openalex.org/W4402945404","https://openalex.org/W3170678675","https://openalex.org/W4362541267","https://openalex.org/W3016659528","https://openalex.org/W7148968656","https://openalex.org/W2980923414","https://openalex.org/W2783417402"],"abstract_inverted_index":{"Lung":[0],"squamous":[1],"cell":[2,66,89],"carcinoma":[3],"(LUSC)":[4],"is":[5,21],"an":[6,82],"aggressive":[7],"malignancy":[8],"characterized":[9,86],"by":[10,87],"high":[11],"cellular":[12],"plasticity":[13,64,173],"and":[14,25,47,65,95,116,151,153,176,180,195],"few":[15],"targeted":[16],"treatment":[17],"options.":[18],"TNIK":[19,30,52,72,107,136,147,161,167,191],"overexpression":[20],"common":[22],"in":[23,68,138,168,193],"LUSC":[24,33,74,139,194],"promotes":[26],"tumor":[27],"growth,":[28],"with":[29,110,174],"inhibition":[31],"sensitizing":[32],"to":[34],"radiotherapy,":[35],"though":[36],"the":[37,113,144,158,169,187],"underlying":[38],"mechanisms":[39,170],"are":[40],"not":[41],"well":[42],"defined.":[43],"Through":[44],"transcriptomic":[45],"analyses":[46],"functional":[48],"assays,":[49],"we":[50,104,129],"identified":[51,130],"as":[53,132],"a":[54,57,77,100,133],"regulator":[55],"of":[56,71,146,160,178,190],"MYC-dependent":[58],"transcriptional":[59],"network":[60],"that":[61,106],"coordinates":[62],"epithelial-mesenchymal":[63,172],"proliferation":[67,175],"LUSC.":[69],"Depletion":[70],"reprogrammed":[73],"cells":[75],"from":[76],"hybrid":[78],"epithelial/mesenchymal":[79],"state":[80,85],"towards":[81],"epithelial,":[83],"senescent-like":[84],"reduced":[88,92],"migration,":[90],"invasion,":[91],"DNA":[93],"synthesis,":[94],"enhanced":[96],"\u03b2-galactosidase":[97],"activity.":[98],"Using":[99],"small-molecule":[101],"screen":[102],"approach,":[103],"found":[105],"inhibitors":[108,192],"cooperated":[109],"agents":[111],"suppressing":[112],"histone":[114],"methyltransferase":[115],"MYC":[117,131,141,155],"binding":[118],"partner":[119],"EZH2,":[120],"which":[121],"further":[122],"suppressed":[123],"partial":[124],"epithelial-to-mesenchymal":[125],"transition":[126],"(pEMT).":[127],"Mechanistically,":[128],"key":[134],"downstream":[135],"effector":[137],"cells:":[140],"depletion":[142],"phenocopied":[143],"effects":[145,159],"loss":[148],"on":[149],"pEMT":[150],"senescence,":[152],"restoring":[154],"expression":[156],"bypassed":[157],"depletion.":[162],"Collectively,":[163],"these":[164],"results":[165],"implicate":[166],"linking":[171],"evasion":[177],"senescence":[179],"provide":[181],"insights":[182],"into":[183],"future":[184],"strategies":[185],"for":[186],"clinical":[188],"deployment":[189],"other":[196],"TNIK-dependent":[197],"malignancies.":[198]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-09-01T00:00:00"}