{"id":"https://openalex.org/W7204757816","doi":"https://doi.org/10.1093/molbev/msag224","title":"Multiscale structural evolution of proline-rich protein genes shapes primate salivary defenses","display_name":"Multiscale structural evolution of proline-rich protein genes shapes primate salivary defenses","publication_year":2026,"publication_date":"2026-08-31","ids":{"openalex":"https://openalex.org/W7204757816","doi":"https://doi.org/10.1093/molbev/msag224","pmid":"https://pubmed.ncbi.nlm.nih.gov/42671077","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13637037"},"language":"en","primary_location":{"id":"doi:10.1093/molbev/msag224","doi":"https://doi.org/10.1093/molbev/msag224","is_oa":true,"landing_page_url":"https://doi.org/10.1093/molbev/msag224","pdf_url":"https://academic.oup.com/mbe/advance-article-pdf/doi/10.1093/molbev/msag224/70881254/msag224.pdf","source":{"id":"https://openalex.org/S57552105","display_name":"Molecular Biology and Evolution","issn_l":"0737-4038","issn":["0737-4038","1537-1719"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Biology and Evolution","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/mbe/advance-article-pdf/doi/10.1093/molbev/msag224/70881254/msag224.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034551937","display_name":"William D. Aguado","orcid":"https://orcid.org/0000-0002-9977-7500","observed_orcids":["https://orcid.org/0000-0002-9977-7500"]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William D Aguado","raw_affiliation_strings":["Department of Anthropology, Rutgers, The State University of New Jersey , New Brunswick, NJ 08901 ,"],"raw_orcid":"https://orcid.org/0000-0002-9977-7500","affiliations":[{"raw_affiliation_string":"Department of Anthropology, Rutgers, The State University of New Jersey , New Brunswick, NJ 08901 ,","institution_ids":["https://openalex.org/I102322142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043048140","display_name":"Charikleia Karageorgiou","orcid":"https://orcid.org/0000-0002-6998-6926","observed_orcids":["https://orcid.org/0000-0002-6998-6926"]},"institutions":[{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charikleia Karageorgiou","raw_affiliation_strings":["Department of Biological Sciences, University at Buffalo, The State University of New York , Buffalo, NY 14260 ,"],"raw_orcid":"https://orcid.org/0000-0002-6998-6926","affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, University at Buffalo, The State University of New York , Buffalo, NY 14260 ,","institution_ids":["https://openalex.org/I63190737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148759906","display_name":"Sarah Kassem","orcid":"https://orcid.org/0009-0007-7392-5310","observed_orcids":["https://orcid.org/0009-0007-7392-5310"]},"institutions":[{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah Kassem","raw_affiliation_strings":["Department of Biological Sciences, University at Buffalo, The State University of New York , Buffalo, NY 14260 ,"],"raw_orcid":"https://orcid.org/0009-0007-7392-5310","affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, University at Buffalo, The State University of New York , Buffalo, NY 14260 ,","institution_ids":["https://openalex.org/I63190737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5117866166","display_name":"Raquel Hernandez-Rojas","orcid":"https://orcid.org/0000-0003-3451-204X","observed_orcids":["https://orcid.org/0000-0003-3451-204X"]},"institutions":[{"id":"https://openalex.org/I168635309","display_name":"University of Calgary","ror":"https://ror.org/03yjb2x39","country_code":"CA","type":"education","lineage":["https://openalex.org/I168635309"]},{"id":"https://openalex.org/I4210159379","display_name":"Kids Saving the Rainforest","ror":"https://ror.org/04a7cz929","country_code":"CR","type":"nonprofit","lineage":["https://openalex.org/I4210159379"]}],"countries":["CA","CR"],"is_corresponding":false,"raw_author_name":"Raquel Hern\u00e1ndez Rojas","raw_affiliation_strings":["Department of Anthropology and Archaeology, University of Calgary , Calgary, AB T2N 1N4 ,","KSTR Wildlife Rescue , Quepos, 60601 ,"],"raw_orcid":"https://orcid.org/0000-0003-3451-204X","affiliations":[{"raw_affiliation_string":"Department of Anthropology and Archaeology, University of Calgary , Calgary, AB T2N 1N4 ,","institution_ids":["https://openalex.org/I168635309"]},{"raw_affiliation_string":"KSTR Wildlife Rescue , Quepos, 60601 ,","institution_ids":["https://openalex.org/I4210159379"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038052465","display_name":"Carrie C. Veilleux","orcid":"https://orcid.org/0000-0003-4441-7521","observed_orcids":["https://orcid.org/0000-0003-4441-7521"]},"institutions":[{"id":"https://openalex.org/I128902783","display_name":"Midwestern University","ror":"https://ror.org/046yatd98","country_code":"US","type":"education","lineage":["https://openalex.org/I128902783"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carrie C Veilleux","raw_affiliation_strings":["Department of Anatomy, Midwestern University , Glendale, AZ 85304 ,"],"raw_orcid":"https://orcid.org/0000-0003-4441-7521","affiliations":[{"raw_affiliation_string":"Department of Anatomy, Midwestern University , Glendale, AZ 85304 ,","institution_ids":["https://openalex.org/I128902783"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087614763","display_name":"Amanda Dawn Melin","orcid":"https://orcid.org/0000-0002-0612-2514","observed_orcids":["https://orcid.org/0000-0002-0612-2514"]},"institutions":[{"id":"https://openalex.org/I168635309","display_name":"University of Calgary","ror":"https://ror.org/03yjb2x39","country_code":"CA","type":"education","lineage":["https://openalex.org/I168635309"]},{"id":"https://openalex.org/I4389425471","display_name":"Alberta Children's Hospital Research Institute","ror":"https://ror.org/00gmyvv50","country_code":"CA","type":"facility","lineage":["https://openalex.org/I168635309","https://openalex.org/I4389425471"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Amanda D Melin","raw_affiliation_strings":["Alberta Children's Hospital Research Institute, University of Calgary , Calgary, AB T2N 4N1 ,","Department of Anthropology and Archaeology, University of Calgary , Calgary, AB T2N 1N4 ,","Department of Medical Genetics, University of Calgary , Calgary, AB T2N 4N1 ,"],"raw_orcid":"https://orcid.org/0000-0002-0612-2514","affiliations":[{"raw_affiliation_string":"Alberta Children's Hospital Research Institute, University of Calgary , Calgary, AB T2N 4N1 ,","institution_ids":["https://openalex.org/I168635309","https://openalex.org/I4389425471"]},{"raw_affiliation_string":"Department of Anthropology and Archaeology, University of Calgary , Calgary, AB T2N 1N4 ,","institution_ids":["https://openalex.org/I168635309"]},{"raw_affiliation_string":"Department of Medical Genetics, University of Calgary , Calgary, AB T2N 4N1 ,","institution_ids":["https://openalex.org/I168635309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003985229","display_name":"Erin R. Vogel","orcid":"https://orcid.org/0000-0001-6304-5423","observed_orcids":["https://orcid.org/0000-0001-6304-5423"]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erin R Vogel","raw_affiliation_strings":["Department of Anthropology, Rutgers, The State University of New Jersey , New Brunswick, NJ 08901 ,"],"raw_orcid":"https://orcid.org/0000-0001-6304-5423","affiliations":[{"raw_affiliation_string":"Department of Anthropology, Rutgers, The State University of New Jersey , New Brunswick, NJ 08901 ,","institution_ids":["https://openalex.org/I102322142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064454790","display_name":"Stefan R\u00fchl","orcid":"https://orcid.org/0000-0003-3888-4908","observed_orcids":["https://orcid.org/0000-0003-3888-4908"]},"institutions":[{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stefan Ruhl","raw_affiliation_strings":["Department of Oral Biology, University at Buffalo, The State University of New York , Buffalo, NY 14214 ,"],"raw_orcid":"https://orcid.org/0000-0003-3888-4908","affiliations":[{"raw_affiliation_string":"Department of Oral Biology, University at Buffalo, The State University of New York , Buffalo, NY 14214 ,","institution_ids":["https://openalex.org/I63190737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089236762","display_name":"\u00d6mer G\u00f6k\u00e7\u00fcmen","orcid":"https://orcid.org/0000-0003-4371-679X","observed_orcids":["https://orcid.org/0000-0003-4371-679X"]},"institutions":[{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Omer Gokcumen","raw_affiliation_strings":["Department of Biological Sciences, University at Buffalo, The State University of New York , Buffalo, NY 14260 ,"],"raw_orcid":"https://orcid.org/0000-0003-4371-679X","affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, University at Buffalo, The State University of New York , Buffalo, NY 14260 ,","institution_ids":["https://openalex.org/I63190737"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027952261","display_name":"Petar Pajic","orcid":"https://orcid.org/0000-0002-6791-294X","observed_orcids":["https://orcid.org/0000-0002-6791-294X"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Petar Pajic","raw_affiliation_strings":["Department of Chemistry, Yale University , New Haven, CT 06511 ,"],"raw_orcid":"https://orcid.org/0000-0002-6791-294X","affiliations":[{"raw_affiliation_string":"Department of Chemistry, Yale University , New Haven, CT 06511 ,","institution_ids":["https://openalex.org/I32971472"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5027952261","https://openalex.org/A5089236762"],"corresponding_institution_ids":["https://openalex.org/I32971472","https://openalex.org/I63190737"],"apc_list":{"value":3418,"currency":"USD","value_usd":3418},"apc_paid":{"value":3418,"currency":"USD","value_usd":3418},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.58967144,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"43","issue":"10","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10434","display_name":"Chromosomal and Genetic Variations","score":0.7470999956130981,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10434","display_name":"Chromosomal and Genetic Variations","score":0.7470999956130981,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.12549999356269836,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.03920000046491623,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/proline-rich-proteins","display_name":"proline-rich proteins","score":0.9940000176429749},{"id":"https://openalex.org/keywords/saliva","display_name":"saliva","score":0.6909999847412109},{"id":"https://openalex.org/keywords/gene-family-evolution","display_name":"gene family evolution","score":0.8569999933242798},{"id":"https://openalex.org/keywords/gene-duplication","display_name":"gene duplication","score":0.8349999785423279},{"id":"https://openalex.org/keywords/chromosomal-inversions","display_name":"chromosomal inversions","score":0.8539999723434448},{"id":"https://openalex.org/keywords/structural-variants","display_name":"structural variants","score":0.8180000185966492},{"id":"https://openalex.org/keywords/trinucleotide-repeats","display_name":"trinucleotide repeats","score":0.7490000128746033},{"id":"https://openalex.org/keywords/histidine-rich-peptides","display_name":"histidine-rich peptides","score":0.9010000228881836},{"id":"https://openalex.org/keywords/colobine-primates","display_name":"colobine primates","score":0.8230000138282776},{"id":"https://openalex.org/keywords/folivory","display_name":"folivory","score":0.9950000047683716},{"id":"https://openalex.org/keywords/dietary-ecology","display_name":"dietary ecology","score":0.8159999847412109},{"id":"https://openalex.org/keywords/evolution-of-gene-regulation","display_name":"gene regulatory evolution","score":0.3630000054836273}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9409999847412109},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.7508000135421753},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5591999888420105},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.538100004196167},{"id":"https://openalex.org/C2780509455","wikidata":"https://www.wikidata.org/wiki/Q7380","display_name":"Primate","level":2,"score":0.5058000087738037},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.4927999973297119},{"id":"https://openalex.org/C27149982","wikidata":"https://www.wikidata.org/wiki/Q3456514","display_name":"Tandem repeat","level":4,"score":0.4284000098705292},{"id":"https://openalex.org/C90132467","wikidata":"https://www.wikidata.org/wiki/Q171184","display_name":"Phylogenetics","level":3,"score":0.4090000092983246},{"id":"https://openalex.org/C84597430","wikidata":"https://www.wikidata.org/wiki/Q106227","display_name":"Locus (genetics)","level":3,"score":0.40529999136924744},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.305400013923645},{"id":"https://openalex.org/C504460877","wikidata":"https://www.wikidata.org/wiki/Q155925","display_name":"Saliva","level":2,"score":0.30410000681877136},{"id":"https://openalex.org/C105176652","wikidata":"https://www.wikidata.org/wiki/Q1147112","display_name":"Comparative genomics","level":5,"score":0.30000001192092896},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.29409998655319214},{"id":"https://openalex.org/C7602840","wikidata":"https://www.wikidata.org/wiki/Q746284","display_name":"Gene duplication","level":3,"score":0.2840000092983246},{"id":"https://openalex.org/C5911399","wikidata":"https://www.wikidata.org/wiki/Q2278983","display_name":"Gene family","level":4,"score":0.26570001244544983},{"id":"https://openalex.org/C174600577","wikidata":"https://www.wikidata.org/wiki/Q5533491","display_name":"Genome evolution","level":4,"score":0.2614000141620636},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.25920000672340393}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011323","descriptor_name":"Primates","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012463","descriptor_name":"Saliva","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012463","descriptor_name":"Saliva","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D012471","descriptor_name":"Salivary Proteins and Peptides","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055273","descriptor_name":"Salivary Proline-Rich Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1093/molbev/msag224","doi":"https://doi.org/10.1093/molbev/msag224","is_oa":true,"landing_page_url":"https://doi.org/10.1093/molbev/msag224","pdf_url":"https://academic.oup.com/mbe/advance-article-pdf/doi/10.1093/molbev/msag224/70881254/msag224.pdf","source":{"id":"https://openalex.org/S57552105","display_name":"Molecular Biology and Evolution","issn_l":"0737-4038","issn":["0737-4038","1537-1719"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Biology and Evolution","raw_type":"journal-article"},{"id":"pmid:42671077","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42671077","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular biology and evolution","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13637037","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13637037/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Biol Evol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/molbev/msag224","doi":"https://doi.org/10.1093/molbev/msag224","is_oa":true,"landing_page_url":"https://doi.org/10.1093/molbev/msag224","pdf_url":"https://academic.oup.com/mbe/advance-article-pdf/doi/10.1093/molbev/msag224/70881254/msag224.pdf","source":{"id":"https://openalex.org/S57552105","display_name":"Molecular Biology and Evolution","issn_l":"0737-4038","issn":["0737-4038","1537-1719"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Biology and Evolution","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"score":0.4457661211490631,"display_name":"Life on land","id":"https://metadata.un.org/sdg/15"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1728126001","display_name":"RoL: Salivary proteome evolution as a framework to elucidate the mechanisms of functional change involving genomic structural variation","funder_award_id":"2049947","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G279537525","display_name":null,"funder_award_id":"RGPIN 2017 ?","funder_id":"https://openalex.org/F4320334593","funder_display_name":"Natural Sciences and Engineering Research Council of Canada"},{"id":"https://openalex.org/G4108796634","display_name":"Doctoral Dissertation Research: The influence of plant secondary metabolites on diet selection, nutrition, and health in wild primates","funder_award_id":"2141917","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G5261800174","display_name":"How we came to our senses: dietary ecology and primate sensory evolution","funder_award_id":"rgpin-2017-03782","funder_id":"https://openalex.org/F4320334593","funder_display_name":"Natural Sciences and Engineering Research Council of Canada"},{"id":"https://openalex.org/G5742085326","display_name":"The origins and evolution of ancient genomic structural variants in hominins","funder_award_id":"2123284","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G6114510613","display_name":null,"funder_award_id":"950-231257","funder_id":"https://openalex.org/F4320320994","funder_display_name":"Canada Research Chairs"},{"id":"https://openalex.org/G6162319426","display_name":"Unraveling the anatomical and molecular adaptations of primate touch","funder_award_id":"2218023","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G6555147327","display_name":null,"funder_award_id":"2508185","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G870725323","display_name":"Postdoctoral Fellowship: PRFB: Impact of MUC1 repeat copy number variation on glycosylation and function","funder_award_id":"2508185","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G9000898339","display_name":"Evolutionary and functional impact of common genomic structural variations","funder_award_id":"R35GM156519","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000923429","display_name":null,"funder_award_id":"2049947","funder_id":"https://openalex.org/F4320335353","funder_display_name":"National Science Foundation of Sri Lanka"},{"id":"https://openalex.org/G9000924285","display_name":null,"funder_award_id":"2123284","funder_id":"https://openalex.org/F4320335353","funder_display_name":"National Science Foundation of Sri Lanka"},{"id":"https://openalex.org/G9000925283","display_name":null,"funder_award_id":"BCS 2218023","funder_id":"https://openalex.org/F4320335353","funder_display_name":"National Science Foundation of Sri Lanka"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320308840","display_name":"Leakey Foundation","ror":"https://ror.org/018kdpd27"},{"id":"https://openalex.org/F4320312581","display_name":"Rutgers, The State University of New Jersey","ror":null},{"id":"https://openalex.org/F4320313823","display_name":"Midwestern University","ror":"https://ror.org/046yatd98"},{"id":"https://openalex.org/F4320320994","display_name":"Canada Research Chairs","ror":"https://ror.org/0517h6h17"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334593","display_name":"Natural Sciences and Engineering Research Council of Canada","ror":"https://ror.org/01h531d29"},{"id":"https://openalex.org/F4320335353","display_name":"National Science Foundation of Sri Lanka","ror":"https://ror.org/010xaa060"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204757816.pdf","grobid_xml":"https://content.openalex.org/works/W7204757816.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2072877913","https://openalex.org/W4413419096","https://openalex.org/W1910386307","https://openalex.org/W4391846182","https://openalex.org/W2030998749","https://openalex.org/W1562821108","https://openalex.org/W2921103961","https://openalex.org/W2181599848","https://openalex.org/W2042457279","https://openalex.org/W2092648097"],"abstract_inverted_index":{"Saliva":[0],"forms":[1],"the":[2,7,23,30,33,56,73,81,105,201],"first":[3],"biochemical":[4],"interface":[5],"with":[6,46,173],"environment,":[8],"mediating":[9],"dietary":[10,52,69],"exposure":[11],"and":[12,51,93,175,195,203],"oral":[13],"defense.":[14],"Proline-rich":[15],"proteins":[16,37,185,206],"in":[17,112,123,207],"saliva":[18],"protect":[19],"plant-eating":[20],"mammals":[21],"from":[22],"harmful":[24],"effects":[25],"of":[26,32,75,205],"consuming":[27],"tannins.":[28],"Yet":[29],"evolution":[31,74,204],"genes":[34,101,164],"encoding":[35,169],"these":[36],"remains":[38],"poorly":[39],"resolved.":[40],"Here,":[41],"integrating":[42],"long-read":[43],"genome":[44],"assemblies":[45],"comparative":[47],"genomics,":[48],"phylogenetics,":[49],"transcriptomics,":[50],"data,":[53],"we":[54],"investigate":[55],"salivary":[57],"proline-rich":[58,82,99,128,184],"protein":[59,83,100,129,159],"gene":[60,91],"family":[61],"across":[62],"27":[63],"primate":[64,114],"species":[65],"to":[66,136],"test":[67],"whether":[68],"ecology":[70],"has":[71],"shaped":[72,87],"this":[76],"locus.":[77],"We":[78,145],"find":[79],"that":[80,152],"locus":[84],"is":[85],"dynamic,":[86],"by":[88],"recurrent":[89],"lineage-specific":[90,142,178],"duplications":[92],"inversions.":[94],"Despite":[95],"pervasive":[96],"structural":[97,193],"variation,":[98],"consistently":[102],"rank":[103],"among":[104],"top":[106],"five":[107],"most":[108],"highly":[109],"expressed":[110],"transcripts":[111],"nonhuman":[113],"parotid":[115],"glands,":[116],"indicating":[117],"constraint":[118],"on":[119],"maintaining":[120],"high":[121],"expression":[122],"saliva.":[124,208],"Humans":[125],"retain":[126],"abundant":[127],"expression,":[130],"but":[131],"at":[132],"reduced":[133],"levels":[134],"relative":[135],"other":[137],"primates,":[138],"potentially":[139],"reflecting":[140],"a":[141,154,177,187],"regulatory":[143],"shift.":[144],"further":[146],"identify":[147],"widespread":[148],"exonic":[149],"tandem":[150],"repeats":[151,168],"provide":[153],"flexible":[155],"mechanism":[156],"for":[157,189],"modulating":[158],"composition.":[160],"Notably,":[161],"colobine":[162],"PRH":[163],"independently":[165],"evolved":[166],"trinucleotide":[167],"histidine-rich":[170],"peptides,":[171],"coinciding":[172],"folivory":[174],"suggesting":[176],"adaptation.":[179],"Together,":[180],"our":[181],"results":[182],"position":[183],"as":[186],"model":[188],"understanding":[190],"how":[191],"large-scale":[192],"rearrangements":[194],"fine-scale":[196],"repeat":[197],"expansions":[198],"jointly":[199],"shape":[200],"diversity":[202]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2026-09-01T00:00:00"}
