{"id":"https://openalex.org/W7204781008","doi":"https://doi.org/10.1016/j.jpain.2026.106427","title":"Sex-specific neuroimmune pathophysiological signatures in a mouse model of chronic back pain","display_name":"Sex-specific neuroimmune pathophysiological signatures in a mouse model of chronic back pain","publication_year":2026,"publication_date":"2026-08-31","ids":{"openalex":"https://openalex.org/W7204781008","doi":"https://doi.org/10.1016/j.jpain.2026.106427","pmid":"https://pubmed.ncbi.nlm.nih.gov/42674133"},"language":"en","primary_location":{"id":"doi:10.1016/j.jpain.2026.106427","doi":"https://doi.org/10.1016/j.jpain.2026.106427","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jpain.2026.106427","pdf_url":"https://www.jpain.org/article/S1526-5900(26)00245-2/pdf","source":{"id":"https://openalex.org/S194302669","display_name":"Journal of Pain","issn_l":"1526-5900","issn":["1526-5900","1528-8447"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Pain","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.jpain.org/article/S1526-5900(26)00245-2/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008803606","display_name":"Aleyah E. Goins","orcid":"https://orcid.org/0000-0002-1834-9994","observed_orcids":["https://orcid.org/0000-0002-1834-9994"]},"institutions":[{"id":"https://openalex.org/I169521973","display_name":"University of New Mexico","ror":"https://ror.org/05fs6jp91","country_code":"US","type":"education","lineage":["https://openalex.org/I169521973"]},{"id":"https://openalex.org/I4405255059","display_name":"University of New Mexico Health Sciences Center","ror":"https://ror.org/02jvjmd55","country_code":"US","type":"education","lineage":["https://openalex.org/I169521973","https://openalex.org/I4405255059"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aleyah E. Goins","raw_affiliation_strings":["Department of Anesthesiology and Critical Care Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM, USA"],"raw_orcid":"https://orcid.org/0000-0002-1834-9994","affiliations":[{"raw_affiliation_string":"Department of Anesthesiology and Critical Care Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM, USA","institution_ids":["https://openalex.org/I169521973","https://openalex.org/I4405255059"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049130324","display_name":"Sachin Goyal","orcid":"https://orcid.org/0000-0002-6490-7555","observed_orcids":["https://orcid.org/0000-0002-6490-7555","https://orcid.org/0000-0001-5128-8612"]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sachin Goyal","raw_affiliation_strings":["Department of Anesthesia, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA"],"raw_orcid":"https://orcid.org/0000-0001-5128-8612","affiliations":[{"raw_affiliation_string":"Department of Anesthesia, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA","institution_ids":["https://openalex.org/I1285204247"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030931169","display_name":"Nesia A. Zurek","orcid":"https://orcid.org/0009-0003-7939-2886","observed_orcids":["https://orcid.org/0009-0003-7939-2886"]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nesia A. Zurek","raw_affiliation_strings":["Department of Anesthesia, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA"],"raw_orcid":"https://orcid.org/0009-0003-7939-2886","affiliations":[{"raw_affiliation_string":"Department of Anesthesia, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA","institution_ids":["https://openalex.org/I1285204247"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033741705","display_name":"Jenna B. Demeter","orcid":"https://orcid.org/0000-0001-5831-9442","observed_orcids":["https://orcid.org/0000-0001-5831-9442"]},"institutions":[{"id":"https://openalex.org/I169521973","display_name":"University of New Mexico","ror":"https://ror.org/05fs6jp91","country_code":"US","type":"education","lineage":["https://openalex.org/I169521973"]},{"id":"https://openalex.org/I4405255059","display_name":"University of New Mexico Health Sciences Center","ror":"https://ror.org/02jvjmd55","country_code":"US","type":"education","lineage":["https://openalex.org/I169521973","https://openalex.org/I4405255059"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jenna B. Demeter","raw_affiliation_strings":["Department of Anesthesiology and Critical Care Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM, USA"],"raw_orcid":"https://orcid.org/0000-0001-5831-9442","affiliations":[{"raw_affiliation_string":"Department of Anesthesiology and Critical Care Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM, USA","institution_ids":["https://openalex.org/I169521973","https://openalex.org/I4405255059"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093791492","display_name":"Katherine Propsom","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katherine Propsom","raw_affiliation_strings":["Department of Anesthesia, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesia, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA","institution_ids":["https://openalex.org/I1285204247"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115579538","display_name":"Alexis Gravelle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I169521973","display_name":"University of New Mexico","ror":"https://ror.org/05fs6jp91","country_code":"US","type":"education","lineage":["https://openalex.org/I169521973"]},{"id":"https://openalex.org/I4405255059","display_name":"University of New Mexico Health Sciences Center","ror":"https://ror.org/02jvjmd55","country_code":"US","type":"education","lineage":["https://openalex.org/I169521973","https://openalex.org/I4405255059"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexis Gravelle","raw_affiliation_strings":["Department of Anesthesiology and Critical Care Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology and Critical Care Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM, USA","institution_ids":["https://openalex.org/I169521973","https://openalex.org/I4405255059"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046915678","display_name":"Shahani Noor","orcid":"https://orcid.org/0009-0000-4446-8279","observed_orcids":["https://orcid.org/0009-0000-4446-8279"]},"institutions":[{"id":"https://openalex.org/I4405255059","display_name":"University of New Mexico Health Sciences Center","ror":"https://ror.org/02jvjmd55","country_code":"US","type":"education","lineage":["https://openalex.org/I169521973","https://openalex.org/I4405255059"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shahani Noor","raw_affiliation_strings":["Department of Neurosciences, University of New Mexico Health Sciences Center, Albuquerque, NM, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosciences, University of New Mexico Health Sciences Center, Albuquerque, NM, USA","institution_ids":["https://openalex.org/I4405255059"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083506938","display_name":"Maddy R. Koch","orcid":"https://orcid.org/0009-0003-9700-1578","observed_orcids":["https://orcid.org/0009-0003-9700-1578"]},"institutions":[{"id":"https://openalex.org/I169521973","display_name":"University of New Mexico","ror":"https://ror.org/05fs6jp91","country_code":"US","type":"education","lineage":["https://openalex.org/I169521973"]},{"id":"https://openalex.org/I4405255059","display_name":"University of New Mexico Health Sciences Center","ror":"https://ror.org/02jvjmd55","country_code":"US","type":"education","lineage":["https://openalex.org/I169521973","https://openalex.org/I4405255059"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maddy R. Koch","raw_affiliation_strings":["Department of Anesthesiology and Critical Care Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM, USA"],"raw_orcid":"https://orcid.org/0009-0003-9700-1578","affiliations":[{"raw_affiliation_string":"Department of Anesthesiology and Critical Care Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM, USA","institution_ids":["https://openalex.org/I169521973","https://openalex.org/I4405255059"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5146879554","display_name":"June Bryan de la Pe\u00f1a","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I169521973","display_name":"University of New Mexico","ror":"https://ror.org/05fs6jp91","country_code":"US","type":"education","lineage":["https://openalex.org/I169521973"]},{"id":"https://openalex.org/I4405255059","display_name":"University of New Mexico Health Sciences Center","ror":"https://ror.org/02jvjmd55","country_code":"US","type":"education","lineage":["https://openalex.org/I169521973","https://openalex.org/I4405255059"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"June Bryan I. de la Pe\u00f1a","raw_affiliation_strings":["Department of Anesthesiology and Critical Care Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology and Critical Care Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM, USA","institution_ids":["https://openalex.org/I169521973","https://openalex.org/I4405255059"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025955142","display_name":"Michael J. Lacagnina","orcid":"https://orcid.org/0000-0003-2468-2467","observed_orcids":["https://orcid.org/0000-0003-2468-2467"]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]},{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael J. Lacagnina","raw_affiliation_strings":["Department of Anesthesia, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Department of Anesthesiology, University of Cincinnati College of Medicine, Cincinnati, OH, USA"],"raw_orcid":"https://orcid.org/0000-0003-2468-2467","affiliations":[{"raw_affiliation_string":"Department of Anesthesia, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Department of Anesthesiology, University of Cincinnati College of Medicine, Cincinnati, OH, USA","institution_ids":["https://openalex.org/I1285204247","https://openalex.org/I63135867"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044741701","display_name":"Sascha R.A. Alles","orcid":"https://orcid.org/0000-0001-8532-8950","observed_orcids":["https://orcid.org/0000-0001-8532-8950"]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]},{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Sascha R.A. Alles","raw_affiliation_strings":["Department of Anesthesia, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Department of Anesthesiology, University of Cincinnati College of Medicine, Cincinnati, OH, USA. Electronic address: sascha.alles@cchmc.org"],"raw_orcid":"https://orcid.org/0000-0001-8532-8950","affiliations":[{"raw_affiliation_string":"Department of Anesthesia, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Department of Anesthesiology, University of Cincinnati College of Medicine, Cincinnati, OH, USA. Electronic address: sascha.alles@cchmc.org","institution_ids":["https://openalex.org/I1285204247","https://openalex.org/I63135867"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5044741701"],"corresponding_institution_ids":["https://openalex.org/I1285204247","https://openalex.org/I63135867"],"apc_list":{"value":4180,"currency":"USD","value_usd":4180},"apc_paid":{"value":4180,"currency":"USD","value_usd":4180},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.59864515,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"50","issue":null,"first_page":"106427","last_page":"106427"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11840","display_name":"Pain Management and Treatment","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10084","display_name":"Musculoskeletal pain and rehabilitation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3612","display_name":"Physical Therapy, Sports Therapy and Rehabilitation"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-back-pain","display_name":"chronic back pain","score":1.0},{"id":"https://openalex.org/keywords/urokinase-type-plasminogen-activator","display_name":"urokinase","score":0.9049999713897705},{"id":"https://openalex.org/keywords/dorsal-root-ganglia","display_name":"dorsal root ganglia","score":0.9610000252723694},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.9440000057220459},{"id":"https://openalex.org/keywords/neuroimmune-axis","display_name":"neuroimmune axis","score":0.7799999713897705},{"id":"https://openalex.org/keywords/mechanical-hypersensitivity","display_name":"mechanical hypersensitivity","score":0.8059999942779541},{"id":"https://openalex.org/keywords/spontaneous-activity","display_name":"spontaneous activity","score":0.6430000066757202},{"id":"https://openalex.org/keywords/myeloid-cells","display_name":"myeloid cells","score":0.843999981880188},{"id":"https://openalex.org/keywords/t-cells","display_name":"T cells","score":0.9539999961853027},{"id":"https://openalex.org/keywords/transcriptomics","display_name":"transcriptomics","score":0.6000000238418579},{"id":"https://openalex.org/keywords/analgesic-targets","display_name":"analgesic targets","score":0.7490000128746033}],"concepts":[{"id":"https://openalex.org/C10162356","wikidata":"https://www.wikidata.org/wiki/Q1135939","display_name":"Pathophysiology","level":2,"score":0.7285000085830688},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5928000211715698},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5758000016212463},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5324000120162964},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.47369998693466187},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4715999960899353},{"id":"https://openalex.org/C2781118164","wikidata":"https://www.wikidata.org/wiki/Q1088113","display_name":"Chronic pain","level":2,"score":0.4641000032424927},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.4465000033378601},{"id":"https://openalex.org/C185263204","wikidata":"https://www.wikidata.org/wiki/Q1154774","display_name":"Electrophysiology","level":2,"score":0.42719998955726624},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.3490000069141388},{"id":"https://openalex.org/C3673659","wikidata":"https://www.wikidata.org/wiki/Q1098125","display_name":"Threshold of pain","level":2,"score":0.33820000290870667},{"id":"https://openalex.org/C2779245659","wikidata":"https://www.wikidata.org/wiki/Q1633866","display_name":"Hyperalgesia","level":4,"score":0.33320000767707825},{"id":"https://openalex.org/C188198153","wikidata":"https://www.wikidata.org/wiki/Q1613840","display_name":"Limiting","level":2,"score":0.31769999861717224},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.29670000076293945},{"id":"https://openalex.org/C2780456743","wikidata":"https://www.wikidata.org/wiki/Q17816630","display_name":"ALCAM","level":3,"score":0.29319998621940613},{"id":"https://openalex.org/C2779794527","wikidata":"https://www.wikidata.org/wiki/Q4116360","display_name":"Visceral pain","level":4,"score":0.2802000045776367},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.2644999921321869},{"id":"https://openalex.org/C172659308","wikidata":"https://www.wikidata.org/wiki/Q412542","display_name":"Nociceptor","level":4,"score":0.25859999656677246},{"id":"https://openalex.org/C2779918689","wikidata":"https://www.wikidata.org/wiki/Q3771842","display_name":"Stimulus (psychology)","level":2,"score":0.25290000438690186}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1016/j.jpain.2026.106427","doi":"https://doi.org/10.1016/j.jpain.2026.106427","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jpain.2026.106427","pdf_url":"https://www.jpain.org/article/S1526-5900(26)00245-2/pdf","source":{"id":"https://openalex.org/S194302669","display_name":"Journal of Pain","issn_l":"1526-5900","issn":["1526-5900","1528-8447"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Pain","raw_type":"journal-article"},{"id":"pmid:42674133","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42674133","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The journal of pain","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.jpain.2026.106427","doi":"https://doi.org/10.1016/j.jpain.2026.106427","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jpain.2026.106427","pdf_url":"https://www.jpain.org/article/S1526-5900(26)00245-2/pdf","source":{"id":"https://openalex.org/S194302669","display_name":"Journal of Pain","issn_l":"1526-5900","issn":["1526-5900","1528-8447"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Pain","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2274437402","display_name":null,"funder_award_id":"SCR_022628","funder_id":"https://openalex.org/F4320309575","funder_display_name":"Cincinnati Children's Hospital Medical Center"},{"id":"https://openalex.org/G5850682332","display_name":null,"funder_award_id":"W81XWH","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6529617309","display_name":"Development of a CCKBR-targeting scFv as Therapy for Chronic Pain Patients","funder_award_id":"UG3NS123958","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G7080086477","display_name":null,"funder_award_id":"SCR_022628","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G843442510","display_name":"BRAIN-PENETRANT SCFV ANTIBODY BLOCK OF P2X4 RECEPTOR FOR THE TREATMENT OF CHRONIC PAIN. NEW AWARD.","funder_award_id":"W81XWH2010930","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"},{"id":"https://openalex.org/G9000877542","display_name":"Prenatal alcohol exposure generates vulnerability to the proinflammatory effects of morphine and adverse neuroimmune consequences","funder_award_id":"R01AA029694","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"}],"funders":[{"id":"https://openalex.org/F4320306078","display_name":"U.S. Department of Defense","ror":"https://ror.org/0447fe631"},{"id":"https://openalex.org/F4320309575","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334348","display_name":"Department of Anesthesiology and Critical Care Medicine, Johns Hopkins Medicine","ror":null},{"id":"https://openalex.org/F4320337330","display_name":"National Institute on Alcohol Abuse and Alcoholism","ror":"https://ror.org/02jzrsm59"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204781008.pdf","grobid_xml":"https://content.openalex.org/works/W7204781008.grobid-xml"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W1593680573","https://openalex.org/W1981659159","https://openalex.org/W2008351172","https://openalex.org/W2023485889","https://openalex.org/W2034374987","https://openalex.org/W2036285583","https://openalex.org/W2039519643","https://openalex.org/W2055043514","https://openalex.org/W2064316257","https://openalex.org/W2072500831","https://openalex.org/W2079432702","https://openalex.org/W2089675869","https://openalex.org/W2105251315","https://openalex.org/W2130057241","https://openalex.org/W2172201406","https://openalex.org/W2177933255","https://openalex.org/W2520597008","https://openalex.org/W2753084136","https://openalex.org/W2786954262","https://openalex.org/W2969537514","https://openalex.org/W2999016253","https://openalex.org/W2999622098","https://openalex.org/W3087286451","https://openalex.org/W3098344115","https://openalex.org/W3176662896","https://openalex.org/W4212916248","https://openalex.org/W4220980437","https://openalex.org/W4280498620","https://openalex.org/W4283314048","https://openalex.org/W4283803060","https://openalex.org/W4295762986","https://openalex.org/W4319598767","https://openalex.org/W4386352397","https://openalex.org/W4387799391","https://openalex.org/W4387937410","https://openalex.org/W4388271682","https://openalex.org/W4388806359","https://openalex.org/W4389207797","https://openalex.org/W4393218994","https://openalex.org/W4396873622","https://openalex.org/W4402625850","https://openalex.org/W4402826027","https://openalex.org/W4403588595","https://openalex.org/W4404677035","https://openalex.org/W4411391583","https://openalex.org/W4413694383","https://openalex.org/W4414681571","https://openalex.org/W7125378094","https://openalex.org/W7126399727"],"related_works":["https://openalex.org/W4394753609","https://openalex.org/W4405674117","https://openalex.org/W7112810434","https://openalex.org/W2768786783","https://openalex.org/W7074132537","https://openalex.org/W657322800","https://openalex.org/W4205501253","https://openalex.org/W2012158291","https://openalex.org/W4399300994","https://openalex.org/W7119488760"],"abstract_inverted_index":{"Chronic":[0],"back":[1],"pain":[2,85],"(CBP)":[3],"affects":[4],"one":[5],"in":[6,63,134,147,154,163,187,196,220,223],"ten":[7],"people":[8],"worldwide,":[9],"limiting":[10],"mobility,":[11],"productivity,":[12],"and":[13,66,76,83,97,116,128,149,176,179,201,234],"quality":[14],"of":[15,28,41,61,92,112,120,160,199,209,227,241,256,260],"life.":[16],"Current":[17],"treatments":[18],"are":[19],"often":[20],"inadequate,":[21],"partly":[22],"due":[23],"to":[24,36,105,137,173,230],"an":[25],"incomplete":[26],"understanding":[27],"their":[29],"mechanisms.":[30],"This":[31,214],"study":[32,215],"explores":[33],"pathophysiological":[34,194,218],"contributions":[35],"CBP":[37,62,200,228],"at":[38,238],"the":[39,42,45,207,239,242,250,254],"level":[40,240],"DRG":[43,94,184],"using":[44],"urokinase-type":[46],"plasminogen":[47],"activator":[48],"(uPA)":[49],"mouse":[50,225],"model":[51,198,226],"(uPA-CBP).":[52],"We":[53,244],"observed":[54],"sustained":[55],"mechanical":[56],"hypersensitivity":[57],"resembling":[58],"clinical":[59],"features":[60],"both":[64],"male":[65,96],"female":[67,98],"uPA-CBP":[68,99,135],"mice":[69,100],"with":[70],"notable":[71],"sex-specific":[72,132,169,192,217],"effects":[73],"on":[74],"cold":[75],"heat":[77],"sensitivity":[78],"as":[79,81,166,168],"well":[80,167],"gait":[82],"spontaneous":[84,117,125],"behaviors.":[86],"Whole-cell":[87],"patch":[88],"clamp":[89],"electrophysiological":[90],"recordings":[91],"lumbar":[93],"from":[95],"reveal":[101],"increased":[102,143],"excitability":[103],"compared":[104,136],"sham":[106,138],"controls":[107],"including":[108],"a":[109,197,224],"higher":[110],"prevalence":[111],"multi-":[113],"vs.":[114],"single-firing":[115],"activity.":[118],"Analysis":[119],"action":[121],"potential":[122,204,247],"waveform,":[123],"depolarizing":[124],"fluctuations":[126],"(DSFs),":[127],"intrinsic":[129],"properties":[130],"revealed":[131,142],"differences":[133],"mice.":[139],"Flow":[140],"cytometry":[141],"CD45+CD11b+":[144],"myeloid":[145],"cells":[146,153],"males":[148],"elevated":[150],"CD45+CD3+CD4+":[151],"T":[152],"females.":[155],"RNA":[156],"sequencing":[157],"identified":[158],"upregulation":[159],"genes":[161],"involved":[162],"immune":[164,235],"response":[165],"transcriptomic":[170],"changes":[171,195,219],"related":[172],"immune,":[174],"glial,":[175],"neuronal":[177],"functions":[178],"crosstalk,":[180],"together":[181],"suggesting":[182],"altered":[183],"neuroimmune":[185,193,251],"interactions":[186],"uPA-CBP.":[188],"These":[189],"findings":[190],"highlight":[191],"uncover":[202,245],"new":[203,246],"targets":[205,248],"for":[206,211,253,258],"development":[208,255],"analgesics":[210,257],"treatment.":[212],"PERSPECTIVE:":[213],"highlights":[216],"behavioral":[221],"profiles":[222,237],"attributed":[229],"differential":[231],"electrophysiological,":[232],"transcriptomic,":[233],"cell":[236],"DRG.":[243],"along":[249],"axis":[252],"treatment":[259],"CBP.":[261]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-09-01T00:00:00"}