{"id":"https://openalex.org/W7204796352","doi":"https://doi.org/10.1530/endoabs.119.ps1-01-04","title":"Structural and biochemical studies of the human IRP2 in complex with RAP reveal multiple regulatory sites","display_name":"Structural and biochemical studies of the human IRP2 in complex with RAP reveal multiple regulatory sites","publication_year":2026,"publication_date":"2026-08-27","ids":{"openalex":"https://openalex.org/W7204796352","doi":"https://doi.org/10.1530/endoabs.119.ps1-01-04"},"language":"en","primary_location":{"id":"doi:10.1530/endoabs.119.ps1-01-04","doi":"https://doi.org/10.1530/endoabs.119.ps1-01-04","is_oa":false,"landing_page_url":"https://doi.org/10.1530/endoabs.119.ps1-01-04","pdf_url":null,"source":{"id":"https://openalex.org/S4306509401","display_name":"Endocrine Abstracts","issn_l":"1470-3947","issn":["1470-3947","1479-6848","2046-0368"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310319937","host_organization_name":"Bioscientifica","host_organization_lineage":["https://openalex.org/P4310319937"],"host_organization_lineage_names":["Bioscientifica"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrine Abstracts","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049773158","display_name":"Karthik Ramanadane","orcid":"https://orcid.org/0000-0001-7188-0250","observed_orcids":["https://orcid.org/0000-0001-7188-0250"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Karthik Ramanadane","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114308049","display_name":"Giorgia Tanzi","orcid":"https://orcid.org/0000-0002-3500-0559","observed_orcids":["https://orcid.org/0000-0002-3500-0559"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Giorgia Tanzi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021667057","display_name":"Luca Scaccini","orcid":"https://orcid.org/0000-0003-1844-1579","observed_orcids":["https://orcid.org/0000-0003-1844-1579"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Luca Scaccini","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148800011","display_name":"Ianni Alessio Di","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ianni Alessio Di","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012549119","display_name":"Andrea Graziadei","orcid":"https://orcid.org/0000-0001-7709-6002","observed_orcids":["https://orcid.org/0000-0001-7709-6002"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrea Graziadei","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062158055","display_name":"Laura Tosatto","orcid":"https://orcid.org/0000-0002-5966-8131","observed_orcids":["https://orcid.org/0000-0002-5966-8131"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Laura Tosatto","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5133915503","display_name":"Federica Miele","orcid":"https://orcid.org/0009-0006-6519-7387","observed_orcids":["https://orcid.org/0009-0006-6519-7387"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Federica Miele","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5089273771","display_name":"Francesca Coscia","orcid":"https://orcid.org/0000-0001-7962-303X","observed_orcids":["https://orcid.org/0000-0001-7962-303X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Francesca Coscia","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.9667999744415283,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.9667999744415283,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":0.005499999970197678,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13481","display_name":"Neurological diseases and metabolism","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/irp2","display_name":"IRP2","score":0.9290000200271606},{"id":"https://openalex.org/keywords/rap","display_name":"rap","score":0.7160000205039978},{"id":"https://openalex.org/keywords/iron-regulatory-protein-1","display_name":"iron regulatory protein 1","score":0.5400000214576721},{"id":"https://openalex.org/keywords/protein-complex-structure","display_name":"protein complex structure","score":0.5460000038146973},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.5239999890327454},{"id":"https://openalex.org/keywords/iron-metabolism-regulation","display_name":"iron metabolism regulation","score":0.6150000095367432},{"id":"https://openalex.org/keywords/translational-control","display_name":"translational regulation","score":0.6209999918937683},{"id":"https://openalex.org/keywords/iron-responsive-element","display_name":"iron-responsive element","score":0.3140000104904175}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5267000198364258},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.33709999918937683},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.29100000858306885},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.266400009393692},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.25369998812675476},{"id":"https://openalex.org/C2780104201","wikidata":"https://www.wikidata.org/wiki/Q130888","display_name":"Drosophila melanogaster","level":3,"score":0.24560000002384186},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2363000065088272},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.2361000031232834},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.22699999809265137},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.2257000058889389}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1530/endoabs.119.ps1-01-04","doi":"https://doi.org/10.1530/endoabs.119.ps1-01-04","is_oa":false,"landing_page_url":"https://doi.org/10.1530/endoabs.119.ps1-01-04","pdf_url":null,"source":{"id":"https://openalex.org/S4306509401","display_name":"Endocrine Abstracts","issn_l":"1470-3947","issn":["1470-3947","1479-6848","2046-0368"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310319937","host_organization_name":"Bioscientifica","host_organization_lineage":["https://openalex.org/P4310319937"],"host_organization_lineage_names":["Bioscientifica"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrine Abstracts","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7064643642","https://openalex.org/W6924920718","https://openalex.org/W2286889211","https://openalex.org/W7052120035","https://openalex.org/W6991766920","https://openalex.org/W6894348410","https://openalex.org/W4291019331","https://openalex.org/W7208124582","https://openalex.org/W7208454334","https://openalex.org/W2611385262"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2026-09-01T00:00:00"}
