{"id":"https://openalex.org/W7204823151","doi":"https://doi.org/10.26434/chemrxiv.15008043/v1","title":"A Composable 3D-Printed Platform for Rapid Sequential Sample Injection in Mass Spectrometry","display_name":"A Composable 3D-Printed Platform for Rapid Sequential Sample Injection in Mass Spectrometry","publication_year":2026,"publication_date":"2026-08-30","ids":{"openalex":"https://openalex.org/W7204823151","doi":"https://doi.org/10.26434/chemrxiv.15008043/v1"},"language":"en","primary_location":{"id":"doi:10.26434/chemrxiv.15008043/v1","doi":"https://doi.org/10.26434/chemrxiv.15008043/v1","is_oa":true,"landing_page_url":"https://doi.org/10.26434/chemrxiv.15008043/v1","pdf_url":"https://chemrxiv.org/doi/pdf/10.26434/chemrxiv.15008043/v1","source":{"id":"https://openalex.org/S4393918830","display_name":"ChemRxiv","issn_l":"2573-2293","issn":["2573-2293"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://chemrxiv.org/doi/pdf/10.26434/chemrxiv.15008043/v1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029112034","display_name":"Olanrewaju Awoyemi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12097938","display_name":"West Virginia University","ror":"https://ror.org/011vxgd24","country_code":"US","type":"education","lineage":["https://openalex.org/I12097938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Olanrewaju Awoyemi","raw_affiliation_strings":["Department of Chemistry","West Virginia University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry","institution_ids":[]},{"raw_affiliation_string":"West Virginia University","institution_ids":["https://openalex.org/I12097938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056165526","display_name":"Amanda Overby","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150149174","display_name":"Mercer University","ror":"https://ror.org/04bk7v425","country_code":"US","type":"education","lineage":["https://openalex.org/I150149174"]},{"id":"https://openalex.org/I2801518522","display_name":"Mercer University Health Sciences Center","ror":"https://ror.org/01g67by91","country_code":"US","type":"education","lineage":["https://openalex.org/I2801518522"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amanda Overby","raw_affiliation_strings":["Department of Chemistry","Mercer University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry","institution_ids":[]},{"raw_affiliation_string":"Mercer University","institution_ids":["https://openalex.org/I150149174","https://openalex.org/I2801518522"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5139527204","display_name":"herbi yuliantoro","orcid":"https://orcid.org/0009-0002-5067-8509","observed_orcids":["https://orcid.org/0009-0002-5067-8509"]},"institutions":[{"id":"https://openalex.org/I186143895","display_name":"Lehigh University","ror":"https://ror.org/012afjb06","country_code":"US","type":"education","lineage":["https://openalex.org/I186143895"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Herbi Yuliantoro","raw_affiliation_strings":["Department of Chemistry","Lehigh University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry","institution_ids":[]},{"raw_affiliation_string":"Lehigh University","institution_ids":["https://openalex.org/I186143895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159758077","display_name":"Samuel Fisher","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12097938","display_name":"West Virginia University","ror":"https://ror.org/011vxgd24","country_code":"US","type":"education","lineage":["https://openalex.org/I12097938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samuel Fisher","raw_affiliation_strings":["Department of Chemistry","West Virginia University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry","institution_ids":[]},{"raw_affiliation_string":"West Virginia University","institution_ids":["https://openalex.org/I12097938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037830220","display_name":"Stephen J. Valentine","orcid":"https://orcid.org/0000-0003-4360-2928","observed_orcids":["https://orcid.org/0000-0003-4360-2928"]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen J. Valentine","raw_affiliation_strings":["Department of Chemistry","University of Louisville"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry","institution_ids":[]},{"raw_affiliation_string":"University of Louisville","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100432738","display_name":"Peng Li","orcid":"https://orcid.org/0000-0002-8332-7142","observed_orcids":["https://orcid.org/0000-0002-8332-7142","https://orcid.org/0000-0002-5235-6311"]},"institutions":[{"id":"https://openalex.org/I186143895","display_name":"Lehigh University","ror":"https://ror.org/012afjb06","country_code":"US","type":"education","lineage":["https://openalex.org/I186143895"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peng Li","raw_affiliation_strings":["Department of Chemistry","Lehigh University"],"raw_orcid":"https://orcid.org/0000-0002-8332-7142","affiliations":[{"raw_affiliation_string":"Department of Chemistry","institution_ids":[]},{"raw_affiliation_string":"Lehigh University","institution_ids":["https://openalex.org/I186143895"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10412","display_name":"Microfluidic and Capillary Electrophoresis Applications","score":0.00419999985024333,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12776","display_name":"Electrohydrodynamics and Fluid Dynamics","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2208","display_name":"Electrical and Electronic Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microchannel-fabrication","display_name":"microchannel fabrication","score":0.5059999823570251},{"id":"https://openalex.org/keywords/carryover","display_name":"carryover","score":0.6970000267028809}],"concepts":[{"id":"https://openalex.org/C151552171","wikidata":"https://www.wikidata.org/wiki/Q163373","display_name":"Pipette","level":2,"score":0.6104000210762024},{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.5654000043869019},{"id":"https://openalex.org/C196806460","wikidata":"https://www.wikidata.org/wiki/Q188603","display_name":"Capillary action","level":2,"score":0.5461000204086304},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.536899983882904},{"id":"https://openalex.org/C198531522","wikidata":"https://www.wikidata.org/wiki/Q485146","display_name":"Sample (material)","level":2,"score":0.5331000089645386},{"id":"https://openalex.org/C8673954","wikidata":"https://www.wikidata.org/wiki/Q138845","display_name":"Microfluidics","level":2,"score":0.4334999918937683},{"id":"https://openalex.org/C113196181","wikidata":"https://www.wikidata.org/wiki/Q485223","display_name":"Analytical Chemistry (journal)","level":2,"score":0.4293999969959259},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4189999997615814},{"id":"https://openalex.org/C2778576202","wikidata":"https://www.wikidata.org/wiki/Q2540164","display_name":"Sample preparation","level":2,"score":0.38339999318122864},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3725000023841858},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3402999937534332},{"id":"https://openalex.org/C21880701","wikidata":"https://www.wikidata.org/wiki/Q2144042","display_name":"Process engineering","level":1,"score":0.326200008392334},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.31439998745918274},{"id":"https://openalex.org/C2778445095","wikidata":"https://www.wikidata.org/wiki/Q18354077","display_name":"Sample complexity","level":2,"score":0.31060001254081726},{"id":"https://openalex.org/C2778648169","wikidata":"https://www.wikidata.org/wiki/Q967768","display_name":"Compatibility (geochemistry)","level":2,"score":0.29760000109672546},{"id":"https://openalex.org/C157764524","wikidata":"https://www.wikidata.org/wiki/Q1383412","display_name":"Throughput","level":3,"score":0.2922999858856201},{"id":"https://openalex.org/C31827203","wikidata":"https://www.wikidata.org/wiki/Q874296","display_name":"Tandem mass spectrometry","level":3,"score":0.2651999890804291},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.25519999861717224},{"id":"https://openalex.org/C198291218","wikidata":"https://www.wikidata.org/wiki/Q190382","display_name":"Ionization","level":3,"score":0.2533999979496002},{"id":"https://openalex.org/C118663420","wikidata":"https://www.wikidata.org/wiki/Q3614983","display_name":"DART ion source","level":5,"score":0.2517000138759613}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.26434/chemrxiv.15008043/v1","doi":"https://doi.org/10.26434/chemrxiv.15008043/v1","is_oa":true,"landing_page_url":"https://doi.org/10.26434/chemrxiv.15008043/v1","pdf_url":"https://chemrxiv.org/doi/pdf/10.26434/chemrxiv.15008043/v1","source":{"id":"https://openalex.org/S4393918830","display_name":"ChemRxiv","issn_l":"2573-2293","issn":["2573-2293"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.26434/chemrxiv.15008043/v1","doi":"https://doi.org/10.26434/chemrxiv.15008043/v1","is_oa":true,"landing_page_url":"https://doi.org/10.26434/chemrxiv.15008043/v1","pdf_url":"https://chemrxiv.org/doi/pdf/10.26434/chemrxiv.15008043/v1","source":{"id":"https://openalex.org/S4393918830","display_name":"ChemRxiv","issn_l":"2573-2293","issn":["2573-2293"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G5095458825","display_name":"Elucidating Factors Affecting the Preservation of Biomolecule Solution Structure for Spray-based Ionization Processes","funder_award_id":"2305137","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204823151.pdf","grobid_xml":"https://content.openalex.org/works/W7204823151.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4386497282","https://openalex.org/W4402862113","https://openalex.org/W1995070833","https://openalex.org/W2998837972","https://openalex.org/W3009172219","https://openalex.org/W3156040070","https://openalex.org/W4367173836","https://openalex.org/W4312082338","https://openalex.org/W2049799032","https://openalex.org/W2472628749"],"abstract_inverted_index":{"We":[0],"developed":[1],"a":[2,18,101,138],"composable":[3],"3D-printed":[4],"platform":[5,15,73,122],"for":[6,76],"rapid":[7,127],"sequential":[8,128],"sample":[9,28,90],"injection":[10],"in":[11,17,137],"mass":[12],"spectrometry.":[13],"The":[14,72],"works":[16],"well":[19],"plate-like":[20],"format":[21],"and":[22,44,82,108,133,141],"allows":[23],"direct":[24],"loading":[25],"of":[26,65,86,98,130],"discrete":[27],"droplets":[29],"by":[30,39],"micropipette":[31],"or":[32],"automated":[33],"liquid":[34],"handling.":[35],"Droplets":[36],"are":[37,45],"separated":[38],"air":[40],"gaps":[41],"during":[42],"transport":[43],"directly":[46],"coupled":[47],"to":[48,62],"MS":[49,70,135],"through":[50],"capillary":[51],"vibrating":[52],"sharp-edge":[53],"spray":[54],"ionization":[55],"(cVSSI).":[56],"Liquid-infused":[57],"surface":[58],"treatment":[59],"was":[60,74,91,110],"used":[61],"improve":[63],"compatibility":[64],"the":[66,121],"3Dprinted":[67],"microchannels":[68],"with":[69,104],"analysis.":[71],"evaluated":[75,111],"device":[77],"operation,":[78],"throughput,":[79],"quantitative":[80,134],"performance,":[81],"carryover.":[83],"A":[84],"throughput":[85],"~20":[87],"s":[88],"per":[89],"achieved":[92],"at":[93],"50":[94],"\u00b5L/min.":[95],"Quantitative":[96],"analysis":[97,129],"lysine":[99],"gave":[100],"linear":[102],"response":[103],"R2":[105],"=":[106],"0.9988,":[107],"carryover":[109],"across":[112],"chemically":[113],"distinct":[114],"small":[115],"molecules.":[116],"These":[117],"results":[118],"demonstrate":[119],"that":[120],"supports":[123],"air-separated":[124],"droplet":[125],"transport,":[126],"different":[131],"samples,":[132],"measurements":[136],"simple,":[139],"modular,":[140],"customizable":[142],"format.":[143]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2026-09-01T00:00:00"}