{"id":"https://openalex.org/W7204818751","doi":"https://doi.org/10.1016/j.prnil.2026.08.005","title":"Lineage-specific circulating tumor DNA markers predict rapid progression in metastatic hormone-sensitive prostate cancer","display_name":"Lineage-specific circulating tumor DNA markers predict rapid progression in metastatic hormone-sensitive prostate cancer","publication_year":2026,"publication_date":"2026-08-01","ids":{"openalex":"https://openalex.org/W7204818751","doi":"https://doi.org/10.1016/j.prnil.2026.08.005"},"language":"en","primary_location":{"id":"doi:10.1016/j.prnil.2026.08.005","doi":"https://doi.org/10.1016/j.prnil.2026.08.005","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.prnil.2026.08.005","pdf_url":"https://www.sciencedirect.com/science/article/pii/S228788822600067X/pdf","source":{"id":"https://openalex.org/S2764768438","display_name":"Prostate International","issn_l":"2287-8882","issn":["2287-8882","2287-903X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","norway-1","oarl","poland-40"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Prostate International","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W7204818751"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.sciencedirect.com/science/article/pii/S228788822600067X/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074553710","display_name":"Hyungseok Cho","orcid":"https://orcid.org/0000-0002-7044-7700","observed_orcids":["https://orcid.org/0000-0002-7044-7700"]},"institutions":[{"id":"https://openalex.org/I104338594","display_name":"Inje University","ror":"https://ror.org/04xqwq985","country_code":"KR","type":"education","lineage":["https://openalex.org/I104338594"]},{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["KR","US"],"is_corresponding":false,"raw_author_name":"Hyungseok Cho","raw_affiliation_strings":["Department of Electrical and Computer Engineering, Texas A&M University, College Station, TX, USA","Department of Nanoscience and Engineering, Center for Nano Manufacturing, Inje University, Gimhae, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, Texas A&M University, College Station, TX, USA","institution_ids":["https://openalex.org/I91045830"]},{"raw_affiliation_string":"Department of Nanoscience and Engineering, Center for Nano Manufacturing, Inje University, Gimhae, Republic of Korea","institution_ids":["https://openalex.org/I104338594"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102024018","display_name":"Won Ik Seo","orcid":"https://orcid.org/0000-0002-3004-101X","observed_orcids":["https://orcid.org/0000-0002-3004-101X"]},"institutions":[{"id":"https://openalex.org/I104338594","display_name":"Inje University","ror":"https://ror.org/04xqwq985","country_code":"KR","type":"education","lineage":["https://openalex.org/I104338594"]},{"id":"https://openalex.org/I4210109935","display_name":"Inje University Busan Paik Hospital","ror":"https://ror.org/01pzf6r50","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I104338594","https://openalex.org/I4210109935","https://openalex.org/I4405258751"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Won Ik Seo","raw_affiliation_strings":["Department of Urology, Busan Paik Hospital, Inje University College of Medicine, Busan, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Busan Paik Hospital, Inje University College of Medicine, Busan, Republic of Korea","institution_ids":["https://openalex.org/I104338594","https://openalex.org/I4210109935"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001393393","display_name":"Jae Il Chung","orcid":"https://orcid.org/0000-0002-8114-1125","observed_orcids":["https://orcid.org/0000-0002-8114-1125"]},"institutions":[{"id":"https://openalex.org/I104338594","display_name":"Inje University","ror":"https://ror.org/04xqwq985","country_code":"KR","type":"education","lineage":["https://openalex.org/I104338594"]},{"id":"https://openalex.org/I4210102912","display_name":"Inje University Haeundae Paik Hospital","ror":"https://ror.org/019641589","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I104338594","https://openalex.org/I4210102912","https://openalex.org/I4405258751"]},{"id":"https://openalex.org/I4210109935","display_name":"Inje University Busan Paik Hospital","ror":"https://ror.org/01pzf6r50","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I104338594","https://openalex.org/I4210109935","https://openalex.org/I4405258751"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Jae Il Chung","raw_affiliation_strings":["Department of Urology, Busan Paik Hospital, Inje University College of Medicine, Busan, Republic of Korea","Department of Urology, Haeundae Paik Hospital, Inje University, Busan, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Busan Paik Hospital, Inje University College of Medicine, Busan, Republic of Korea","institution_ids":["https://openalex.org/I104338594","https://openalex.org/I4210109935"]},{"raw_affiliation_string":"Department of Urology, Haeundae Paik Hospital, Inje University, Busan, Republic of Korea","institution_ids":["https://openalex.org/I104338594","https://openalex.org/I4210102912"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019050469","display_name":"Seok\u2010Soo Byun","orcid":"https://orcid.org/0000-0001-9356-9500","observed_orcids":["https://orcid.org/0000-0001-9356-9500","https://orcid.org/0000-0001-7979-9035"]},"institutions":[{"id":"https://openalex.org/I2803058125","display_name":"Seoul National University Bundang Hospital","ror":"https://ror.org/00cb3km46","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I139264467","https://openalex.org/I2802835388","https://openalex.org/I2803058125"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Seok-Soo Byun","raw_affiliation_strings":["Department of Urology, Seoul National University Bundang Hospital, Seongnam, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Seoul National University Bundang Hospital, Seongnam, Republic of Korea","institution_ids":["https://openalex.org/I2803058125"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052439030","display_name":"Sung Kyu Hong","orcid":"https://orcid.org/0000-0002-8344-6774","observed_orcids":["https://orcid.org/0000-0002-8344-6774"]},"institutions":[{"id":"https://openalex.org/I2803058125","display_name":"Seoul National University Bundang Hospital","ror":"https://ror.org/00cb3km46","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I139264467","https://openalex.org/I2802835388","https://openalex.org/I2803058125"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sung Kyu Hong","raw_affiliation_strings":["Department of Urology, Seoul National University Bundang Hospital, Seongnam, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Seoul National University Bundang Hospital, Seongnam, Republic of Korea","institution_ids":["https://openalex.org/I2803058125"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153331939","display_name":"Sun Gyu Choi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210102912","display_name":"Inje University Haeundae Paik Hospital","ror":"https://ror.org/019641589","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I104338594","https://openalex.org/I4210102912","https://openalex.org/I4405258751"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sun Gyu Choi","raw_affiliation_strings":["Department of Statistics, Biomedical Research Institute, Haeundae Paik Hospital, Inje University, Busan, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Statistics, Biomedical Research Institute, Haeundae Paik Hospital, Inje University, Busan, Republic of Korea","institution_ids":["https://openalex.org/I4210102912"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5137444975","display_name":"Jiwon Cha","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I104338594","display_name":"Inje University","ror":"https://ror.org/04xqwq985","country_code":"KR","type":"education","lineage":["https://openalex.org/I104338594"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jiwon Cha","raw_affiliation_strings":["Department of Nanoscience and Engineering, Center for Nano Manufacturing, Inje University, Gimhae, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nanoscience and Engineering, Center for Nano Manufacturing, Inje University, Gimhae, Republic of Korea","institution_ids":["https://openalex.org/I104338594"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026673993","display_name":"Ki-Ho Han","orcid":"https://orcid.org/0000-0002-9102-1581","observed_orcids":["https://orcid.org/0000-0002-9102-1581"]},"institutions":[{"id":"https://openalex.org/I104338594","display_name":"Inje University","ror":"https://ror.org/04xqwq985","country_code":"KR","type":"education","lineage":["https://openalex.org/I104338594"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Ki-Ho Han","raw_affiliation_strings":["Department of Nanoscience and Engineering, Center for Nano Manufacturing, Inje University, Gimhae, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nanoscience and Engineering, Center for Nano Manufacturing, Inje University, Gimhae, Republic of Korea","institution_ids":["https://openalex.org/I104338594"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100615153","display_name":"Jae\u2010Seung Chung","orcid":"https://orcid.org/0000-0001-9672-2216","observed_orcids":["https://orcid.org/0000-0001-9672-2216"]},"institutions":[{"id":"https://openalex.org/I104338594","display_name":"Inje University","ror":"https://ror.org/04xqwq985","country_code":"KR","type":"education","lineage":["https://openalex.org/I104338594"]},{"id":"https://openalex.org/I4210102912","display_name":"Inje University Haeundae Paik Hospital","ror":"https://ror.org/019641589","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I104338594","https://openalex.org/I4210102912","https://openalex.org/I4405258751"]},{"id":"https://openalex.org/I4210109935","display_name":"Inje University Busan Paik Hospital","ror":"https://ror.org/01pzf6r50","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I104338594","https://openalex.org/I4210109935","https://openalex.org/I4405258751"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Jae-Seung Chung","raw_affiliation_strings":["Department of Urology, Busan Paik Hospital, Inje University College of Medicine, Busan, Republic of Korea","Department of Urology, Haeundae Paik Hospital, Inje University, Busan, Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0001-9672-2216","affiliations":[{"raw_affiliation_string":"Department of Urology, Busan Paik Hospital, Inje University College of Medicine, Busan, Republic of Korea","institution_ids":["https://openalex.org/I104338594","https://openalex.org/I4210109935"]},{"raw_affiliation_string":"Department of Urology, Haeundae Paik Hospital, Inje University, Busan, Republic of Korea","institution_ids":["https://openalex.org/I104338594","https://openalex.org/I4210102912"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5001393393","https://openalex.org/A5100615153"],"corresponding_institution_ids":["https://openalex.org/I104338594","https://openalex.org/I4210102912","https://openalex.org/I4210109935"],"apc_list":{"value":1800,"currency":"USD","value_usd":1800},"apc_paid":{"value":1800,"currency":"USD","value_usd":1800},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metastatic-hormone-sensitive-prostate-cancer","display_name":"metastatic hormone-sensitive prostate cancer","score":0.9089999794960022},{"id":"https://openalex.org/keywords/circulating-tumor-dna","display_name":"circulating tumor DNA","score":0.9459999799728394},{"id":"https://openalex.org/keywords/prostate-specific-antigen","display_name":"prostate-specific antigen","score":0.7730000019073486},{"id":"https://openalex.org/keywords/prostate-specific-membrane-antigen","display_name":"prostate-specific membrane antigen","score":0.996999979019165},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7950000166893005},{"id":"https://openalex.org/keywords/risk-stratification","display_name":"risk stratification","score":0.9409999847412109},{"id":"https://openalex.org/keywords/time-to-progression","display_name":"time to progression","score":0.7360000014305115},{"id":"https://openalex.org/keywords/liquid-biopsy","display_name":"liquid biopsy","score":0.5080000162124634},{"id":"https://openalex.org/keywords/droplet-digital-pcr","display_name":"droplet digital PCR","score":0.7789999842643738}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9251999855041504},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.8320000171661377},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6955000162124634},{"id":"https://openalex.org/C61238886","wikidata":"https://www.wikidata.org/wiki/Q5121689","display_name":"Circulating tumor cell","level":4,"score":0.6922000050544739},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6227999925613403},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.600600004196167},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.5489000082015991},{"id":"https://openalex.org/C2781406297","wikidata":"https://www.wikidata.org/wiki/Q409450","display_name":"Prostate-specific antigen","level":4,"score":0.5353999733924866},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.5250999927520752},{"id":"https://openalex.org/C3020404979","wikidata":"https://www.wikidata.org/wiki/Q1058438","display_name":"Risk stratification","level":2,"score":0.5234000086784363},{"id":"https://openalex.org/C2780739268","wikidata":"https://www.wikidata.org/wiki/Q2112244","display_name":"Progression-free survival","level":3,"score":0.37869998812675476},{"id":"https://openalex.org/C87874733","wikidata":"https://www.wikidata.org/wiki/Q18039844","display_name":"PCA3","level":4,"score":0.3707999885082245},{"id":"https://openalex.org/C48126324","wikidata":"https://www.wikidata.org/wiki/Q5276136","display_name":"Digital polymerase chain reaction","level":4,"score":0.36890000104904175},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.36469998955726624},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.35260000824928284},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.33559998869895935},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3337000012397766},{"id":"https://openalex.org/C2780283643","wikidata":"https://www.wikidata.org/wiki/Q2110267","display_name":"Primary tumor","level":4,"score":0.32600000500679016},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.31700000166893005},{"id":"https://openalex.org/C3019894029","wikidata":"https://www.wikidata.org/wiki/Q332823","display_name":"Overall survival","level":2,"score":0.31529998779296875},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.2768999934196472}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.prnil.2026.08.005","doi":"https://doi.org/10.1016/j.prnil.2026.08.005","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.prnil.2026.08.005","pdf_url":"https://www.sciencedirect.com/science/article/pii/S228788822600067X/pdf","source":{"id":"https://openalex.org/S2764768438","display_name":"Prostate International","issn_l":"2287-8882","issn":["2287-8882","2287-903X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","norway-1","oarl","poland-40"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Prostate International","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.prnil.2026.08.005","doi":"https://doi.org/10.1016/j.prnil.2026.08.005","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.prnil.2026.08.005","pdf_url":"https://www.sciencedirect.com/science/article/pii/S228788822600067X/pdf","source":{"id":"https://openalex.org/S2764768438","display_name":"Prostate International","issn_l":"2287-8882","issn":["2287-8882","2287-903X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","norway-1","oarl","poland-40"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Prostate International","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204818751.pdf","grobid_xml":"https://content.openalex.org/works/W7204818751.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W1991581123","https://openalex.org/W2011284201","https://openalex.org/W2072013249","https://openalex.org/W2150865892","https://openalex.org/W2257993785","https://openalex.org/W2410760771","https://openalex.org/W2482123039","https://openalex.org/W2590954301","https://openalex.org/W2760699482","https://openalex.org/W2785084154","https://openalex.org/W2787804990","https://openalex.org/W2801398567","https://openalex.org/W2802053856","https://openalex.org/W2899540665","https://openalex.org/W2921646286","https://openalex.org/W2962711538","https://openalex.org/W2966792020","https://openalex.org/W3088242837","https://openalex.org/W3107431244","https://openalex.org/W3127573510","https://openalex.org/W3217081290","https://openalex.org/W4205790916","https://openalex.org/W4213053261","https://openalex.org/W4213140514","https://openalex.org/W4223443163","https://openalex.org/W4286501114","https://openalex.org/W4311855704","https://openalex.org/W4321018302","https://openalex.org/W4321115913","https://openalex.org/W4353034879","https://openalex.org/W4366550455","https://openalex.org/W4382932884","https://openalex.org/W4394567440","https://openalex.org/W4396231607","https://openalex.org/W4412994611","https://openalex.org/W4413868298","https://openalex.org/W4415340075","https://openalex.org/W4416074731"],"related_works":["https://openalex.org/W7212032181","https://openalex.org/W4399394785","https://openalex.org/W7133504364","https://openalex.org/W4416121977","https://openalex.org/W2947838246","https://openalex.org/W3014472365","https://openalex.org/W3172178421","https://openalex.org/W4391071032","https://openalex.org/W4410419313","https://openalex.org/W7138935816"],"abstract_inverted_index":{"Background":[0],"Fast":[1],"progression":[2,37,89,131,155,192],"from":[3,73,193],"metastatic":[4,10,39],"hormone-sensitive":[5],"prostate":[6,12,41],"cancer":[7,13,42],"(mHSPC)":[8],"to":[9,38,90,118,130,195],"castration-resistant":[11,40],"(mCRPC)":[14],"is":[15],"associated":[16,35,126,153],"with":[17,36,59,127,154,177,204],"poor":[18],"prognosis.":[19],"We":[20,54],"evaluated":[21],"whether":[22],"baseline":[23,63],"plasma":[24,74],"circulating":[25],"tumor":[26],"DNA-derived":[27],"prostate-specific":[28,31],"antigen":[29,33],"and":[30,43,75,83,101,122,145,172,185,197],"membrane":[32],"were":[34,94,124,152],"improved":[44],"risk":[45,200],"stratification":[46,201],"beyond":[47],"conventional":[48],"serum":[49,178],"biomarkers":[50],"in":[51,165,202],"mHSPC.":[52,205],"Methods":[53],"prospectively":[55],"analyzed":[56],"35":[57],"patients":[58,116,203],"mHSPC":[60,194],"who":[61],"underwent":[62],"ctDNA":[64,70],"analysis":[65,158],"using":[66,77,96],"droplet":[67,78],"digital":[68,79],"PCR.":[69],"was":[71,88],"extracted":[72],"quantified":[76],"PCR":[80],"targeting":[81],"PSA":[82,179],"PSMA.":[84],"The":[85],"primary":[86],"endpoint":[87],"mCRPC.":[91,119],"Survival":[92],"analyses":[93],"performed":[95],"Kaplan\u2013Meier":[97],"methods,":[98],"Cox":[99,137],"regression,":[100],"restricted":[102],"mean":[103],"survival":[104],"time":[105,129,167],"(RMST).":[106],"Results":[107],"During":[108],"a":[109],"median":[110],"follow-up":[111],"of":[112],"29":[113],"months,":[114],"24":[115,160],"progressed":[117],"Elevated":[120],"ctDNA-PSA":[121,139,169,184],"ctDNA-PSMA":[123,146,173],"significantly":[125],"shorter":[128],"(both":[132],"P":[133,142,149],"<":[134],"0.001).":[135],"In":[136],"analyses,":[138],"(HR":[140,147],"1.82,":[141],"=":[143,150],"0.002)":[144],"1.59,":[148],"0.009)":[151],"risk.":[156],"RMST":[157],"at":[159],"months":[161],"demonstrated":[162],"greater":[163],"reductions":[164],"progression-free":[166],"for":[168,191],"(\u221210.8":[170],"months)":[171,175],"(\u22128.7":[174],"compared":[176],"(\u22127.3":[180],"months).":[181],"Conclusions":[182],"Baseline":[183],"PSMA":[186],"provide":[187],"complementary":[188],"prognostic":[189],"information":[190],"mCRPC":[196],"may":[198],"improve":[199]},"counts_by_year":[],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2026-09-01T00:00:00"}
