{"id":"https://openalex.org/W7204788187","doi":"https://doi.org/10.20473/mog.v34i22026.99-106","title":"The role of synbiotics as adjunctive therapy in prolonging latency period in Preterm Premature Rupture of Membranes","display_name":"The role of synbiotics as adjunctive therapy in prolonging latency period in Preterm Premature Rupture of Membranes","publication_year":2026,"publication_date":"2026-08-28","ids":{"openalex":"https://openalex.org/W7204788187","doi":"https://doi.org/10.20473/mog.v34i22026.99-106"},"language":"en","primary_location":{"id":"doi:10.20473/mog.v34i22026.99-106","doi":"https://doi.org/10.20473/mog.v34i22026.99-106","is_oa":true,"landing_page_url":"https://doi.org/10.20473/mog.v34i22026.99-106","pdf_url":"https://e-journal.unair.ac.id/MOG/article/download/77358/40128","source":{"id":"https://openalex.org/S4210227320","display_name":"Majalah Obstetri & Ginekologi","issn_l":"0854-0381","issn":["0854-0381","2598-1013"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/P4310315151","host_organization_name":"Airlangga University","host_organization_lineage":["https://openalex.org/P4310315151"],"host_organization_lineage_names":["Airlangga University"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Majalah Obstetri &amp; Ginekologi","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://e-journal.unair.ac.id/MOG/article/download/77358/40128","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009277531","display_name":"S Donel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I92961808","display_name":"Riau University","ror":"https://ror.org/00nk7p507","country_code":"ID","type":"education","lineage":["https://openalex.org/I92961808"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Donel S","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Faculty of Medicine, University of Riau, Pekanbaru"],"raw_orcid":"https://orcid.org/0000-0002-9282-3551","affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Faculty of Medicine, University of Riau, Pekanbaru","institution_ids":["https://openalex.org/I92961808"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030846973","display_name":"A Nururrochman Hidayatullah","orcid":"https://orcid.org/0009-0000-5964-1361","observed_orcids":["https://orcid.org/0009-0000-5964-1361"]},"institutions":[{"id":"https://openalex.org/I92961808","display_name":"Riau University","ror":"https://ror.org/00nk7p507","country_code":"ID","type":"education","lineage":["https://openalex.org/I92961808"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Amiruddin Hidayatullah","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Faculty of Medicine, University of Riau, Pekanbaru"],"raw_orcid":"https://orcid.org/0009-0000-5964-1361","affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Faculty of Medicine, University of Riau, Pekanbaru","institution_ids":["https://openalex.org/I92961808"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063775545","display_name":"Maya Savira","orcid":"https://orcid.org/0000-0003-4663-030X","observed_orcids":["https://orcid.org/0000-0003-4663-030X"]},"institutions":[{"id":"https://openalex.org/I92961808","display_name":"Riau University","ror":"https://ror.org/00nk7p507","country_code":"ID","type":"education","lineage":["https://openalex.org/I92961808"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Maya Savira","raw_affiliation_strings":["Department of Microbiology, Faculty of Medicine, University of Riau, Pekanbaru, Indonesia"],"raw_orcid":"https://orcid.org/0000-0003-4663-030X","affiliations":[{"raw_affiliation_string":"Department of Microbiology, Faculty of Medicine, University of Riau, Pekanbaru, Indonesia","institution_ids":["https://openalex.org/I92961808"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I92961808"],"apc_list":{"value":200000,"currency":"IDR","value_usd":13},"apc_paid":{"value":200000,"currency":"IDR","value_usd":13},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"34","issue":"2","first_page":"99","last_page":"106"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11290","display_name":"Preterm Birth and Chorioamnionitis","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11290","display_name":"Preterm Birth and Chorioamnionitis","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10141","display_name":"Probiotics and Fermented Foods","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10453","display_name":"Maternal and Perinatal Health Interventions","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/synbiotics","display_name":"synbiotics","score":0.9819999933242798},{"id":"https://openalex.org/keywords/preterm-premature-rupture-of-membranes","display_name":"preterm premature rupture of membranes","score":0.9760000109672546},{"id":"https://openalex.org/keywords/latency-period","display_name":"latency period","score":0.8410000205039978},{"id":"https://openalex.org/keywords/probiotics","display_name":"probiotics","score":0.7860000133514404},{"id":"https://openalex.org/keywords/prebiotics","display_name":"prebiotics","score":1.0},{"id":"https://openalex.org/keywords/adjunctive-therapy","display_name":"adjunctive therapy","score":0.828000009059906},{"id":"https://openalex.org/keywords/preterm-birth-prevention","display_name":"preterm birth prevention","score":0.7910000085830688},{"id":"https://openalex.org/keywords/cefotaxime","display_name":"cefotaxime","score":0.9589999914169312},{"id":"https://openalex.org/keywords/inflammation-modulation","display_name":"inflammation modulation","score":0.5550000071525574},{"id":"https://openalex.org/keywords/perinatal-outcomes","display_name":"perinatal outcomes","score":0.9589999914169312}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8860999941825867},{"id":"https://openalex.org/C2779337445","wikidata":"https://www.wikidata.org/wiki/Q2375654","display_name":"Synbiotics","level":4,"score":0.6869000196456909},{"id":"https://openalex.org/C2777102558","wikidata":"https://www.wikidata.org/wiki/Q11703370","display_name":"Premature rupture of membranes","level":4,"score":0.680400013923645},{"id":"https://openalex.org/C143590678","wikidata":"https://www.wikidata.org/wiki/Q2699232","display_name":"Latency stage","level":2,"score":0.6492999792098999},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.5411999821662903},{"id":"https://openalex.org/C2778719061","wikidata":"https://www.wikidata.org/wiki/Q417968","display_name":"Cefotaxime","level":3,"score":0.5401999950408936},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.4625000059604645},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.420199990272522},{"id":"https://openalex.org/C2778376644","wikidata":"https://www.wikidata.org/wiki/Q2253111","display_name":"Gestational age","level":3,"score":0.41749998927116394},{"id":"https://openalex.org/C131872663","wikidata":"https://www.wikidata.org/wiki/Q5284418","display_name":"Obstetrics","level":1,"score":0.4138000011444092},{"id":"https://openalex.org/C2993906978","wikidata":"https://www.wikidata.org/wiki/Q2297155","display_name":"Perinatal period","level":3,"score":0.41260001063346863},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.3659000098705292},{"id":"https://openalex.org/C46973012","wikidata":"https://www.wikidata.org/wiki/Q28627","display_name":"Gestation","level":3,"score":0.36559998989105225},{"id":"https://openalex.org/C2776344615","wikidata":"https://www.wikidata.org/wiki/Q625506","display_name":"Premature birth","level":4,"score":0.3337000012397766},{"id":"https://openalex.org/C82876162","wikidata":"https://www.wikidata.org/wiki/Q17096504","display_name":"Latency (audio)","level":2,"score":0.28850001096725464},{"id":"https://openalex.org/C63363279","wikidata":"https://www.wikidata.org/wiki/Q5133848","display_name":"Clinical significance","level":2,"score":0.267300009727478},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.26269999146461487}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.20473/mog.v34i22026.99-106","doi":"https://doi.org/10.20473/mog.v34i22026.99-106","is_oa":true,"landing_page_url":"https://doi.org/10.20473/mog.v34i22026.99-106","pdf_url":"https://e-journal.unair.ac.id/MOG/article/download/77358/40128","source":{"id":"https://openalex.org/S4210227320","display_name":"Majalah Obstetri & Ginekologi","issn_l":"0854-0381","issn":["0854-0381","2598-1013"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/P4310315151","host_organization_name":"Airlangga University","host_organization_lineage":["https://openalex.org/P4310315151"],"host_organization_lineage_names":["Airlangga University"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Majalah Obstetri &amp; Ginekologi","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.20473/mog.v34i22026.99-106","doi":"https://doi.org/10.20473/mog.v34i22026.99-106","is_oa":true,"landing_page_url":"https://doi.org/10.20473/mog.v34i22026.99-106","pdf_url":"https://e-journal.unair.ac.id/MOG/article/download/77358/40128","source":{"id":"https://openalex.org/S4210227320","display_name":"Majalah Obstetri & Ginekologi","issn_l":"0854-0381","issn":["0854-0381","2598-1013"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/P4310315151","host_organization_name":"Airlangga University","host_organization_lineage":["https://openalex.org/P4310315151"],"host_organization_lineage_names":["Airlangga University"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Majalah Obstetri &amp; Ginekologi","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320317162","display_name":"Universitas Riau","ror":"https://ror.org/05gnea559"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204788187.pdf","grobid_xml":"https://content.openalex.org/works/W7204788187.grobid-xml"},"referenced_works_count":16,"referenced_works":["https://openalex.org/W1979125967","https://openalex.org/W2286838622","https://openalex.org/W2592645007","https://openalex.org/W2735479982","https://openalex.org/W2784869994","https://openalex.org/W2898156903","https://openalex.org/W2903812953","https://openalex.org/W2954153169","https://openalex.org/W3037186989","https://openalex.org/W3174745890","https://openalex.org/W3207063123","https://openalex.org/W4284701406","https://openalex.org/W4307366509","https://openalex.org/W4382236955","https://openalex.org/W4384924256","https://openalex.org/W4405703205"],"related_works":["https://openalex.org/W7118066855","https://openalex.org/W1781082913","https://openalex.org/W2530497409","https://openalex.org/W4415682757","https://openalex.org/W2197638291","https://openalex.org/W7165683581","https://openalex.org/W6995980466","https://openalex.org/W4252707498","https://openalex.org/W2063950334","https://openalex.org/W3122218622"],"abstract_inverted_index":{"HIGHLIGHTS":[0],"Synbiotics":[1,283],"significantly":[2,75,261],"prolonged":[3],"the":[4,30,42,69,87,94,120,125,177,186,198,203,238,249,264,273,292,304],"latency":[5,24,95,126,199,258,293],"period":[6,25,96,259,294],"in":[7,55,97,132,152,237,263,272,290,295],"women":[8,99,160,231],"with":[9,100,162,216,233],"preterm":[10,73,101,163,296,307],"premature":[11,102,164,297],"rupture":[12,103,165,298],"of":[13,45,63,68,72,89,104,114,157,166,228,299,306],"membranes":[14,105,167,300],"(PPROM).":[15,106],"The":[16,39,107,194,240,257],"intervention":[17,187,250,265],"group":[18,32,242,251,266,275],"receiving":[19],"synbiotics":[20,46],"showed":[21],"a":[22,112,217],"longer":[23,262],"(>7":[26,267],"days)":[27,268],"compared":[28,269],"to":[29,51,77,85,207,270],"control":[31,178,241,274],"(OR":[33,276],"=":[34,37,277,280],"9.53,":[35],"p":[36,222,279],"0.0126).":[38,281],"study":[40,83],"supports":[41],"potential":[43],"use":[44],"as":[47,202],"an":[48,286],"adjunctive":[49],"therapy":[50,289],"improve":[52],"perinatal":[53,78,130],"outcomes":[54,131],"PPROM":[56,133,206,234],"cases.":[57,134],"ABSTRACT":[58],"Objective:":[59],"Preterm":[60],"Premature":[61],"Rupture":[62],"Membranes":[64],"(PPROM)":[65,168],"is":[66],"one":[67],"main":[70],"causes":[71],"birth,":[74],"contributing":[76],"morbidity":[79],"and":[80,116,123,136,148,171,183,185,192,246,255],"mortality.":[81],"This":[82,138],"aims":[84],"evaluate":[86],"effect":[88],"synbiotic":[90],"administration":[91],"on":[92],"prolonging":[93,291],"pregnant":[98,159,230],"research":[108],"explores":[109],"whether":[110],"synbiotics,":[111],"combination":[113],"probiotics":[115],"prebiotics,":[117],"can":[118,284],"modulate":[119],"inflammatory":[121],"response":[122],"extend":[124],"period,":[127,200],"potentially":[128,302],"improving":[129],"Materials":[135],"Methods:":[137],"randomized":[139],"controlled":[140],"trial":[141],"was":[142,197,260],"conducted":[143],"at":[144,221],"Arifin":[145],"Achmad":[146],"Hospital":[147],"other":[149],"affiliated":[150],"hospitals":[151],"Pekanbaru,":[153],"Indonesia.":[154],"A":[155,226],"total":[156,227],"32":[158,229],"diagnosed":[161,232],"were":[169,210,235],"enrolled":[170,236],"randomly":[172],"assigned":[173],"into":[174],"two":[175],"groups:":[176],"group,":[179,188],"which":[180,189],"received":[181,190,244,253],"cefotaxime":[182,191,245,254],"placebo,":[184,247],"synbiotics.":[193,256],"primary":[195],"outcome":[196],"defined":[201],"time":[204],"from":[205],"delivery.":[208],"Data":[209],"analyzed":[211],"using":[212],"SPSS":[213],"version":[214],"25,":[215],"significance":[218],"level":[219],"set":[220],"<":[223],"0.05.":[224],"Results:":[225],"study.":[239],"(n=16)":[243,252],"while":[248],"that":[271],"9.53;":[278],"Conclusion:":[282],"be":[285],"effective":[287],"adjunct":[288],"(PPROM),":[301],"reducing":[303],"risk":[305],"birth.":[308]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-09-01T00:00:00"}
