{"id":"https://openalex.org/W7204801613","doi":"https://doi.org/10.64898/2026.08.26.746684","title":"Cell-intrinsic complement C3 suppresses IFN-\u03b2 production in macrophages","display_name":"Cell-intrinsic complement C3 suppresses IFN-\u03b2 production in macrophages","publication_year":2026,"publication_date":"2026-08-31","ids":{"openalex":"https://openalex.org/W7204801613","doi":"https://doi.org/10.64898/2026.08.26.746684"},"language":"en","primary_location":{"id":"doi:10.64898/2026.08.26.746684","doi":"https://doi.org/10.64898/2026.08.26.746684","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.26.746684","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/08/31/2026.08.26.746684.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/08/31/2026.08.26.746684.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5117648080","display_name":"Stine Kristensen","orcid":"https://orcid.org/0009-0000-6249-5633","observed_orcids":["https://orcid.org/0009-0000-6249-5633"]},"institutions":[{"id":"https://openalex.org/I204778367","display_name":"Norwegian University of Science and Technology","ror":"https://ror.org/05xg72x27","country_code":"NO","type":"education","lineage":["https://openalex.org/I204778367"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Stine Kristensen","raw_affiliation_strings":["Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway"],"raw_orcid":"https://orcid.org/0009-0000-6249-5633","affiliations":[{"raw_affiliation_string":"Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway","institution_ids":["https://openalex.org/I204778367"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092041119","display_name":"Charlotte \u00c5rseth","orcid":"https://orcid.org/0009-0003-8485-2568","observed_orcids":["https://orcid.org/0009-0003-8485-2568"]},"institutions":[{"id":"https://openalex.org/I204778367","display_name":"Norwegian University of Science and Technology","ror":"https://ror.org/05xg72x27","country_code":"NO","type":"education","lineage":["https://openalex.org/I204778367"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Charlotte \u00c5rseth","raw_affiliation_strings":["Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway"],"raw_orcid":"https://orcid.org/0009-0003-8485-2568","affiliations":[{"raw_affiliation_string":"Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway","institution_ids":["https://openalex.org/I204778367"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069832309","display_name":"Maria Yurchenko","orcid":"https://orcid.org/0000-0002-0516-4747","observed_orcids":["https://orcid.org/0000-0002-0516-4747"]},"institutions":[{"id":"https://openalex.org/I1281400175","display_name":"Oslo University Hospital","ror":"https://ror.org/00j9c2840","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I1281400175"]},{"id":"https://openalex.org/I204778367","display_name":"Norwegian University of Science and Technology","ror":"https://ror.org/05xg72x27","country_code":"NO","type":"education","lineage":["https://openalex.org/I204778367"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Maria Yurchenko","raw_affiliation_strings":["Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway","Department of Immunology, Oslo University Hospital, Oslo, Norway"],"raw_orcid":"https://orcid.org/0000-0002-0516-4747","affiliations":[{"raw_affiliation_string":"Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway","institution_ids":["https://openalex.org/I204778367"]},{"raw_affiliation_string":"Department of Immunology, Oslo University Hospital, Oslo, Norway","institution_ids":["https://openalex.org/I1281400175"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034820103","display_name":"Liv Ryan","orcid":"https://orcid.org/0000-0002-7127-6958","observed_orcids":["https://orcid.org/0000-0002-7127-6958"]},"institutions":[{"id":"https://openalex.org/I204778367","display_name":"Norwegian University of Science and Technology","ror":"https://ror.org/05xg72x27","country_code":"NO","type":"education","lineage":["https://openalex.org/I204778367"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Liv Ryan","raw_affiliation_strings":["Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway"],"raw_orcid":"https://orcid.org/0000-0002-7127-6958","affiliations":[{"raw_affiliation_string":"Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway","institution_ids":["https://openalex.org/I204778367"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148766561","display_name":"Ida Fjellv\u00e6r","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204778367","display_name":"Norwegian University of Science and Technology","ror":"https://ror.org/05xg72x27","country_code":"NO","type":"education","lineage":["https://openalex.org/I204778367"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Ida Fjellv\u00e6r","raw_affiliation_strings":["Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway","institution_ids":["https://openalex.org/I204778367"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011176090","display_name":"Kashif Rasheed","orcid":"https://orcid.org/0000-0002-8945-5559","observed_orcids":["https://orcid.org/0000-0002-8945-5559"]},"institutions":[{"id":"https://openalex.org/I204778367","display_name":"Norwegian University of Science and Technology","ror":"https://ror.org/05xg72x27","country_code":"NO","type":"education","lineage":["https://openalex.org/I204778367"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Kashif Rasheed","raw_affiliation_strings":["Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway"],"raw_orcid":"https://orcid.org/0000-0002-8945-5559","affiliations":[{"raw_affiliation_string":"Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway","institution_ids":["https://openalex.org/I204778367"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080803792","display_name":"Sindre Ullmann","orcid":"https://orcid.org/0000-0003-1763-941X","observed_orcids":["https://orcid.org/0000-0003-1763-941X"]},"institutions":[{"id":"https://openalex.org/I204778367","display_name":"Norwegian University of Science and Technology","ror":"https://ror.org/05xg72x27","country_code":"NO","type":"education","lineage":["https://openalex.org/I204778367"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Sindre Ullmann","raw_affiliation_strings":["Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway"],"raw_orcid":"https://orcid.org/0000-0003-1763-941X","affiliations":[{"raw_affiliation_string":"Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway","institution_ids":["https://openalex.org/I204778367"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032762089","display_name":"Claudia Kemper","orcid":"https://orcid.org/0000-0003-4196-1417","observed_orcids":["https://orcid.org/0000-0003-4196-1417"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Claudia Kemper","raw_affiliation_strings":["National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH), Complement and Inflammation Research Section (CIRS), Bethesda, MD, USA"],"raw_orcid":"https://orcid.org/0000-0003-4196-1417","affiliations":[{"raw_affiliation_string":"National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH), Complement and Inflammation Research Section (CIRS), Bethesda, MD, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062296713","display_name":"Harald Husebye","orcid":"https://orcid.org/0000-0002-8828-1059","observed_orcids":["https://orcid.org/0000-0002-8828-1059"]},"institutions":[{"id":"https://openalex.org/I204778367","display_name":"Norwegian University of Science and Technology","ror":"https://ror.org/05xg72x27","country_code":"NO","type":"education","lineage":["https://openalex.org/I204778367"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Harald Husebye","raw_affiliation_strings":["Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway"],"raw_orcid":"https://orcid.org/0000-0002-8828-1059","affiliations":[{"raw_affiliation_string":"Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway","institution_ids":["https://openalex.org/I204778367"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069390047","display_name":"Terje Espevik","orcid":"https://orcid.org/0000-0003-0354-5068","observed_orcids":["https://orcid.org/0000-0003-0354-5068"]},"institutions":[{"id":"https://openalex.org/I204778367","display_name":"Norwegian University of Science and Technology","ror":"https://ror.org/05xg72x27","country_code":"NO","type":"education","lineage":["https://openalex.org/I204778367"]},{"id":"https://openalex.org/I4210104358","display_name":"St Olav's University Hospital","ror":"https://ror.org/01a4hbq44","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I4210104358"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Terje Espevik","raw_affiliation_strings":["Clinic of Laboratory Medicine, St. Olavs Hospital, Trondheim, Norway","Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway"],"raw_orcid":"https://orcid.org/0000-0003-0354-5068","affiliations":[{"raw_affiliation_string":"Clinic of Laboratory Medicine, St. Olavs Hospital, Trondheim, Norway","institution_ids":["https://openalex.org/I4210104358"]},{"raw_affiliation_string":"Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway","institution_ids":["https://openalex.org/I204778367"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011458022","display_name":"Trude Helen Flo","orcid":"https://orcid.org/0000-0002-2569-0381","observed_orcids":["https://orcid.org/0000-0002-2569-0381"]},"institutions":[{"id":"https://openalex.org/I204778367","display_name":"Norwegian University of Science and Technology","ror":"https://ror.org/05xg72x27","country_code":"NO","type":"education","lineage":["https://openalex.org/I204778367"]}],"countries":["NO"],"is_corresponding":true,"raw_author_name":"Trude Helen Flo","raw_affiliation_strings":["Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway"],"raw_orcid":"https://orcid.org/0000-0002-2569-0381","affiliations":[{"raw_affiliation_string":"Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway","institution_ids":["https://openalex.org/I204778367"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5011458022"],"corresponding_institution_ids":["https://openalex.org/I204778367"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.6035000085830688,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.6035000085830688,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.32710000872612,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.03400000184774399,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/complement-c3","display_name":"complement C3","score":0.9509999752044678},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.996999979019165},{"id":"https://openalex.org/keywords/irf3-phosphorylation","display_name":"IRF3 phosphorylation","score":0.7929999828338623},{"id":"https://openalex.org/keywords/tbk1","display_name":"TBK1","score":0.7210000157356262},{"id":"https://openalex.org/keywords/interferon-stimulated-genes","display_name":"interferon-stimulated genes","score":0.8980000019073486},{"id":"https://openalex.org/keywords/lipopolysaccharide-stimulation","display_name":"lipopolysaccharide stimulation","score":0.7059999704360962},{"id":"https://openalex.org/keywords/c3-convertase","display_name":"C3 convertase","score":0.9240000247955322},{"id":"https://openalex.org/keywords/inflammation-regulation","display_name":"inflammation regulation","score":0.5019999742507935},{"id":"https://openalex.org/keywords/thp-1-cells","display_name":"THP-1 cells","score":0.6919999718666077}],"concepts":[{"id":"https://openalex.org/C2780209191","wikidata":"https://www.wikidata.org/wiki/Q14914339","display_name":"IRF3","level":4,"score":0.7531999945640564},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6650999784469604},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.557200014591217},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.5220000147819519},{"id":"https://openalex.org/C111684460","wikidata":"https://www.wikidata.org/wiki/Q334848","display_name":"Complement system","level":3,"score":0.5077999830245972},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.48019999265670776},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.46000000834465027},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4521999955177307},{"id":"https://openalex.org/C2776070231","wikidata":"https://www.wikidata.org/wiki/Q14914098","display_name":"TLR4","level":3,"score":0.42899999022483826},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.4050999879837036},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.39809998869895935},{"id":"https://openalex.org/C2779836521","wikidata":"https://www.wikidata.org/wiki/Q14914081","display_name":"TLR7","level":5,"score":0.38260000944137573},{"id":"https://openalex.org/C71318922","wikidata":"https://www.wikidata.org/wiki/Q426181","display_name":"Complement component 5","level":4,"score":0.3702999949455261},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.36719998717308044},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3499999940395355},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3418000042438507},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.31029999256134033},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.3009999990463257},{"id":"https://openalex.org/C77957584","wikidata":"https://www.wikidata.org/wiki/Q1133550","display_name":"Gene knockout","level":3,"score":0.2858999967575073},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.28279998898506165},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.2824999988079071},{"id":"https://openalex.org/C175773311","wikidata":"https://www.wikidata.org/wiki/Q5156412","display_name":"Complement receptor","level":4,"score":0.2750999927520752},{"id":"https://openalex.org/C2107291","wikidata":"https://www.wikidata.org/wiki/Q14886885","display_name":"Mediator","level":2,"score":0.2727000117301941},{"id":"https://openalex.org/C174510640","wikidata":"https://www.wikidata.org/wiki/Q489618","display_name":"HEK 293 cells","level":3,"score":0.2703999876976013},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.2651999890804291},{"id":"https://openalex.org/C14356644","wikidata":"https://www.wikidata.org/wiki/Q14911975","display_name":"Factor H","level":4,"score":0.26350000500679016},{"id":"https://openalex.org/C112313634","wikidata":"https://www.wikidata.org/wiki/Q7886648","display_name":"Complement (music)","level":5,"score":0.26339998841285706},{"id":"https://openalex.org/C2780841837","wikidata":"https://www.wikidata.org/wiki/Q24741149","display_name":"Interferon gamma","level":3,"score":0.25929999351501465},{"id":"https://openalex.org/C182704531","wikidata":"https://www.wikidata.org/wiki/Q1364740","display_name":"Knockout mouse","level":3,"score":0.2587999999523163},{"id":"https://openalex.org/C136015124","wikidata":"https://www.wikidata.org/wiki/Q13566093","display_name":"Complement component 2","level":5,"score":0.25099998712539673}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.08.26.746684","doi":"https://doi.org/10.64898/2026.08.26.746684","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.26.746684","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/08/31/2026.08.26.746684.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.08.26.746684","doi":"https://doi.org/10.64898/2026.08.26.746684","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.26.746684","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/08/31/2026.08.26.746684.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6000000238418579}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2372118239","display_name":null,"funder_award_id":"223255/F50","funder_id":"https://openalex.org/F4320323299","funder_display_name":"Norges Forskningsr\u00e5d"},{"id":"https://openalex.org/G500342811","display_name":null,"funder_award_id":"223255","funder_id":"https://openalex.org/F4320323299","funder_display_name":"Norges Forskningsr\u00e5d"},{"id":"https://openalex.org/G6993876518","display_name":null,"funder_award_id":"223255/F50","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320311040","display_name":"Norges Teknisk-Naturvitenskapelige Universitet","ror":"https://ror.org/05xg72x27"},{"id":"https://openalex.org/F4320322752","display_name":"Helse Midt-Norge","ror":"https://ror.org/04t838f48"},{"id":"https://openalex.org/F4320323299","display_name":"Norges Forskningsr\u00e5d","ror":"https://ror.org/00epmv149"},{"id":"https://openalex.org/F4320331442","display_name":"Olav Thon Stiftelsen","ror":"https://ror.org/014am8n90"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334494","display_name":"Fakultet for medisin og helsevitenskap, Norges Teknisk-Naturvitenskapelige Universitet","ror":null},{"id":"https://openalex.org/F4320337083","display_name":"Faculty of Medicine and Health, University of Sydney","ror":null},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204801613.pdf","grobid_xml":"https://content.openalex.org/works/W7204801613.grobid-xml"},"referenced_works_count":1,"referenced_works":["https://openalex.org/W2170021421"],"related_works":["https://openalex.org/W4413237166","https://openalex.org/W4413236907","https://openalex.org/W4313428213","https://openalex.org/W2413306740","https://openalex.org/W2093462174","https://openalex.org/W2255823216","https://openalex.org/W1952974980","https://openalex.org/W7117121821","https://openalex.org/W4310229385","https://openalex.org/W6989461302"],"abstract_inverted_index":{"Abstract":[0],"The":[1],"cell-intrinsic":[2,57,184,200,229],"complement":[3,18,138,201,230],"system":[4,202],"has":[5],"emerged":[6],"as":[7,186],"an":[8],"important":[9],"orchestrator":[10],"of":[11,14,80,86,96,104,137,155,189,198,228],"a":[12,40,102,187],"variety":[13],"cell-physiological":[15],"processes,":[16],"with":[17,21,112,153],"components":[19],"interacting":[20],"intracellular":[22,36],"effector":[23],"systems":[24],"to":[25,29,207,235],"regulate":[26],"cellular":[27],"responses":[28,62,206,234],"pathogens":[30],"or":[31],"noxious":[32],"stimuli.":[33],"For":[34],"instance,":[35],"C5":[37],"signaling":[38],"through":[39],"mitochondrial":[41],"C5a":[42],"receptor":[43],"(C5aR1)":[44],"controls":[45],"IL-1\u03b2":[46],"production":[47,73,164,191,217],"in":[48,63,147,165,192,203,218,231],"human":[49,150,167,193],"monocytes":[50],"and":[51,83,89,101,109,116,141,169],"macrophages.":[52,64],"Here,":[53],"we":[54],"investigated":[55],"whether":[56],"C3":[58,67,125,145,157,176,185,214],"similarly":[59],"regulates":[60],"inflammatory":[61,205,233],"In":[65],"LPS-stimulated":[66,148],"knockout":[68],"THP-1-derived":[69],"macrophages,":[70,151,194],"interferon":[71],"(IFN)-\u03b2":[72],"was":[74,121],"increased,":[75],"accompanied":[76],"by":[77,220],"elevated":[78],"expression":[79],"interferon-stimulated":[81],"genes":[82],"enhanced":[84,113],"secretion":[85],"IFN-induced":[87],"cytokines":[88],"chemokines.":[90],"C3-deficient":[91],"cells":[92],"showed":[93],"increased":[94],"phosphorylation":[95,120],"IRF3":[97,108,114],"at":[98],"Ser":[99],"396":[100],"stabilization":[103],"the":[105,156,196,199,226],"interaction":[106],"between":[107],"TBK1,":[110],"along":[111],"dimerization":[115],"nuclear":[117],"translocation.":[118],"TBK1":[119,133],"unaffected,":[122],"indicating":[123],"that":[124,173],"limits":[126],"IRF3-TBK1":[127,222],"complex":[128,223],"formation":[129],"rather":[130],"than":[131],"upstream":[132],"activation.":[134],"Small-molecule":[135],"inhibitors":[136],"factors":[139],"B":[140],"D":[142],"restored":[143],"full-length":[144,213],"abundance":[146],"primary":[149,166],"consistent":[152],"inhibition":[154],"convertase.":[158],"It":[159],"also":[160],"reduced":[161],"LPS-induced":[162],"IFN-\u03b2":[163,178,190,216],"macrophages":[168,219],"THP-1":[170],"cells,":[171],"suggesting":[172],"full-length,":[174],"uncleaved":[175],"suppresses":[177,215],"production.":[179],"Collectively,":[180],"these":[181],"findings":[182],"identify":[183],"suppressor":[188],"highlighting":[195,225],"importance":[197],"fine-tuning":[204],"pathogens.":[208,236],"One":[209],"sentence":[210],"summary":[211],"Cell-intrinsic,":[212],"limiting":[221],"formation,":[224],"role":[227],"regulating":[232]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-09-01T00:00:00"}
