{"id":"https://openalex.org/W7204808753","doi":"https://doi.org/10.52578/3134-8114-2026-4-75-89","title":"PHYLOGENETIC ANALYSIS OF INTERFERON-ALPHA IN CATTLE","display_name":"PHYLOGENETIC ANALYSIS OF INTERFERON-ALPHA IN CATTLE","publication_year":2026,"publication_date":"2026-08-28","ids":{"openalex":"https://openalex.org/W7204808753","doi":"https://doi.org/10.52578/3134-8114-2026-4-75-89"},"language":"en","primary_location":{"id":"doi:10.52578/3134-8114-2026-4-75-89","doi":"https://doi.org/10.52578/3134-8114-2026-4-75-89","is_oa":true,"landing_page_url":"https://doi.org/10.52578/3134-8114-2026-4-75-89","pdf_url":"https://vet.wkau.kz/index.php/ahb/article/download/208/281","source":{"id":"https://openalex.org/S7407056761","display_name":"Animal Health and Biosafety","issn_l":"3134-8114","issn":["3134-8114","3134-8122"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Animal Health and Biosafety","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://vet.wkau.kz/index.php/ahb/article/download/208/281","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5095091006","display_name":"Nailya Tursunbay","orcid":"https://orcid.org/0000-0002-6604-4247","observed_orcids":["https://orcid.org/0000-0002-6604-4247"]},"institutions":[{"id":"https://openalex.org/I4210136233","display_name":"Zhangir Khan West Kazakhstan Agrarian Technical University","ror":"https://ror.org/03h8f2y52","country_code":"KZ","type":"education","lineage":["https://openalex.org/I4210136233"]}],"countries":["KZ"],"is_corresponding":false,"raw_author_name":"N. Tursunbay","raw_affiliation_strings":["National Center of Biotechnology","Zhangir Khan University, Zhangir Khan West Kazakhstan Agrarian Technical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Center of Biotechnology","institution_ids":[]},{"raw_affiliation_string":"Zhangir Khan University, Zhangir Khan West Kazakhstan Agrarian Technical University","institution_ids":["https://openalex.org/I4210136233"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102849415","display_name":"Elena Shevtsova","orcid":"https://orcid.org/0000-0002-7221-5866","observed_orcids":["https://orcid.org/0000-0002-7221-5866"]},"institutions":[{"id":"https://openalex.org/I4210101002","display_name":"National Center for Biotechnology","ror":"https://ror.org/00xhcc696","country_code":"KZ","type":"facility","lineage":["https://openalex.org/I4210101002"]},{"id":"https://openalex.org/I4210104776","display_name":"Centro Nacional de Biotecnolog\u00eda","ror":"https://ror.org/015w4v032","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210104776"]}],"countries":["ES","KZ"],"is_corresponding":false,"raw_author_name":"E. Shevtsova","raw_affiliation_strings":["National Center for Biotechnology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Center for Biotechnology","institution_ids":["https://openalex.org/I4210101002","https://openalex.org/I4210104776"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014597348","display_name":"Anara Ryskeldina","orcid":"https://orcid.org/0000-0002-7100-2711","observed_orcids":["https://orcid.org/0000-0002-7100-2711"]},"institutions":[{"id":"https://openalex.org/I4210101002","display_name":"National Center for Biotechnology","ror":"https://ror.org/00xhcc696","country_code":"KZ","type":"facility","lineage":["https://openalex.org/I4210101002"]},{"id":"https://openalex.org/I4210104776","display_name":"Centro Nacional de Biotecnolog\u00eda","ror":"https://ror.org/015w4v032","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210104776"]}],"countries":["ES","KZ"],"is_corresponding":false,"raw_author_name":"A. Ryskeldina","raw_affiliation_strings":["National Center for Biotechnology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Center for Biotechnology","institution_ids":["https://openalex.org/I4210101002","https://openalex.org/I4210104776"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066206005","display_name":"\u041a.\u041a. \u041c\u0443\u043a\u0430\u043d\u043e\u0432","orcid":"https://orcid.org/0000-0002-0502-9238","observed_orcids":["https://orcid.org/0000-0002-0502-9238"]},"institutions":[{"id":"https://openalex.org/I4210101002","display_name":"National Center for Biotechnology","ror":"https://ror.org/00xhcc696","country_code":"KZ","type":"facility","lineage":["https://openalex.org/I4210101002"]},{"id":"https://openalex.org/I4210104776","display_name":"Centro Nacional de Biotecnolog\u00eda","ror":"https://ror.org/015w4v032","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210104776"]}],"countries":["ES","KZ"],"is_corresponding":false,"raw_author_name":"K. Mukanov","raw_affiliation_strings":["National Center for Biotechnology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Center for Biotechnology","institution_ids":["https://openalex.org/I4210101002","https://openalex.org/I4210104776"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5139661449","display_name":"A. Nametov","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210136233","display_name":"Zhangir Khan West Kazakhstan Agrarian Technical University","ror":"https://ror.org/03h8f2y52","country_code":"KZ","type":"education","lineage":["https://openalex.org/I4210136233"]}],"countries":["KZ"],"is_corresponding":false,"raw_author_name":"A. Nametov","raw_affiliation_strings":["Zhangir Khan University, Zhangir Khan West Kazakhstan Agrarian Technical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zhangir Khan University, Zhangir Khan West Kazakhstan Agrarian Technical University","institution_ids":["https://openalex.org/I4210136233"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5139712608","display_name":"\u0410. \u0428\u0435\u0432\u0446\u043e\u0432","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210101002","display_name":"National Center for Biotechnology","ror":"https://ror.org/00xhcc696","country_code":"KZ","type":"facility","lineage":["https://openalex.org/I4210101002"]},{"id":"https://openalex.org/I4210104776","display_name":"Centro Nacional de Biotecnolog\u00eda","ror":"https://ror.org/015w4v032","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210104776"]}],"countries":["ES","KZ"],"is_corresponding":false,"raw_author_name":"A. Shevtsov","raw_affiliation_strings":["National Center for Biotechnology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Center for Biotechnology","institution_ids":["https://openalex.org/I4210101002","https://openalex.org/I4210104776"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010260366","display_name":"\u0410. \u041a\u0430\u0438\u0440\u0436\u0430\u043d\u043e\u0432\u0430","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210101002","display_name":"National Center for Biotechnology","ror":"https://ror.org/00xhcc696","country_code":"KZ","type":"facility","lineage":["https://openalex.org/I4210101002"]},{"id":"https://openalex.org/I4210104776","display_name":"Centro Nacional de Biotecnolog\u00eda","ror":"https://ror.org/015w4v032","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210104776"]}],"countries":["ES","KZ"],"is_corresponding":false,"raw_author_name":"A. Kairzhanova","raw_affiliation_strings":["National Center for Biotechnology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Center for Biotechnology","institution_ids":["https://openalex.org/I4210101002","https://openalex.org/I4210104776"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"82","issue":"4","first_page":"75","last_page":"89"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10594","display_name":"Genetic and phenotypic traits in livestock","score":0.006099999882280827,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interferon-alpha","display_name":"interferon-alpha","score":0.9850000143051147},{"id":"https://openalex.org/keywords/type-i-interferon","display_name":"type I interferon","score":0.8289999961853027},{"id":"https://openalex.org/keywords/multigene-family-evolution","display_name":"multigene family evolution","score":0.7350000143051147},{"id":"https://openalex.org/keywords/kalmyk-cattle","display_name":"Kalmyk cattle","score":0.8930000066757202},{"id":"https://openalex.org/keywords/bovidae","display_name":"Bovidae","score":0.871999979019165},{"id":"https://openalex.org/keywords/phylogenetic-analysis","display_name":"phylogenetic analysis","score":0.6389999985694885},{"id":"https://openalex.org/keywords/interferon-subtypes","display_name":"interferon subtypes","score":0.7039999961853027},{"id":"https://openalex.org/keywords/cattle","display_name":"cattle","score":0.6179999709129333},{"id":"https://openalex.org/keywords/bos-indicus","display_name":"Bos indicus","score":0.968999981880188},{"id":"https://openalex.org/keywords/bos-javanicus","display_name":"Bos javanicus","score":0.8539999723434448},{"id":"https://openalex.org/keywords/bison","display_name":"bison","score":0.953000009059906},{"id":"https://openalex.org/keywords/bos-mutus","display_name":"Bos mutus","score":0.9779999852180481},{"id":"https://openalex.org/keywords/bubalus","display_name":"Bubalus","score":0.9710000157356262},{"id":"https://openalex.org/keywords/pseudogenization","display_name":"pseudogenization","score":0.7310000061988831},{"id":"https://openalex.org/keywords/gene-duplication","display_name":"gene duplication","score":0.46799999475479126},{"id":"https://openalex.org/keywords/nested-pcr","display_name":"nested PCR","score":0.45899999141693115},{"id":"https://openalex.org/keywords/colony-pcr","display_name":"colony PCR","score":0.7089999914169312}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8374999761581421},{"id":"https://openalex.org/C193252679","wikidata":"https://www.wikidata.org/wiki/Q242125","display_name":"Phylogenetic tree","level":3,"score":0.8234000205993652},{"id":"https://openalex.org/C2777712803","wikidata":"https://www.wikidata.org/wiki/Q25497","display_name":"Bovidae","level":2,"score":0.6953999996185303},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6133999824523926},{"id":"https://openalex.org/C8185291","wikidata":"https://www.wikidata.org/wiki/Q2844457","display_name":"Amplicon","level":4,"score":0.505299985408783},{"id":"https://openalex.org/C90132467","wikidata":"https://www.wikidata.org/wiki/Q171184","display_name":"Phylogenetics","level":3,"score":0.43549999594688416},{"id":"https://openalex.org/C22799545","wikidata":"https://www.wikidata.org/wiki/Q1805805","display_name":"Maximum parsimony","level":5,"score":0.37869998812675476},{"id":"https://openalex.org/C17757408","wikidata":"https://www.wikidata.org/wiki/Q4135516","display_name":"genomic DNA","level":3,"score":0.37720000743865967},{"id":"https://openalex.org/C2781078984","wikidata":"https://www.wikidata.org/wiki/Q107205","display_name":"Mega-","level":2,"score":0.37310001254081726},{"id":"https://openalex.org/C26619641","wikidata":"https://www.wikidata.org/wiki/Q3142246","display_name":"Phylogenetic network","level":4,"score":0.35179999470710754},{"id":"https://openalex.org/C2777563447","wikidata":"https://www.wikidata.org/wiki/Q7243397","display_name":"Primer (cosmetics)","level":2,"score":0.35030001401901245},{"id":"https://openalex.org/C51679486","wikidata":"https://www.wikidata.org/wiki/Q380546","display_name":"DNA sequencing","level":3,"score":0.3418000042438507},{"id":"https://openalex.org/C49105822","wikidata":"https://www.wikidata.org/wiki/Q176996","display_name":"Polymerase chain reaction","level":3,"score":0.3285999894142151},{"id":"https://openalex.org/C27149982","wikidata":"https://www.wikidata.org/wiki/Q3456514","display_name":"Tandem repeat","level":4,"score":0.3179999887943268},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.31790000200271606},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.31060001254081726},{"id":"https://openalex.org/C61053724","wikidata":"https://www.wikidata.org/wiki/Q1154615","display_name":"Sequence analysis","level":3,"score":0.29010000824928284},{"id":"https://openalex.org/C76818968","wikidata":"https://www.wikidata.org/wiki/Q181940","display_name":"Sanger sequencing","level":4,"score":0.28690001368522644},{"id":"https://openalex.org/C2776817793","wikidata":"https://www.wikidata.org/wiki/Q6553369","display_name":"Lineage (genetic)","level":3,"score":0.2784000039100647},{"id":"https://openalex.org/C45484198","wikidata":"https://www.wikidata.org/wiki/Q827246","display_name":"Sequence alignment","level":4,"score":0.2535000145435333}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.52578/3134-8114-2026-4-75-89","doi":"https://doi.org/10.52578/3134-8114-2026-4-75-89","is_oa":true,"landing_page_url":"https://doi.org/10.52578/3134-8114-2026-4-75-89","pdf_url":"https://vet.wkau.kz/index.php/ahb/article/download/208/281","source":{"id":"https://openalex.org/S7407056761","display_name":"Animal Health and Biosafety","issn_l":"3134-8114","issn":["3134-8114","3134-8122"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Animal Health and Biosafety","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.52578/3134-8114-2026-4-75-89","doi":"https://doi.org/10.52578/3134-8114-2026-4-75-89","is_oa":true,"landing_page_url":"https://doi.org/10.52578/3134-8114-2026-4-75-89","pdf_url":"https://vet.wkau.kz/index.php/ahb/article/download/208/281","source":{"id":"https://openalex.org/S7407056761","display_name":"Animal Health and Biosafety","issn_l":"3134-8114","issn":["3134-8114","3134-8122"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Animal Health and Biosafety","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204808753.pdf","grobid_xml":"https://content.openalex.org/works/W7204808753.grobid-xml"},"referenced_works_count":21,"referenced_works":["https://openalex.org/W1555507143","https://openalex.org/W2000177767","https://openalex.org/W2017519756","https://openalex.org/W2029275361","https://openalex.org/W2048912867","https://openalex.org/W2060926084","https://openalex.org/W2062018285","https://openalex.org/W2073526502","https://openalex.org/W2078646756","https://openalex.org/W2128296317","https://openalex.org/W2132748059","https://openalex.org/W2163512735","https://openalex.org/W2177259980","https://openalex.org/W2332367372","https://openalex.org/W2778151539","https://openalex.org/W2888347958","https://openalex.org/W3005200385","https://openalex.org/W3090742303","https://openalex.org/W4379876383","https://openalex.org/W4389086892","https://openalex.org/W4404837302"],"related_works":["https://openalex.org/W1966965634","https://openalex.org/W3090742303","https://openalex.org/W1555507143","https://openalex.org/W2368478189","https://openalex.org/W2351147872","https://openalex.org/W190481761","https://openalex.org/W2060453401","https://openalex.org/W2375975023","https://openalex.org/W282735004","https://openalex.org/W2358243284"],"abstract_inverted_index":{"Interferons-\u03b1":[0],"(IFN-\u03b1)":[1],"in":[2,26,42,98,115,144,247],"cattle":[3,44,299],"belong":[4],"to":[5,34,46],"the":[6,31,73,99,131,141,168,177,198,244,258,278,308],"multigene":[7,263],"family":[8],"of":[9,30,49,58,91,123,152,162,167,171,220,261,268,283,294,307,317],"type":[10],"I":[11],"interferons,":[12],"whose":[13],"evolution":[14,260],"is":[15],"associated":[16,190],"with":[17,140,164,191,209,226,270],"duplications,":[18],"deletions,":[19],"pseudogenization,":[20],"and":[21,36,77,88,197,239,273,300,314],"nomenclatural":[22],"ambiguity":[23,267],"regarding":[24],"subtypes":[25],"Bovidae.":[27,50],"The":[28,102,180,213,265,287],"aim":[29],"study":[32,183],"was":[33,53,128,217],"obtain":[35],"phylogenetically":[37],"characterize":[38],"IFN-\u03b1":[39,61,113,245,284,295,319],"gene":[40],"fragments":[41,62],"Kalmyk":[43,298],"relative":[45],"reference":[47,103],"sequences":[48,95,114,120,181,227,296],"Genomic":[51],"DNA":[52],"isolated":[54],"from":[55,228,297],"hair":[56],"follicles":[57],"three":[59],"animals.":[60],"were":[63,80,96,174,184],"amplified":[64],"using":[65,82,130],"a":[66,108,149,252,262,302],"two-step":[67],"nested":[68],"PCR":[69,147,157],"method,":[70],"cloned":[71],"into":[72],"pGEM-T":[74],"Easy":[75],"vector,":[76],"recombinant":[78,318],"clones":[79,160,222],"selected":[81],"colony":[83,156],"PCR.":[84],"After":[85],"Sanger":[86],"sequencing":[87],"manual":[89],"verification":[90],"contigs,":[92],"68":[93,173,221],"high-quality":[94],"included":[97,117],"phylogenetic":[100],"analysis.":[101,179],"dataset,":[104],"generated":[105],"based":[106,135],"on":[107,136],"BLAST":[109],"search":[110],"for":[111,176,280,304],"Bovidae":[112,248],"NCBI,":[116],"143":[118],"unique":[119],"after":[121],"removal":[122],"redundant":[124],"entries.":[125],"Phylogenetic":[126],"reconstruction":[127],"performed":[129],"maximum":[132],"likelihood":[133],"method":[134],"amino":[137],"acid":[138],"alignment":[139],"JTT+G":[142],"model":[143,255],"MEGA12.":[145],"Nested":[146],"yielded":[148],"specific":[150],"amplicon":[151],"approximately":[153],"550":[154],"bp;":[155],"identified":[158,266],"74":[159],"out":[161,219],"96":[163],"an":[165,291],"insert":[166],"expected":[169],"size,":[170],"which":[172],"used":[175],"final":[178],"under":[182],"distributed":[185],"across":[186,205],"six":[187],"major":[188],"clusters":[189,269],"Bo-alpha-A,":[192],"Bo-alpha-B,":[193],"alpha-C,":[194],"alpha-F,":[195],"alpha-G,":[196],"mixed":[199],"alpha-1/H-like/B-like":[200],"cluster,":[201],"as":[202,204],"well":[203],"two":[206],"transitional":[207],"zones":[208],"reduced":[210],"bootstrap":[211],"support.":[212],"most":[214],"represented":[215],"cluster":[216],"alpha-G\u201426":[218],"(38.2%).":[223],"Mixed":[224],"clustering":[225],"Bos":[229,231,233,237],"taurus,":[230],"indicus,":[232],"javanicus,":[234],"Bison":[235],"bison,":[236],"mutus,":[238],"Bubalus":[240],"spp.":[241],"confirms":[242],"that":[243],"structure":[246],"does":[249],"not":[250],"follow":[251],"simple":[253],"species-specific":[254],"but":[256],"reflects":[257],"complex":[259],"family.":[264],"different":[271],"historical":[272],"automatic":[274],"NCBI":[275],"annotations":[276],"underscores":[277],"need":[279],"cautious":[281],"interpretation":[282],"subtype":[285],"affiliation.":[286],"data":[288],"obtained":[289],"form":[290],"initial":[292],"library":[293],"provide":[301],"basis":[303],"further":[305],"analysis":[306],"full":[309],"IFNA":[310],"locus,":[311],"individual":[312],"genotyping,":[313],"functional":[315],"evaluation":[316],"variants.":[320]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-09-01T00:00:00"}