{"id":"https://openalex.org/W7204804677","doi":"https://doi.org/10.64898/2026.08.28.747839","title":"Complementary Models of Cardiometabolic Stress Reveal Conserved Molecular Programs Driving Cardiac Remodeling","display_name":"Complementary Models of Cardiometabolic Stress Reveal Conserved Molecular Programs Driving Cardiac Remodeling","publication_year":2026,"publication_date":"2026-08-31","ids":{"openalex":"https://openalex.org/W7204804677","doi":"https://doi.org/10.64898/2026.08.28.747839","pmid":"https://pubmed.ncbi.nlm.nih.gov/42922618","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13684543"},"language":"en","primary_location":{"id":"doi:10.64898/2026.08.28.747839","doi":"https://doi.org/10.64898/2026.08.28.747839","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.28.747839","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/08/31/2026.08.28.747839.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/08/31/2026.08.28.747839.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5148818307","display_name":"Maaria Saeed","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maaria Saeed","raw_affiliation_strings":["Department of Anesthesiology, Critical Care and Pain Medicine, University of Texas Health Science Center, Houston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Critical Care and Pain Medicine, University of Texas Health Science Center, Houston","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059164196","display_name":"Hyun-Jung Jung","orcid":"https://orcid.org/0000-0002-7004-2017","observed_orcids":["https://orcid.org/0000-0002-7004-2017","https://orcid.org/0000-0002-4398-173X"]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hyun-Jung Jung","raw_affiliation_strings":["Department of Anesthesiology, Critical Care and Pain Medicine, University of Texas Health Science Center, Houston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Critical Care and Pain Medicine, University of Texas Health Science Center, Houston","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047980172","display_name":"Bo Ryung Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bo Ryung Lee","raw_affiliation_strings":["Department of Anesthesiology, Critical Care and Pain Medicine, University of Texas Health Science Center, Houston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Critical Care and Pain Medicine, University of Texas Health Science Center, Houston","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064873484","display_name":"Swapna Patil","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Swapna Patil","raw_affiliation_strings":["Department of Anesthesiology, Critical Care and Pain Medicine, University of Texas Health Science Center, Houston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Critical Care and Pain Medicine, University of Texas Health Science Center, Houston","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077904974","display_name":"Ripon Sarkar","orcid":"https://orcid.org/0000-0003-1393-6222","observed_orcids":["https://orcid.org/0000-0003-1393-6222"]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ripon Sarkar","raw_affiliation_strings":["Department of Anesthesiology, Critical Care and Pain Medicine, University of Texas Health Science Center, Houston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Critical Care and Pain Medicine, University of Texas Health Science Center, Houston","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012755429","display_name":"Connor W. Lantz","orcid":"https://orcid.org/0000-0003-3317-6486","observed_orcids":["https://orcid.org/0000-0003-3317-6486"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Connor Lantz","raw_affiliation_strings":["Comprehensive Transplant Center, Department of Surgery, Feinberg School of Medicine, Northwestern University, Chicago"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Comprehensive Transplant Center, Department of Surgery, Feinberg School of Medicine, Northwestern University, Chicago","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014318517","display_name":"Mi Jeong Heo","orcid":"https://orcid.org/0000-0002-5420-2797","observed_orcids":["https://orcid.org/0000-0002-5420-2797","https://orcid.org/0009-0000-2363-5867"]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mi Jeong Heo","raw_affiliation_strings":["Department of Anesthesiology, Critical Care and Pain Medicine, University of Texas Health Science Center, Houston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Critical Care and Pain Medicine, University of Texas Health Science Center, Houston","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Alexandra Serrato","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexandra Serrato","raw_affiliation_strings":["Department of Anesthesiology, Critical Care and Pain Medicine, University of Texas Health Science Center, Houston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Critical Care and Pain Medicine, University of Texas Health Science Center, Houston","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148803915","display_name":"Yu A An","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yu A An","raw_affiliation_strings":["Department of Anesthesiology, Critical Care and Pain Medicine, University of Texas Health Science Center, Houston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Critical Care and Pain Medicine, University of Texas Health Science Center, Houston","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015401193","display_name":"Kang Ho Kim","orcid":"https://orcid.org/0000-0003-2480-5308","observed_orcids":["https://orcid.org/0000-0003-2480-5308"]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kang Ho Kim","raw_affiliation_strings":["Department of Anesthesiology, Critical Care and Pain Medicine, University of Texas Health Science Center, Houston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Critical Care and Pain Medicine, University of Texas Health Science Center, Houston","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017134250","display_name":"Matthew DeBerge","orcid":"https://orcid.org/0000-0002-9786-0327","observed_orcids":["https://orcid.org/0000-0002-9786-0327"]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Matthew DeBerge","raw_affiliation_strings":["Department of Anesthesiology, Critical Care and Pain Medicine, University of Texas Health Science Center, Houston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Critical Care and Pain Medicine, University of Texas Health Science Center, Houston","institution_ids":["https://openalex.org/I919571938"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5017134250"],"corresponding_institution_ids":["https://openalex.org/I919571938"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.86080002784729,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.86080002784729,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.11550000309944153,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.004900000058114529,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/heart-failure-with-preserved-ejection-fraction","display_name":"heart failure with preserved ejection fraction","score":0.9359999895095825},{"id":"https://openalex.org/keywords/cardiac-remodeling","display_name":"cardiac remodeling","score":0.972000002861023},{"id":"https://openalex.org/keywords/plasminogen-activator-inhibitor-1","display_name":"plasminogen activator inhibitor-1","score":0.9800000190734863},{"id":"https://openalex.org/keywords/pai-1-inhibition","display_name":"PAI-1 inhibition","score":0.8550000190734863},{"id":"https://openalex.org/keywords/hepatic-steatosis","display_name":"hepatic steatosis","score":0.699999988079071},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.7099999785423279},{"id":"https://openalex.org/keywords/high-fat-diet","display_name":"high-fat diet","score":0.7649999856948853},{"id":"https://openalex.org/keywords/l-name","display_name":"L-NAME","score":0.7770000100135803},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.5389999747276306}],"concepts":[{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.6051999926567078},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5974000096321106},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.5281000137329102},{"id":"https://openalex.org/C199216141","wikidata":"https://www.wikidata.org/wiki/Q4995178","display_name":"Conserved sequence","level":4,"score":0.5163999795913696},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5076000094413757},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.42480000853538513},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.40950000286102295},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4011000096797943},{"id":"https://openalex.org/C111566952","wikidata":"https://www.wikidata.org/wiki/Q1303462","display_name":"Cardiac function curve","level":3,"score":0.3937999904155731},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.34869998693466187},{"id":"https://openalex.org/C3018791406","wikidata":"https://www.wikidata.org/wiki/Q945225","display_name":"Cardiac hypertrophy","level":3,"score":0.34700000286102295},{"id":"https://openalex.org/C2107291","wikidata":"https://www.wikidata.org/wiki/Q14886885","display_name":"Mediator","level":2,"score":0.33959999680519104},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3082999885082245},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2962000072002411},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.29089999198913574},{"id":"https://openalex.org/C183683566","wikidata":"https://www.wikidata.org/wiki/Q5038741","display_name":"Cardiovascular physiology","level":2,"score":0.28850001096725464},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.28439998626708984},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.27720001339912415},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.27239999175071716},{"id":"https://openalex.org/C2780578515","wikidata":"https://www.wikidata.org/wiki/Q657193","display_name":"Metabolic syndrome","level":3,"score":0.2637999951839447},{"id":"https://openalex.org/C2780675426","wikidata":"https://www.wikidata.org/wiki/Q410485","display_name":"Plasminogen activator inhibitor-1","level":3,"score":0.2628999948501587},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2551000118255615}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.64898/2026.08.28.747839","doi":"https://doi.org/10.64898/2026.08.28.747839","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.28.747839","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/08/31/2026.08.28.747839.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:13684543","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13684543/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13684543/pdf/nihpp-2026.08.28.747839v1.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv","raw_type":"Text"},{"id":"pmid:42922618","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42922618","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.64898/2026.08.28.747839","doi":"https://doi.org/10.64898/2026.08.28.747839","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.28.747839","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/08/31/2026.08.28.747839.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9907000064849854,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G293715275","display_name":null,"funder_award_id":"P30-CA-016672","funder_id":"https://openalex.org/F4320332521","funder_display_name":"University of Texas MD Anderson Cancer Center"},{"id":"https://openalex.org/G3133594102","display_name":"Contributions of liver eicosanoid metabolism to cardiometabolic heart failure","funder_award_id":"25TPA1463689","funder_id":"https://openalex.org/F4320306230","funder_display_name":"American Heart Association"},{"id":"https://openalex.org/G9000873034","display_name":"THE ROLE OF HEPATOKINE ORM2 IN ADIPOSE TISSUE INFLAMMATION","funder_award_id":"R01DK126656","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000878657","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA016672","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"},{"id":"https://openalex.org/F4320313675","display_name":"University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332521","display_name":"University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204804677.pdf","grobid_xml":"https://content.openalex.org/works/W7204804677.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7220973654","https://openalex.org/W4403246064","https://openalex.org/W4288535448","https://openalex.org/W4407273374","https://openalex.org/W4415829266","https://openalex.org/W7155493681","https://openalex.org/W4411973918","https://openalex.org/W7213944459","https://openalex.org/W7221820836","https://openalex.org/W7160886945"],"abstract_inverted_index":{"Background:":[0],"Cardiometabolic":[1],"diseases":[2],"frequently":[3],"involve":[4],"concurrent":[5],"cardiovascular":[6,83,192],"and":[7,34,54,92,143,182,195],"hepatic":[8,51,151],"dysfunction,":[9],"yet":[10],"the":[11,133],"conserved":[12,25,112,126,174],"molecular":[13,26,113,175],"mechanisms":[14],"underlying":[15],"these":[16],"systemic":[17],"responses":[18,27,110],"remain":[19],"poorly":[20],"defined.":[21],"Objectives:":[22],"To":[23],"identify":[24,196],"across":[28,60,167],"complementary":[29,62,168],"manifestations":[30,67,169],"of":[31,68,137,170,202],"cardiometabolic":[32,69,171],"stress":[33,172],"determine":[35],"whether":[36],"integrated":[37],"multi-organ":[38],"analyses":[39,107,166],"reveal":[40],"therapeutically":[41],"actionable":[42],"targets":[43,194],"for":[44,190],"heart":[45,76],"failure.":[46],"Methods:":[47],"Cardiac":[48],"functional":[49],"phenotyping,":[50],"injury":[52],"profiling,":[53],"bulk":[55],"RNA":[56],"sequencing":[57],"were":[58],"performed":[59],"three":[61],"mouse":[63],"models":[64,181],"representing":[65],"distinct":[66],"stress:":[70],"high-fat":[71,96],"diet":[72,86,97],"plus":[73],"L-NAME":[74],"(HFD+LN)-induced":[75],"failure":[77],"with":[78],"preserved":[79],"ejection":[80],"fraction":[81],"(HFpEF;":[82],"disease),":[84],"Western":[85],"(WD)-induced":[87],"obesity":[88],"(systemic":[89],"metabolic":[90,103],"stress),":[91],"choline-deficient,":[93],"L-amino":[94],"acid-defined,":[95],"(CDAHFD)-induced":[98],"steatotic":[99],"liver":[100],"disease":[101,180],"(hepatic":[102],"stress).":[104],"Comparative":[105],"transcriptomic":[106],"distinguished":[108],"organ-specific":[109,159],"from":[111],"signatures.":[114],"Results:":[115],",":[116],"encoding":[117],"plasminogen":[118],"activator":[119],"inhibitor-1":[120],"(PAI-1),":[121],"emerging":[122],"as":[123,198],"a":[124,187,199],"highly":[125],"candidate":[127],"that":[128,177],"exhibited":[129],"preferential":[130],"induction":[131],"in":[132,147,205],"heart.":[134],"Pharmacologic":[135],"inhibition":[136],"PAI-1":[138,197],"significantly":[139],"improved":[140],"cardiac":[141,203],"function":[142],"attenuated":[144],"adverse":[145],"remodeling":[146,204],"established":[148],"HFpEF,":[149],"whereas":[150],"pathology":[152],"was":[153],"comparatively":[154],"less":[155],"affected,":[156],"indicating":[157],"differential":[158],"dependence":[160],"on":[161],"this":[162],"pathway.":[163],"Conclusions:":[164],"Integrated":[165],"identified":[173],"signatures":[176],"transcend":[178],"individual":[179],"organs.":[183],"These":[184],"findings":[185],"establish":[186],"comparative":[188],"framework":[189],"discovering":[191],"therapeutic":[193],"promising":[200],"mediator":[201],"HFpEF.":[206]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-09-01T00:00:00"}
