{"id":"https://openalex.org/W7204829081","doi":"https://doi.org/10.64898/2026.08.27.26361470","title":"Characterizing Preschool Children\u2019s Multi-Matrix Air Pollutant Exposures Across Home and Early Childhood Education Settings: A Paired Silicone Wristband Study Protocol","display_name":"Characterizing Preschool Children\u2019s Multi-Matrix Air Pollutant Exposures Across Home and Early Childhood Education Settings: A Paired Silicone Wristband Study Protocol","publication_year":2026,"publication_date":"2026-08-31","ids":{"openalex":"https://openalex.org/W7204829081","doi":"https://doi.org/10.64898/2026.08.27.26361470","pmid":"https://pubmed.ncbi.nlm.nih.gov/42922794","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13684695"},"language":"en","primary_location":{"id":"doi:10.64898/2026.08.27.26361470","doi":"https://doi.org/10.64898/2026.08.27.26361470","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.27.26361470","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/08/31/2026.08.27.26361470.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.medrxiv.org/content/medrxiv/early/2026/08/31/2026.08.27.26361470.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032282495","display_name":"Abby D. Mutic","orcid":"https://orcid.org/0000-0003-2374-622X","observed_orcids":["https://orcid.org/0000-0003-2374-622X"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Abby D. Mutic","raw_affiliation_strings":["Nell Hodgson Woodruff School of Nursing, Emory University, Atlanta, GA"],"raw_orcid":"https://orcid.org/0000-0003-2374-622X","affiliations":[{"raw_affiliation_string":"Nell Hodgson Woodruff School of Nursing, Emory University, Atlanta, GA","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103088543","display_name":"Linda McCauley","orcid":"https://orcid.org/0000-0002-3779-3791","observed_orcids":["https://orcid.org/0000-0002-3779-3791"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Linda A. McCauley","raw_affiliation_strings":["Nell Hodgson Woodruff School of Nursing, Emory University, Atlanta, GA"],"raw_orcid":"https://orcid.org/0000-0002-3779-3791","affiliations":[{"raw_affiliation_string":"Nell Hodgson Woodruff School of Nursing, Emory University, Atlanta, GA","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148810836","display_name":"Angelina Andrew","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Angelina Andrew","raw_affiliation_strings":["University of North Carolina at Chapel Hill, Chapel Hill, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Carolina at Chapel Hill, Chapel Hill, NC","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042721747","display_name":"Anne M. Fitzpatrick","orcid":"https://orcid.org/0000-0002-2933-5926","observed_orcids":["https://orcid.org/0000-0002-2933-5926"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anne M. Fitzpatrick","raw_affiliation_strings":["Department of Pediatrics, Emory University School of Medicine, Atlanta, GA"],"raw_orcid":"https://orcid.org/0000-0002-2933-5926","affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Emory University School of Medicine, Atlanta, GA","institution_ids":["https://openalex.org/I150468666"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5032282495"],"corresponding_institution_ids":["https://openalex.org/I150468666"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11002","display_name":"Indoor Air Quality and Microbial Exposure","score":0.8939999938011169,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11002","display_name":"Indoor Air Quality and Microbial Exposure","score":0.8939999938011169,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10190","display_name":"Air Quality and Health Impacts","score":0.0925000011920929,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/preschool-children","display_name":"preschool children","score":0.7770000100135803},{"id":"https://openalex.org/keywords/early-childhood-education-settings","display_name":"early childhood education settings","score":0.9660000205039978},{"id":"https://openalex.org/keywords/indoor-air-pollution","display_name":"indoor air pollution","score":0.8650000095367432},{"id":"https://openalex.org/keywords/silicone-wristbands","display_name":"silicone wristbands","score":0.6190000176429749},{"id":"https://openalex.org/keywords/volatile-organic-compounds","display_name":"volatile organic compounds","score":0.8930000066757202},{"id":"https://openalex.org/keywords/particulate-matter","display_name":"particulate matter","score":0.9990000128746033},{"id":"https://openalex.org/keywords/urinary-biomarkers","display_name":"urinary biomarkers","score":0.7710000276565552},{"id":"https://openalex.org/keywords/pediatric-respiratory-health","display_name":"children's respiratory health","score":0.6460000276565552},{"id":"https://openalex.org/keywords/indoor-microenvironments","display_name":"indoor microenvironments","score":0.5059999823570251}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7735000252723694},{"id":"https://openalex.org/C2780385302","wikidata":"https://www.wikidata.org/wiki/Q367158","display_name":"Protocol (science)","level":3,"score":0.5710999965667725},{"id":"https://openalex.org/C2776640315","wikidata":"https://www.wikidata.org/wiki/Q7315941","display_name":"Respondent","level":2,"score":0.5575000047683716},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.5343000292778015},{"id":"https://openalex.org/C27415008","wikidata":"https://www.wikidata.org/wiki/Q7256382","display_name":"Psychological intervention","level":2,"score":0.5041999816894531},{"id":"https://openalex.org/C2777082460","wikidata":"https://www.wikidata.org/wiki/Q3377398","display_name":"Early childhood","level":2,"score":0.39820000529289246},{"id":"https://openalex.org/C198531522","wikidata":"https://www.wikidata.org/wiki/Q485146","display_name":"Sample (material)","level":2,"score":0.3815000057220459},{"id":"https://openalex.org/C129848803","wikidata":"https://www.wikidata.org/wiki/Q2564360","display_name":"Sample size determination","level":2,"score":0.35679998993873596},{"id":"https://openalex.org/C2779769944","wikidata":"https://www.wikidata.org/wiki/Q146439","display_name":"Silicone","level":2,"score":0.336899995803833},{"id":"https://openalex.org/C126314574","wikidata":"https://www.wikidata.org/wiki/Q2364111","display_name":"Air quality index","level":2,"score":0.30959999561309814},{"id":"https://openalex.org/C65469","wikidata":"https://www.wikidata.org/wiki/Q905504","display_name":"Indoor air quality","level":2,"score":0.30489999055862427},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.28790000081062317},{"id":"https://openalex.org/C3018197256","wikidata":"https://www.wikidata.org/wiki/Q842424","display_name":"Urine sample","level":3,"score":0.27709999680519104},{"id":"https://openalex.org/C194828623","wikidata":"https://www.wikidata.org/wiki/Q2861470","display_name":"Emergency medicine","level":1,"score":0.2770000100135803},{"id":"https://openalex.org/C2987853052","wikidata":"https://www.wikidata.org/wiki/Q131123","display_name":"Air pollutants","level":3,"score":0.26109999418258667},{"id":"https://openalex.org/C2779951463","wikidata":"https://www.wikidata.org/wiki/Q7268788","display_name":"Quality of life (healthcare)","level":2,"score":0.25440001487731934}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.64898/2026.08.27.26361470","doi":"https://doi.org/10.64898/2026.08.27.26361470","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.27.26361470","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/08/31/2026.08.27.26361470.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},{"id":"pmid:42922794","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42922794","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"medRxiv : the preprint server for health sciences","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13684695","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13684695/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.64898/2026.08.27.26361470","doi":"https://doi.org/10.64898/2026.08.27.26361470","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.27.26361470","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/08/31/2026.08.27.26361470.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9907000064849854}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000897616","display_name":"Center for Children\u2019s Health Assessment, Research Translation, and Combating Environmental Racism (CHARTER)","funder_award_id":"P2CES033430","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"}],"funders":[{"id":"https://openalex.org/F4320337353","display_name":"National Institute of Nursing Research","ror":"https://ror.org/01y3zfr79"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204829081.pdf","grobid_xml":"https://content.openalex.org/works/W7204829081.grobid-xml"},"referenced_works_count":26,"referenced_works":["https://openalex.org/W1977220166","https://openalex.org/W1994017384","https://openalex.org/W1995658571","https://openalex.org/W2004905348","https://openalex.org/W2059225753","https://openalex.org/W2070398931","https://openalex.org/W2130672301","https://openalex.org/W2137460360","https://openalex.org/W2143342727","https://openalex.org/W2208828712","https://openalex.org/W2257880509","https://openalex.org/W2264575387","https://openalex.org/W2292911436","https://openalex.org/W2346275821","https://openalex.org/W2411553975","https://openalex.org/W2521968352","https://openalex.org/W2582406074","https://openalex.org/W2734957490","https://openalex.org/W2738753086","https://openalex.org/W2781900458","https://openalex.org/W2794603845","https://openalex.org/W2802010775","https://openalex.org/W2806114580","https://openalex.org/W2897435555","https://openalex.org/W4302306884","https://openalex.org/W4312093654"],"related_works":["https://openalex.org/W4401540228","https://openalex.org/W2981598108","https://openalex.org/W7134134663","https://openalex.org/W2281525394","https://openalex.org/W2424747114","https://openalex.org/W2990859970","https://openalex.org/W1968526093","https://openalex.org/W1795389048","https://openalex.org/W3088702790","https://openalex.org/W7009676421"],"abstract_inverted_index":{"Background:":[0],"Children":[1],"spend":[2],"more":[3],"than":[4],"90%":[5],"of":[6,62],"their":[7],"time":[8],"indoors,":[9],"and":[10,30,45,66,73,86,97,130,138,145,148,159,164,172,177,186,198,208,219],"early":[11],"childhood":[12],"education":[13],"settings":[14,92],"(ECEs)":[15],"are":[16,227],"an":[17],"understudied,":[18],"high-occupant-density":[19],"indoor":[20,118,216],"microenvironment":[21],"where":[22],"exposure":[23],"to":[24,49,102],"volatile":[25],"organic":[26],"compounds,":[27],"particulate":[28],"matter,":[29],"other":[31],"toxicants":[32],"has":[33],"been":[34],"documented.":[35],"Limited":[36],"knowledge":[37],"exists":[38],"on":[39],"ECE-specific":[40],"exposures":[41,50],"affecting":[42],"young":[43],"children":[44,65],"how":[46],"they":[47],"compare":[48],"in":[51,77,124,223,229],"the":[52,204],"home.":[53],"Methods:":[54],"This":[55,181],"prospective,":[56],"repeated-measures":[57],"pilot":[58,182],"study":[59,214],"targeted":[60],"enrollment":[61,101],"44":[63],"preschool-aged":[64],"8":[67],"ECE":[68,131,139,199],"staff":[69,132],"across":[70,93,196],"two":[71,125],"geographically":[72],"sociodemographically":[74],"distinct":[75],"ECEs":[76],"metropolitan":[78],"Atlanta,":[79],"Georgia.":[80],"Paired":[81],"silicone":[82,193],"wristbands,":[83],"one":[84,87],"home-designated":[85],"ECE-designated,":[88],"were":[89],"exchanged":[90],"between":[91],"three":[94],"consecutive":[95],"days":[96],"nights":[98],"beginning":[99],"at":[100],"characterize":[103],"microenvironment-specific":[104],"exposure.":[105],"A":[106],"single":[107],"spot":[108],"urine":[109,168],"sample":[110,169,206],"was":[111,122,151],"also":[112],"collected":[113],"from":[114],"each":[115],"child.":[116],"Continuous":[117],"air":[119,217],"quality":[120],"monitoring":[121],"conducted":[123],"classrooms":[126],"per":[127],"site.":[128],"Caregivers":[129],"completed":[133],"structured":[134],"questionnaires":[135],"assessing":[136],"home":[137,197],"environmental":[140],"characteristics,":[141],"child":[142],"respiratory":[143,221],"risk,":[144],"protocol":[146,195],"feasibility":[147,185],"acceptability.":[149],"Feasibility":[150,225],"evaluated":[152],"using":[153],"eight":[154],"pre-specified":[155],"indicators":[156],"spanning":[157],"recruitment":[158],"enrollment,":[160],"wristband":[161,194],"wear":[162],"duration":[163],"loss":[165],"by":[166,175],"microenvironment,":[167],"collection":[170],"completeness,":[171],"survey":[173],"completion":[174],"instrument":[176],"respondent":[178],"group.":[179],"Conclusion:":[180],"will":[183,202],"establish":[184],"acceptability":[187],"parameters":[188],"for":[189,211],"a":[190,212,230],"paired,":[191],"multi-matrix":[192],"microenvironments.":[200],"Findings":[201],"inform":[203],"design,":[205],"size,":[207],"power":[209],"calculations":[210],"subsequent":[213],"testing":[215],"interventions":[218],"pediatric":[220],"outcomes":[222,226],"ECEs.":[224],"reported":[228],"companion":[231],"manuscript.":[232]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-09-01T00:00:00"}