{"id":"https://openalex.org/W7204801996","doi":"https://doi.org/10.1111/pcn.70128","title":"From public preferences to clinical tasks in anti\u2010amyloid therapy for Alzheimer's disease","display_name":"From public preferences to clinical tasks in anti\u2010amyloid therapy for Alzheimer's disease","publication_year":2026,"publication_date":"2026-08-31","ids":{"openalex":"https://openalex.org/W7204801996","doi":"https://doi.org/10.1111/pcn.70128","pmid":"https://pubmed.ncbi.nlm.nih.gov/42671152"},"language":"en","primary_location":{"id":"doi:10.1111/pcn.70128","doi":"https://doi.org/10.1111/pcn.70128","is_oa":true,"landing_page_url":"https://doi.org/10.1111/pcn.70128","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/pcn.70128","source":{"id":"https://openalex.org/S111042112","display_name":"Psychiatry and Clinical Neurosciences","issn_l":"1323-1316","issn":["1323-1316","1440-1819"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Psychiatry and Clinical Neurosciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/pcn.70128","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026366759","display_name":"Kyohei Otani","orcid":"https://orcid.org/0000-0001-7395-8031","observed_orcids":["https://orcid.org/0000-0001-7395-8031"]},"institutions":[{"id":"https://openalex.org/I4405287379","display_name":"Kakogawa Central City Hospital","ror":"https://ror.org/050shcx07","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4405256237","https://openalex.org/I4405287379"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Kyohei Otani","raw_affiliation_strings":["Department of Psychiatry Kakogawa Central City Hospital  Kakogawa Japan"],"raw_orcid":"https://orcid.org/0000-0001-7395-8031","affiliations":[{"raw_affiliation_string":"Department of Psychiatry Kakogawa Central City Hospital  Kakogawa Japan","institution_ids":["https://openalex.org/I4405287379"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5026366759"],"corresponding_institution_ids":["https://openalex.org/I4405287379"],"apc_list":{"value":3240,"currency":"USD","value_usd":3240},"apc_paid":null,"fwci":1.4322,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.7313177,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.8809000253677368,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.8809000253677368,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.10610000044107437,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10804","display_name":"Health Systems, Economic Evaluations, Quality of Life","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/2002","display_name":"Economics and Econometrics"},"field":{"id":"https://openalex.org/fields/20","display_name":"Economics, Econometrics and Finance"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anti-amyloid-therapy","display_name":"anti-amyloid therapy","score":0.8669999837875366},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9710000157356262},{"id":"https://openalex.org/keywords/lecanemab","display_name":"lecanemab","score":0.9990000128746033},{"id":"https://openalex.org/keywords/public-preferences","display_name":"public preferences","score":0.675000011920929},{"id":"https://openalex.org/keywords/care-pathways","display_name":"care pathways","score":0.6050000190734863},{"id":"https://openalex.org/keywords/shared-decision-making","display_name":"shared decision-making","score":0.8389999866485596},{"id":"https://openalex.org/keywords/treatment-monitoring","display_name":"treatment monitoring","score":0.8799999952316284},{"id":"https://openalex.org/keywords/treatment-discontinuation","display_name":"treatment discontinuation","score":0.7419999837875366},{"id":"https://openalex.org/keywords/psychosocial-care","display_name":"psychosocial care","score":0.9010000228881836},{"id":"https://openalex.org/keywords/japanese-patients","display_name":"Japanese patients","score":0.47999998927116394}],"concepts":[{"id":"https://openalex.org/C150966472","wikidata":"https://www.wikidata.org/wiki/Q3410145","display_name":"Psychosocial","level":2,"score":0.8324999809265137},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.6121000051498413},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4894999861717224},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4375999867916107},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.39079999923706055},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.3686999976634979},{"id":"https://openalex.org/C138816342","wikidata":"https://www.wikidata.org/wiki/Q189603","display_name":"Public health","level":2,"score":0.36660000681877136},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.36070001125335693},{"id":"https://openalex.org/C512399662","wikidata":"https://www.wikidata.org/wiki/Q3505712","display_name":"Family medicine","level":1,"score":0.35989999771118164},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.35510000586509705},{"id":"https://openalex.org/C2989236134","wikidata":"https://www.wikidata.org/wiki/Q31207","display_name":"Patient care","level":2,"score":0.34529998898506165},{"id":"https://openalex.org/C2777487392","wikidata":"https://www.wikidata.org/wiki/Q481201","display_name":"Absolute (philosophy)","level":2,"score":0.30660000443458557},{"id":"https://openalex.org/C2992221801","wikidata":"https://www.wikidata.org/wiki/Q5165398","display_name":"Continuing care","level":2,"score":0.29030001163482666},{"id":"https://openalex.org/C2776511598","wikidata":"https://www.wikidata.org/wiki/Q7144993","display_name":"Patient participation","level":3,"score":0.27950000762939453},{"id":"https://openalex.org/C160735492","wikidata":"https://www.wikidata.org/wiki/Q31207","display_name":"Health care","level":2,"score":0.2793999910354614},{"id":"https://openalex.org/C2781249084","wikidata":"https://www.wikidata.org/wiki/Q908656","display_name":"Preference","level":2,"score":0.2685000002384186}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1111/pcn.70128","doi":"https://doi.org/10.1111/pcn.70128","is_oa":true,"landing_page_url":"https://doi.org/10.1111/pcn.70128","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/pcn.70128","source":{"id":"https://openalex.org/S111042112","display_name":"Psychiatry and Clinical Neurosciences","issn_l":"1323-1316","issn":["1323-1316","1440-1819"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Psychiatry and Clinical Neurosciences","raw_type":"journal-article"},{"id":"pmid:42671152","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42671152","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Psychiatry and clinical neurosciences","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1111/pcn.70128","doi":"https://doi.org/10.1111/pcn.70128","is_oa":true,"landing_page_url":"https://doi.org/10.1111/pcn.70128","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/pcn.70128","source":{"id":"https://openalex.org/S111042112","display_name":"Psychiatry and Clinical Neurosciences","issn_l":"1323-1316","issn":["1323-1316","1440-1819"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Psychiatry and Clinical Neurosciences","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204801996.pdf","grobid_xml":"https://content.openalex.org/works/W7204801996.grobid-xml"},"referenced_works_count":6,"referenced_works":["https://openalex.org/W4310461604","https://openalex.org/W4412134449","https://openalex.org/W4417300360","https://openalex.org/W7154714431","https://openalex.org/W7155625406","https://openalex.org/W7161806620"],"related_works":["https://openalex.org/W7222879025","https://openalex.org/W4409336831","https://openalex.org/W7161806620","https://openalex.org/W4409503304","https://openalex.org/W7166838046","https://openalex.org/W4403055087","https://openalex.org/W7118066912","https://openalex.org/W7223045695","https://openalex.org/W7116990952","https://openalex.org/W4379981496"],"abstract_inverted_index":{"Tajika":[0],"and":[1,49,61],"colleagues":[2],"found":[3],"that,":[4],"among":[5],"Japanese":[6],"respondents":[7],"willing":[8],"to":[9],"consider":[10],"lecanemab,":[11],"the":[12,18,41],"median":[13],"smallest":[14],"worthwhile":[15],"difference":[16],"exceeded":[17],"absolute":[19],"benefit":[20],"used":[21],"in":[22],"their":[23],"study":[24],"scenario.":[25],"This":[26],"commentary":[27],"argues":[28],"that":[29],"this":[30],"expectation-efficacy":[31],"gap":[32],"should":[33],"be":[34],"translated":[35],"into":[36],"concrete":[37],"clinical":[38],"tasks":[39],"across":[40],"anti-amyloid":[42],"care":[43],"pathway,":[44],"including":[45],"expectation":[46],"assessment,":[47],"biomarker":[48],"eligibility":[50],"counseling,":[51],"shared":[52],"decision-making,":[53],"treatment":[54],"monitoring,":[55],"support":[56],"for":[57],"non-initiation":[58],"or":[59],"discontinuation,":[60],"continuing":[62],"psychosocial":[63],"care.":[64]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-09-01T00:00:00"}