{"id":"https://openalex.org/W7204803689","doi":"https://doi.org/10.1038/s41467-026-77034-w","title":"ER\u03b1 Micromap (\u00b5Map) proximity labeling reveals fulvestrant mechanisms","display_name":"ER\u03b1 Micromap (\u00b5Map) proximity labeling reveals fulvestrant mechanisms","publication_year":2026,"publication_date":"2026-08-31","ids":{"openalex":"https://openalex.org/W7204803689","doi":"https://doi.org/10.1038/s41467-026-77034-w","pmid":"https://pubmed.ncbi.nlm.nih.gov/42816507","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13627678"},"language":"en","primary_location":{"id":"doi:10.1038/s41467-026-77034-w","doi":"https://doi.org/10.1038/s41467-026-77034-w","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-026-77034-w","pdf_url":"https://www.nature.com/articles/s41467-026-77034-w_reference.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41467-026-77034-w_reference.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5145398299","display_name":"Chun Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chun Li","raw_affiliation_strings":["Department of Chemistry, Princeton University, Princeton, NJ, USA","Merck Center for Catalysis at Princeton University, Princeton, NJ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Princeton University, Princeton, NJ, USA","institution_ids":["https://openalex.org/I20089843"]},{"raw_affiliation_string":"Merck Center for Catalysis at Princeton University, Princeton, NJ, USA","institution_ids":["https://openalex.org/I20089843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5134489061","display_name":"Zihan Dong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zihan Dong","raw_affiliation_strings":["Department of Chemistry, Princeton University, Princeton, NJ, USA","Merck Center for Catalysis at Princeton University, Princeton, NJ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Princeton University, Princeton, NJ, USA","institution_ids":["https://openalex.org/I20089843"]},{"raw_affiliation_string":"Merck Center for Catalysis at Princeton University, Princeton, NJ, USA","institution_ids":["https://openalex.org/I20089843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071745580","display_name":"Romain O. Georges","orcid":"https://orcid.org/0000-0001-8207-609X","observed_orcids":["https://orcid.org/0000-0001-8207-609X"]},"institutions":[{"id":"https://openalex.org/I4210091812","display_name":"Bristol-Myers Squibb (United States)","ror":"https://ror.org/00gtmwv55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Romain O. Georges","raw_affiliation_strings":["Bristol Myers Squibb, San Diego, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bristol Myers Squibb, San Diego, CA, USA","institution_ids":["https://openalex.org/I4210091812"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045360552","display_name":"Kristina Danga","orcid":"https://orcid.org/0000-0001-7886-0041","observed_orcids":["https://orcid.org/0000-0001-7886-0041"]},"institutions":[{"id":"https://openalex.org/I4210091812","display_name":"Bristol-Myers Squibb (United States)","ror":"https://ror.org/00gtmwv55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kristina Danga","raw_affiliation_strings":["Bristol Myers Squibb, San Diego, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bristol Myers Squibb, San Diego, CA, USA","institution_ids":["https://openalex.org/I4210091812"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006311746","display_name":"Ciaran P. Seath","orcid":"https://orcid.org/0000-0002-6774-128X","observed_orcids":["https://orcid.org/0000-0002-6774-128X"]},"institutions":[{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]},{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ciaran P. Seath","raw_affiliation_strings":["Cornell University, Ithaca, NY, USA","Department of Chemistry, Princeton University, Princeton, NJ, USA","Merck Center for Catalysis at Princeton University, Princeton, NJ, USA"],"raw_orcid":"https://orcid.org/0000-0002-6774-128X","affiliations":[{"raw_affiliation_string":"Cornell University, Ithaca, NY, USA","institution_ids":["https://openalex.org/I205783295"]},{"raw_affiliation_string":"Department of Chemistry, Princeton University, Princeton, NJ, USA","institution_ids":["https://openalex.org/I20089843"]},{"raw_affiliation_string":"Merck Center for Catalysis at Princeton University, Princeton, NJ, USA","institution_ids":["https://openalex.org/I20089843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062185348","display_name":"Yuka Amako","orcid":"https://orcid.org/0000-0002-0754-5623","observed_orcids":["https://orcid.org/0000-0002-0754-5623"]},"institutions":[{"id":"https://openalex.org/I4210091812","display_name":"Bristol-Myers Squibb (United States)","ror":"https://ror.org/00gtmwv55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuka Amako","raw_affiliation_strings":["Bristol Myers Squibb, Cambridge, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bristol Myers Squibb, Cambridge, MA, USA","institution_ids":["https://openalex.org/I4210091812"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085307154","display_name":"Jack L. Sloane","orcid":"https://orcid.org/0000-0002-2564-1002","observed_orcids":["https://orcid.org/0000-0002-2564-1002"]},"institutions":[{"id":"https://openalex.org/I4210091812","display_name":"Bristol-Myers Squibb (United States)","ror":"https://ror.org/00gtmwv55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jack L. Sloane","raw_affiliation_strings":["Bristol Myers Squibb, Cambridge, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bristol Myers Squibb, Cambridge, MA, USA","institution_ids":["https://openalex.org/I4210091812"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046260042","display_name":"Aya M. Kelly","orcid":"https://orcid.org/0009-0004-8764-7161","observed_orcids":["https://orcid.org/0009-0004-8764-7161"]},"institutions":[{"id":"https://openalex.org/I4210091812","display_name":"Bristol-Myers Squibb (United States)","ror":"https://ror.org/00gtmwv55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aya M. Kelly","raw_affiliation_strings":["Bristol Myers Squibb, Cambridge, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bristol Myers Squibb, Cambridge, MA, USA","institution_ids":["https://openalex.org/I4210091812"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014106434","display_name":"Joel W. Thompson","orcid":"https://orcid.org/0000-0002-5131-3248","observed_orcids":["https://orcid.org/0000-0002-5131-3248"]},"institutions":[{"id":"https://openalex.org/I4210091812","display_name":"Bristol-Myers Squibb (United States)","ror":"https://ror.org/00gtmwv55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Joel W. Thompson","raw_affiliation_strings":["Bristol Myers Squibb, San Diego, CA, USA. joel.thompson@bms.com"],"raw_orcid":"https://orcid.org/0000-0002-5131-3248","affiliations":[{"raw_affiliation_string":"Bristol Myers Squibb, San Diego, CA, USA. joel.thompson@bms.com","institution_ids":["https://openalex.org/I4210091812"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025805979","display_name":"David W. C. MacMillan","orcid":"https://orcid.org/0000-0001-6447-0587","observed_orcids":["https://orcid.org/0000-0001-6447-0587"]},"institutions":[{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"David W. C. MacMillan","raw_affiliation_strings":["Department of Chemistry, Princeton University, Princeton, NJ, USA. dmacmill@princeton.edu","Merck Center for Catalysis at Princeton University, Princeton, NJ, USA. dmacmill@princeton.edu"],"raw_orcid":"https://orcid.org/0000-0001-6447-0587","affiliations":[{"raw_affiliation_string":"Department of Chemistry, Princeton University, Princeton, NJ, USA. dmacmill@princeton.edu","institution_ids":["https://openalex.org/I20089843"]},{"raw_affiliation_string":"Merck Center for Catalysis at Princeton University, Princeton, NJ, USA. dmacmill@princeton.edu","institution_ids":["https://openalex.org/I20089843"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5014106434","https://openalex.org/A5025805979"],"corresponding_institution_ids":["https://openalex.org/I20089843","https://openalex.org/I4210091812"],"apc_list":{"value":6990,"currency":"USD","value_usd":6990},"apc_paid":{"value":6990,"currency":"USD","value_usd":6990},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.63492677,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13127","display_name":"Biotin and Related Studies","score":0.003700000001117587,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fulvestrant","display_name":"fulvestrant","score":0.843999981880188},{"id":"https://openalex.org/keywords/estrogen-receptor-alpha","display_name":"estrogen receptor alpha","score":0.9919999837875366},{"id":"https://openalex.org/keywords/selective-estrogen-receptor-degrader","display_name":"selective estrogen receptor degrader","score":0.9369999766349792},{"id":"https://openalex.org/keywords/pml-nuclear-bodies","display_name":"PML nuclear bodies","score":0.8659999966621399},{"id":"https://openalex.org/keywords/senescence","display_name":"senescence","score":0.7950000166893005},{"id":"https://openalex.org/keywords/gene-expression-signatures","display_name":"gene expression signatures","score":0.7639999985694885},{"id":"https://openalex.org/keywords/mechanism-of-action","display_name":"mechanism of action","score":0.5180000066757202}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5478000044822693},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4410000145435333},{"id":"https://openalex.org/C2780482068","wikidata":"https://www.wikidata.org/wiki/Q5508491","display_name":"Fulvestrant","level":5,"score":0.3707999885082245},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3391000032424927},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.30059999227523804},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2937999963760376},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.25940001010894775},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2542000114917755},{"id":"https://openalex.org/C174510640","wikidata":"https://www.wikidata.org/wiki/Q489618","display_name":"HEK 293 cells","level":3,"score":0.2526000142097473},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.24560000002384186}],"mesh":[{"descriptor_ui":"D000077267","descriptor_name":"Fulvestrant","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D004958","descriptor_name":"Estradiol","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D004958","descriptor_name":"Estradiol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047628","descriptor_name":"Estrogen Receptor alpha","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D047628","descriptor_name":"Estrogen Receptor alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D061986","descriptor_name":"MCF-7 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1038/s41467-026-77034-w","doi":"https://doi.org/10.1038/s41467-026-77034-w","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-026-77034-w","pdf_url":"https://www.nature.com/articles/s41467-026-77034-w_reference.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13627678","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13627678/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13627678/pdf/41467_2026_Article_77034.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nat Commun","raw_type":"Text"},{"id":"pmid:42816507","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42816507","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature communications","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:7908341e66e245d7a3640dbc8585579c","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/7908341e66e245d7a3640dbc8585579c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications, Vol 17, Iss 1 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41467-026-77034-w","doi":"https://doi.org/10.1038/s41467-026-77034-w","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-026-77034-w","pdf_url":"https://www.nature.com/articles/s41467-026-77034-w_reference.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8560000061988831,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2336141174","display_name":"BD FACSymphony A3: A multi-laser analytical flow cytometer for the Princeton University Flow Cytometry Resource Facility","funder_award_id":"1s10od028592-01a1","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320307115","display_name":"Bristol-Myers Squibb","ror":"https://ror.org/00gtmwv55"},{"id":"https://openalex.org/F4320309292","display_name":"Princeton University","ror":"https://ror.org/00hx57361"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204803689.pdf","grobid_xml":"https://content.openalex.org/works/W7204803689.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1193138090","https://openalex.org/W2022977599","https://openalex.org/W4403586749","https://openalex.org/W2083225720","https://openalex.org/W1987508761","https://openalex.org/W2019311111","https://openalex.org/W2964142306","https://openalex.org/W4311392611","https://openalex.org/W4387692979","https://openalex.org/W7208770535"],"abstract_inverted_index":{"Estrogen":[0],"Receptor":[1],"alpha":[2],"(ER\u03b1)":[3],"is":[4],"the":[5,53,60,135],"primary":[6],"driver":[7],"in":[8,38],"ER+":[9],"breast":[10,136],"cancer":[11,137],"and":[12,35,88,103,115,124,149],"can":[13],"be":[14],"targeted":[15],"using":[16],"small":[17],"molecules":[18],"such":[19],"as":[20],"fulvestrant,":[21],"a":[22,117,129,151],"selective":[23],"estrogen":[24,141,156],"receptor":[25,142,157],"degrader":[26],"(SERD).":[27],"Despite":[28],"being":[29],"approved":[30],"over":[31],"two":[32],"decades":[33],"ago":[34],"used":[36,128],"regularly":[37],"post-menopausal":[39],"women,":[40],"its":[41,147],"precise":[42],"anti-tumor":[43],"mechanism":[44,112,148],"remains":[45],"unclear,":[46],"with":[47],"several":[48],"reports":[49],"showing":[50],"efficacy":[51],"without":[52],"requirement":[54],"for":[55,119,153],"ER\u03b1":[56,90,122],"degradation.":[57],"To":[58],"investigate":[59],"molecular":[61],"basis":[62],"of":[63,113],"fulvestrant\u2019s":[64],"action,":[65],"we":[66],"employed":[67],"split":[68],"intein-based":[69],"\u00b5Map":[70],"photo-proximity":[71],"labeling":[72],"to":[73,92,99,132],"profile":[74],"ER\u03b1-associated":[75],"interactions.":[76,143],"Our":[77],"findings":[78,145],"reveal":[79,133],"that":[80],"fulvestrant":[81,139],"displaces":[82],"oncogenic":[83],"interactions":[84],"induced":[85],"by":[86],"estradiol":[87],"promotes":[89],"translocation":[91],"promyelocytic":[93],"leukemia":[94],"(PML)":[95],"nuclear":[96],"bodies,":[97],"leading":[98],"altered":[100],"transcriptional":[101],"signatures":[102],"senescence.":[104],"Overall,":[105],"this":[106],"study":[107,127],"offers":[108],"insights":[109],"into":[110],"SERD":[111],"action":[114],"establishes":[116],"framework":[118,152],"evaluating":[120,154],"additional":[121],"modulators":[123],"degraders.":[125],"This":[126],"proximity-labeling":[130],"technique":[131],"how":[134],"drug":[138],"alters":[140],"The":[144],"clarify":[146],"provide":[150],"next-generation":[155],"therapies.":[158]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2026-09-01T00:00:00"}