{"id":"https://openalex.org/W7204764491","doi":"https://doi.org/10.2174/0118715230490161260817050347","title":"Matrix Metalloproteinases as Mediators of Cutaneous Wound Healing and Tissue Repair","display_name":"Matrix Metalloproteinases as Mediators of Cutaneous Wound Healing and Tissue Repair","publication_year":2026,"publication_date":"2026-08-25","ids":{"openalex":"https://openalex.org/W7204764491","doi":"https://doi.org/10.2174/0118715230490161260817050347","pmid":"https://pubmed.ncbi.nlm.nih.gov/42695312"},"language":"en","primary_location":{"id":"doi:10.2174/0118715230490161260817050347","doi":"https://doi.org/10.2174/0118715230490161260817050347","is_oa":false,"landing_page_url":"https://doi.org/10.2174/0118715230490161260817050347","pdf_url":null,"source":{"id":"https://openalex.org/S2764656217","display_name":"Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry","issn_l":"1568-0142","issn":["1568-0142","1871-5230","1875-6131","1875-614X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","medline","norway-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anti-Inflammatory &amp; Anti-Allergy Agents in Medicinal Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006401405","display_name":"Alankar Shrivastav","orcid":"https://orcid.org/0000-0001-5890-5214","observed_orcids":["https://orcid.org/0000-0001-5890-5214"]},"institutions":[{"id":"https://openalex.org/I2801192375","display_name":"IFTM University","ror":"https://ror.org/02v2sn747","country_code":"IN","type":"education","lineage":["https://openalex.org/I2801192375"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Alankar Shrivastav","raw_affiliation_strings":["Pharmacy Academy, Faculty of Pharmacy, IFTM University, Moradabad, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacy Academy, Faculty of Pharmacy, IFTM University, Moradabad, India","institution_ids":["https://openalex.org/I2801192375"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085806946","display_name":"Harpreet Singh","orcid":"https://orcid.org/0000-0001-5229-6569","observed_orcids":["https://orcid.org/0000-0001-5229-6569","https://orcid.org/0009-0005-7698-1815"]},"institutions":[{"id":"https://openalex.org/I2801192375","display_name":"IFTM University","ror":"https://ror.org/02v2sn747","country_code":"IN","type":"education","lineage":["https://openalex.org/I2801192375"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Harpreet Singh","raw_affiliation_strings":["School of Pharmaceutical Sciences,Faculty of Pharmacy, IFTM University, Moradabad, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmaceutical Sciences,Faculty of Pharmacy, IFTM University, Moradabad, India","institution_ids":["https://openalex.org/I2801192375"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5134232160","display_name":"Navneet Verma","orcid":"https://orcid.org/0000-0002-3803-8456","observed_orcids":["https://orcid.org/0000-0002-3803-8456"]},"institutions":[{"id":"https://openalex.org/I2801192375","display_name":"IFTM University","ror":"https://ror.org/02v2sn747","country_code":"IN","type":"education","lineage":["https://openalex.org/I2801192375"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Navneet Verma","raw_affiliation_strings":["Pharmacy Academy, Faculty of Pharmacy, IFTM University, Moradabad, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacy Academy, Faculty of Pharmacy, IFTM University, Moradabad, India","institution_ids":["https://openalex.org/I2801192375"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061997846","display_name":"Arun Kumar Mishra","orcid":"https://orcid.org/0000-0002-8569-988X","observed_orcids":["https://orcid.org/0000-0002-8569-988X"]},"institutions":[{"id":"https://openalex.org/I2801192375","display_name":"IFTM University","ror":"https://ror.org/02v2sn747","country_code":"IN","type":"education","lineage":["https://openalex.org/I2801192375"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Arun Kumar Mishra","raw_affiliation_strings":["SOS School of Pharmacy, SOS School of Pharmacy, IFTMUniversity, Moradabad, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SOS School of Pharmacy, SOS School of Pharmacy, IFTMUniversity, Moradabad, India","institution_ids":["https://openalex.org/I2801192375"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5006401405"],"corresponding_institution_ids":["https://openalex.org/I2801192375"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.63469529,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"25","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.7958999872207642,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.7958999872207642,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.20180000364780426,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13725","display_name":"Pineapple and bromelain studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/matrix-metalloproteinases","display_name":"matrix metalloproteinases","score":1.0},{"id":"https://openalex.org/keywords/cutaneous-wound-healing","display_name":"skin wound healing","score":0.9789999723434448},{"id":"https://openalex.org/keywords/tissue-repair","display_name":"tissue repair","score":0.8790000081062317},{"id":"https://openalex.org/keywords/extracellular-matrix-remodeling","display_name":"extracellular matrix remodeling","score":0.9449999928474426},{"id":"https://openalex.org/keywords/tissue-inhibitors-of-metalloproteinases","display_name":"tissue inhibitors of metalloproteinases","score":0.8349999785423279},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.6100000143051147},{"id":"https://openalex.org/keywords/re-epithelialization","display_name":"re-epithelialization","score":0.984000027179718},{"id":"https://openalex.org/keywords/fibrosis","display_name":"fibrosis","score":0.7459999918937683},{"id":"https://openalex.org/keywords/chronic-wounds","display_name":"chronic wounds","score":0.9929999709129333},{"id":"https://openalex.org/keywords/scar-formation","display_name":"scar formation","score":0.9369999766349792},{"id":"https://openalex.org/keywords/matrix-metalloproteinase-inhibitors","display_name":"matrix metalloproteinase inhibitors","score":0.5270000100135803}],"concepts":[{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.8849999904632568},{"id":"https://openalex.org/C2780269544","wikidata":"https://www.wikidata.org/wiki/Q1509074","display_name":"Wound healing","level":2,"score":0.7883999943733215},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.7813000082969666},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.642300009727478},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5503000020980835},{"id":"https://openalex.org/C2993873987","wikidata":"https://www.wikidata.org/wiki/Q184753","display_name":"Wound closure","level":3,"score":0.5116999745368958},{"id":"https://openalex.org/C3019223276","wikidata":"https://www.wikidata.org/wiki/Q212410","display_name":"Proteolytic enzymes","level":3,"score":0.4724999964237213},{"id":"https://openalex.org/C2781051411","wikidata":"https://www.wikidata.org/wiki/Q2078852","display_name":"Chronic wound","level":3,"score":0.44909998774528503},{"id":"https://openalex.org/C3020610862","wikidata":"https://www.wikidata.org/wiki/Q1540285","display_name":"Tissue repair","level":2,"score":0.4390000104904175},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.4138000011444092},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.3774000108242035},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.37070000171661377},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3368000090122223},{"id":"https://openalex.org/C106487976","wikidata":"https://www.wikidata.org/wiki/Q685816","display_name":"Matrix (chemical analysis)","level":2,"score":0.32100000977516174},{"id":"https://openalex.org/C55728118","wikidata":"https://www.wikidata.org/wiki/Q425402","display_name":"Metalloproteinase","level":3,"score":0.3012999892234802},{"id":"https://openalex.org/C2776581183","wikidata":"https://www.wikidata.org/wiki/Q25104725","display_name":"Tissue remodeling","level":3,"score":0.28040000796318054},{"id":"https://openalex.org/C2780381497","wikidata":"https://www.wikidata.org/wiki/Q463418","display_name":"Fibroblast","level":3,"score":0.27889999747276306},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2768000066280365},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.2624000012874603},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2619999945163727},{"id":"https://openalex.org/C137738243","wikidata":"https://www.wikidata.org/wiki/Q189092","display_name":"Cell migration","level":3,"score":0.2587999999523163},{"id":"https://openalex.org/C190567982","wikidata":"https://www.wikidata.org/wiki/Q7535422","display_name":"Skin repair","level":3,"score":0.25440001487731934}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.2174/0118715230490161260817050347","doi":"https://doi.org/10.2174/0118715230490161260817050347","is_oa":false,"landing_page_url":"https://doi.org/10.2174/0118715230490161260817050347","pdf_url":null,"source":{"id":"https://openalex.org/S2764656217","display_name":"Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry","issn_l":"1568-0142","issn":["1568-0142","1871-5230","1875-6131","1875-614X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","medline","norway-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anti-Inflammatory &amp; Anti-Allergy Agents in Medicinal Chemistry","raw_type":"journal-article"},{"id":"pmid:42695312","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42695312","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anti-inflammatory & anti-allergy agents in medicinal chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W53846948","https://openalex.org/W7220386392","https://openalex.org/W2008956592","https://openalex.org/W4291677010","https://openalex.org/W2742501995","https://openalex.org/W1997830990","https://openalex.org/W2011569383","https://openalex.org/W1973756962","https://openalex.org/W1975510222","https://openalex.org/W2148923267"],"abstract_inverted_index":{"Matrix":[0],"metalloproteinases":[1],"(MMPs)":[2],"play":[3],"an":[4],"essential":[5],"role":[6],"in":[7,43,78,87],"the":[8,36,55,93,105,130,148],"intricate":[9],"process":[10],"of":[11,14,29,35,107,112,139,151],"wound":[12,64,88,113,157],"healing":[13],"skin":[15],"by":[16],"creating":[17],"a":[18,27],"sequential":[19],"inflammation,":[20],"tissue":[21,44],"generation,":[22],"and":[23,40,46,60,66,90,98,125,134],"remodelling.":[24],"MMPs":[25,108,133],"are":[26,41],"family":[28],"proteolytic":[30],"enzymes":[31],"that":[32],"degrade":[33],"components":[34],"extracellular":[37],"matrix":[38],"(ECM)":[39],"involved":[42],"repair":[45],"regeneration.":[47],"Their":[48],"controlled":[49],"activity":[50,154],"is":[51],"critical":[52],"for":[53,63,67,95],"maintaining":[54],"balance":[56],"between":[57,132],"ECM":[58,123],"deposition":[59],"degradation":[61],"required":[62],"closure":[65],"determining":[68],"whether":[69],"excessive":[70,99,152],"fibrosis":[71],"occurs":[72],"or":[73,85],"chronic":[74,96],"wounds":[75,97],"form.":[76],"Alterations":[77],"either":[79],"direction":[80],"would":[81],"lead":[82],"to":[83,146],"dysfunction":[84],"improvement":[86],"healing,":[89,114],"could":[91],"be":[92],"cause":[94],"scar":[100],"formation.":[101],"This":[102],"review":[103],"discusses":[104],"roles":[106],"at":[109],"different":[110],"stages":[111],"primarily":[115],"focusing":[116],"on":[117],"their":[118,135],"functions":[119],"during":[120,155],"inflammatory":[121],"responses,":[122],"remodelling,":[124],"reepithelialization.":[126],"We":[127],"have":[128],"discussed":[129],"interplay":[131],"TIMPs":[136],"(Tissue":[137],"Inhibitors":[138],"Metalloproteinases),":[140],"as":[141,143],"well":[142],"therapeutic":[144],"strategies":[145],"modulate":[147],"adverse":[149],"effects":[150],"MMP":[153],"cutaneous":[156],"healing.":[158]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2026-09-01T00:00:00"}
