{"id":"https://openalex.org/W7204771473","doi":"https://doi.org/10.64898/2026.08.28.747849","title":"Cereblon on Steroids: Beyond the Canonical Ligand Space","display_name":"Cereblon on Steroids: Beyond the Canonical Ligand Space","publication_year":2026,"publication_date":"2026-08-31","ids":{"openalex":"https://openalex.org/W7204771473","doi":"https://doi.org/10.64898/2026.08.28.747849"},"language":"en","primary_location":{"id":"doi:10.64898/2026.08.28.747849","doi":"https://doi.org/10.64898/2026.08.28.747849","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.28.747849","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/08/31/2026.08.28.747849.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/08/31/2026.08.28.747849.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103236012","display_name":"Alexander Herrmann","orcid":"https://orcid.org/0000-0002-4241-942X","observed_orcids":["https://orcid.org/0000-0002-4241-942X"]},"institutions":[{"id":"https://openalex.org/I4210165766","display_name":"Max Planck Institute for Biology","ror":"https://ror.org/0243gzr89","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210165766"]},{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Alexander Herrmann","raw_affiliation_strings":["Interfaculty Institute of Biochemistry, University of T\u00fcbingen, T\u00fcbingen, Germany","Max Planck Institute for Biology, T\u00fcbingen, Germany"],"raw_orcid":"https://orcid.org/0000-0002-4241-942X","affiliations":[{"raw_affiliation_string":"Interfaculty Institute of Biochemistry, University of T\u00fcbingen, T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I8087733"]},{"raw_affiliation_string":"Max Planck Institute for Biology, T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I4210165766"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087431265","display_name":"Christopher Heim","orcid":"https://orcid.org/0000-0001-8711-8607","observed_orcids":["https://orcid.org/0000-0001-8711-8607"]},"institutions":[{"id":"https://openalex.org/I4210112031","display_name":"NanoTemper Technologies (Germany)","ror":"https://ror.org/01c3zvj45","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210112031"]},{"id":"https://openalex.org/I4210165766","display_name":"Max Planck Institute for Biology","ror":"https://ror.org/0243gzr89","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210165766"]},{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christopher Heim","raw_affiliation_strings":["Interfaculty Institute of Biochemistry, University of T\u00fcbingen, T\u00fcbingen, Germany","Max Planck Institute for Biology, T\u00fcbingen, Germany","NanoTemper Technologies GmbH, Munich, Germany"],"raw_orcid":"https://orcid.org/0000-0001-8711-8607","affiliations":[{"raw_affiliation_string":"Interfaculty Institute of Biochemistry, University of T\u00fcbingen, T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I8087733"]},{"raw_affiliation_string":"Max Planck Institute for Biology, T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I4210165766"]},{"raw_affiliation_string":"NanoTemper Technologies GmbH, Munich, Germany","institution_ids":["https://openalex.org/I4210112031"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007798099","display_name":"Samuel A. Maiwald","orcid":"https://orcid.org/0000-0002-7235-2748","observed_orcids":["https://orcid.org/0000-0002-7235-2748"]},"institutions":[{"id":"https://openalex.org/I4210150093","display_name":"Max Planck Institute of Biochemistry","ror":"https://ror.org/04py35477","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210150093"]},{"id":"https://openalex.org/I4210165766","display_name":"Max Planck Institute for Biology","ror":"https://ror.org/0243gzr89","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210165766"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Samuel Maiwald","raw_affiliation_strings":["Max Planck Institute for Biology, T\u00fcbingen, Germany","Max Planck Institute of Biochemistry, Martinsried, Germany"],"raw_orcid":"https://orcid.org/0000-0002-7235-2748","affiliations":[{"raw_affiliation_string":"Max Planck Institute for Biology, T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I4210165766"]},{"raw_affiliation_string":"Max Planck Institute of Biochemistry, Martinsried, Germany","institution_ids":["https://openalex.org/I4210150093"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013469802","display_name":"Iuliia Boichenko","orcid":"https://orcid.org/0000-0001-9835-244X","observed_orcids":["https://orcid.org/0000-0001-9835-244X"]},"institutions":[{"id":"https://openalex.org/I4210165766","display_name":"Max Planck Institute for Biology","ror":"https://ror.org/0243gzr89","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210165766"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Iuliia Boichenko","raw_affiliation_strings":["Max Planck Institute for Biology, T\u00fcbingen, Germany"],"raw_orcid":"https://orcid.org/0000-0001-9835-244X","affiliations":[{"raw_affiliation_string":"Max Planck Institute for Biology, T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I4210165766"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088211325","display_name":"Martin Neuenschwander","orcid":"https://orcid.org/0000-0002-3114-7975","observed_orcids":["https://orcid.org/0000-0002-3114-7975"]},"institutions":[{"id":"https://openalex.org/I205582932","display_name":"Max Delbr\u00fcck Center","ror":"https://ror.org/04p5ggc03","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I205582932"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Martin Neuenschwander","raw_affiliation_strings":["Screening Unit, Max Delbr\u00fcck Center, Berlin, Germany"],"raw_orcid":"https://orcid.org/0000-0002-3114-7975","affiliations":[{"raw_affiliation_string":"Screening Unit, Max Delbr\u00fcck Center, Berlin, Germany","institution_ids":["https://openalex.org/I205582932"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063823739","display_name":"Andreas Oder","orcid":"https://orcid.org/0009-0004-9852-3818","observed_orcids":["https://orcid.org/0009-0004-9852-3818"]},"institutions":[{"id":"https://openalex.org/I205582932","display_name":"Max Delbr\u00fcck Center","ror":"https://ror.org/04p5ggc03","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I205582932"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Andreas Oder","raw_affiliation_strings":["Screening Unit, Max Delbr\u00fcck Center, Berlin, Germany"],"raw_orcid":"https://orcid.org/0009-0004-9852-3818","affiliations":[{"raw_affiliation_string":"Screening Unit, Max Delbr\u00fcck Center, Berlin, Germany","institution_ids":["https://openalex.org/I205582932"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083605128","display_name":"Birte Hernandez Alvarez","orcid":"https://orcid.org/0000-0003-0635-8698","observed_orcids":["https://orcid.org/0000-0003-0635-8698"]},"institutions":[{"id":"https://openalex.org/I4210165766","display_name":"Max Planck Institute for Biology","ror":"https://ror.org/0243gzr89","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210165766"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Birte Hernandez Alvarez","raw_affiliation_strings":["Max Planck Institute for Biology, T\u00fcbingen, Germany"],"raw_orcid":"https://orcid.org/0000-0003-0635-8698","affiliations":[{"raw_affiliation_string":"Max Planck Institute for Biology, T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I4210165766"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030962194","display_name":"Andrei N. Lupas","orcid":"https://orcid.org/0000-0002-1959-4836","observed_orcids":["https://orcid.org/0000-0002-1959-4836"]},"institutions":[{"id":"https://openalex.org/I4210165766","display_name":"Max Planck Institute for Biology","ror":"https://ror.org/0243gzr89","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210165766"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Andrei N. Lupas","raw_affiliation_strings":["Max Planck Institute for Biology, T\u00fcbingen, Germany"],"raw_orcid":"https://orcid.org/0000-0002-1959-4836","affiliations":[{"raw_affiliation_string":"Max Planck Institute for Biology, T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I4210165766"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075104061","display_name":"Jens Peter von Kries","orcid":"https://orcid.org/0000-0003-4716-4988","observed_orcids":["https://orcid.org/0000-0003-4716-4988"]},"institutions":[{"id":"https://openalex.org/I205582932","display_name":"Max Delbr\u00fcck Center","ror":"https://ror.org/04p5ggc03","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I205582932"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jens Peter von Kries","raw_affiliation_strings":["Screening Unit, Max Delbr\u00fcck Center, Berlin, Germany"],"raw_orcid":"https://orcid.org/0000-0003-4716-4988","affiliations":[{"raw_affiliation_string":"Screening Unit, Max Delbr\u00fcck Center, Berlin, Germany","institution_ids":["https://openalex.org/I205582932"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061964483","display_name":"Marcus D. Hartmann","orcid":"https://orcid.org/0000-0001-6937-5677","observed_orcids":["https://orcid.org/0000-0001-6937-5677"]},"institutions":[{"id":"https://openalex.org/I4210165766","display_name":"Max Planck Institute for Biology","ror":"https://ror.org/0243gzr89","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210165766"]},{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Marcus D. Hartmann","raw_affiliation_strings":["Interfaculty Institute of Biochemistry, University of T\u00fcbingen, T\u00fcbingen, Germany","Max Planck Institute for Biology, T\u00fcbingen, Germany"],"raw_orcid":"https://orcid.org/0000-0001-6937-5677","affiliations":[{"raw_affiliation_string":"Interfaculty Institute of Biochemistry, University of T\u00fcbingen, T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I8087733"]},{"raw_affiliation_string":"Max Planck Institute for Biology, T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I4210165766"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5061964483"],"corresponding_institution_ids":["https://openalex.org/I4210165766","https://openalex.org/I8087733"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12534","display_name":"Protein Degradation and Inhibitors","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12534","display_name":"Protein Degradation and Inhibitors","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cereblon","display_name":"cereblon","score":0.9700000286102295},{"id":"https://openalex.org/keywords/targeted-protein-degradation","display_name":"targeted protein degradation","score":0.8820000290870667},{"id":"https://openalex.org/keywords/cortisone","display_name":"cortisone","score":0.9710000157356262},{"id":"https://openalex.org/keywords/bicyclic-lactams","display_name":"bicyclic lactams","score":0.8450000286102295},{"id":"https://openalex.org/keywords/phthalide-derivatives","display_name":"phthalide derivatives","score":0.777999997138977},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.8519999980926514}],"concepts":[{"id":"https://openalex.org/C2778540781","wikidata":"https://www.wikidata.org/wiki/Q21112029","display_name":"Cereblon","level":5,"score":0.7050999999046326},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6484000086784363},{"id":"https://openalex.org/C2780557392","wikidata":"https://www.wikidata.org/wiki/Q523796","display_name":"Linker","level":2,"score":0.6089000105857849},{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.5989000201225281},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.4657000005245209},{"id":"https://openalex.org/C99726746","wikidata":"https://www.wikidata.org/wiki/Q906396","display_name":"Chemical space","level":3,"score":0.4562999904155731},{"id":"https://openalex.org/C51639874","wikidata":"https://www.wikidata.org/wiki/Q167149","display_name":"Plasma protein binding","level":2,"score":0.3382999897003174},{"id":"https://openalex.org/C24961977","wikidata":"https://www.wikidata.org/wiki/Q225972","display_name":"Bicyclic molecule","level":2,"score":0.33410000801086426},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.3336000144481659},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.3172000050544739},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3021000027656555},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.28040000796318054},{"id":"https://openalex.org/C2780283098","wikidata":"https://www.wikidata.org/wiki/Q4688960","display_name":"Affinities","level":2,"score":0.26930001378059387},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.26669999957084656},{"id":"https://openalex.org/C179464577","wikidata":"https://www.wikidata.org/wiki/Q1632589","display_name":"Jurkat cells","level":4,"score":0.2599000036716461},{"id":"https://openalex.org/C2776016237","wikidata":"https://www.wikidata.org/wiki/Q178430","display_name":"Lysine","level":3,"score":0.25519999861717224},{"id":"https://openalex.org/C2777604212","wikidata":"https://www.wikidata.org/wiki/Q407944","display_name":"Imide","level":2,"score":0.2549000084400177}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.64898/2026.08.28.747849","doi":"https://doi.org/10.64898/2026.08.28.747849","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.28.747849","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/08/31/2026.08.28.747849.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pure.mpg.de:item_3728460","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/21.11116/0000-0013-7FCE-6","pdf_url":null,"source":{"id":"https://openalex.org/S4306400654","display_name":"MPG.PuRe (Max Planck Society)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I149899117","host_organization_name":"Max Planck Society","host_organization_lineage":["https://openalex.org/I149899117"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/preprint"}],"best_oa_location":{"id":"doi:10.64898/2026.08.28.747849","doi":"https://doi.org/10.64898/2026.08.28.747849","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.28.747849","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/08/31/2026.08.28.747849.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G6607683866","display_name":null,"funder_award_id":"ID23\u20101","funder_id":"https://openalex.org/F4320320887","funder_display_name":"European Synchrotron Radiation Facility"}],"funders":[{"id":"https://openalex.org/F4320320887","display_name":"European Synchrotron Radiation Facility","ror":"https://ror.org/02550n020"},{"id":"https://openalex.org/F4320322434","display_name":"Max-Planck-Gesellschaft","ror":"https://ror.org/01hhn8329"},{"id":"https://openalex.org/F4320322463","display_name":"Paul Scherrer Institut","ror":"https://ror.org/03eh3y714"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204771473.pdf","grobid_xml":"https://content.openalex.org/works/W7204771473.grobid-xml"},"referenced_works_count":18,"referenced_works":["https://openalex.org/W1987995025","https://openalex.org/W2007615306","https://openalex.org/W2026053775","https://openalex.org/W2124026197","https://openalex.org/W2159211495","https://openalex.org/W2161413435","https://openalex.org/W2224661388","https://openalex.org/W3111864750","https://openalex.org/W4213051931","https://openalex.org/W4248872320","https://openalex.org/W4284888202","https://openalex.org/W4306810360","https://openalex.org/W4308500192","https://openalex.org/W4317214432","https://openalex.org/W4411983851","https://openalex.org/W4412629733","https://openalex.org/W4413346119","https://openalex.org/W7117477185"],"related_works":["https://openalex.org/W7167767297","https://openalex.org/W3165402840","https://openalex.org/W7221984602","https://openalex.org/W4400672753","https://openalex.org/W2891071960","https://openalex.org/W4306810360","https://openalex.org/W4409048837","https://openalex.org/W7168268502","https://openalex.org/W4310497494","https://openalex.org/W4319460915"],"abstract_inverted_index":{"Abstract":[0],"Cereblon":[1],"(CRBN)":[2],"is":[3],"widely":[4],"used":[5],"in":[6,120],"targeted":[7],"protein":[8],"degradation,":[9],"but":[10],"its":[11,114],"ligand":[12,32,61,156,179],"space":[13,33],"has":[14],"remained":[15],"dominated":[16],"by":[17,48],"a":[18,68,74,121],"narrow":[19],"set":[20],"of":[21,43,76,87,158,182,189,211],"cyclic":[22],"imide":[23,128],"chemotypes.":[24],"Here,":[25],"we":[26],"show":[27],"that":[28,147],"the":[29,91,102,117,126,145,154,177,183,204],"accessible":[30,165],"CRBN":[31,81,104,191,212,223],"extends":[34],"substantially":[35],"beyond":[36],"this":[37,133],"canonical":[38,92,127,190],"space.":[39],"A":[40],"high-throughput":[41],"screen":[42],">":[44],"40,000":[45],"compounds,":[46,72],"followed":[47],"orthogonal":[49],"biophysical":[50],"validation,":[51],"X-ray":[52],"crystallography":[53],"and":[54,73,141,170,193,207,214],"SAR":[55,131],"analyses,":[56],"identified":[57,178],"several":[58,86,194],"chemically":[59],"distinct":[60,83],"classes.":[62],"These":[63],"include":[64],"linear":[65],"acetyl-based":[66],"motifs,":[67],"phthalide-derived":[69],"scaffold,":[70],"steroidal":[71,149],"range":[75],"bicyclic":[77],"ligands.":[78],"They":[79],"engage":[80],"through":[82],"recognition":[84,213],"modes,":[85],"which":[88],"deviate":[89],"from":[90],"hydrogen-bonding":[93],"pattern.":[94],"Steroidal":[95],"scaffolds":[96,166],"were":[97],"particularly":[98],"notable:":[99],"cortisone":[100],"binds":[101],"human":[103],"thalidomide-binding":[105],"domain":[106],"with":[107,113,167],"an":[108],"affinity":[109,169],"comparable":[110],"to":[111,153],"thalidomide,":[112],"A-ring":[115],"occupying":[116],"tri-tryptophan":[118],"pocket":[119],"glutarimide-like":[122],"orientation":[123],"despite":[124],"lacking":[125],"NH":[129],"donor.":[130],"within":[132],"series":[134],"showed":[135,195],"substantial":[136],"tolerance":[137],"for":[138,173,219],"chemical":[139],"modification":[140],"scaffold":[142],"simplification,":[143],"raising":[144],"possibility":[146],"endogenous":[148],"metabolites":[150],"may":[151],"contribute":[152],"physiological":[155,209],"landscape":[157,210],"CRBN.":[159],"Bicyclic":[160],"lactams":[161],"additionally":[162],"provided":[163],"synthetically":[164],"tunable":[168],"promising":[171],"sites":[172],"linker":[174],"attachment.":[175],"Across":[176],"classes,":[180],"none":[181],"tested":[184],"representatives":[185],"induced":[186],"detectable":[187],"degradation":[188],"neosubstrates,":[192],"largely":[196],"clean":[197],"proteomic":[198],"profiles.":[199],"Together,":[200],"these":[201],"findings":[202],"broaden":[203],"chemical,":[205],"mechanistic":[206],"potential":[208],"provide":[215],"diverse":[216],"starting":[217],"points":[218],"alternative,":[220],"potentially":[221],"neosubstrate-sparing":[222],"recruiters.":[224]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-09-01T00:00:00"}