{"id":"https://openalex.org/W7204770709","doi":"https://doi.org/10.3390/molecules31173032","title":"Chemistry and Biological Activity of 11H-Indeno[1,2-b]quinoxalin-11-ones and Tryptanthrins, Their Oximes, and Related Analogues","display_name":"Chemistry and Biological Activity of 11H-Indeno[1,2-b]quinoxalin-11-ones and Tryptanthrins, Their Oximes, and Related Analogues","publication_year":2026,"publication_date":"2026-08-28","ids":{"openalex":"https://openalex.org/W7204770709","doi":"https://doi.org/10.3390/molecules31173032","pmid":"https://pubmed.ncbi.nlm.nih.gov/42738692","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13567725"},"language":"en","primary_location":{"id":"doi:10.3390/molecules31173032","doi":"https://doi.org/10.3390/molecules31173032","is_oa":true,"landing_page_url":"https://doi.org/10.3390/molecules31173032","pdf_url":null,"source":{"id":"https://openalex.org/S108911230","display_name":"Molecules","issn_l":"1420-3049","issn":["1420-3049","1433-1373"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","medline","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/molecules31173032","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013186412","display_name":"Igor A. Schepetkin","orcid":"https://orcid.org/0000-0003-2139-8110","observed_orcids":["https://orcid.org/0000-0003-2139-8110"]},"institutions":[{"id":"https://openalex.org/I23732399","display_name":"Montana State University","ror":"https://ror.org/02w0trx84","country_code":"US","type":"education","lineage":["https://openalex.org/I23732399","https://openalex.org/I4210126032"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Igor A. Schepetkin","raw_affiliation_strings":["Department of Plant Science and Plant Pathology, Montana State University, Bozeman, MT 59717, USA"],"raw_orcid":"https://orcid.org/0000-0003-2139-8110","affiliations":[{"raw_affiliation_string":"Department of Plant Science and Plant Pathology, Montana State University, Bozeman, MT 59717, USA","institution_ids":["https://openalex.org/I23732399"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065544727","display_name":"\u041c\u0430\u0440\u043a \u0411\u043e\u0440\u0438\u0441\u043e\u0432\u0438\u0447 \u041f\u043b\u043e\u0442\u043d\u0438\u043a\u043e\u0432","orcid":"https://orcid.org/0000-0002-0548-6586","observed_orcids":["https://orcid.org/0000-0002-0548-6586"]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I4210118499","display_name":"Tomsk National Research Medical Center","ror":"https://ror.org/01z0w8p93","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210118499"]},{"id":"https://openalex.org/I4210146658","display_name":"Research Institute of Pharmacology and Regenerative Medicine named ED Goldberg","ror":"https://ror.org/044171329","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210110862","https://openalex.org/I4210146658"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Mark B. Plotnikov","raw_affiliation_strings":["Department of Pharmacology, Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk 634028, Russia"],"raw_orcid":"https://orcid.org/0000-0002-0548-6586","affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk 634028, Russia","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210118499","https://openalex.org/I4210146658"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036515281","display_name":"Anastasia R. Kovrizhina","orcid":"https://orcid.org/0000-0002-9316-0964","observed_orcids":["https://orcid.org/0000-0002-9316-0964"]},"institutions":[{"id":"https://openalex.org/I30849647","display_name":"Tomsk Polytechnic University","ror":"https://ror.org/00a45v709","country_code":"RU","type":"education","lineage":["https://openalex.org/I30849647"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Anastasia R. Kovrizhina","raw_affiliation_strings":["Kizhner Research Center, Tomsk Polytechnic University, Tomsk 634050, Russia"],"raw_orcid":"https://orcid.org/0000-0002-9316-0964","affiliations":[{"raw_affiliation_string":"Kizhner Research Center, Tomsk Polytechnic University, Tomsk 634050, Russia","institution_ids":["https://openalex.org/I30849647"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076540388","display_name":"\u0410ndrei I. Khlebnikov","orcid":"https://orcid.org/0000-0002-3022-4510","observed_orcids":["https://orcid.org/0000-0002-3022-4510"]},"institutions":[{"id":"https://openalex.org/I30849647","display_name":"Tomsk Polytechnic University","ror":"https://ror.org/00a45v709","country_code":"RU","type":"education","lineage":["https://openalex.org/I30849647"]}],"countries":["RU"],"is_corresponding":true,"raw_author_name":"Andrei I. Khlebnikov","raw_affiliation_strings":["Kizhner Research Center, Tomsk Polytechnic University, Tomsk 634050, Russia"],"raw_orcid":"https://orcid.org/0000-0002-3022-4510","affiliations":[{"raw_affiliation_string":"Kizhner Research Center, Tomsk Polytechnic University, Tomsk 634050, Russia","institution_ids":["https://openalex.org/I30849647"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5013186412","https://openalex.org/A5076540388"],"corresponding_institution_ids":["https://openalex.org/I23732399","https://openalex.org/I30849647"],"apc_list":{"value":2700,"currency":"CHF","value_usd":3258},"apc_paid":{"value":2700,"currency":"CHF","value_usd":3258},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"31","issue":"17","first_page":"3032","last_page":"3032"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12318","display_name":"Quinazolinone synthesis and applications","score":0.7109000086784363,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T12318","display_name":"Quinazolinone synthesis and applications","score":0.7109000086784363,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13160","display_name":"Synthesis and Biological Evaluation","score":0.19750000536441803,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.021199999377131462,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tryptanthrin","display_name":"tryptanthrin","score":0.9279999732971191},{"id":"https://openalex.org/keywords/ketoximes","display_name":"ketoximes","score":0.6629999876022339},{"id":"https://openalex.org/keywords/tetracyclic-heterocycles","display_name":"tetracyclic heterocycles","score":0.7860000133514404},{"id":"https://openalex.org/keywords/nitric-oxide-release","display_name":"nitric oxide release","score":0.906000018119812},{"id":"https://openalex.org/keywords/dna-intercalation","display_name":"DNA intercalation","score":0.734000027179718},{"id":"https://openalex.org/keywords/topoisomerase-inhibition","display_name":"topoisomerase inhibition","score":0.8610000014305115},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.8119999766349792},{"id":"https://openalex.org/keywords/cardioprotection","display_name":"cardioprotection","score":0.8510000109672546},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.8690000176429749},{"id":"https://openalex.org/keywords/antimicrobial-activity","display_name":"antimicrobial activity","score":0.7120000123977661},{"id":"https://openalex.org/keywords/antiviral-activity","display_name":"antiviral activity","score":0.9079999923706055},{"id":"https://openalex.org/keywords/antidiabetic-activity","display_name":"antidiabetic activity","score":0.9750000238418579},{"id":"https://openalex.org/keywords/prodrugs","display_name":"prodrugs","score":0.7889999747276306},{"id":"https://openalex.org/keywords/oral-bioavailability","display_name":"oral bioavailability","score":0.5860000252723694},{"id":"https://openalex.org/keywords/structure-activity-optimization","display_name":"structure-activity optimization","score":0.44200000166893005}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8238000273704529},{"id":"https://openalex.org/C108215921","wikidata":"https://www.wikidata.org/wiki/Q603741","display_name":"Prodrug","level":2,"score":0.6194000244140625},{"id":"https://openalex.org/C116073593","wikidata":"https://www.wikidata.org/wiki/Q864491","display_name":"Biological activity","level":3,"score":0.49869999289512634},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.45559999346733093},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.40709999203681946},{"id":"https://openalex.org/C2779676291","wikidata":"https://www.wikidata.org/wiki/Q25325349","display_name":"Cardioprotection","level":3,"score":0.4052000045776367},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.38830000162124634},{"id":"https://openalex.org/C181389837","wikidata":"https://www.wikidata.org/wiki/Q461809","display_name":"Bioavailability","level":2,"score":0.3693999946117401},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3662000000476837},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3621000051498413},{"id":"https://openalex.org/C2776568683","wikidata":"https://www.wikidata.org/wiki/Q23005640","display_name":"Moiety","level":2,"score":0.34119999408721924},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.32350000739097595},{"id":"https://openalex.org/C24107716","wikidata":"https://www.wikidata.org/wiki/Q123619","display_name":"Nucleic acid","level":2,"score":0.3231000006198883},{"id":"https://openalex.org/C49853544","wikidata":"https://www.wikidata.org/wiki/Q206229","display_name":"Biomolecule","level":2,"score":0.3037000000476837},{"id":"https://openalex.org/C2779095896","wikidata":"https://www.wikidata.org/wiki/Q864401","display_name":"Bioisostere","level":4,"score":0.30219998955726624},{"id":"https://openalex.org/C180000673","wikidata":"https://www.wikidata.org/wiki/Q899268","display_name":"Isostere","level":2,"score":0.2930999994277954},{"id":"https://openalex.org/C147897179","wikidata":"https://www.wikidata.org/wiki/Q407828","display_name":"Topoisomerase","level":3,"score":0.2924000024795532},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.28380000591278076},{"id":"https://openalex.org/C2777667214","wikidata":"https://www.wikidata.org/wiki/Q70702","display_name":"Alkaloid","level":2,"score":0.2777000069618225},{"id":"https://openalex.org/C193042331","wikidata":"https://www.wikidata.org/wiki/Q1772003","display_name":"Structure\u2013activity relationship","level":3,"score":0.26510000228881836},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.26429998874664307},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.2614000141620636},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.2590999901294708},{"id":"https://openalex.org/C114373084","wikidata":"https://www.wikidata.org/wiki/Q273499","display_name":"Chemical synthesis","level":3,"score":0.25540000200271606},{"id":"https://openalex.org/C178910836","wikidata":"https://www.wikidata.org/wiki/Q2196961","display_name":"Molecular model","level":2,"score":0.25209999084472656}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010091","descriptor_name":"Oximes","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D010091","descriptor_name":"Oximes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010091","descriptor_name":"Oximes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011799","descriptor_name":"Quinazolines","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D011799","descriptor_name":"Quinazolines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011799","descriptor_name":"Quinazolines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011810","descriptor_name":"Quinoxalines","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D011810","descriptor_name":"Quinoxalines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011810","descriptor_name":"Quinoxalines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.3390/molecules31173032","doi":"https://doi.org/10.3390/molecules31173032","is_oa":true,"landing_page_url":"https://doi.org/10.3390/molecules31173032","pdf_url":null,"source":{"id":"https://openalex.org/S108911230","display_name":"Molecules","issn_l":"1420-3049","issn":["1420-3049","1433-1373"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","medline","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules","raw_type":"journal-article"},{"id":"pmid:42738692","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42738692","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules (Basel, Switzerland)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13567725","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13567725/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:50e6c909b29b43d6bab197496bdb5ae0","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/50e6c909b29b43d6bab197496bdb5ae0","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Molecules, Vol 31, Iss 17, p 3032 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/molecules31173032","doi":"https://doi.org/10.3390/molecules31173032","is_oa":true,"landing_page_url":"https://doi.org/10.3390/molecules31173032","pdf_url":null,"source":{"id":"https://openalex.org/S108911230","display_name":"Molecules","issn_l":"1420-3049","issn":["1420-3049","1433-1373"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","medline","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2860440486","display_name":null,"funder_award_id":"24-15-00334","funder_id":"https://openalex.org/F4320324099","funder_display_name":"Russian Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320324099","display_name":"Russian Science Foundation","ror":"https://ror.org/03y2gwe85"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":324,"referenced_works":["https://openalex.org/W608106980","https://openalex.org/W1482472850","https://openalex.org/W1570800388","https://openalex.org/W1582771675","https://openalex.org/W1603472158","https://openalex.org/W1661809356","https://openalex.org/W1964219846","https://openalex.org/W1965286878","https://openalex.org/W1969700977","https://openalex.org/W1969765413","https://openalex.org/W1977641857","https://openalex.org/W1979123156","https://openalex.org/W1980952222","https://openalex.org/W1985968189","https://openalex.org/W1986543684","https://openalex.org/W1986559713","https://openalex.org/W1987786291","https://openalex.org/W1991997091","https://openalex.org/W1992999907","https://openalex.org/W1995873550","https://openalex.org/W2001664108","https://openalex.org/W2002964590","https://openalex.org/W2009612717","https://openalex.org/W2010677658","https://openalex.org/W2013474089","https://openalex.org/W2013578773","https://openalex.org/W2018032020","https://openalex.org/W2018863380","https://openalex.org/W2018870897","https://openalex.org/W2024592995","https://openalex.org/W2031223359","https://openalex.org/W2033319743","https://openalex.org/W2041570125","https://openalex.org/W2050886338","https://openalex.org/W2061128142","https://openalex.org/W2063864204","https://openalex.org/W2067587129","https://openalex.org/W2067700384","https://openalex.org/W2068766234","https://openalex.org/W2072785587","https://openalex.org/W2074974381","https://openalex.org/W2077923814","https://openalex.org/W2080667065","https://openalex.org/W2081754414","https://openalex.org/W2083931271","https://openalex.org/W2084346018","https://openalex.org/W2084932146","https://openalex.org/W2085908291","https://openalex.org/W2086041680","https://openalex.org/W2090057886","https://openalex.org/W2093631772","https://openalex.org/W2105651504","https://openalex.org/W2106557745","https://openalex.org/W2107944043","https://openalex.org/W2110142586","https://openalex.org/W2115365839","https://openalex.org/W2116480298","https://openalex.org/W2116734310","https://openalex.org/W2117911046","https://openalex.org/W2125143857","https://openalex.org/W2128781208","https://openalex.org/W2130076204","https://openalex.org/W2131685445","https://openalex.org/W2133605381","https://openalex.org/W2141873900","https://openalex.org/W2143339726","https://openalex.org/W2150651872","https://openalex.org/W2154666375","https://openalex.org/W2156835140","https://openalex.org/W2180684249","https://openalex.org/W2194100220","https://openalex.org/W2262454006","https://openalex.org/W2278839253","https://openalex.org/W2286678624","https://openalex.org/W2291277737","https://openalex.org/W2317325743","https://openalex.org/W2320165253","https://openalex.org/W2326502204","https://openalex.org/W2331903636","https://openalex.org/W2332754891","https://openalex.org/W2339265905","https://openalex.org/W2404357279","https://openalex.org/W2519701916","https://openalex.org/W2529855509","https://openalex.org/W2547733777","https://openalex.org/W2554052453","https://openalex.org/W2574029448","https://openalex.org/W2584148150","https://openalex.org/W2591079983","https://openalex.org/W2732320566","https://openalex.org/W2751165022","https://openalex.org/W2755915654","https://openalex.org/W2757983810","https://openalex.org/W2765968786","https://openalex.org/W2769908909","https://openalex.org/W2770017595","https://openalex.org/W2775069015","https://openalex.org/W2778119694","https://openalex.org/W2784299734","https://openalex.org/W2792241204","https://openalex.org/W2800525511","https://openalex.org/W2800594817","https://openalex.org/W2805403410","https://openalex.org/W2809040279","https://openalex.org/W2809453026","https://openalex.org/W2810895131","https://openalex.org/W2887483204","https://openalex.org/W2887728924","https://openalex.org/W2894875946","https://openalex.org/W2896909997","https://openalex.org/W2897286465","https://openalex.org/W2897589562","https://openalex.org/W2904214782","https://openalex.org/W2908523772","https://openalex.org/W2917653117","https://openalex.org/W2918575008","https://openalex.org/W2928792451","https://openalex.org/W2943479452","https://openalex.org/W2944365360","https://openalex.org/W2944482348","https://openalex.org/W2950718560","https://openalex.org/W2951116386","https://openalex.org/W2952952102","https://openalex.org/W2966791570","https://openalex.org/W2966923919","https://openalex.org/W2969430332","https://openalex.org/W2972100432","https://openalex.org/W2975358522","https://openalex.org/W2979031016","https://openalex.org/W2995209914","https://openalex.org/W2996259866","https://openalex.org/W3002400935","https://openalex.org/W3005001253","https://openalex.org/W3005971589","https://openalex.org/W3009375947","https://openalex.org/W3009890527","https://openalex.org/W3010113588","https://openalex.org/W3011335652","https://openalex.org/W3011940615","https://openalex.org/W3012013856","https://openalex.org/W3013002870","https://openalex.org/W3013850781","https://openalex.org/W3017190776","https://openalex.org/W3019791383","https://openalex.org/W3021339469","https://openalex.org/W3021543211","https://openalex.org/W3023845582","https://openalex.org/W3024505225","https://openalex.org/W3026306953","https://openalex.org/W3035193078","https://openalex.org/W3039788576","https://openalex.org/W3043851936","https://openalex.org/W3048086849","https://openalex.org/W3049340088","https://openalex.org/W3080768191","https://openalex.org/W3081476372","https://openalex.org/W3082628966","https://openalex.org/W3084213042","https://openalex.org/W3107556470","https://openalex.org/W3109251977","https://openalex.org/W3112399583","https://openalex.org/W3116976821","https://openalex.org/W3123344071","https://openalex.org/W3123557119","https://openalex.org/W3126332085","https://openalex.org/W3130059343","https://openalex.org/W3157316353","https://openalex.org/W3158767049","https://openalex.org/W3164704391","https://openalex.org/W3175268592","https://openalex.org/W3185070319","https://openalex.org/W3197608470","https://openalex.org/W3197766230","https://openalex.org/W3199618438","https://openalex.org/W3199671262","https://openalex.org/W3201000578","https://openalex.org/W3206608796","https://openalex.org/W3209443150","https://openalex.org/W3214555669","https://openalex.org/W3216662077","https://openalex.org/W4200165546","https://openalex.org/W4200415670","https://openalex.org/W4205451426","https://openalex.org/W4206552485","https://openalex.org/W4206667531","https://openalex.org/W4211056282","https://openalex.org/W4211179278","https://openalex.org/W4212775794","https://openalex.org/W4213176190","https://openalex.org/W4214608083","https://openalex.org/W4214864394","https://openalex.org/W4220843809","https://openalex.org/W4220915416","https://openalex.org/W4221023876","https://openalex.org/W4224260624","https://openalex.org/W4224264101","https://openalex.org/W4225314451","https://openalex.org/W4242082346","https://openalex.org/W4248324024","https://openalex.org/W4280611512","https://openalex.org/W4281697647","https://openalex.org/W4283217293","https://openalex.org/W4283328835","https://openalex.org/W4283812903","https://openalex.org/W4290790569","https://openalex.org/W4291010290","https://openalex.org/W4292452155","https://openalex.org/W4293527523","https://openalex.org/W4295419556","https://openalex.org/W4295539261","https://openalex.org/W4296191226","https://openalex.org/W4297002792","https://openalex.org/W4297872464","https://openalex.org/W4308388221","https://openalex.org/W4309066232","https://openalex.org/W4310243192","https://openalex.org/W4310736974","https://openalex.org/W4311288007","https://openalex.org/W4311515842","https://openalex.org/W4313158668","https://openalex.org/W4317213630","https://openalex.org/W4317770174","https://openalex.org/W4318219157","https://openalex.org/W4318482981","https://openalex.org/W4320709874","https://openalex.org/W4320920545","https://openalex.org/W4322500213","https://openalex.org/W4360983088","https://openalex.org/W4361294936","https://openalex.org/W4364378125","https://openalex.org/W4367548625","https://openalex.org/W4378213059","https://openalex.org/W4380884452","https://openalex.org/W4380987565","https://openalex.org/W4382068496","https://openalex.org/W4382752083","https://openalex.org/W4385318162","https://openalex.org/W4386575228","https://openalex.org/W4387032978","https://openalex.org/W4387661748","https://openalex.org/W4387668925","https://openalex.org/W4387676152","https://openalex.org/W4387699662","https://openalex.org/W4388651195","https://openalex.org/W4388849313","https://openalex.org/W4388914278","https://openalex.org/W4389613879","https://openalex.org/W4390340463","https://openalex.org/W4390591162","https://openalex.org/W4391097413","https://openalex.org/W4391610045","https://openalex.org/W4392011013","https://openalex.org/W4392513923","https://openalex.org/W4392658877","https://openalex.org/W4392857744","https://openalex.org/W4393041810","https://openalex.org/W4395663275","https://openalex.org/W4396767788","https://openalex.org/W4398763835","https://openalex.org/W4399050152","https://openalex.org/W4399067336","https://openalex.org/W4399379059","https://openalex.org/W4399498390","https://openalex.org/W4399623865","https://openalex.org/W4399901128","https://openalex.org/W4400051546","https://openalex.org/W4400233343","https://openalex.org/W4400280573","https://openalex.org/W4400312503","https://openalex.org/W4400583928","https://openalex.org/W4400591790","https://openalex.org/W4400894793","https://openalex.org/W4401483989","https://openalex.org/W4401512743","https://openalex.org/W4401752112","https://openalex.org/W4401805759","https://openalex.org/W4402036339","https://openalex.org/W4402639514","https://openalex.org/W4402877268","https://openalex.org/W4402909353","https://openalex.org/W4402984212","https://openalex.org/W4403005048","https://openalex.org/W4403479151","https://openalex.org/W4403585318","https://openalex.org/W4403685329","https://openalex.org/W4404733306","https://openalex.org/W4404821828","https://openalex.org/W4404919389","https://openalex.org/W4405918331","https://openalex.org/W4406392599","https://openalex.org/W4407065107","https://openalex.org/W4407756067","https://openalex.org/W4407857233","https://openalex.org/W4408329777","https://openalex.org/W4408389506","https://openalex.org/W4409283618","https://openalex.org/W4409993996","https://openalex.org/W4410017040","https://openalex.org/W4410037572","https://openalex.org/W4410629314","https://openalex.org/W4411171210","https://openalex.org/W4411384416","https://openalex.org/W4412522199","https://openalex.org/W4412600514","https://openalex.org/W4413094438","https://openalex.org/W4413436905","https://openalex.org/W4413835328","https://openalex.org/W4414153557","https://openalex.org/W4414447700","https://openalex.org/W4415224352","https://openalex.org/W4415817248","https://openalex.org/W4415817587","https://openalex.org/W4416821100","https://openalex.org/W4417214693","https://openalex.org/W7117574265","https://openalex.org/W7124900803","https://openalex.org/W7128516269","https://openalex.org/W7128686022","https://openalex.org/W7135220934","https://openalex.org/W7147598613","https://openalex.org/W7160529270","https://openalex.org/W7163003236","https://openalex.org/W7202263961","https://openalex.org/W7202364922"],"related_works":["https://openalex.org/W2897286465","https://openalex.org/W4412176208","https://openalex.org/W7212087216","https://openalex.org/W2061145373","https://openalex.org/W1964261684","https://openalex.org/W2072281037","https://openalex.org/W3164704391","https://openalex.org/W4297872464","https://openalex.org/W2949528788","https://openalex.org/W2089568900"],"abstract_inverted_index":{"Nitrogen-containing":[0],"fused":[1],"tetracyclic":[2,85,244],"systems,":[3],"exemplified":[4],"by":[5],"the":[6,11,34,75,103,119,123],"synthetic":[7],"11H-indeno[1,2-b]quinoxalin-11-one":[8],"core":[9],"and":[10,29,39,60,63,79,87,94,106,112,126,161,168,173,176,192,203,213,228],"natural":[12],"alkaloid":[13],"tryptanthrin":[14],"(indolo[2,1-b]quinazolin-6,12-dione),":[15],"constitute":[16],"structural":[17],"scaffolds":[18],"whose":[19],"rigid,":[20],"planar":[21],"architecture":[22],"enables":[23,64],"high-affinity":[24],"interaction":[25],"with":[26,132,145,240],"nucleic":[27],"acids":[28],"kinase":[30,204],"active":[31],"sites.":[32],"Converting":[33],"exocyclic":[35],"carbonyls":[36],"at":[37],"C-11":[38],"C-6,":[40],"respectively,":[41],"into":[42],"oximes":[43,139],"has":[44],"become":[45],"a":[46,148],"productive":[47],"strategy":[48],"in":[49,156,171],"medicinal":[50],"chemistry.":[51],"This":[52],"transformation":[53],"modulates":[54],"frontier":[55],"orbital":[56],"energies,":[57],"installs":[58],"N,O-":[59],"N,N-chelating":[61],"pharmacophores,":[62],"nitric":[65],"oxide":[66],"(NO)":[67],"release.":[68],"Here,":[69],"we":[70],"summarize":[71],"current":[72],"knowledge":[73],"of":[74,83,158,182],"synthesis,":[76],"stereochemical":[77,237],"characterization,":[78],"diverse":[80],"biological":[81],"activities":[82,194],"these":[84],"ketoximes":[86,245],"related":[88],"derivatives.":[89],"Microwave,":[90],"sonochemical,":[91],"visible-light":[92],"photocatalytic,":[93],"multicomponent":[95],"methods":[96],"now":[97],"afford":[98],"efficient,":[99],"economical":[100],"routes":[101],"to":[102,232],"parent":[104],"ketones":[105],"their":[107,153,164,177],"oximes.":[108],"X-ray":[109],"crystallography,":[110],"spectroscopy,":[111],"density":[113],"functional":[114],"theory":[115],"have":[116],"firmly":[117],"established":[118],"thermodynamic":[120],"preference":[121],"for":[122,152,249],"E-oxime":[124],"configuration":[125],"clarified":[127],"how":[128],"this":[129],"geometry,":[130],"along":[131],"potential":[133],"target-induced":[134],"isomerization,":[135],"shapes":[136],"binding.":[137],"The":[138],"bind":[140],"c-Jun":[141],"N-terminal":[142],"kinases":[143],"(JNK1\u20133)":[144],"high":[146],"affinity,":[147],"property":[149],"that":[150],"accounts":[151],"neuroprotective":[154],"effects":[155],"models":[157],"cerebral":[159],"ischemia":[160],"Alzheimer-like":[162],"pathology,":[163],"dual":[165],"JNK":[166],"inhibition":[167],"NO-mediated":[169],"cardioprotection":[170],"hypertension":[172],"myocardial":[174],"infarction,":[175],"anti-inflammatory":[178],"activity":[179],"via":[180],"suppression":[181],"NF-\u03baB/AP-1":[183],"signaling.":[184],"Broader":[185],"studies":[186],"also":[187],"document":[188],"anticancer,":[189],"antimicrobial,":[190],"antiviral,":[191],"antidiabetic":[193],"arising":[195],"from":[196],"DNA":[197],"intercalation,":[198],"topoisomerase":[199],"inhibition,":[200],"metal-ion":[201],"coordination,":[202],"blockade.":[205],"Compelling":[206],"preclinical":[207],"profiles":[208],"notwithstanding,":[209],"low":[210],"oral":[211],"bioavailability":[212],"rapid":[214],"hepatic":[215],"clearance":[216],"remain":[217],"major":[218],"pharmacokinetic":[219],"obstacles.":[220],"Ongoing":[221],"work":[222],"on":[223],"new":[224],"formulations,":[225],"prodrug":[226],"strategies,":[227],"structure\u2013activity":[229],"optimization":[230],"seeks":[231],"slow":[233],"systemic":[234],"elimination.":[235],"Precise":[236],"definition":[238],"combined":[239],"pleiotropic":[241],"pharmacology":[242],"positions":[243],"as":[246],"attractive":[247],"candidates":[248],"next-generation":[250],"agents":[251],"against":[252],"complex":[253],"multifactorial":[254],"diseases.":[255]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-09-01T00:00:00"}
