{"id":"https://openalex.org/W7204779785","doi":"https://doi.org/10.64898/2026.08.28.747860","title":"Transient reprogramming limits AP-1-associated chromatin opening and transposable element activation to preserve hematopoietic stem cell function during aging and stress","display_name":"Transient reprogramming limits AP-1-associated chromatin opening and transposable element activation to preserve hematopoietic stem cell function during aging and stress","publication_year":2026,"publication_date":"2026-08-31","ids":{"openalex":"https://openalex.org/W7204779785","doi":"https://doi.org/10.64898/2026.08.28.747860"},"language":"en","primary_location":{"id":"doi:10.64898/2026.08.28.747860","doi":"https://doi.org/10.64898/2026.08.28.747860","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.28.747860","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/08/31/2026.08.28.747860.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/08/31/2026.08.28.747860.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113471324","display_name":"Audrey Porquet","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]},{"id":"https://openalex.org/I2801843802","display_name":"Institut Gustave Roussy","ror":"https://ror.org/0321g0743","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2801843802"]},{"id":"https://openalex.org/I4405257098","display_name":"Cellules souches h\u00e9matopo\u00ef\u00e9tiques et d\u00e9veloppement des h\u00e9mopathies my\u00e9lo\u00efdes","ror":"https://ror.org/04wkrkf28","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I277688954","https://openalex.org/I2801843802","https://openalex.org/I4405257098"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Audrey Porquet","raw_affiliation_strings":["University Paris-Saclay, Gustave Roussy, INSERM U1287, Hematopoietic stem cells and the development of myeloid malignancies, F-94805, Villejuif, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Paris-Saclay, Gustave Roussy, INSERM U1287, Hematopoietic stem cells and the development of myeloid malignancies, F-94805, Villejuif, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I277688954","https://openalex.org/I2801843802","https://openalex.org/I4405257098"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052851931","display_name":"Mathieu Bohm","orcid":"https://orcid.org/0000-0001-5090-1569","observed_orcids":["https://orcid.org/0000-0001-5090-1569"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]},{"id":"https://openalex.org/I2801843802","display_name":"Institut Gustave Roussy","ror":"https://ror.org/0321g0743","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2801843802"]},{"id":"https://openalex.org/I4405257098","display_name":"Cellules souches h\u00e9matopo\u00ef\u00e9tiques et d\u00e9veloppement des h\u00e9mopathies my\u00e9lo\u00efdes","ror":"https://ror.org/04wkrkf28","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I277688954","https://openalex.org/I2801843802","https://openalex.org/I4405257098"]},{"id":"https://openalex.org/I4405270361","display_name":"Inovarion (France)","ror":"https://ror.org/00j7y6z55","country_code":"FR","type":"company","lineage":["https://openalex.org/I4405270361"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Mathieu Bohm","raw_affiliation_strings":["Inovarion, 75005 Paris, France","University Paris-Saclay, Gustave Roussy, INSERM U1287, Hematopoietic stem cells and the development of myeloid malignancies, F-94805, Villejuif, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inovarion, 75005 Paris, France","institution_ids":["https://openalex.org/I4405270361"]},{"raw_affiliation_string":"University Paris-Saclay, Gustave Roussy, INSERM U1287, Hematopoietic stem cells and the development of myeloid malignancies, F-94805, Villejuif, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I277688954","https://openalex.org/I2801843802","https://openalex.org/I4405257098"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5119030337","display_name":"Hassan Ait-Ougouram","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]},{"id":"https://openalex.org/I2801843802","display_name":"Institut Gustave Roussy","ror":"https://ror.org/0321g0743","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2801843802"]},{"id":"https://openalex.org/I4405257098","display_name":"Cellules souches h\u00e9matopo\u00ef\u00e9tiques et d\u00e9veloppement des h\u00e9mopathies my\u00e9lo\u00efdes","ror":"https://ror.org/04wkrkf28","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I277688954","https://openalex.org/I2801843802","https://openalex.org/I4405257098"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Hassan Ait-Ougouram","raw_affiliation_strings":["University Paris-Saclay, Gustave Roussy, INSERM U1287, Hematopoietic stem cells and the development of myeloid malignancies, F-94805, Villejuif, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Paris-Saclay, Gustave Roussy, INSERM U1287, Hematopoietic stem cells and the development of myeloid malignancies, F-94805, Villejuif, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I277688954","https://openalex.org/I2801843802","https://openalex.org/I4405257098"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148760915","display_name":"Thu-Ha Trinh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I15057530","display_name":"Universit\u00e9 de Bordeaux","ror":"https://ror.org/057qpr032","country_code":"FR","type":"education","lineage":["https://openalex.org/I15057530"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4405259646","display_name":"BoRdeaux Institute of onCology","ror":"https://ror.org/02gezhp66","country_code":"FR","type":"facility","lineage":["https://openalex.org/I15057530","https://openalex.org/I154526488","https://openalex.org/I4405259646"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Thu-H\u00e0 Trinh","raw_affiliation_strings":["INSERM Unit 1312 BRIC, University of Bordeaux, Bordeaux, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM Unit 1312 BRIC, University of Bordeaux, Bordeaux, France","institution_ids":["https://openalex.org/I15057530","https://openalex.org/I154526488","https://openalex.org/I4405259646"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036660104","display_name":"Rabie Chelbi","orcid":"https://orcid.org/0000-0001-5994-328X","observed_orcids":["https://orcid.org/0000-0001-5994-328X"]},"institutions":[{"id":"https://openalex.org/I4405270361","display_name":"Inovarion (France)","ror":"https://ror.org/00j7y6z55","country_code":"FR","type":"company","lineage":["https://openalex.org/I4405270361"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Rabie Chelbi","raw_affiliation_strings":["Inovarion, 75005 Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inovarion, 75005 Paris, France","institution_ids":["https://openalex.org/I4405270361"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043101112","display_name":"Mengliang Ye","orcid":"https://orcid.org/0000-0002-1988-4358","observed_orcids":["https://orcid.org/0000-0002-1988-4358"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2746051580","display_name":"Universit\u00e9 Paris Sciences et Lettres","ror":"https://ror.org/013cjyk83","country_code":"FR","type":"education","lineage":["https://openalex.org/I2746051580"]},{"id":"https://openalex.org/I80043","display_name":"Institut Curie","ror":"https://ror.org/04t0gwh46","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I80043"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Mengliang Ye","raw_affiliation_strings":["INSERM U932, Institut Curie, Paris Sciences-et-Lettres Research University, 75005 Paris"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM U932, Institut Curie, Paris Sciences-et-Lettres Research University, 75005 Paris","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I2746051580","https://openalex.org/I80043"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062891938","display_name":"Ollivier Milhavet","orcid":"https://orcid.org/0000-0001-6236-0499","observed_orcids":["https://orcid.org/0000-0001-6236-0499"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I19894307","display_name":"Universit\u00e9 de Montpellier","ror":"https://ror.org/051escj72","country_code":"FR","type":"education","lineage":["https://openalex.org/I19894307"]},{"id":"https://openalex.org/I4210095750","display_name":"Institute for Regenerative Medicine & Biotherapy","ror":"https://ror.org/00b8mh310","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I19894307","https://openalex.org/I4210095750"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Ollivier Milhavet","raw_affiliation_strings":["IRBM, University of Montpellier, INSERM, CNRS UMR1183, Montpellier, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IRBM, University of Montpellier, INSERM, CNRS UMR1183, Montpellier, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I19894307","https://openalex.org/I4210095750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051212502","display_name":"Jean-Marc Lema\u0131\u0302tre","orcid":"https://orcid.org/0000-0002-6492-5219","observed_orcids":["https://orcid.org/0000-0002-6492-5219"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I19894307","display_name":"Universit\u00e9 de Montpellier","ror":"https://ror.org/051escj72","country_code":"FR","type":"education","lineage":["https://openalex.org/I19894307"]},{"id":"https://openalex.org/I4210095750","display_name":"Institute for Regenerative Medicine & Biotherapy","ror":"https://ror.org/00b8mh310","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I19894307","https://openalex.org/I4210095750"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jean-Marc Lema\u00eetre","raw_affiliation_strings":["IRBM, University of Montpellier, INSERM, CNRS UMR1183, Montpellier, France"],"raw_orcid":"https://orcid.org/0000-0002-6492-5219","affiliations":[{"raw_affiliation_string":"IRBM, University of Montpellier, INSERM, CNRS UMR1183, Montpellier, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I19894307","https://openalex.org/I4210095750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091358858","display_name":"Nathalie M Droin","orcid":"https://orcid.org/0000-0002-6099-5324","observed_orcids":["https://orcid.org/0000-0002-6099-5324"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]},{"id":"https://openalex.org/I2801843802","display_name":"Institut Gustave Roussy","ror":"https://ror.org/0321g0743","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2801843802"]},{"id":"https://openalex.org/I4405257098","display_name":"Cellules souches h\u00e9matopo\u00ef\u00e9tiques et d\u00e9veloppement des h\u00e9mopathies my\u00e9lo\u00efdes","ror":"https://ror.org/04wkrkf28","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I277688954","https://openalex.org/I2801843802","https://openalex.org/I4405257098"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Nathalie Droin","raw_affiliation_strings":["University Paris Saclay, Gustave Roussy, INSERM, Fundamental genomics Platform, F-94805, Villejuif, France","University Paris-Saclay, Gustave Roussy, INSERM U1287, Hematopoietic stem cells and the development of myeloid malignancies, F-94805, Villejuif, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Paris Saclay, Gustave Roussy, INSERM, Fundamental genomics Platform, F-94805, Villejuif, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I2801843802"]},{"raw_affiliation_string":"University Paris-Saclay, Gustave Roussy, INSERM U1287, Hematopoietic stem cells and the development of myeloid malignancies, F-94805, Villejuif, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I277688954","https://openalex.org/I2801843802","https://openalex.org/I4405257098"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022279472","display_name":"Elina Zueva","orcid":"https://orcid.org/0000-0002-6276-5127","observed_orcids":["https://orcid.org/0000-0002-6276-5127"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2746051580","display_name":"Universit\u00e9 Paris Sciences et Lettres","ror":"https://ror.org/013cjyk83","country_code":"FR","type":"education","lineage":["https://openalex.org/I2746051580"]},{"id":"https://openalex.org/I80043","display_name":"Institut Curie","ror":"https://ror.org/04t0gwh46","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I80043"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Elina Zueva","raw_affiliation_strings":["INSERM U932, Institut Curie, Paris Sciences-et-Lettres Research University, 75005 Paris"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM U932, Institut Curie, Paris Sciences-et-Lettres Research University, 75005 Paris","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I2746051580","https://openalex.org/I80043"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043228140","display_name":"Catherine M. Sawai","orcid":"https://orcid.org/0000-0002-2509-474X","observed_orcids":["https://orcid.org/0000-0002-2509-474X"]},"institutions":[{"id":"https://openalex.org/I15057530","display_name":"Universit\u00e9 de Bordeaux","ror":"https://ror.org/057qpr032","country_code":"FR","type":"education","lineage":["https://openalex.org/I15057530"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4405259646","display_name":"BoRdeaux Institute of onCology","ror":"https://ror.org/02gezhp66","country_code":"FR","type":"facility","lineage":["https://openalex.org/I15057530","https://openalex.org/I154526488","https://openalex.org/I4405259646"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Catherine M. Sawai","raw_affiliation_strings":["INSERM Unit 1312 BRIC, University of Bordeaux, Bordeaux, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM Unit 1312 BRIC, University of Bordeaux, Bordeaux, France","institution_ids":["https://openalex.org/I15057530","https://openalex.org/I154526488","https://openalex.org/I4405259646"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088738166","display_name":"Emilie Elvira\u2010Matelot","orcid":"https://orcid.org/0000-0002-4017-6436","observed_orcids":["https://orcid.org/0000-0002-4017-6436"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]},{"id":"https://openalex.org/I2801843802","display_name":"Institut Gustave Roussy","ror":"https://ror.org/0321g0743","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2801843802"]},{"id":"https://openalex.org/I4405257098","display_name":"Cellules souches h\u00e9matopo\u00ef\u00e9tiques et d\u00e9veloppement des h\u00e9mopathies my\u00e9lo\u00efdes","ror":"https://ror.org/04wkrkf28","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I277688954","https://openalex.org/I2801843802","https://openalex.org/I4405257098"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Emilie Elvira-Matelot","raw_affiliation_strings":["University Paris-Saclay, Gustave Roussy, INSERM U1287, Hematopoietic stem cells and the development of myeloid malignancies, F-94805, Villejuif, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Paris-Saclay, Gustave Roussy, INSERM U1287, Hematopoietic stem cells and the development of myeloid malignancies, F-94805, Villejuif, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I277688954","https://openalex.org/I2801843802","https://openalex.org/I4405257098"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004178281","display_name":"Fran\u00e7oise Porteu","orcid":"https://orcid.org/0000-0002-2403-4163","observed_orcids":["https://orcid.org/0000-0002-2403-4163"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]},{"id":"https://openalex.org/I2801843802","display_name":"Institut Gustave Roussy","ror":"https://ror.org/0321g0743","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2801843802"]},{"id":"https://openalex.org/I4405257098","display_name":"Cellules souches h\u00e9matopo\u00ef\u00e9tiques et d\u00e9veloppement des h\u00e9mopathies my\u00e9lo\u00efdes","ror":"https://ror.org/04wkrkf28","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I277688954","https://openalex.org/I2801843802","https://openalex.org/I4405257098"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Fran\u00e7oise Porteu","raw_affiliation_strings":["University Paris-Saclay, Gustave Roussy, INSERM U1287, Hematopoietic stem cells and the development of myeloid malignancies, F-94805, Villejuif, France"],"raw_orcid":"https://orcid.org/0000-0002-2403-4163","affiliations":[{"raw_affiliation_string":"University Paris-Saclay, Gustave Roussy, INSERM U1287, Hematopoietic stem cells and the development of myeloid malignancies, F-94805, Villejuif, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I277688954","https://openalex.org/I2801843802","https://openalex.org/I4405257098"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":12,"corresponding_author_ids":["https://openalex.org/A5004178281"],"corresponding_institution_ids":["https://openalex.org/I154526488","https://openalex.org/I277688954","https://openalex.org/I2801843802","https://openalex.org/I4405257098"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9688000082969666,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9688000082969666,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.017500000074505806,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hematopoietic-stem-cell-aging","display_name":"hematopoietic stem cell aging","score":0.9819999933242798},{"id":"https://openalex.org/keywords/yamanaka-factors","display_name":"Yamanaka factors","score":0.9549999833106995},{"id":"https://openalex.org/keywords/oct4","display_name":"Oct4","score":0.6959999799728394},{"id":"https://openalex.org/keywords/sox2","display_name":"SOX2","score":0.968999981880188},{"id":"https://openalex.org/keywords/klf4","display_name":"KLF4","score":0.9990000128746033},{"id":"https://openalex.org/keywords/c-myc","display_name":"c-Myc","score":0.9990000128746033},{"id":"https://openalex.org/keywords/ap-1-transcription-factor","display_name":"AP-1 transcription factor","score":0.8040000200271606},{"id":"https://openalex.org/keywords/chromatin-accessibility","display_name":"chromatin accessibility","score":0.9950000047683716},{"id":"https://openalex.org/keywords/dna-damage","display_name":"DNA damage","score":0.7419999837875366},{"id":"https://openalex.org/keywords/hematopoietic-recovery","display_name":"hematopoietic recovery","score":0.921999990940094},{"id":"https://openalex.org/keywords/myeloid-bias","display_name":"myeloid bias","score":0.9309999942779541},{"id":"https://openalex.org/keywords/reverse-transcriptase-inhibition","display_name":"reverse transcriptase inhibition","score":0.7770000100135803},{"id":"https://openalex.org/keywords/epigenetic-remodeling","display_name":"epigenetic remodeling","score":0.8579999804496765}],"concepts":[{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.791700005531311},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7207000255584717},{"id":"https://openalex.org/C77255625","wikidata":"https://www.wikidata.org/wiki/Q402093","display_name":"Reprogramming","level":3,"score":0.7016000151634216},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6087999939918518},{"id":"https://openalex.org/C167227067","wikidata":"https://www.wikidata.org/wiki/Q5113739","display_name":"Chromatin remodeling","level":4,"score":0.6029000282287598},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.5753999948501587},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.5342000126838684},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.49160000681877136},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.47870001196861267},{"id":"https://openalex.org/C4918238","wikidata":"https://www.wikidata.org/wiki/Q121438","display_name":"Transposable element","level":4,"score":0.4700999855995178},{"id":"https://openalex.org/C2778086970","wikidata":"https://www.wikidata.org/wiki/Q514525","display_name":"Hematopoietic stem cell","level":4,"score":0.46389999985694885},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.429500013589859},{"id":"https://openalex.org/C186310378","wikidata":"https://www.wikidata.org/wiki/Q941796","display_name":"Psychological repression","level":4,"score":0.39570000767707825},{"id":"https://openalex.org/C117717151","wikidata":"https://www.wikidata.org/wiki/Q3589155","display_name":"Epigenome","level":5,"score":0.3846000134944916},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.38019999861717224},{"id":"https://openalex.org/C522857546","wikidata":"https://www.wikidata.org/wiki/Q2070979","display_name":"Senescence","level":2,"score":0.37860000133514404},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.3580000102519989},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.3301999866962433},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.30169999599456787},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.2994000017642975},{"id":"https://openalex.org/C2777116130","wikidata":"https://www.wikidata.org/wiki/Q4082046","display_name":"Polycomb-group proteins","level":5,"score":0.2987000048160553},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.28600001335144043},{"id":"https://openalex.org/C81444415","wikidata":"https://www.wikidata.org/wiki/Q7243535","display_name":"Priming (agriculture)","level":3,"score":0.27070000767707825},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.267300009727478},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.26440000534057617},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.2621999979019165},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.2612000107765198},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.2612000107765198},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.25999999046325684},{"id":"https://openalex.org/C131934819","wikidata":"https://www.wikidata.org/wiki/Q135390","display_name":"Biogenesis","level":3,"score":0.25589999556541443}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.08.28.747860","doi":"https://doi.org/10.64898/2026.08.28.747860","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.28.747860","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/08/31/2026.08.28.747860.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.08.28.747860","doi":"https://doi.org/10.64898/2026.08.28.747860","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.28.747860","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/08/31/2026.08.28.747860.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G282091250","display_name":null,"funder_award_id":"UMS44","funder_id":"https://openalex.org/F4320320893","funder_display_name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale"},{"id":"https://openalex.org/G4620981541","display_name":"The role of transposable element-induced inflammation in hematopoietic aging and rejuvenation","funder_award_id":"ANR-23-CE14-0017","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G7080048889","display_name":null,"funder_award_id":"ANR-23","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"}],"funders":[{"id":"https://openalex.org/F4320320883","display_name":"Agence Nationale de la Recherche","ror":"https://ror.org/00rbzpz17"},{"id":"https://openalex.org/F4320320893","display_name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","ror":"https://ror.org/02vjkv261"},{"id":"https://openalex.org/F4320322361","display_name":"Fondation ARC pour la Recherche sur le Cancer","ror":"https://ror.org/0489qz649"},{"id":"https://openalex.org/F4320324826","display_name":"Institut Gustave-Roussy","ror":"https://ror.org/0321g0743"},{"id":"https://openalex.org/F4320331650","display_name":"Soci\u00e9t\u00e9 Fran\u00e7aise d'H\u00e9matologie","ror":"https://ror.org/0263nzc55"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204779785.pdf","grobid_xml":"https://content.openalex.org/works/W7204779785.grobid-xml"},"referenced_works_count":1,"referenced_works":["https://openalex.org/W4412538392"],"related_works":["https://openalex.org/W7221104250","https://openalex.org/W7160250429","https://openalex.org/W4417017158","https://openalex.org/W4405050186","https://openalex.org/W2036055444","https://openalex.org/W4402022786","https://openalex.org/W7098965834","https://openalex.org/W7117885870","https://openalex.org/W4280566403","https://openalex.org/W7171498301"],"abstract_inverted_index":{"Abstract":[0],"Hematopoietic":[1],"stem":[2],"cell":[3],"(HSC)":[4],"aging":[5,61],"is":[6],"associated":[7],"with":[8,20],"epigenetic":[9],"remodeling,":[10],"yet":[11],"the":[12,41],"molecular":[13],"mechanisms":[14],"driving":[15],"these":[16,133],"changes,":[17],"their":[18],"overlap":[19],"stress-induced":[21],"alterations,":[22],"and":[23,47,54,58,72,91,104,118,148],"whether":[24],"this":[25],"course":[26],"can":[27],"be":[28],"durably":[29,52],"reset":[30],"remain":[31],"incompletely":[32],"understood.":[33],"Here,":[34],"we":[35],"show":[36],"that":[37],"transient":[38],"induction":[39],"of":[40,93,106,126],"Yamanaka":[42],"factors":[43],"OCT4,":[44],"SOX2,":[45],"KLF4,":[46],"MYC":[48],"in":[49,62,112],"young":[50],"mice":[51,114],"delays":[53],"partially":[55],"reverses":[56],"physiological":[57],"LPS-driven":[59],"HSC":[60,107,120,130,149],"mice.":[63],"Transient":[64],"reprogramming":[65],"improved":[66,119],"hematopoietic":[67],"reconstitution,":[68],"reduced":[69,79,115],"myeloid":[70],"bias,":[71],"limited":[73],"DNA":[74,116],"damage.":[75],"Multi-omic":[76],"analyses":[77],"revealed":[78],"chromatin":[80,137],"accessibility":[81],"at":[82],"AP-1-enriched":[83],"regulatory":[84],"regions,":[85],"attenuated":[86],"age-associated":[87],"AP-1":[88,98],"transcriptional":[89],"programs,":[90],"repression":[92],"transposable":[94],"elements":[95],"(TEs).":[96],"Pharmacological":[97],"inhibition":[99,111],"prevented":[100],"LPS-induced":[101],"TE":[102,127,146],"activation":[103,147],"loss":[105],"clonogenicity.":[108],"Reverse":[109],"transcriptase":[110],"aged":[113],"damage":[117],"function,":[121],"demonstrating":[122],"a":[123,140],"functional":[124],"contribution":[125],"activity":[128],"to":[129],"decline.":[131],"Together,":[132],"findings":[134],"identify":[135],"AP-1-associated":[136],"remodeling":[138],"as":[139],"candidate":[141],"mechanism":[142],"linking":[143],"inflammatory":[144],"stress,":[145],"aging.":[150]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-09-01T00:00:00"}
