{"id":"https://openalex.org/W7204808446","doi":"https://doi.org/10.64898/2026.08.28.747818","title":"Metastatic founder cell candidates resemble preimplantation embryonic blastomeres","display_name":"Metastatic founder cell candidates resemble preimplantation embryonic blastomeres","publication_year":2026,"publication_date":"2026-08-31","ids":{"openalex":"https://openalex.org/W7204808446","doi":"https://doi.org/10.64898/2026.08.28.747818"},"language":"en","primary_location":{"id":"doi:10.64898/2026.08.28.747818","doi":"https://doi.org/10.64898/2026.08.28.747818","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.28.747818","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.64898/2026.08.28.747818","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037252648","display_name":"Huiqin K\u00f6rkel-Qu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3129555431","display_name":"University Hospital Regensburg","ror":"https://ror.org/01226dv09","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I3129555431"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Huiqin K\u00f6rkel-Qu","raw_affiliation_strings":["Chair of Experimental Medicine and Therapy Research, University Hospital of Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chair of Experimental Medicine and Therapy Research, University Hospital of Regensburg, Germany","institution_ids":["https://openalex.org/I3129555431"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113149959","display_name":"Elia Raya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3129555431","display_name":"University Hospital Regensburg","ror":"https://ror.org/01226dv09","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I3129555431"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Elia Raya","raw_affiliation_strings":["Chair of Experimental Medicine and Therapy Research, University Hospital of Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chair of Experimental Medicine and Therapy Research, University Hospital of Regensburg, Germany","institution_ids":["https://openalex.org/I3129555431"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081092446","display_name":"Miodrag Gu\u017evi\u0107","orcid":"https://orcid.org/0000-0001-8089-3969","observed_orcids":["https://orcid.org/0000-0001-8089-3969"]},"institutions":[{"id":"https://openalex.org/I3129555431","display_name":"University Hospital Regensburg","ror":"https://ror.org/01226dv09","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I3129555431"]},{"id":"https://openalex.org/I4210157716","display_name":"Caritas-Krankenhaus St. Josef","ror":"https://ror.org/04w9ddv64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210157716"]},{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Miodrag Guzvic","raw_affiliation_strings":["Chair of Experimental Medicine and Therapy Research, University Hospital of Regensburg, Germany","Department of Urology, Caritas-Hospital St. Josef, University of Regensburg, Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chair of Experimental Medicine and Therapy Research, University Hospital of Regensburg, Germany","institution_ids":["https://openalex.org/I3129555431"]},{"raw_affiliation_string":"Department of Urology, Caritas-Hospital St. Josef, University of Regensburg, Regensburg, Germany","institution_ids":["https://openalex.org/I4210157716","https://openalex.org/I60668342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010827664","display_name":"Christoph Irlbeck","orcid":"https://orcid.org/0000-0002-0097-5639","observed_orcids":["https://orcid.org/0000-0002-0097-5639"]},"institutions":[{"id":"https://openalex.org/I3129555431","display_name":"University Hospital Regensburg","ror":"https://ror.org/01226dv09","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I3129555431"]},{"id":"https://openalex.org/I4210111966","display_name":"Fraunhofer Institute for Toxicology and Experimental Medicine","ror":"https://ror.org/02byjcr11","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210111966","https://openalex.org/I4923324"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christoph Irlbeck","raw_affiliation_strings":["Chair of Experimental Medicine and Therapy Research, University Hospital of Regensburg, Germany","Division of Personalized Tumor Therapy, Fraunhofer Institute of Experimental Medicine and Toxicology, Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chair of Experimental Medicine and Therapy Research, University Hospital of Regensburg, Germany","institution_ids":["https://openalex.org/I3129555431"]},{"raw_affiliation_string":"Division of Personalized Tumor Therapy, Fraunhofer Institute of Experimental Medicine and Toxicology, Regensburg, Germany","institution_ids":["https://openalex.org/I4210111966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003564853","display_name":"Tobias Mederer","orcid":"https://orcid.org/0000-0002-7274-3546","observed_orcids":["https://orcid.org/0000-0002-7274-3546"]},"institutions":[{"id":"https://openalex.org/I3129555431","display_name":"University Hospital Regensburg","ror":"https://ror.org/01226dv09","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I3129555431"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Tobias Mederer","raw_affiliation_strings":["Department of Thoracic Surgery, University Hospital of Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic Surgery, University Hospital of Regensburg, Germany","institution_ids":["https://openalex.org/I3129555431"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5094219202","display_name":"Daniel Spitzl","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3129555431","display_name":"University Hospital Regensburg","ror":"https://ror.org/01226dv09","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I3129555431"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Daniel Spitzl","raw_affiliation_strings":["Chair of Experimental Medicine and Therapy Research, University Hospital of Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chair of Experimental Medicine and Therapy Research, University Hospital of Regensburg, Germany","institution_ids":["https://openalex.org/I3129555431"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063465126","display_name":"Zbigniew T. Czy\u017c","orcid":"https://orcid.org/0009-0001-5634-3024","observed_orcids":["https://orcid.org/0009-0001-5634-3024"]},"institutions":[{"id":"https://openalex.org/I3129555431","display_name":"University Hospital Regensburg","ror":"https://ror.org/01226dv09","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I3129555431"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Zbigniew Czyz","raw_affiliation_strings":["Chair of Experimental Medicine and Therapy Research, University Hospital of Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chair of Experimental Medicine and Therapy Research, University Hospital of Regensburg, Germany","institution_ids":["https://openalex.org/I3129555431"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148828529","display_name":"Leon Schunicht","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3129555431","display_name":"University Hospital Regensburg","ror":"https://ror.org/01226dv09","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I3129555431"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Leon Schunicht","raw_affiliation_strings":["Chair of Experimental Medicine and Therapy Research, University Hospital of Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chair of Experimental Medicine and Therapy Research, University Hospital of Regensburg, Germany","institution_ids":["https://openalex.org/I3129555431"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113602017","display_name":"Stephan Seitz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210157716","display_name":"Caritas-Krankenhaus St. Josef","ror":"https://ror.org/04w9ddv64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210157716"]},{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Stephan Seitz","raw_affiliation_strings":["University Medical Center Regensburg, Department of Obstetrics and Gynecology, Caritas Hospital St. Josef, University of Regensburg, Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Medical Center Regensburg, Department of Obstetrics and Gynecology, Caritas Hospital St. Josef, University of Regensburg, Regensburg, Germany","institution_ids":["https://openalex.org/I4210157716","https://openalex.org/I60668342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084529807","display_name":"Jonas Roth","orcid":"https://orcid.org/0009-0004-3399-415X","observed_orcids":["https://orcid.org/0009-0004-3399-415X"]},"institutions":[{"id":"https://openalex.org/I4210157716","display_name":"Caritas-Krankenhaus St. Josef","ror":"https://ror.org/04w9ddv64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210157716"]},{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jonas Roth","raw_affiliation_strings":["University Medical Center Regensburg, Department of Obstetrics and Gynecology, Caritas Hospital St. Josef, University of Regensburg, Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Medical Center Regensburg, Department of Obstetrics and Gynecology, Caritas Hospital St. Josef, University of Regensburg, Regensburg, Germany","institution_ids":["https://openalex.org/I4210157716","https://openalex.org/I60668342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5137293507","display_name":"Brigitte Rack","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210155144","display_name":"University Hospital Ulm","ror":"https://ror.org/05emabm63","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210155144"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Brigitte Rack","raw_affiliation_strings":["Department of Gynecology, Ulm University Hospital, Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynecology, Ulm University Hospital, Ulm, Germany","institution_ids":["https://openalex.org/I4210155144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027231412","display_name":"Nadia Harbeck","orcid":"https://orcid.org/0000-0002-9744-7372","observed_orcids":["https://orcid.org/0000-0002-9744-7372"]},"institutions":[{"id":"https://openalex.org/I3018771216","display_name":"LMU Klinikum","ror":"https://ror.org/02jet3w32","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I3018771216","https://openalex.org/I8204097"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Nadia Harbeck","raw_affiliation_strings":["Breast Center, Department of Obstetrics and Gynecology and Comprehensive Cancer Center (CCC Munich LMU), LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Breast Center, Department of Obstetrics and Gynecology and Comprehensive Cancer Center (CCC Munich LMU), LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Munich, Germany","institution_ids":["https://openalex.org/I3018771216","https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148804912","display_name":"Hasan Kurdieh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3129555431","display_name":"University Hospital Regensburg","ror":"https://ror.org/01226dv09","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I3129555431"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Hasan Kurdieh","raw_affiliation_strings":["Chair of Experimental Medicine and Therapy Research, University Hospital of Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chair of Experimental Medicine and Therapy Research, University Hospital of Regensburg, Germany","institution_ids":["https://openalex.org/I3129555431"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052261613","display_name":"Roman Mayr","orcid":"https://orcid.org/0000-0003-1796-3260","observed_orcids":["https://orcid.org/0000-0003-1796-3260"]},"institutions":[{"id":"https://openalex.org/I4210157716","display_name":"Caritas-Krankenhaus St. Josef","ror":"https://ror.org/04w9ddv64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210157716"]},{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Roman Mayr","raw_affiliation_strings":["Department of Urology, Caritas-Hospital St. Josef, University of Regensburg, Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Caritas-Hospital St. Josef, University of Regensburg, Regensburg, Germany","institution_ids":["https://openalex.org/I4210157716","https://openalex.org/I60668342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5149822535","display_name":"Max Burger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210157716","display_name":"Caritas-Krankenhaus St. Josef","ror":"https://ror.org/04w9ddv64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210157716"]},{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Max Burger","raw_affiliation_strings":["Department of Urology, Caritas-Hospital St. Josef, University of Regensburg, Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Caritas-Hospital St. Josef, University of Regensburg, Regensburg, Germany","institution_ids":["https://openalex.org/I4210157716","https://openalex.org/I60668342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046777956","display_name":"Tobias Robold","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210123056","display_name":"Krankenhaus Barmherzige Br\u00fcder","ror":"https://ror.org/02pdsdw78","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210123056"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Tobias Robold","raw_affiliation_strings":["Department of Thoracic Surgery, Hospital Barmherzige Br\u00fcder, Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic Surgery, Hospital Barmherzige Br\u00fcder, Regensburg, Germany","institution_ids":["https://openalex.org/I4210123056"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103050972","display_name":"Hans\u2010Stefan Hofmann","orcid":"https://orcid.org/0000-0002-5316-5875","observed_orcids":["https://orcid.org/0000-0002-5316-5875"]},"institutions":[{"id":"https://openalex.org/I4210123056","display_name":"Krankenhaus Barmherzige Br\u00fcder","ror":"https://ror.org/02pdsdw78","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210123056"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Hans-Stefan Hofmann","raw_affiliation_strings":["Department of Thoracic Surgery, Hospital Barmherzige Br\u00fcder, Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic Surgery, Hospital Barmherzige Br\u00fcder, Regensburg, Germany","institution_ids":["https://openalex.org/I4210123056"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5123647542","display_name":"Markus Weber","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210123056","display_name":"Krankenhaus Barmherzige Br\u00fcder","ror":"https://ror.org/02pdsdw78","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210123056"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Markus Weber","raw_affiliation_strings":["Sarcoma and musculoskeletal tumors center, Hospital Barmherzige Br\u00fcder, Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sarcoma and musculoskeletal tumors center, Hospital Barmherzige Br\u00fcder, Regensburg, Germany","institution_ids":["https://openalex.org/I4210123056"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005871829","display_name":"Matthias Maak","orcid":"https://orcid.org/0000-0002-8506-4841","observed_orcids":["https://orcid.org/0000-0002-8506-4841"]},"institutions":[{"id":"https://openalex.org/I2802619606","display_name":"TUM Klinikum","ror":"https://ror.org/04jc43x05","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Matthias Maak","raw_affiliation_strings":["Department of Surgery, Hospital rechts der Isar, Technical University of Munich, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Hospital rechts der Isar, Technical University of Munich, Munich, Germany","institution_ids":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072141956","display_name":"Klaus\u2010Peter Janssen","orcid":"https://orcid.org/0000-0002-4707-7887","observed_orcids":["https://orcid.org/0000-0002-4707-7887"]},"institutions":[{"id":"https://openalex.org/I2802619606","display_name":"TUM Klinikum","ror":"https://ror.org/04jc43x05","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Klaus-Peter Janssen","raw_affiliation_strings":["Department of Surgery, Hospital rechts der Isar, Technical University of Munich, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Hospital rechts der Isar, Technical University of Munich, Munich, Germany","institution_ids":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045551253","display_name":"Sarah M. H\u00fccker","orcid":"https://orcid.org/0000-0002-6167-0265","observed_orcids":["https://orcid.org/0000-0002-6167-0265"]},"institutions":[{"id":"https://openalex.org/I4210111966","display_name":"Fraunhofer Institute for Toxicology and Experimental Medicine","ror":"https://ror.org/02byjcr11","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210111966","https://openalex.org/I4923324"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sarah H\u00fccker","raw_affiliation_strings":["Division of Personalized Tumor Therapy, Fraunhofer Institute of Experimental Medicine and Toxicology, Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Personalized Tumor Therapy, Fraunhofer Institute of Experimental Medicine and Toxicology, Regensburg, Germany","institution_ids":["https://openalex.org/I4210111966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022112869","display_name":"Stefan Kirsch","orcid":"https://orcid.org/0000-0002-6238-7170","observed_orcids":["https://orcid.org/0000-0002-6238-7170"]},"institutions":[{"id":"https://openalex.org/I4210111966","display_name":"Fraunhofer Institute for Toxicology and Experimental Medicine","ror":"https://ror.org/02byjcr11","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210111966","https://openalex.org/I4923324"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Stefan Kirsch","raw_affiliation_strings":["Division of Personalized Tumor Therapy, Fraunhofer Institute of Experimental Medicine and Toxicology, Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Personalized Tumor Therapy, Fraunhofer Institute of Experimental Medicine and Toxicology, Regensburg, Germany","institution_ids":["https://openalex.org/I4210111966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059655862","display_name":"Melanie Werner\u2010Klein","orcid":"https://orcid.org/0000-0002-5677-9346","observed_orcids":["https://orcid.org/0000-0002-5677-9346"]},"institutions":[{"id":"https://openalex.org/I3129555431","display_name":"University Hospital Regensburg","ror":"https://ror.org/01226dv09","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I3129555431"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Melanie Werner-Klein","raw_affiliation_strings":["Chair of Experimental Medicine and Therapy Research, University Hospital of Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chair of Experimental Medicine and Therapy Research, University Hospital of Regensburg, Germany","institution_ids":["https://openalex.org/I3129555431"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026440273","display_name":"Anthony C.F. Perry","orcid":"https://orcid.org/0000-0003-3136-5355","observed_orcids":["https://orcid.org/0000-0003-3136-5355"]},"institutions":[{"id":"https://openalex.org/I51601045","display_name":"University of Bath","ror":"https://ror.org/002h8g185","country_code":"GB","type":"education","lineage":["https://openalex.org/I51601045"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Anthony C.F Perry","raw_affiliation_strings":["Laboratory of Mammalian Molecular Embryology, Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Mammalian Molecular Embryology, Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, UK","institution_ids":["https://openalex.org/I51601045"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066380716","display_name":"Christoph A. Klein","orcid":"https://orcid.org/0000-0001-7128-1725","observed_orcids":["https://orcid.org/0000-0001-7128-1725"]},"institutions":[{"id":"https://openalex.org/I3129555431","display_name":"University Hospital Regensburg","ror":"https://ror.org/01226dv09","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I3129555431"]},{"id":"https://openalex.org/I4210111966","display_name":"Fraunhofer Institute for Toxicology and Experimental Medicine","ror":"https://ror.org/02byjcr11","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210111966","https://openalex.org/I4923324"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Christoph A. Klein","raw_affiliation_strings":["Chair of Experimental Medicine and Therapy Research, University Hospital of Regensburg, Germany","Division of Personalized Tumor Therapy, Fraunhofer Institute of Experimental Medicine and Toxicology, Regensburg, Germany"],"raw_orcid":"https://orcid.org/0000-0001-7128-1725","affiliations":[{"raw_affiliation_string":"Chair of Experimental Medicine and Therapy Research, University Hospital of Regensburg, Germany","institution_ids":["https://openalex.org/I3129555431"]},{"raw_affiliation_string":"Division of Personalized Tumor Therapy, Fraunhofer Institute of Experimental Medicine and Toxicology, Regensburg, Germany","institution_ids":["https://openalex.org/I4210111966"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":11,"corresponding_author_ids":["https://openalex.org/A5066380716"],"corresponding_institution_ids":["https://openalex.org/I3129555431","https://openalex.org/I4210111966"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/disseminated-tumor-cells","display_name":"disseminated tumor cells","score":0.9829999804496765},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.7260000109672546},{"id":"https://openalex.org/keywords/founder-cells","display_name":"founder cells","score":0.6759999990463257},{"id":"https://openalex.org/keywords/epcam","display_name":"EpCAM","score":0.7940000295639038},{"id":"https://openalex.org/keywords/single-cell-transcriptomics","display_name":"single-cell transcriptomics","score":0.7250000238418579},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.9190000295639038},{"id":"https://openalex.org/keywords/cancer-stemness","display_name":"cancer stemness","score":0.5099999904632568},{"id":"https://openalex.org/keywords/bone-marrow","display_name":"bone marrow","score":0.5820000171661377},{"id":"https://openalex.org/keywords/lymph-nodes","display_name":"lymph nodes","score":0.9229999780654907},{"id":"https://openalex.org/keywords/metastatic-risk-prediction","display_name":"metastatic risk prediction","score":0.6349999904632568},{"id":"https://openalex.org/keywords/cancer-cell-line-encyclopedia","display_name":"Cancer Cell Line Encyclopedia","score":0.7789999842643738}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7084000110626221},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.6054999828338623},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.5715000033378601},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5113999843597412},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.46720001101493835},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4602999985218048},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4487999975681305},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.44369998574256897},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.38670000433921814},{"id":"https://openalex.org/C2779012181","wikidata":"https://www.wikidata.org/wiki/Q2750567","display_name":"Cytokeratin","level":3,"score":0.38339999318122864},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.3443000018596649},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.34360000491142273},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.33869999647140503},{"id":"https://openalex.org/C55427017","wikidata":"https://www.wikidata.org/wiki/Q1638475","display_name":"Cancer stem cell","level":3,"score":0.33809998631477356},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3321000039577484},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.31139999628067017},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.29580000042915344},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.29179999232292175},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.28110000491142273},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.27469998598098755},{"id":"https://openalex.org/C68760520","wikidata":"https://www.wikidata.org/wiki/Q882097","display_name":"Blastomere","level":4,"score":0.26899999380111694},{"id":"https://openalex.org/C15729860","wikidata":"https://www.wikidata.org/wiki/Q2329919","display_name":"Progenitor","level":4,"score":0.25609999895095825}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.08.28.747818","doi":"https://doi.org/10.64898/2026.08.28.747818","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.28.747818","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.08.28.747818","doi":"https://doi.org/10.64898/2026.08.28.747818","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.28.747818","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G1387417213","display_name":null,"funder_award_id":"111536","funder_id":"https://openalex.org/F4320323556","funder_display_name":"Deutsche Krebshilfe"}],"funders":[{"id":"https://openalex.org/F4320323556","display_name":"Deutsche Krebshilfe","ror":"https://ror.org/01wxdd722"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":57,"referenced_works":["https://openalex.org/W1538548942","https://openalex.org/W1964194222","https://openalex.org/W1971958507","https://openalex.org/W1981218638","https://openalex.org/W1989215251","https://openalex.org/W1995209724","https://openalex.org/W2001883065","https://openalex.org/W2007439698","https://openalex.org/W2013167503","https://openalex.org/W2019389478","https://openalex.org/W2027525624","https://openalex.org/W2033291585","https://openalex.org/W2038479043","https://openalex.org/W2043398720","https://openalex.org/W2056507674","https://openalex.org/W2080264320","https://openalex.org/W2089155477","https://openalex.org/W2100681150","https://openalex.org/W2108122736","https://openalex.org/W2108296770","https://openalex.org/W2114104545","https://openalex.org/W2115792588","https://openalex.org/W2130049720","https://openalex.org/W2138022504","https://openalex.org/W2161587504","https://openalex.org/W2316095770","https://openalex.org/W2565834876","https://openalex.org/W2756457223","https://openalex.org/W2795867722","https://openalex.org/W2800104500","https://openalex.org/W2889628524","https://openalex.org/W2895456557","https://openalex.org/W2907514116","https://openalex.org/W2915423594","https://openalex.org/W2931036699","https://openalex.org/W3002770500","https://openalex.org/W3013151148","https://openalex.org/W3027387006","https://openalex.org/W3033457790","https://openalex.org/W3090130779","https://openalex.org/W3091907956","https://openalex.org/W3113331104","https://openalex.org/W3120974422","https://openalex.org/W3164692211","https://openalex.org/W3180289833","https://openalex.org/W4200386511","https://openalex.org/W4220956414","https://openalex.org/W4280598116","https://openalex.org/W4286779598","https://openalex.org/W4297503840","https://openalex.org/W4318678659","https://openalex.org/W4378953806","https://openalex.org/W4404958050","https://openalex.org/W4410447949","https://openalex.org/W4414767914","https://openalex.org/W4416901311","https://openalex.org/W4417010967"],"related_works":["https://openalex.org/W4393088358","https://openalex.org/W4406809985","https://openalex.org/W7165088992","https://openalex.org/W4399578182","https://openalex.org/W2406230943","https://openalex.org/W4393096683","https://openalex.org/W4415904528","https://openalex.org/W2439132109","https://openalex.org/W2912064886","https://openalex.org/W2791665307"],"abstract_inverted_index":{"Abstract":[0],"Disseminated":[1],"cancer":[2,62,110,192],"cells":[3,34,40,59,76,111,164],"(DCC)":[4],"in":[5,41,64,165,175,198],"non-metastatic":[6,44,89],"carcinoma":[7],"patient":[8],"bone":[9],"marrow":[10],"(BM)":[11],"are":[12],"predictive":[13],"of":[14,51,56,103,125,144,191],"metastasis.":[15],"Those":[16],"detected":[17],"by":[18],"epithelial":[19],"cytokeratin":[20],"or":[21,66],"EpCAM":[22],"expression":[23,156,173],"have":[24],"poorly-characterized":[25],"transcription":[26],"profiles":[27,157,174],"due":[28],"to":[29,118],"their":[30],"extreme":[31],"rarity:":[32],"1\u223c2":[33],"per":[35],"2x":[36],"10":[37],"6":[38],"BM":[39,65],"every":[42],"third":[43],"patient.":[45],"We":[46],"here":[47],"characterize":[48],"the":[49,93,113,141,149,189],"transcriptomes":[50],"DCCs.":[52],"Single-cell":[53],"RNA-sequencing":[54],"(scRNA-seq)":[55],"864":[57],"EpCAM-positive":[58],"(from":[60],"1,151":[61],"patients)":[63],"lymph":[67],"nodes":[68],"(LN)":[69],"revealed":[70],"plasma,":[71],"immune,":[72],"myeloid,":[73],"erythroid":[74],"progenitor":[75],"and":[77,84,99,121,180,193],"two":[78],"candidate":[79],"DCC":[80,127],"populations,":[81],"termed":[82],"M0-DCC":[83,138,154],"M1-DCC.":[85],"M0-DCC,":[86],"mostly":[87],"from":[88,148,162],"M0-stage":[90],"patients,":[91],"displayed":[92],"highest":[94,131],"known":[95],"adult":[96],"stemness":[97],"scores,":[98],"were":[100],"transcriptomically":[101],"reminiscent":[102],"human":[104,145],"cleavage-stage,":[105],"preimplantation":[106],"embryos.":[107,123],"M1-DCC":[108],"represented":[109],"undergoing":[112],"epithelial-mesenchymal":[114],"transition":[115],"(EMT),":[116],"corresponding":[117],"later,":[119],"implanting":[120],"gastrulating":[122],"Detection":[124],"early-embryo-like":[126],"categorised":[128],"patients":[129],"at":[130],"risk":[132],"for":[133],"metastatic":[134,142,181],"progression.":[135],"Furthermore,":[136],"high":[137],"scores":[139],"predicted":[140],"potential":[143],"cell":[146,183],"lines":[147],"Cancer":[150],"Cell":[151],"Line":[152],"Encyclopedia.":[153],"gene":[155,172],"can":[158],"be":[159],"reversibly":[160],"induced":[161],"M1-DCC-like":[163],"vitro":[166],".":[167],"The":[168],"close":[169],"correspondence":[170],"between":[171],"immediate":[176],"early":[177],"embryonic":[178],"development":[179],"founder":[182],"candidates":[184],"provides":[185],"strong":[186],"evidence":[187],"that":[188],"onset":[190],"metastasis":[194],"recruits":[195],"mechanisms":[196],"employed":[197],"fertilization.":[199]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2026-09-01T00:00:00"}
