{"id":"https://openalex.org/W7204814943","doi":"https://doi.org/10.64898/2026.08.28.746934","title":"ChemIntelligence Enables Antibody-Free, Ultra-Low-Input Profiling of Lysine Lactylation and Diverse Acyl-Proteomes","display_name":"ChemIntelligence Enables Antibody-Free, Ultra-Low-Input Profiling of Lysine Lactylation and Diverse Acyl-Proteomes","publication_year":2026,"publication_date":"2026-08-31","ids":{"openalex":"https://openalex.org/W7204814943","doi":"https://doi.org/10.64898/2026.08.28.746934"},"language":"en","primary_location":{"id":"doi:10.64898/2026.08.28.746934","doi":"https://doi.org/10.64898/2026.08.28.746934","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.28.746934","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/08/31/2026.08.28.746934.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/08/31/2026.08.28.746934.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101677397","display_name":"Chang Shao","orcid":"https://orcid.org/0000-0003-2366-5833","observed_orcids":["https://orcid.org/0000-0003-2366-5833"]},"institutions":[{"id":"https://openalex.org/I131434179","display_name":"Nanjing University of Chinese Medicine","ror":"https://ror.org/04523zj19","country_code":"CN","type":"education","lineage":["https://openalex.org/I131434179"]},{"id":"https://openalex.org/I161716053","display_name":"China Pharmaceutical University","ror":"https://ror.org/01sfm2718","country_code":"CN","type":"education","lineage":["https://openalex.org/I161716053"]},{"id":"https://openalex.org/I4391767909","display_name":"State Key Laboratory of Natural Medicine","ror":"https://ror.org/01as92r37","country_code":"CN","type":"facility","lineage":["https://openalex.org/I161716053","https://openalex.org/I4391767909"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chang Shao","raw_affiliation_strings":["Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine in Prevention and Treatment of Tumor, the First Clinical Medical College, Nanjing University of Chinese Medicine, 138 Xianlin Avenue, Nanjing, 210023, China","State Key Laboratory of Natural Medicines, China Pharmaceutical University, Tongjiaxiang No. 24, Nanjing, 210009, Jiangsu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine in Prevention and Treatment of Tumor, the First Clinical Medical College, Nanjing University of Chinese Medicine, 138 Xianlin Avenue, Nanjing, 210023, China","institution_ids":["https://openalex.org/I131434179"]},{"raw_affiliation_string":"State Key Laboratory of Natural Medicines, China Pharmaceutical University, Tongjiaxiang No. 24, Nanjing, 210009, Jiangsu, China","institution_ids":["https://openalex.org/I161716053","https://openalex.org/I4391767909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114231301","display_name":"Zimeng He","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161716053","display_name":"China Pharmaceutical University","ror":"https://ror.org/01sfm2718","country_code":"CN","type":"education","lineage":["https://openalex.org/I161716053"]},{"id":"https://openalex.org/I4391767909","display_name":"State Key Laboratory of Natural Medicine","ror":"https://ror.org/01as92r37","country_code":"CN","type":"facility","lineage":["https://openalex.org/I161716053","https://openalex.org/I4391767909"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zimeng He","raw_affiliation_strings":["State Key Laboratory of Natural Medicines, China Pharmaceutical University, Tongjiaxiang No. 24, Nanjing, 210009, Jiangsu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Natural Medicines, China Pharmaceutical University, Tongjiaxiang No. 24, Nanjing, 210009, Jiangsu, China","institution_ids":["https://openalex.org/I161716053","https://openalex.org/I4391767909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148797856","display_name":"Qi Yuan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161716053","display_name":"China Pharmaceutical University","ror":"https://ror.org/01sfm2718","country_code":"CN","type":"education","lineage":["https://openalex.org/I161716053"]},{"id":"https://openalex.org/I4391767909","display_name":"State Key Laboratory of Natural Medicine","ror":"https://ror.org/01as92r37","country_code":"CN","type":"facility","lineage":["https://openalex.org/I161716053","https://openalex.org/I4391767909"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qi Yuan","raw_affiliation_strings":["State Key Laboratory of Natural Medicines, China Pharmaceutical University, Tongjiaxiang No. 24, Nanjing, 210009, Jiangsu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Natural Medicines, China Pharmaceutical University, Tongjiaxiang No. 24, Nanjing, 210009, Jiangsu, China","institution_ids":["https://openalex.org/I161716053","https://openalex.org/I4391767909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056492342","display_name":"Victor Giurcoiu","orcid":"https://orcid.org/0000-0002-1190-6954","observed_orcids":["https://orcid.org/0000-0002-1190-6954"]},"institutions":[{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Victor-George Giurcoiu","raw_affiliation_strings":["Computational Mass Spectrometry, TUM School of Life Sciences, Technical University of Munich, Maximus-von-Imhof-Forum 3, Freising, 85334, Freising, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational Mass Spectrometry, TUM School of Life Sciences, Technical University of Munich, Maximus-von-Imhof-Forum 3, Freising, 85334, Freising, Germany","institution_ids":["https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5128146182","display_name":"Xiangyu He","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161716053","display_name":"China Pharmaceutical University","ror":"https://ror.org/01sfm2718","country_code":"CN","type":"education","lineage":["https://openalex.org/I161716053"]},{"id":"https://openalex.org/I4391767909","display_name":"State Key Laboratory of Natural Medicine","ror":"https://ror.org/01as92r37","country_code":"CN","type":"facility","lineage":["https://openalex.org/I161716053","https://openalex.org/I4391767909"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiangyu He","raw_affiliation_strings":["State Key Laboratory of Natural Medicines, China Pharmaceutical University, Tongjiaxiang No. 24, Nanjing, 210009, Jiangsu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Natural Medicines, China Pharmaceutical University, Tongjiaxiang No. 24, Nanjing, 210009, Jiangsu, China","institution_ids":["https://openalex.org/I161716053","https://openalex.org/I4391767909"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Xu Cao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161716053","display_name":"China Pharmaceutical University","ror":"https://ror.org/01sfm2718","country_code":"CN","type":"education","lineage":["https://openalex.org/I161716053"]},{"id":"https://openalex.org/I4391767909","display_name":"State Key Laboratory of Natural Medicine","ror":"https://ror.org/01as92r37","country_code":"CN","type":"facility","lineage":["https://openalex.org/I161716053","https://openalex.org/I4391767909"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xu Cao","raw_affiliation_strings":["State Key Laboratory of Natural Medicines, China Pharmaceutical University, Tongjiaxiang No. 24, Nanjing, 210009, Jiangsu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Natural Medicines, China Pharmaceutical University, Tongjiaxiang No. 24, Nanjing, 210009, Jiangsu, China","institution_ids":["https://openalex.org/I161716053","https://openalex.org/I4391767909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101781796","display_name":"Haoran Huang","orcid":"https://orcid.org/0009-0000-1921-738X","observed_orcids":["https://orcid.org/0009-0000-1921-738X"]},"institutions":[{"id":"https://openalex.org/I4210165226","display_name":"Thermo Fisher Scientific (China)","ror":"https://ror.org/05jtcqr88","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210142480","https://openalex.org/I4210165226"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haoran Huang","raw_affiliation_strings":["Thermo Fisher Scientific (China) Co. Ltd, Hong Kong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Thermo Fisher Scientific (China) Co. Ltd, Hong Kong, China","institution_ids":["https://openalex.org/I4210165226"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5130038857","display_name":"Yuebo Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161716053","display_name":"China Pharmaceutical University","ror":"https://ror.org/01sfm2718","country_code":"CN","type":"education","lineage":["https://openalex.org/I161716053"]},{"id":"https://openalex.org/I4391767909","display_name":"State Key Laboratory of Natural Medicine","ror":"https://ror.org/01as92r37","country_code":"CN","type":"facility","lineage":["https://openalex.org/I161716053","https://openalex.org/I4391767909"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuebo Zhang","raw_affiliation_strings":["State Key Laboratory of Natural Medicines, China Pharmaceutical University, Tongjiaxiang No. 24, Nanjing, 210009, Jiangsu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Natural Medicines, China Pharmaceutical University, Tongjiaxiang No. 24, Nanjing, 210009, Jiangsu, China","institution_ids":["https://openalex.org/I161716053","https://openalex.org/I4391767909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148761713","display_name":"Yueyang Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161716053","display_name":"China Pharmaceutical University","ror":"https://ror.org/01sfm2718","country_code":"CN","type":"education","lineage":["https://openalex.org/I161716053"]},{"id":"https://openalex.org/I4391767909","display_name":"State Key Laboratory of Natural Medicine","ror":"https://ror.org/01as92r37","country_code":"CN","type":"facility","lineage":["https://openalex.org/I161716053","https://openalex.org/I4391767909"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yueyang Zhang","raw_affiliation_strings":["State Key Laboratory of Natural Medicines, China Pharmaceutical University, Tongjiaxiang No. 24, Nanjing, 210009, Jiangsu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Natural Medicines, China Pharmaceutical University, Tongjiaxiang No. 24, Nanjing, 210009, Jiangsu, China","institution_ids":["https://openalex.org/I161716053","https://openalex.org/I4391767909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088533762","display_name":"Dexiang Wang","orcid":"https://orcid.org/0000-0002-3820-9585","observed_orcids":["https://orcid.org/0000-0002-3820-9585"]},"institutions":[{"id":"https://openalex.org/I161716053","display_name":"China Pharmaceutical University","ror":"https://ror.org/01sfm2718","country_code":"CN","type":"education","lineage":["https://openalex.org/I161716053"]},{"id":"https://openalex.org/I4391767909","display_name":"State Key Laboratory of Natural Medicine","ror":"https://ror.org/01as92r37","country_code":"CN","type":"facility","lineage":["https://openalex.org/I161716053","https://openalex.org/I4391767909"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dexiang Wang","raw_affiliation_strings":["State Key Laboratory of Natural Medicines, China Pharmaceutical University, Tongjiaxiang No. 24, Nanjing, 210009, Jiangsu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Natural Medicines, China Pharmaceutical University, Tongjiaxiang No. 24, Nanjing, 210009, Jiangsu, China","institution_ids":["https://openalex.org/I161716053","https://openalex.org/I4391767909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102630088","display_name":"Qihe Jiang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161716053","display_name":"China Pharmaceutical University","ror":"https://ror.org/01sfm2718","country_code":"CN","type":"education","lineage":["https://openalex.org/I161716053"]},{"id":"https://openalex.org/I4391767909","display_name":"State Key Laboratory of Natural Medicine","ror":"https://ror.org/01as92r37","country_code":"CN","type":"facility","lineage":["https://openalex.org/I161716053","https://openalex.org/I4391767909"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qihe Jiang","raw_affiliation_strings":["State Key Laboratory of Natural Medicines, China Pharmaceutical University, Tongjiaxiang No. 24, Nanjing, 210009, Jiangsu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Natural Medicines, China Pharmaceutical University, Tongjiaxiang No. 24, Nanjing, 210009, Jiangsu, China","institution_ids":["https://openalex.org/I161716053","https://openalex.org/I4391767909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015758417","display_name":"Zizhang Guo","orcid":"https://orcid.org/0000-0002-0099-8013","observed_orcids":["https://orcid.org/0000-0002-0099-8013"]},"institutions":[{"id":"https://openalex.org/I4210152119","display_name":"Jiangsu Province Hospital","ror":"https://ror.org/04py1g812","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152119"]},{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zizhang Guo","raw_affiliation_strings":["Department of Thoracic Surgery, The First Affiliated Hospital with Nanjing Medical University, Guangzhou Road No. 300, Nanjing, 210029, Jiangsu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic Surgery, The First Affiliated Hospital with Nanjing Medical University, Guangzhou Road No. 300, Nanjing, 210029, Jiangsu, China","institution_ids":["https://openalex.org/I4210152119","https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018454768","display_name":"Haiping Hao","orcid":"https://orcid.org/0000-0003-2522-7546","observed_orcids":["https://orcid.org/0000-0003-2522-7546"]},"institutions":[{"id":"https://openalex.org/I161716053","display_name":"China Pharmaceutical University","ror":"https://ror.org/01sfm2718","country_code":"CN","type":"education","lineage":["https://openalex.org/I161716053"]},{"id":"https://openalex.org/I4391767909","display_name":"State Key Laboratory of Natural Medicine","ror":"https://ror.org/01as92r37","country_code":"CN","type":"facility","lineage":["https://openalex.org/I161716053","https://openalex.org/I4391767909"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haiping Hao","raw_affiliation_strings":["State Key Laboratory of Natural Medicines, China Pharmaceutical University, Tongjiaxiang No. 24, Nanjing, 210009, Jiangsu, China"],"raw_orcid":"https://orcid.org/0000-0003-2522-7546","affiliations":[{"raw_affiliation_string":"State Key Laboratory of Natural Medicines, China Pharmaceutical University, Tongjiaxiang No. 24, Nanjing, 210009, Jiangsu, China","institution_ids":["https://openalex.org/I161716053","https://openalex.org/I4391767909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031508585","display_name":"Mathias Wilhelm","orcid":"https://orcid.org/0000-0002-9224-3258","observed_orcids":["https://orcid.org/0000-0002-9224-3258"]},"institutions":[{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Mathias Wilhelm","raw_affiliation_strings":["Computational Mass Spectrometry, TUM School of Life Sciences, Technical University of Munich, Maximus-von-Imhof-Forum 3, Freising, 85334, Freising, Germany","Munich Data Science Institute (MDSI), Technical University of Munich, Walther-von-Dyck-Str. 10, Garching, 85748, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational Mass Spectrometry, TUM School of Life Sciences, Technical University of Munich, Maximus-von-Imhof-Forum 3, Freising, 85334, Freising, Germany","institution_ids":["https://openalex.org/I62916508"]},{"raw_affiliation_string":"Munich Data Science Institute (MDSI), Technical University of Munich, Walther-von-Dyck-Str. 10, Garching, 85748, Germany","institution_ids":["https://openalex.org/I62916508"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021551476","display_name":"Hui Ye","orcid":"https://orcid.org/0000-0002-1771-7732","observed_orcids":["https://orcid.org/0000-0002-1771-7732","https://orcid.org/0000-0002-7416-1558"]},"institutions":[{"id":"https://openalex.org/I161716053","display_name":"China Pharmaceutical University","ror":"https://ror.org/01sfm2718","country_code":"CN","type":"education","lineage":["https://openalex.org/I161716053"]},{"id":"https://openalex.org/I4391767909","display_name":"State Key Laboratory of Natural Medicine","ror":"https://ror.org/01as92r37","country_code":"CN","type":"facility","lineage":["https://openalex.org/I161716053","https://openalex.org/I4391767909"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Hui Ye","raw_affiliation_strings":["State Key Laboratory of Natural Medicines, China Pharmaceutical University, Tongjiaxiang No. 24, Nanjing, 210009, Jiangsu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Natural Medicines, China Pharmaceutical University, Tongjiaxiang No. 24, Nanjing, 210009, Jiangsu, China","institution_ids":["https://openalex.org/I161716053","https://openalex.org/I4391767909"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5021551476"],"corresponding_institution_ids":["https://openalex.org/I161716053","https://openalex.org/I4391767909"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11440","display_name":"Click Chemistry and Applications","score":0.0052999998442828655,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lysine-lactylation","display_name":"lysine lactylation","score":0.9810000061988831},{"id":"https://openalex.org/keywords/lysine-acylation","display_name":"lysine acylation","score":0.949999988079071},{"id":"https://openalex.org/keywords/parallel-reaction-monitoring","display_name":"parallel reaction monitoring","score":0.6890000104904175},{"id":"https://openalex.org/keywords/single-cell-proteomics","display_name":"single-cell proteomics","score":0.8799999952316284},{"id":"https://openalex.org/keywords/low-input-proteomics","display_name":"low-input proteomics","score":0.5099999904632568}],"concepts":[{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.7156000137329102},{"id":"https://openalex.org/C187191949","wikidata":"https://www.wikidata.org/wiki/Q1138496","display_name":"Profiling (computer programming)","level":2,"score":0.6840999722480774},{"id":"https://openalex.org/C2776016237","wikidata":"https://www.wikidata.org/wiki/Q178430","display_name":"Lysine","level":3,"score":0.5834000110626221},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5407999753952026},{"id":"https://openalex.org/C177606310","wikidata":"https://www.wikidata.org/wiki/Q5674297","display_name":"Adaptability","level":2,"score":0.46779999136924744},{"id":"https://openalex.org/C2776923573","wikidata":"https://www.wikidata.org/wiki/Q2294884","display_name":"Derivatization","level":3,"score":0.4253999888896942},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38760000467300415},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3788999915122986},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3368000090122223},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.322299987077713},{"id":"https://openalex.org/C19275194","wikidata":"https://www.wikidata.org/wiki/Q222903","display_name":"Multiplexing","level":2,"score":0.31150001287460327},{"id":"https://openalex.org/C43521106","wikidata":"https://www.wikidata.org/wiki/Q2165493","display_name":"Pipeline (software)","level":2,"score":0.2969000041484833},{"id":"https://openalex.org/C2911029443","wikidata":"https://www.wikidata.org/wiki/Q21296145","display_name":"Human proteins","level":3,"score":0.289000004529953},{"id":"https://openalex.org/C11804247","wikidata":"https://www.wikidata.org/wiki/Q896177","display_name":"Protein\u2013protein interaction","level":2,"score":0.2851000130176544},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.2840000092983246},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.2791999876499176},{"id":"https://openalex.org/C2983668108","wikidata":"https://www.wikidata.org/wiki/Q280453","display_name":"Spectral analysis","level":3,"score":0.2720000147819519},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.2700999975204468},{"id":"https://openalex.org/C10010492","wikidata":"https://www.wikidata.org/wiki/Q3142557","display_name":"Protein sequencing","level":4,"score":0.2540000081062317},{"id":"https://openalex.org/C174510640","wikidata":"https://www.wikidata.org/wiki/Q489618","display_name":"HEK 293 cells","level":3,"score":0.2533000111579895},{"id":"https://openalex.org/C2993175405","wikidata":"https://www.wikidata.org/wiki/Q8054","display_name":"Bacterial protein","level":3,"score":0.25060001015663147}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.08.28.746934","doi":"https://doi.org/10.64898/2026.08.28.746934","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.28.746934","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/08/31/2026.08.28.746934.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.08.28.746934","doi":"https://doi.org/10.64898/2026.08.28.746934","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.28.746934","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/08/31/2026.08.28.746934.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.4000000059604645}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1954179933","display_name":null,"funder_award_id":"82173783","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4045557974","display_name":null,"funder_award_id":"2021YFA1301300","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5631211406","display_name":null,"funder_award_id":"2021YFA1301300","funder_id":"https://openalex.org/F4320322769","funder_display_name":"Natural Science Foundation of Jiangsu Province"},{"id":"https://openalex.org/G6087836920","display_name":null,"funder_award_id":"G20582017001","funder_id":"https://openalex.org/F4320336033","funder_display_name":"Overseas Expertise Introduction Project for Discipline Innovation"},{"id":"https://openalex.org/G6406741938","display_name":null,"funder_award_id":"BK20241590","funder_id":"https://openalex.org/F4320322769","funder_display_name":"Natural Science Foundation of Jiangsu Province"},{"id":"https://openalex.org/G642038914","display_name":null,"funder_award_id":"82404703","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7861510550","display_name":null,"funder_award_id":"82322068","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7869963002","display_name":null,"funder_award_id":"2632022YC03","funder_id":"https://openalex.org/F4320335787","funder_display_name":"Fundamental Research Funds for the Central Universities"},{"id":"https://openalex.org/G7990560482","display_name":null,"funder_award_id":"2021YFA1301300","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321605","display_name":"Government of Jiangsu Province","ror":"https://ror.org/004svx814"},{"id":"https://openalex.org/F4320322769","display_name":"Natural Science Foundation of Jiangsu Province","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null},{"id":"https://openalex.org/F4320335787","display_name":"Fundamental Research Funds for the Central Universities","ror":null},{"id":"https://openalex.org/F4320336033","display_name":"Overseas Expertise Introduction Project for Discipline Innovation","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204814943.pdf","grobid_xml":"https://content.openalex.org/works/W7204814943.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2159276924","https://openalex.org/W4400362490","https://openalex.org/W3164814771","https://openalex.org/W4402983359","https://openalex.org/W4312945366","https://openalex.org/W2091037376","https://openalex.org/W7172304886","https://openalex.org/W3030040881","https://openalex.org/W2262264910","https://openalex.org/W7129008800"],"abstract_inverted_index":{"ABSTRACT":[0],"Lysine":[1],"acylations,":[2],"including":[3],"lactylation":[4],"(Klac),":[5],"are":[6],"pivotal":[7],"regulators":[8],"of":[9,36,107,118],"cellular":[10],"physiology.":[11],"However,":[12],"their":[13],"analysis":[14],"is":[15],"currently":[16],"bottlenecked":[17],"by":[18,62],"antibody":[19],"enrichment":[20],"strategies":[21],"that":[22,54,104,168],"suffer":[23],"from":[24,112,177],"sequence":[25],"bias":[26],"and":[27,40,123,150,157,172],"require":[28],"milligram-scale":[29],"protein":[30],"inputs,":[31],"severely":[32],"precluding":[33],"the":[34],"profiling":[35,151],"scarce":[37],"clinical":[38,121],"biopsies":[39],"rare":[41],"cell":[42,119],"populations.":[43],"Here":[44],"we":[45,91],"present":[46],"ChemIntelligence":[47,93,136],",":[48,95],"an":[49],"acyl-NHS":[50],"chemistry-empowered":[51],"derivatization":[52],"strategy":[53],"rapidly":[55],"generates":[56],"unprecedented":[57],"acylation-specific":[58],"spectral":[59,89],"libraries,":[60],"exemplified":[61],"over":[63],"2.5\u00d710":[64],"5":[65],"human":[66],"Klac":[67,81,108,129],"peptides,":[68],"enabling":[69],"cross-species":[70],"reference":[71],"atlases.":[72],"Integrated":[73],"with":[74],"Prosit-based":[75],"rescoring,":[76],"these":[77,155],"libraries":[78],"substantially":[79],"increase":[80],"identifications":[82],"across":[83],"diverse":[84],"proteomic":[85],"datasets.":[86],"Leveraging":[87],"this":[88],"resource,":[90],"devised":[92],"Scope":[94],"a":[96,161],"reproducible,":[97],"multiplexed":[98],"parallel":[99],"reaction":[100],"monitoring":[101],"(PRM)":[102],"platform":[103],"quantifies":[105],"hundreds":[106],"peptides":[109],"per":[110],"injection":[111],"as":[113,115],"little":[114],"\u223c200":[116],"ng":[117],"lysates,":[120],"biopsies,":[122],"even":[124],"true":[125],"single":[126],"cells\u2014revealing":[127],"functional":[128,175],"signatures":[130],"inaccessible":[131],"to":[132,141],"conventional":[133],"methods.":[134],"The":[135],"pipeline":[137],"also":[138],"extends":[139],"seamlessly":[140],"lysine":[142],"nicotinylation,":[143],"underscoring":[144],"its":[145],"broad":[146],"adaptability":[147],"for":[148,165],"discovering":[149],"new":[152],"acylations.":[153],"Together,":[154],"chemical":[156],"computational":[158],"advances":[159],"establish":[160],"scalable,":[162],"antibody-free":[163],"framework":[164],"acyl-proteome":[166],"mapping":[167],"overcomes":[169],"input":[170],"constraints":[171],"enables":[173],"deep":[174],"insights":[176],"otherwise":[178],"intractable":[179],"biological":[180],"samples.":[181]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-09-01T00:00:00"}
