{"id":"https://openalex.org/W7204770731","doi":"https://doi.org/10.2174/0129496632446167260818103513","title":"Unraveling Hemophilia in the Modern Era: From Pathogenesis to Emerging Therapies","display_name":"Unraveling Hemophilia in the Modern Era: From Pathogenesis to Emerging Therapies","publication_year":2026,"publication_date":"2026-08-28","ids":{"openalex":"https://openalex.org/W7204770731","doi":"https://doi.org/10.2174/0129496632446167260818103513"},"language":"en","primary_location":{"id":"doi:10.2174/0129496632446167260818103513","doi":"https://doi.org/10.2174/0129496632446167260818103513","is_oa":false,"landing_page_url":"https://doi.org/10.2174/0129496632446167260818103513","pdf_url":null,"source":{"id":"https://openalex.org/S4404674970","display_name":"Current advances in medicine.","issn_l":"2949-6632","issn":["2949-6632","2949-6640"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Advances in Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5137409183","display_name":"Hridika Jain","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405260619","display_name":"Sagar Institute of Research, Technology & Science \u2013 Pharmacy","ror":"https://ror.org/041naj703","country_code":"IN","type":"education","lineage":["https://openalex.org/I4405260619"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Hridika Jain","raw_affiliation_strings":["Sagar Institute of Research, Technology & Science-Pharmacy, Bhopal Madhya Pradesh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sagar Institute of Research, Technology & Science-Pharmacy, Bhopal Madhya Pradesh, India","institution_ids":["https://openalex.org/I4405260619"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070139581","display_name":"Swati Rathore","orcid":"https://orcid.org/0000-0002-7665-5164","observed_orcids":["https://orcid.org/0000-0002-7665-5164"]},"institutions":[{"id":"https://openalex.org/I4405260619","display_name":"Sagar Institute of Research, Technology & Science \u2013 Pharmacy","ror":"https://ror.org/041naj703","country_code":"IN","type":"education","lineage":["https://openalex.org/I4405260619"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Swati Rathore","raw_affiliation_strings":["Sagar Institute of Research, Technology & Science-Pharmacy, Bhopal Madhya Pradesh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sagar Institute of Research, Technology & Science-Pharmacy, Bhopal Madhya Pradesh, India","institution_ids":["https://openalex.org/I4405260619"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5138875844","display_name":"Dr. Nilesh Jain","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405260619","display_name":"Sagar Institute of Research, Technology & Science \u2013 Pharmacy","ror":"https://ror.org/041naj703","country_code":"IN","type":"education","lineage":["https://openalex.org/I4405260619"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Nilesh Jain","raw_affiliation_strings":["Sagar Institute of Research, Technology & Science-Pharmacy, Bhopal Madhya Pradesh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sagar Institute of Research, Technology & Science-Pharmacy, Bhopal Madhya Pradesh, India","institution_ids":["https://openalex.org/I4405260619"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059714591","display_name":"R. B. Goswami","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405260619","display_name":"Sagar Institute of Research, Technology & Science \u2013 Pharmacy","ror":"https://ror.org/041naj703","country_code":"IN","type":"education","lineage":["https://openalex.org/I4405260619"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"R.B. Goswami","raw_affiliation_strings":["Sagar Institute of Research, Technology & Science-Pharmacy, Bhopal Madhya Pradesh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sagar Institute of Research, Technology & Science-Pharmacy, Bhopal Madhya Pradesh, India","institution_ids":["https://openalex.org/I4405260619"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5070139581"],"corresponding_institution_ids":["https://openalex.org/I4405260619"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"02","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11280","display_name":"Hemophilia Treatment and Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11280","display_name":"Hemophilia Treatment and Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11917","display_name":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hemophilia","display_name":"hemophilia","score":0.8539999723434448},{"id":"https://openalex.org/keywords/hemophilia-a","display_name":"hemophilia A","score":0.9959999918937683},{"id":"https://openalex.org/keywords/hemophilia-b","display_name":"hemophilia B","score":1.0},{"id":"https://openalex.org/keywords/x-linked-bleeding-disorder","display_name":"X-linked bleeding disorder","score":0.7210000157356262},{"id":"https://openalex.org/keywords/inhibitor-development","display_name":"inhibitor development","score":0.6830000281333923},{"id":"https://openalex.org/keywords/prophylaxis","display_name":"prophylaxis","score":0.7929999828338623},{"id":"https://openalex.org/keywords/gene-therapy","display_name":"gene therapy","score":0.7250000238418579},{"id":"https://openalex.org/keywords/adeno-associated-virus-vectors","display_name":"adeno-associated virus vectors","score":0.8330000042915344},{"id":"https://openalex.org/keywords/crispr","display_name":"CRISPR","score":0.8769999742507935},{"id":"https://openalex.org/keywords/emicizumab","display_name":"emicizumab","score":0.9570000171661377},{"id":"https://openalex.org/keywords/fitusiran","display_name":"fitusiran","score":0.9919999837875366},{"id":"https://openalex.org/keywords/concizumab","display_name":"concizumab","score":0.9980000257492065},{"id":"https://openalex.org/keywords/factor-substitution","display_name":"factor substitution","score":0.5440000295639038},{"id":"https://openalex.org/keywords/pathophysiology","display_name":"pathophysiology","score":0.6110000014305115},{"id":"https://openalex.org/keywords/diagnosis","display_name":"diagnosis","score":0.4339999854564667}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8191999793052673},{"id":"https://openalex.org/C2781221834","wikidata":"https://www.wikidata.org/wiki/Q425360","display_name":"Factor IX","level":2,"score":0.589900016784668},{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.5385000109672546},{"id":"https://openalex.org/C2778382381","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Coagulation","level":2,"score":0.4878000020980835},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.48649999499320984},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.43639999628067017},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.43459999561309814},{"id":"https://openalex.org/C3020646304","wikidata":"https://www.wikidata.org/wiki/Q1773974","display_name":"Prophylactic treatment","level":2,"score":0.3849000036716461},{"id":"https://openalex.org/C2779951463","wikidata":"https://www.wikidata.org/wiki/Q7268788","display_name":"Quality of life (healthcare)","level":2,"score":0.3239000141620636},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.314300000667572},{"id":"https://openalex.org/C2992139802","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Clotting factor","level":2,"score":0.30649998784065247},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3034000098705292},{"id":"https://openalex.org/C2778961111","wikidata":"https://www.wikidata.org/wiki/Q5940878","display_name":"Recombinant factor VIIa","level":2,"score":0.29750001430511475},{"id":"https://openalex.org/C3020284061","wikidata":"https://www.wikidata.org/wiki/Q5194613","display_name":"Curative treatment","level":3,"score":0.2840000092983246},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.28290000557899475},{"id":"https://openalex.org/C2778384578","wikidata":"https://www.wikidata.org/wiki/Q16930687","display_name":"Therapeutic approach","level":3,"score":0.2711000144481659},{"id":"https://openalex.org/C140608501","wikidata":"https://www.wikidata.org/wiki/Q7318358","display_name":"Review article","level":2,"score":0.26339998841285706},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.25690001249313354},{"id":"https://openalex.org/C2779931649","wikidata":"https://www.wikidata.org/wiki/Q416510","display_name":"C1-inhibitor","level":3,"score":0.25540000200271606},{"id":"https://openalex.org/C3018928802","wikidata":"https://www.wikidata.org/wiki/Q83185","display_name":"Gene transfer","level":3,"score":0.25290000438690186}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.2174/0129496632446167260818103513","doi":"https://doi.org/10.2174/0129496632446167260818103513","is_oa":false,"landing_page_url":"https://doi.org/10.2174/0129496632446167260818103513","pdf_url":null,"source":{"id":"https://openalex.org/S4404674970","display_name":"Current advances in medicine.","issn_l":"2949-6632","issn":["2949-6632","2949-6640"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Advances in Medicine","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7171698725","https://openalex.org/W4415670474","https://openalex.org/W7167816019","https://openalex.org/W4414520457","https://openalex.org/W7125417900","https://openalex.org/W4411743988","https://openalex.org/W7163183277","https://openalex.org/W4401168986","https://openalex.org/W7214245456","https://openalex.org/W3046017135"],"abstract_inverted_index":{"Introduction:":[0],"Hemophilia":[1,171,219],"is":[2,220],"a":[3,11,38,141,193,221],"rare":[4],"X-linked":[5],"inherited":[6],"bleeding":[7,31,123,156],"disorder":[8,223],"caused":[9],"by":[10],"deficiency":[12],"of":[13,41,80,117,137,161,170,231],"coagulation":[14],"factor":[15,20,96,183,233],"VIII":[16,184],"(hemophilia":[17,22],"A)":[18],"/":[19],"IX":[21,186],"B),":[23],"resulting":[24],"in":[25,135,155],"impaired":[26],"clot":[27],"formation":[28],"and":[29,47,60,82,100,112,127,149,158,173,185,203,209,214,226,242,252,258,263],"recurrent":[30],"episodes.":[32],"This":[33,245],"review":[34,70,246],"aims":[35],"to":[36,63],"provide":[37],"comprehensive":[39,68],"overview":[40],"the":[42],"epidemiology,":[43],"pathophysiology,":[44],"diagnostic":[45],"approaches,":[46,211],"evolving":[48,227],"therapeutic":[49],"strategies":[50],"for":[51,261],"hemophilia.":[52],"It":[53],"focuses":[54],"on":[55,89,176],"current":[56],"treatments,":[57],"inhibitor":[58,101,132],"complications,":[59],"emerging":[61,236],"therapies":[62,237],"improve":[64,212],"outcomes.":[65],"Methods:":[66],"A":[67,172],"literature":[69,90],"was":[71,87],"conducted":[72],"using":[73,206],"established":[74],"databases,":[75],"including":[76,146,180],"PubMed,":[77],"Scopus,":[78],"Web":[79],"Science,":[81],"Google":[83],"Scholar.":[84],"Particular":[85],"emphasis":[86],"placed":[88],"covering":[91],"gene":[92,150,204],"therapy,":[93,151,179],"extended":[94,181],"half-life":[95,182],"concentrates,":[97],"non-factor":[98,147],"therapies,":[99,145,197],"management.":[102],"Results:":[103],"The":[104,164],"study":[105],"found":[106],"that":[107,167],"hemophilia":[108],"primarily":[109],"affects":[110],"males":[111],"presents":[113],"with":[114,187,235],"varying":[115],"degrees":[116],"severity.":[118],"Prophylactic":[119],"therapy":[120,205],"significantly":[121,239],"reduces":[122],"rates":[124],"(by":[125],"~70-90%)":[126],"prevents":[128],"joint":[129],"damage.":[130],"However,":[131],"development":[133,191],"(seen":[134],"~20-30%":[136],"severe":[138],"cases)":[139],"remains":[140,192],"key":[142,248],"challenge.":[143,195],"Emerging":[144,196],"treatments":[148],"show":[152,166],"substantial":[153],"improvement":[154],"control":[157],"patient":[159],"quality":[160],"life.":[162],"Discussion:":[163],"findings":[165],"effective":[168],"management":[169],"B":[174],"relies":[175],"early":[177],"prophylactic":[178],"pharmacokinetic-guided":[188],"dosing.":[189],"Inhibitor":[190],"major":[194],"such":[198],"as":[199],"Emicizumab,":[200],"Fitusiran,":[201],"Concizumab,":[202],"AAV":[207],"vectors":[208],"CRISPR":[210],"outcomes":[213,241],"reduce":[215],"treatment":[216,228],"burden.":[217],"Conclusion:":[218],"lifelong":[222],"requiring":[224],"individualized":[225],"strategies.":[229],"Integration":[230],"conventional":[232],"replacement":[234],"has":[238],"improved":[240],"reduced":[243],"morbidity.":[244],"highlights":[247],"challenges,":[249],"recent":[250],"advances,":[251],"future":[253],"directions,":[254],"providing":[255],"an":[256],"updated":[257],"concise":[259],"resource":[260],"clinical":[262],"research":[264],"applications.":[265]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2026-09-01T00:00:00"}
