{"id":"https://openalex.org/W7204757609","doi":"https://doi.org/10.1177/10711007261471156","title":"Platelet-Rich Plasma vs Corticosteroid Injection for Morton Neuroma: A Prospective Unblinded Randomized Comparative Study","display_name":"Platelet-Rich Plasma vs Corticosteroid Injection for Morton Neuroma: A Prospective Unblinded Randomized Comparative Study","publication_year":2026,"publication_date":"2026-08-30","ids":{"openalex":"https://openalex.org/W7204757609","doi":"https://doi.org/10.1177/10711007261471156","pmid":"https://pubmed.ncbi.nlm.nih.gov/42670187"},"language":"en","primary_location":{"id":"doi:10.1177/10711007261471156","doi":"https://doi.org/10.1177/10711007261471156","is_oa":true,"landing_page_url":"https://doi.org/10.1177/10711007261471156","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1177/10711007261471156?download=true","source":{"id":"https://openalex.org/S41600865","display_name":"Foot & Ankle International","issn_l":"1071-1007","issn":["1071-1007","1944-7876"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Foot &amp; Ankle International","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://journals.sagepub.com/doi/pdf/10.1177/10711007261471156?download=true","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078188171","display_name":"Gil Genuth","orcid":"https://orcid.org/0009-0008-5259-0854","observed_orcids":["https://orcid.org/0009-0008-5259-0854"]},"institutions":[{"id":"https://openalex.org/I2800586481","display_name":"Assuta Medical Center","ror":"https://ror.org/04qkymg17","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2800586481"]}],"countries":["IL"],"is_corresponding":true,"raw_author_name":"Gil Genuth","raw_affiliation_strings":["Assuta Medical Centre, Tel Aviv, Israel"],"raw_orcid":"https://orcid.org/0009-0008-5259-0854","affiliations":[{"raw_affiliation_string":"Assuta Medical Centre, Tel Aviv, Israel","institution_ids":["https://openalex.org/I2800586481"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038771116","display_name":"Peter Stavrou","orcid":"https://orcid.org/0000-0002-5226-9517","observed_orcids":["https://orcid.org/0000-0002-5226-9517"]},"institutions":[{"id":"https://openalex.org/I1320133117","display_name":"Royal Adelaide Hospital","ror":"https://ror.org/00carf720","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I1320133117","https://openalex.org/I4392738059"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Peter Stavrou","raw_affiliation_strings":["Royal Adelaide Hospital, Adelaide, South Australia, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Royal Adelaide Hospital, Adelaide, South Australia, Australia","institution_ids":["https://openalex.org/I1320133117"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5126777712","display_name":"Chris Brown","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802931750","display_name":"Flinders Medical Centre","ror":"https://ror.org/020aczd56","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2802931750"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Chris Brown","raw_affiliation_strings":["Flinders Medical Centre, Adelaide, South Australia, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Flinders Medical Centre, Adelaide, South Australia, Australia","institution_ids":["https://openalex.org/I2802931750"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002183773","display_name":"Lukas Daniel Iselin","orcid":"https://orcid.org/0000-0002-3300-6519","observed_orcids":["https://orcid.org/0000-0002-3300-6519"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lukas D. Iselin","raw_affiliation_strings":["Orthopadische Klinik Luzern AG, Luzern, Switzerland"],"raw_orcid":"https://orcid.org/0000-0002-3300-6519","affiliations":[{"raw_affiliation_string":"Orthopadische Klinik Luzern AG, Luzern, Switzerland","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5078188171"],"corresponding_institution_ids":["https://openalex.org/I2800586481"],"apc_list":{"value":4150,"currency":"USD","value_usd":4150},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.67403584,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"47","issue":"10","first_page":"1305","last_page":"1313"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10455","display_name":"Foot and Ankle Surgery","score":0.4000999927520752,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10455","display_name":"Foot and Ankle Surgery","score":0.4000999927520752,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11570","display_name":"Periodontal Regeneration and Treatments","score":0.21899999678134918,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11068","display_name":"Tendon Structure and Treatment","score":0.10649999976158142,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/morton-s-neuroma","display_name":"Morton's neuroma","score":0.9850000143051147},{"id":"https://openalex.org/keywords/platelet-rich-plasma","display_name":"platelet-rich plasma","score":0.996999979019165},{"id":"https://openalex.org/keywords/corticosteroid-injection","display_name":"corticosteroid injection","score":0.9940000176429749},{"id":"https://openalex.org/keywords/forefoot-pain","display_name":"forefoot pain","score":0.9120000004768372},{"id":"https://openalex.org/keywords/leukocyte-poor-prp","display_name":"leukocyte-poor PRP","score":0.875},{"id":"https://openalex.org/keywords/promis-physical-function","display_name":"PROMIS physical function","score":0.7419999837875366},{"id":"https://openalex.org/keywords/pain-interference","display_name":"pain interference","score":0.9769999980926514},{"id":"https://openalex.org/keywords/injection-complications","display_name":"injection complications","score":0.6470000147819519},{"id":"https://openalex.org/keywords/conservative-treatment-failure","display_name":"conservative treatment failure","score":0.652999997138977}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9801999926567078},{"id":"https://openalex.org/C2776804153","wikidata":"https://www.wikidata.org/wiki/Q210420","display_name":"Corticosteroid","level":2,"score":0.7982000112533569},{"id":"https://openalex.org/C2778934081","wikidata":"https://www.wikidata.org/wiki/Q1981345","display_name":"Neuroma","level":2,"score":0.6184999942779541},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.560699999332428},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.48570001125335693},{"id":"https://openalex.org/C2778903070","wikidata":"https://www.wikidata.org/wiki/Q2211240","display_name":"Triamcinolone acetonide","level":2,"score":0.4724999964237213},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.4666000008583069},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.43130001425743103},{"id":"https://openalex.org/C2776577363","wikidata":"https://www.wikidata.org/wiki/Q16989664","display_name":"Forefoot","level":3,"score":0.4187000095844269},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.39079999923706055},{"id":"https://openalex.org/C81182388","wikidata":"https://www.wikidata.org/wiki/Q353963","display_name":"Complication","level":2,"score":0.37540000677108765},{"id":"https://openalex.org/C142424586","wikidata":"https://www.wikidata.org/wiki/Q7307572","display_name":"Refractory (planetary science)","level":2,"score":0.3528999984264374},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.3077999949455261},{"id":"https://openalex.org/C205545832","wikidata":"https://www.wikidata.org/wiki/Q17156455","display_name":"Young adult","level":2,"score":0.2741999924182892},{"id":"https://openalex.org/C3019396726","wikidata":"https://www.wikidata.org/wiki/Q25104748","display_name":"Conservative treatment","level":2,"score":0.2651999890804291},{"id":"https://openalex.org/C198433322","wikidata":"https://www.wikidata.org/wiki/Q3910099","display_name":"Predictive value of tests","level":2,"score":0.2621999979019165},{"id":"https://openalex.org/C2780858735","wikidata":"https://www.wikidata.org/wiki/Q423965","display_name":"Acoustic neuroma","level":2,"score":0.25270000100135803},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.25119999051094055}],"mesh":[{"descriptor_ui":"D000070607","descriptor_name":"Morton Neuroma","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D000070607","descriptor_name":"Morton Neuroma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000070607","descriptor_name":"Morton Neuroma","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D000305","descriptor_name":"Adrenal Cortex Hormones","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000305","descriptor_name":"Adrenal Cortex Hormones","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010147","descriptor_name":"Pain Measurement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053657","descriptor_name":"Platelet-Rich Plasma","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1177/10711007261471156","doi":"https://doi.org/10.1177/10711007261471156","is_oa":true,"landing_page_url":"https://doi.org/10.1177/10711007261471156","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1177/10711007261471156?download=true","source":{"id":"https://openalex.org/S41600865","display_name":"Foot & Ankle International","issn_l":"1071-1007","issn":["1071-1007","1944-7876"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Foot &amp; Ankle International","raw_type":"journal-article"},{"id":"pmid:42670187","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42670187","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Foot & ankle international","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1177/10711007261471156","doi":"https://doi.org/10.1177/10711007261471156","is_oa":true,"landing_page_url":"https://doi.org/10.1177/10711007261471156","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1177/10711007261471156?download=true","source":{"id":"https://openalex.org/S41600865","display_name":"Foot & Ankle International","issn_l":"1071-1007","issn":["1071-1007","1944-7876"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Foot &amp; Ankle International","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204757609.pdf","grobid_xml":"https://content.openalex.org/works/W7204757609.grobid-xml"},"referenced_works_count":21,"referenced_works":["https://openalex.org/W1985735431","https://openalex.org/W2006120363","https://openalex.org/W2071693038","https://openalex.org/W2088310298","https://openalex.org/W2103227881","https://openalex.org/W2106697014","https://openalex.org/W2339386541","https://openalex.org/W2410527853","https://openalex.org/W2514537120","https://openalex.org/W2894634236","https://openalex.org/W2896243120","https://openalex.org/W2968566082","https://openalex.org/W3007997057","https://openalex.org/W3015464273","https://openalex.org/W3133992336","https://openalex.org/W4308554317","https://openalex.org/W4377969153","https://openalex.org/W4391850281","https://openalex.org/W4400205072","https://openalex.org/W4412044467","https://openalex.org/W7137997572"],"related_works":[],"abstract_inverted_index":{"Background:":[0],"Morton":[1,55,254],"neuroma":[2,56,103,175,235],"is":[3],"a":[4,29,60],"common":[5],"cause":[6],"of":[7,77,250,273],"forefoot":[8],"pain,":[9],"often":[10,20],"refractory":[11],"to":[12],"conservative":[13,78],"treatment.":[14,79],"Corticosteroid":[15],"injections":[16,69],"provide":[17],"variable":[18],"and":[19,50,87,94,97,110,115,155,198,232,261],"temporary":[21],"relief.":[22],"Platelet-rich":[23],"plasma":[24],"(PRP)":[25],"has":[26],"emerged":[27],"as":[28],"potential":[30],"biologic":[31],"alternative;":[32],"however,":[33,127],"comparative":[34,43,282],"evidence":[35],"remains":[36],"limited.":[37],"Methods:":[38],"This":[39],"prospective":[40,281],"unblinded":[41],"randomized":[42],"study":[44],"included":[45,102],"60":[46],"patients":[47,72],"with":[48,58,131,228,241],"clinically":[49],"magnetic":[51],"resonance":[52],"imaging":[53],"(MRI)\u2013confirmed":[54],"treated":[57],"either":[59],"single":[61],"corticosteroid":[62,215,242],"injection":[63],"(n=30)":[64],"or":[65,280],"3":[66],"leukocyte-poor":[67],"PRP":[68,128,181,225,251],"(n=30).":[70],"All":[71],"had":[73],"failed":[74],"\u22656":[75],"months":[76,109,239],"Primary":[80],"outcomes":[81,101,133,231],"were":[82,118,196,205],"PROMIS":[83,116,141,156],"Physical":[84],"Function":[85],"(PF)":[86],"Pain":[88],"Interference":[89],"(PI)":[90],"scores":[91,117],"at":[92,107,134,237],"baseline":[93],"3,":[95],"6,":[96],"12":[98,139,238],"months.":[99],"Secondary":[100],"size":[104,176,236],"on":[105],"MRI":[106],"6":[108,173],"complications.":[111],"Results:":[112],"Baseline":[113],"characteristics":[114],"comparable":[119,199,206],"between":[120,200,207],"groups.":[121,201],"Both":[122],"groups":[123],"demonstrated":[124],"significant":[125],"improvement;":[126],"was":[129,143,158,177,226],"associated":[130,227],"better":[132],"all":[135],"time":[136],"points.":[137],"At":[138,172],"months,":[140,174],"PF":[142],"61.8":[144],"\u00b1":[145,149,160,164,184,188],"6.2":[146],"vs":[147,162,186],"55.2":[148],"6.8":[150,165],"(":[151,166],"P":[152,167,191],"<":[153,192],".001),":[154,169],"PI":[157],"38.4":[159],"6.1":[161],"44.2":[163],"=":[168],"favoring":[170],"PRP.":[171],"smaller":[178],"in":[179,213,234,267],"the":[180,214],"group":[182],"(4.2":[183],"1.1":[185],"5.8":[187],"1.4":[189],"mm;":[190],".001).":[193],"Complication":[194],"rates":[195,204],"low":[197],"Post-injection":[202],"pain":[203],"groups;":[208],"Minor":[209],"complications":[210],"occurred":[211],"only":[212],"group,":[216],"although":[217],"differences":[218],"did":[219],"not":[220],"reach":[221],"statistical":[222],"significance.":[223],"Conclusion:":[224],"improved":[229],"clinical":[230],"reduction":[233],"compared":[240],"injection.":[243],"Although":[244],"these":[245],"findings":[246],"support":[247],"further":[248],"investigation":[249],"for":[252],"symptomatic":[253],"neuroma,":[255],"they":[256],"should":[257],"be":[258],"interpreted":[259],"cautiously":[260],"considered":[262],"hypothesis":[263],"generating":[264],"pending":[265],"confirmation":[266],"larger,":[268],"methodologically":[269],"rigorous":[270],"studies.":[271],"Level":[272,275],"Evidence:":[274],"II,":[276],"lesser":[277],"quality":[278],"RCT":[279],"study.":[283]},"counts_by_year":[],"updated_date":"2026-10-13T10:08:12.033832","created_date":"2026-09-01T00:00:00"}