{"id":"https://openalex.org/W7204816376","doi":"https://doi.org/10.64898/2026.08.29.748043","title":"Integrin \u03b111 is enriched in quiescence and promotes cell-cycle re-entry through destabilisation of the CDK inhibitor p27","display_name":"Integrin \u03b111 is enriched in quiescence and promotes cell-cycle re-entry through destabilisation of the CDK inhibitor p27","publication_year":2026,"publication_date":"2026-08-31","ids":{"openalex":"https://openalex.org/W7204816376","doi":"https://doi.org/10.64898/2026.08.29.748043"},"language":"en","primary_location":{"id":"doi:10.64898/2026.08.29.748043","doi":"https://doi.org/10.64898/2026.08.29.748043","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.29.748043","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/08/31/2026.08.29.748043.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/08/31/2026.08.29.748043.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019205416","display_name":"Ekjot Kaur","orcid":"https://orcid.org/0000-0002-7937-6646","observed_orcids":["https://orcid.org/0000-0002-7937-6646"]},"institutions":[{"id":"https://openalex.org/I4210161592","display_name":"MRC London Institute of Medical Sciences","ror":"https://ror.org/05p1n6x86","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210161592","https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Ekjot Kaur","raw_affiliation_strings":["MRC Laboratory of Medical Sciences, London, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0002-7937-6646","affiliations":[{"raw_affiliation_string":"MRC Laboratory of Medical Sciences, London, United Kingdom","institution_ids":["https://openalex.org/I4210161592"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014302703","display_name":"Jordan A. Holt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210161592","display_name":"MRC London Institute of Medical Sciences","ror":"https://ror.org/05p1n6x86","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210161592","https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jordan A. Holt","raw_affiliation_strings":["MRC Laboratory of Medical Sciences, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Laboratory of Medical Sciences, London, United Kingdom","institution_ids":["https://openalex.org/I4210161592"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060335417","display_name":"Rona Wilson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Rona Wilson","raw_affiliation_strings":["School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030794646","display_name":"Van Kelly","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Van Kelly","raw_affiliation_strings":["School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148786658","display_name":"Elena Gomez Marin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210161592","display_name":"MRC London Institute of Medical Sciences","ror":"https://ror.org/05p1n6x86","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210161592","https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Elena Gomez-Marin","raw_affiliation_strings":["MRC Laboratory of Medical Sciences, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Laboratory of Medical Sciences, London, United Kingdom","institution_ids":["https://openalex.org/I4210161592"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023529498","display_name":"Bojan \u017dunar","orcid":"https://orcid.org/0000-0002-6855-7222","observed_orcids":["https://orcid.org/0000-0002-6855-7222"]},"institutions":[{"id":"https://openalex.org/I181343428","display_name":"University of Zagreb","ror":"https://ror.org/00mv6sv71","country_code":"HR","type":"education","lineage":["https://openalex.org/I181343428"]}],"countries":["HR"],"is_corresponding":false,"raw_author_name":"Bojan Zunar","raw_affiliation_strings":["Laboratory for Biochemistry, Department of Chemistry and Biochemistry, University of Zagreb Faculty of Food Technology and Biotechnology, Zagreb, Croatia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Biochemistry, Department of Chemistry and Biochemistry, University of Zagreb Faculty of Food Technology and Biotechnology, Zagreb, Croatia","institution_ids":["https://openalex.org/I181343428"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148821070","display_name":"Alasdair Daniels","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210161592","display_name":"MRC London Institute of Medical Sciences","ror":"https://ror.org/05p1n6x86","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210161592","https://openalex.org/I47508984"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Alasdair Daniels","raw_affiliation_strings":["Department of Mathematics, Imperial College London, London, United Kingdom","MRC Laboratory of Medical Sciences, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mathematics, Imperial College London, London, United Kingdom","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"MRC Laboratory of Medical Sciences, London, United Kingdom","institution_ids":["https://openalex.org/I4210161592"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063178819","display_name":"Rozita Adib","orcid":"https://orcid.org/0000-0002-9012-6779","observed_orcids":["https://orcid.org/0000-0002-9012-6779"]},"institutions":[{"id":"https://openalex.org/I4210161592","display_name":"MRC London Institute of Medical Sciences","ror":"https://ror.org/05p1n6x86","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210161592","https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Rozita Adib","raw_affiliation_strings":["MRC Laboratory of Medical Sciences, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Laboratory of Medical Sciences, London, United Kingdom","institution_ids":["https://openalex.org/I4210161592"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064292789","display_name":"Philipp Thomas","orcid":"https://orcid.org/0000-0003-4919-8452","observed_orcids":["https://orcid.org/0000-0003-4919-8452"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Philipp Thomas","raw_affiliation_strings":["Department of Mathematics, Imperial College London, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mathematics, Imperial College London, London, United Kingdom","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052661284","display_name":"Boris Lenhard","orcid":"https://orcid.org/0000-0002-1114-1509","observed_orcids":["https://orcid.org/0000-0002-1114-1509"]},"institutions":[{"id":"https://openalex.org/I4210161592","display_name":"MRC London Institute of Medical Sciences","ror":"https://ror.org/05p1n6x86","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210161592","https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Boris Lenhard","raw_affiliation_strings":["MRC Laboratory of Medical Sciences, London, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0002-1114-1509","affiliations":[{"raw_affiliation_string":"MRC Laboratory of Medical Sciences, London, United Kingdom","institution_ids":["https://openalex.org/I4210161592"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042861631","display_name":"Tony Ly","orcid":"https://orcid.org/0000-0002-8650-5215","observed_orcids":["https://orcid.org/0000-0002-8650-5215"]},"institutions":[{"id":"https://openalex.org/I177639307","display_name":"University of Dundee","ror":"https://ror.org/03h2bxq36","country_code":"GB","type":"education","lineage":["https://openalex.org/I177639307"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Tony Ly","raw_affiliation_strings":["Faculty of Life Sciences, University of Dundee, Dundee, United Kingdom","School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0002-8650-5215","affiliations":[{"raw_affiliation_string":"Faculty of Life Sciences, University of Dundee, Dundee, United Kingdom","institution_ids":["https://openalex.org/I177639307"]},{"raw_affiliation_string":"School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073719596","display_name":"Alexis R. Barr","orcid":"https://orcid.org/0000-0002-6684-8114","observed_orcids":["https://orcid.org/0000-0002-6684-8114"]},"institutions":[{"id":"https://openalex.org/I4210161592","display_name":"MRC London Institute of Medical Sciences","ror":"https://ror.org/05p1n6x86","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210161592","https://openalex.org/I47508984"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Alexis R. Barr","raw_affiliation_strings":["Institute of Clinical Sciences, Imperial College London, United Kingdom","MRC Laboratory of Medical Sciences, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Clinical Sciences, Imperial College London, United Kingdom","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"MRC Laboratory of Medical Sciences, London, United Kingdom","institution_ids":["https://openalex.org/I4210161592"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5019205416"],"corresponding_institution_ids":["https://openalex.org/I4210161592"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12065","display_name":"Hippo pathway signaling and YAP/TAZ","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12065","display_name":"Hippo pathway signaling and YAP/TAZ","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/integrin-alpha11","display_name":"integrin \u03b111","score":0.9279999732971191},{"id":"https://openalex.org/keywords/itga11","display_name":"ITGA11","score":0.8539999723434448},{"id":"https://openalex.org/keywords/cellular-quiescence","display_name":"quiescent cells","score":0.8650000095367432},{"id":"https://openalex.org/keywords/cell-cycle-re-entry","display_name":"cell cycle re-entry","score":0.9100000262260437},{"id":"https://openalex.org/keywords/p27-degradation","display_name":"p27 degradation","score":0.8560000061988831},{"id":"https://openalex.org/keywords/skp2","display_name":"Skp2","score":0.8799999952316284},{"id":"https://openalex.org/keywords/yap","display_name":"YAP","score":0.6819999814033508},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.44600000977516174},{"id":"https://openalex.org/keywords/cellular-senescence","display_name":"cellular senescence","score":0.6370000243186951}],"concepts":[{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7754999995231628},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.5317000150680542},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.47760000824928284},{"id":"https://openalex.org/C2778298596","wikidata":"https://www.wikidata.org/wiki/Q17143494","display_name":"CDK inhibitor","level":5,"score":0.4758000075817108},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4702000021934509},{"id":"https://openalex.org/C124320809","wikidata":"https://www.wikidata.org/wiki/Q46292","display_name":"Cyclin-dependent kinase","level":4,"score":0.43619999289512634},{"id":"https://openalex.org/C195687474","wikidata":"https://www.wikidata.org/wiki/Q409715","display_name":"Integrin","level":3,"score":0.41929998993873596},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.4092000126838684},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.39570000767707825},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.39399999380111694},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38499999046325684},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3702000081539154},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.34599998593330383},{"id":"https://openalex.org/C147025567","wikidata":"https://www.wikidata.org/wiki/Q16335140","display_name":"Cellular model","level":3,"score":0.3158000111579895},{"id":"https://openalex.org/C174510640","wikidata":"https://www.wikidata.org/wiki/Q489618","display_name":"HEK 293 cells","level":3,"score":0.31299999356269836},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.30169999599456787},{"id":"https://openalex.org/C106487976","wikidata":"https://www.wikidata.org/wiki/Q685816","display_name":"Matrix (chemical analysis)","level":2,"score":0.30000001192092896},{"id":"https://openalex.org/C2780381497","wikidata":"https://www.wikidata.org/wiki/Q463418","display_name":"Fibroblast","level":3,"score":0.29429998993873596},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.2919999957084656},{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.2750000059604645},{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.251800000667572}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.08.29.748043","doi":"https://doi.org/10.64898/2026.08.29.748043","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.29.748043","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/08/31/2026.08.29.748043.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.08.29.748043","doi":"https://doi.org/10.64898/2026.08.29.748043","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.29.748043","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/08/31/2026.08.29.748043.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3974205725","display_name":null,"funder_award_id":"MC-A658-5TY60","funder_id":"https://openalex.org/F4320314731","funder_display_name":"UK Research and Innovation"},{"id":"https://openalex.org/G5403519449","display_name":null,"funder_award_id":"C63833/A25729","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"},{"id":"https://openalex.org/G615387187","display_name":null,"funder_award_id":"MC\u2010A658\u20105TY60","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G7672037313","display_name":"Energy-Use Minimization in Residuals Management in the Personal Care Product Industry","funder_award_id":"218305","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G7747780707","display_name":null,"funder_award_id":"MR/T018429/1","funder_id":"https://openalex.org/F4320314731","funder_display_name":"UK Research and Innovation"},{"id":"https://openalex.org/G8626878921","display_name":"From bacteria to mammalian cells: Interrogating single-cell dynamics using agent-based stochastic models","funder_award_id":"MR/T018429/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G977211138","display_name":"Addressing copper pollution in South Europe by robustifying whole-cell copper biosensors through cell wall engineering","funder_award_id":"IP-2024-05-5224","funder_id":"https://openalex.org/F4320322674","funder_display_name":"Hrvatska Zaklada za Znanost"}],"funders":[{"id":"https://openalex.org/F4320314731","display_name":"UK Research and Innovation","ror":"https://ror.org/001aqnf71"},{"id":"https://openalex.org/F4320319985","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67"},{"id":"https://openalex.org/F4320319990","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08"},{"id":"https://openalex.org/F4320320283","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10"},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320320322","display_name":"University of Bath","ror":"https://ror.org/002h8g185"},{"id":"https://openalex.org/F4320322674","display_name":"Hrvatska Zaklada za Znanost","ror":"https://ror.org/03n51vw80"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320336039","display_name":"NIHR Imperial Biomedical Research Centre","ror":"https://ror.org/01kmhx639"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204816376.pdf","grobid_xml":"https://content.openalex.org/works/W7204816376.grobid-xml"},"referenced_works_count":64,"referenced_works":["https://openalex.org/W140927742","https://openalex.org/W1494520636","https://openalex.org/W1576773659","https://openalex.org/W1907686361","https://openalex.org/W1970891016","https://openalex.org/W1978720331","https://openalex.org/W1978918363","https://openalex.org/W1987170068","https://openalex.org/W1989197126","https://openalex.org/W2011818472","https://openalex.org/W2012040044","https://openalex.org/W2024946775","https://openalex.org/W2032101051","https://openalex.org/W2039154280","https://openalex.org/W2054873254","https://openalex.org/W2061619522","https://openalex.org/W2065782380","https://openalex.org/W2073996456","https://openalex.org/W2079025331","https://openalex.org/W2085149748","https://openalex.org/W2094051261","https://openalex.org/W2101244168","https://openalex.org/W2102628825","https://openalex.org/W2112933956","https://openalex.org/W2115852450","https://openalex.org/W2117365291","https://openalex.org/W2117841435","https://openalex.org/W2121619780","https://openalex.org/W2145067395","https://openalex.org/W2146337514","https://openalex.org/W2149357952","https://openalex.org/W2152602162","https://openalex.org/W2157370973","https://openalex.org/W2165673443","https://openalex.org/W2171813323","https://openalex.org/W2259938310","https://openalex.org/W2262370504","https://openalex.org/W2603712266","https://openalex.org/W2617467085","https://openalex.org/W2724348609","https://openalex.org/W2748768502","https://openalex.org/W2758838459","https://openalex.org/W2769870963","https://openalex.org/W2884435515","https://openalex.org/W2911928150","https://openalex.org/W2922397855","https://openalex.org/W2950843205","https://openalex.org/W2968449628","https://openalex.org/W2980292252","https://openalex.org/W3092091792","https://openalex.org/W3103368541","https://openalex.org/W3146579363","https://openalex.org/W3176210729","https://openalex.org/W3184729641","https://openalex.org/W4206682086","https://openalex.org/W4388735884","https://openalex.org/W4388735893","https://openalex.org/W4388735902","https://openalex.org/W4405621614","https://openalex.org/W4406235137","https://openalex.org/W4406766802","https://openalex.org/W4413495365","https://openalex.org/W7126012743","https://openalex.org/W7223351463"],"related_works":["https://openalex.org/W1970472050","https://openalex.org/W2088357355","https://openalex.org/W2157921578","https://openalex.org/W1995696138","https://openalex.org/W2091535783","https://openalex.org/W1973190082","https://openalex.org/W68487835","https://openalex.org/W3136405212","https://openalex.org/W2754919186","https://openalex.org/W1558846872"],"abstract_inverted_index":{"Abstract":[0],"Proteins":[1],"that":[2,66,142,157],"distinguish":[3],"quiescent":[4],"cells":[5],"from":[6,92,161],"other":[7],"non-proliferative":[8],"states":[9],"and":[10,65,72,99,106],"actively":[11],"regulate":[12],"their":[13],"return":[14],"to":[15,29,147,163],"proliferation":[16,80],"remain":[17],"poorly":[18],"understood.":[19],"Here,":[20],"we":[21,42,44],"combined":[22],"quantitative":[23],"proteomics":[24],"with":[25],"functional":[26,38,138],"image-based":[27],"screening":[28],"identify":[30,134],"regulators":[31],"of":[32,58,81,114,119,150],"the":[33,37,123,151,159],"quiescence-to-proliferation":[34],"transition.":[35],"Amongst":[36],"quiescence":[39,60,139,162],"signature":[40,140],"proteins":[41],"identified,":[43],"focussed":[45],"on":[46],"integrin":[47],"\u03b111":[48],"(":[49],"ITGA11":[50,76,95,129,135],")":[51],"which":[52],"is":[53,77,86],"induced":[54],"across":[55],"multiple":[56],"models":[57],"reversible":[59],"in":[61,70],"distinct":[62],"cell":[63,110],"types":[64],"has":[67],"low":[68],"expression":[69,105],"proliferating":[71],"senescent":[73],"cells.":[74],"Although":[75],"dispensable":[78],"for":[79,88],"asynchronously":[82],"cycling":[83],"cells,":[84],"it":[85],"required":[87],"efficient":[89],"cell-cycle":[90,124],"re-entry":[91,125],"quiescence.":[93],"Mechanistically,":[94],"promotes":[96],"YAP":[97,120],"accumulation":[98],"nuclear":[100],"localization,":[101],"thereby":[102],"sustaining":[103],"SKP2":[104],"p27":[107],"degradation":[108],"during":[109],"cycle":[111],"re-entry.":[112],"Depletion":[113],"p27,":[115],"or":[116],"pharmacological":[117],"activation":[118],"signalling":[121],"rescues":[122],"defect":[126],"caused":[127],"by":[128],"depletion.":[130],"Together,":[131],"these":[132],"findings":[133],"as":[136],"a":[137,155],"protein":[141],"couples":[143],"extracellular":[144],"matrix":[145],"sensing":[146],"YAP-dependent":[148],"regulation":[149],"Skp2-p27":[152],"axis,":[153],"revealing":[154],"mechanism":[156],"controls":[158],"transition":[160],"proliferation.":[164]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-09-01T00:00:00"}
