{"id":"https://openalex.org/W7204754669","doi":"https://doi.org/10.3390/ani16172704","title":"Asexual Development and Virulence Are Not Affected by Knockout of Five Sexual-Stage Candidate Genes in Toxoplasma gondii","display_name":"Asexual Development and Virulence Are Not Affected by Knockout of Five Sexual-Stage Candidate Genes in Toxoplasma gondii","publication_year":2026,"publication_date":"2026-08-31","ids":{"openalex":"https://openalex.org/W7204754669","doi":"https://doi.org/10.3390/ani16172704","pmid":"https://pubmed.ncbi.nlm.nih.gov/42738492"},"language":"en","primary_location":{"id":"doi:10.3390/ani16172704","doi":"https://doi.org/10.3390/ani16172704","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ani16172704","pdf_url":null,"source":{"id":"https://openalex.org/S4210168508","display_name":"Animals","issn_l":"2076-2615","issn":["2076-2615"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Animals","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/ani16172704","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5137252004","display_name":"Xing Tian","orcid":"https://orcid.org/0009-0000-4013-8520","observed_orcids":["https://orcid.org/0009-0000-4013-8520"]},"institutions":[{"id":"https://openalex.org/I119868032","display_name":"Shanxi Agricultural University","ror":"https://ror.org/05e9f5362","country_code":"CN","type":"education","lineage":["https://openalex.org/I119868032"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xing Tian","raw_affiliation_strings":["Shanxi Key Laboratory of Animal Disease Research, Prevention and Control, College of Veterinary Medicine, Shanxi Agricultural University, Jinzhong 030801, China"],"raw_orcid":"https://orcid.org/0009-0000-4013-8520","affiliations":[{"raw_affiliation_string":"Shanxi Key Laboratory of Animal Disease Research, Prevention and Control, College of Veterinary Medicine, Shanxi Agricultural University, Jinzhong 030801, China","institution_ids":["https://openalex.org/I119868032"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5126504187","display_name":"Chen-Ran Tian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I119868032","display_name":"Shanxi Agricultural University","ror":"https://ror.org/05e9f5362","country_code":"CN","type":"education","lineage":["https://openalex.org/I119868032"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chen-Ran Tian","raw_affiliation_strings":["Shanxi Key Laboratory of Animal Disease Research, Prevention and Control, College of Veterinary Medicine, Shanxi Agricultural University, Jinzhong 030801, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanxi Key Laboratory of Animal Disease Research, Prevention and Control, College of Veterinary Medicine, Shanxi Agricultural University, Jinzhong 030801, China","institution_ids":["https://openalex.org/I119868032"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5137266414","display_name":"Xin-Sheng Lu","orcid":"https://orcid.org/0009-0003-1528-3904","observed_orcids":["https://orcid.org/0009-0003-1528-3904"]},"institutions":[{"id":"https://openalex.org/I119868032","display_name":"Shanxi Agricultural University","ror":"https://ror.org/05e9f5362","country_code":"CN","type":"education","lineage":["https://openalex.org/I119868032"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xin-Sheng Lu","raw_affiliation_strings":["Shanxi Key Laboratory of Animal Disease Research, Prevention and Control, College of Veterinary Medicine, Shanxi Agricultural University, Jinzhong 030801, China"],"raw_orcid":"https://orcid.org/0009-0003-1528-3904","affiliations":[{"raw_affiliation_string":"Shanxi Key Laboratory of Animal Disease Research, Prevention and Control, College of Veterinary Medicine, Shanxi Agricultural University, Jinzhong 030801, China","institution_ids":["https://openalex.org/I119868032"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023754067","display_name":"WEN-bo HAO","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I119868032","display_name":"Shanxi Agricultural University","ror":"https://ror.org/05e9f5362","country_code":"CN","type":"education","lineage":["https://openalex.org/I119868032"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wen-Bo Hao","raw_affiliation_strings":["Shanxi Key Laboratory of Animal Disease Research, Prevention and Control, College of Veterinary Medicine, Shanxi Agricultural University, Jinzhong 030801, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanxi Key Laboratory of Animal Disease Research, Prevention and Control, College of Veterinary Medicine, Shanxi Agricultural University, Jinzhong 030801, China","institution_ids":["https://openalex.org/I119868032"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101492949","display_name":"Zhi Zheng","orcid":"https://orcid.org/0000-0002-9455-0059","observed_orcids":["https://orcid.org/0000-0002-9455-0059","https://orcid.org/0009-0006-6974-4472"]},"institutions":[{"id":"https://openalex.org/I119868032","display_name":"Shanxi Agricultural University","ror":"https://ror.org/05e9f5362","country_code":"CN","type":"education","lineage":["https://openalex.org/I119868032"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhi Zheng","raw_affiliation_strings":["Shanxi Key Laboratory of Animal Disease Research, Prevention and Control, College of Veterinary Medicine, Shanxi Agricultural University, Jinzhong 030801, China"],"raw_orcid":"https://orcid.org/0009-0006-6974-4472","affiliations":[{"raw_affiliation_string":"Shanxi Key Laboratory of Animal Disease Research, Prevention and Control, College of Veterinary Medicine, Shanxi Agricultural University, Jinzhong 030801, China","institution_ids":["https://openalex.org/I119868032"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002669392","display_name":"Jun-Jun He","orcid":"https://orcid.org/0000-0003-3188-4550","observed_orcids":["https://orcid.org/0000-0003-3188-4550"]},"institutions":[{"id":"https://openalex.org/I195019228","display_name":"Yunnan Agricultural University","ror":"https://ror.org/04dpa3g90","country_code":"CN","type":"education","lineage":["https://openalex.org/I195019228"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jun-Jun He","raw_affiliation_strings":["The Yunnan Key Laboratory of Veterinary Etiological Biology, College of Veterinary Medicine, Yunnan Agricultural University, Kunming 650201, China"],"raw_orcid":"https://orcid.org/0000-0003-3188-4550","affiliations":[{"raw_affiliation_string":"The Yunnan Key Laboratory of Veterinary Etiological Biology, College of Veterinary Medicine, Yunnan Agricultural University, Kunming 650201, China","institution_ids":["https://openalex.org/I195019228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001246506","display_name":"Xing\u2010Quan Zhu","orcid":"https://orcid.org/0000-0003-2530-4628","observed_orcids":["https://orcid.org/0000-0003-2530-4628"]},"institutions":[{"id":"https://openalex.org/I119868032","display_name":"Shanxi Agricultural University","ror":"https://ror.org/05e9f5362","country_code":"CN","type":"education","lineage":["https://openalex.org/I119868032"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xing-Quan Zhu","raw_affiliation_strings":["Shanxi Key Laboratory of Animal Disease Research, Prevention and Control, College of Veterinary Medicine, Shanxi Agricultural University, Jinzhong 030801, China"],"raw_orcid":"https://orcid.org/0000-0003-2530-4628","affiliations":[{"raw_affiliation_string":"Shanxi Key Laboratory of Animal Disease Research, Prevention and Control, College of Veterinary Medicine, Shanxi Agricultural University, Jinzhong 030801, China","institution_ids":["https://openalex.org/I119868032"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029402426","display_name":"Xiao-Nan Zheng","orcid":"https://orcid.org/0009-0004-6224-3603","observed_orcids":["https://orcid.org/0009-0004-6224-3603"]},"institutions":[{"id":"https://openalex.org/I119868032","display_name":"Shanxi Agricultural University","ror":"https://ror.org/05e9f5362","country_code":"CN","type":"education","lineage":["https://openalex.org/I119868032"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiao-Nan Zheng","raw_affiliation_strings":["Shanxi Key Laboratory of Animal Disease Research, Prevention and Control, College of Veterinary Medicine, Shanxi Agricultural University, Jinzhong 030801, China"],"raw_orcid":"https://orcid.org/0009-0004-6224-3603","affiliations":[{"raw_affiliation_string":"Shanxi Key Laboratory of Animal Disease Research, Prevention and Control, College of Veterinary Medicine, Shanxi Agricultural University, Jinzhong 030801, China","institution_ids":["https://openalex.org/I119868032"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5001246506","https://openalex.org/A5029402426"],"corresponding_institution_ids":["https://openalex.org/I119868032"],"apc_list":{"value":2400,"currency":"CHF","value_usd":2896},"apc_paid":{"value":2400,"currency":"CHF","value_usd":2896},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.70365927,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"16","issue":"17","first_page":"2704","last_page":"2704"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11155","display_name":"Toxoplasma gondii Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11155","display_name":"Toxoplasma gondii Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12691","display_name":"Coccidia and coccidiosis research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11154","display_name":"Parasitic infections in humans and animals","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/toxoplasma-gondii","display_name":"Toxoplasma gondii","score":1.0},{"id":"https://openalex.org/keywords/sexual-stages","display_name":"sexual stages","score":0.7429999709129333},{"id":"https://openalex.org/keywords/oocysts","display_name":"oocysts","score":0.6050000190734863},{"id":"https://openalex.org/keywords/asexual-development","display_name":"asexual development","score":0.6759999990463257},{"id":"https://openalex.org/keywords/virulence","display_name":"virulence","score":0.8080000281333923},{"id":"https://openalex.org/keywords/subtilisin-like-protease","display_name":"subtilisin-like protease","score":0.9959999918937683},{"id":"https://openalex.org/keywords/gene-knockout","display_name":"gene knockout","score":0.45899999141693115},{"id":"https://openalex.org/keywords/cyst-formation","display_name":"cyst formation","score":0.6970000267028809},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.3319999873638153},{"id":"https://openalex.org/keywords/transmission-blocking","display_name":"transmission blocking","score":0.5450000166893005},{"id":"https://openalex.org/keywords/single-cell-transcriptomics","display_name":"single-cell transcriptomics","score":0.5659999847412109},{"id":"https://openalex.org/keywords/weighted-gene-co-expression-network-analysis","display_name":"weighted gene co-expression network analysis","score":0.8019999861717224}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9222000241279602},{"id":"https://openalex.org/C2778128430","wikidata":"https://www.wikidata.org/wiki/Q131003","display_name":"Toxoplasma gondii","level":3,"score":0.7799000144004822},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.6970999836921692},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.6665999889373779},{"id":"https://openalex.org/C69991583","wikidata":"https://www.wikidata.org/wiki/Q1423575","display_name":"Candidate gene","level":3,"score":0.6407999992370605},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6208999752998352},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5823000073432922},{"id":"https://openalex.org/C182704531","wikidata":"https://www.wikidata.org/wiki/Q1364740","display_name":"Knockout mouse","level":3,"score":0.5633999705314636},{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.5570999979972839},{"id":"https://openalex.org/C77957584","wikidata":"https://www.wikidata.org/wiki/Q1133550","display_name":"Gene knockout","level":3,"score":0.5321000218391418},{"id":"https://openalex.org/C182220744","wikidata":"https://www.wikidata.org/wiki/Q7251226","display_name":"Proteases","level":3,"score":0.3878999948501587},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.374099999666214},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.3643999993801117},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.3594000041484833},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3452000021934509},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.3212999999523163},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.30640000104904175},{"id":"https://openalex.org/C2779148672","wikidata":"https://www.wikidata.org/wiki/Q25326537","display_name":"Reference genes","level":4,"score":0.30390000343322754},{"id":"https://openalex.org/C2778375072","wikidata":"https://www.wikidata.org/wiki/Q5909198","display_name":"Host\u2013pathogen interaction","level":4,"score":0.28630000352859497},{"id":"https://openalex.org/C2776863245","wikidata":"https://www.wikidata.org/wiki/Q2324689","display_name":"Schistosoma mansoni","level":4,"score":0.2712000012397766},{"id":"https://openalex.org/C2781152039","wikidata":"https://www.wikidata.org/wiki/Q7318278","display_name":"Reverse vaccinology","level":4,"score":0.263700008392334},{"id":"https://openalex.org/C71928629","wikidata":"https://www.wikidata.org/wiki/Q804206","display_name":"Parasite hosting","level":2,"score":0.25929999351501465},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.25690001249313354},{"id":"https://openalex.org/C153726182","wikidata":"https://www.wikidata.org/wiki/Q3720909","display_name":"Intracellular parasite","level":3,"score":0.25619998574256897},{"id":"https://openalex.org/C24284526","wikidata":"https://www.wikidata.org/wiki/Q204785","display_name":"Zinc finger","level":4,"score":0.25200000405311584}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/ani16172704","doi":"https://doi.org/10.3390/ani16172704","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ani16172704","pdf_url":null,"source":{"id":"https://openalex.org/S4210168508","display_name":"Animals","issn_l":"2076-2615","issn":["2076-2615"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Animals","raw_type":"journal-article"},{"id":"pmid:42738492","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42738492","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Animals : an open access journal from MDPI","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13564330","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13564330/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13564330/pdf/animals-16-02704.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Animals (Basel)","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:bd2b55a66ed64da29cb7190a16471754","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/bd2b55a66ed64da29cb7190a16471754","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Animals, Vol 16, Iss 17, p 2704 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/ani16172704","doi":"https://doi.org/10.3390/ani16172704","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ani16172704","pdf_url":null,"source":{"id":"https://openalex.org/S4210168508","display_name":"Animals","issn_l":"2076-2615","issn":["2076-2615"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Animals","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1068607417","display_name":null,"funder_award_id":"2021XG001","funder_id":"https://openalex.org/F4320335595","funder_display_name":"National Natural Science Foundation of China-Yunnan Joint Fund"},{"id":"https://openalex.org/G3464223066","display_name":null,"funder_award_id":"2021XG001","funder_id":"https://openalex.org/F4320328120","funder_display_name":"Shanxi Agricultural University"},{"id":"https://openalex.org/G4164257243","display_name":null,"funder_award_id":"U2202201","funder_id":"https://openalex.org/F4320335595","funder_display_name":"National Natural Science Foundation of China-Yunnan Joint Fund"},{"id":"https://openalex.org/G4775097144","display_name":null,"funder_award_id":"U2202201","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8671566811","display_name":null,"funder_award_id":"2021XG001","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320328120","display_name":"Shanxi Agricultural University","ror":"https://ror.org/05e9f5362"},{"id":"https://openalex.org/F4320335227","display_name":"Bijzonder Onderzoeksfonds UGent","ror":"https://ror.org/00cv9y106"},{"id":"https://openalex.org/F4320335595","display_name":"National Natural Science Foundation of China-Yunnan Joint Fund","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W1554488048","https://openalex.org/W1580003617","https://openalex.org/W1967567650","https://openalex.org/W1969766619","https://openalex.org/W2045507265","https://openalex.org/W2093020034","https://openalex.org/W2093377893","https://openalex.org/W2118614500","https://openalex.org/W2142327485","https://openalex.org/W2155592146","https://openalex.org/W2473194265","https://openalex.org/W2565958256","https://openalex.org/W2602505844","https://openalex.org/W2770646498","https://openalex.org/W2914480421","https://openalex.org/W2926432634","https://openalex.org/W2980566308","https://openalex.org/W3109280925","https://openalex.org/W3117286581","https://openalex.org/W3123199762","https://openalex.org/W3175388032","https://openalex.org/W3194580176","https://openalex.org/W4206187723","https://openalex.org/W4210857788","https://openalex.org/W4280578208","https://openalex.org/W4295309668","https://openalex.org/W4311481146","https://openalex.org/W4311588962","https://openalex.org/W4320711710","https://openalex.org/W4366481724","https://openalex.org/W4380680937","https://openalex.org/W4387130535","https://openalex.org/W4389671973","https://openalex.org/W4391251082","https://openalex.org/W4393229690","https://openalex.org/W4398141147","https://openalex.org/W4404078277","https://openalex.org/W4405761814","https://openalex.org/W4413330608","https://openalex.org/W4413860775","https://openalex.org/W4414004156","https://openalex.org/W7126190337"],"related_works":[],"abstract_inverted_index":{"Toxoplasma":[0,245],"gondii":[1],"is":[2,53],"a":[3,220],"widespread":[4],"intracellular":[5],"parasite":[6],"posing":[7],"serious":[8],"risks":[9],"to":[10,21,127],"immunocompromised":[11],"individuals":[12],"and":[13,16,94,191,233,248],"pregnant":[14],"women,":[15],"causing":[17],"significant":[18,144],"economic":[19],"losses":[20],"the":[22,46,101,110,140,158,162,180],"livestock":[23],"industry.":[24],"Current":[25],"clinical":[26],"drugs":[27],"mainly":[28],"target":[29],"acute-stage":[30],"tachyzoites":[31,190],"but":[32,52,186],"are":[33,205],"ineffective":[34],"against":[35],"chronic":[36],"cysts,":[37],"necessitating":[38],"new":[39],"interventions.":[40],"The":[41],"parasite\u2019s":[42],"sexual":[43,218,246],"stage":[44,122],"in":[45,146,151,189,217],"feline":[47,131,183],"intestine":[48,73],"remains":[49],"poorly":[50],"understood":[51],"critical":[54],"for":[55,207,240],"transmission.":[56],"Here,":[57],"based":[58],"on":[59,244],"our":[60,195],"unpublished":[61],"weighted":[62],"gene":[63],"co-expression":[64],"network":[65],"analysis":[66],"of":[67,71,139,173],"single-cell":[68],"transcriptomic":[69,168],"data":[70,169],"cat":[72],"after":[74],"infection":[75,132],"with":[76,194],"T.":[77],"gondii,":[78],"we":[79,116],"selected":[80],"five":[81],"previously":[82],"uncharacterized":[83],"genes,":[84,235],"including":[85],"three":[86],"CCCH-type":[87],"zinc":[88],"finger":[89],"proteins":[90],"(TGME49_257130,":[91],"TGME49_500318,":[92],"TGME49_313740)":[93],"two":[95],"subtilisin-like":[96],"proteases":[97],"(TGME49_248760/sub7,":[98],"TGME49_235950/sub8).":[99],"Using":[100],"CRISPR-Cas9":[102],"system,":[103],"individual":[104],"knockout":[105,141,231],"strains":[106,142,232],"were":[107,176],"generated":[108],"from":[109,157],"type":[111],"II":[112],"Pru":[113],"strain.":[114],"And,":[115],"performed":[117],"phenotypic":[118,196],"assessments":[119],"at":[120,179],"this":[121],"as":[123],"an":[124,237],"essential":[125],"validation":[126],"confirm":[128],"neutrality":[129],"before":[130],"experiments.":[133],"Phenotypic":[134],"analyses":[135],"revealed":[136],"that":[137,171,202,222],"none":[138],"showed":[143],"differences":[145],"vitro":[147],"growth,":[148],"replication,":[149],"egress,":[150],"vivo":[152],"virulence,":[153],"or":[154,182],"cyst":[155],"formation":[156],"wild-type":[159],"strain,":[160],"corroborating":[161],"transcriptional":[163],"prediction.":[164],"Publicly":[165],"available":[166],"ToxoDB":[167],"confirmed":[170],"four":[172],"these":[174,199,203],"genes":[175,204],"highly":[177],"expressed":[178,188],"oocyst":[181],"enteroepithelial":[184],"stages,":[185],"barely":[187],"bradyzoites,":[192],"consistent":[193],"observations.":[197],"Collectively,":[198],"findings":[200],"indicate":[201],"dispensable":[206],"asexual":[208],"development,":[209],"while":[210],"their":[211],"expression":[212],"pattern":[213],"suggests":[214],"potential":[215],"involvement":[216],"reproduction,":[219],"hypothesis":[221],"warrants":[223],"direct":[224],"experimental":[225,238],"validation.":[226],"This":[227],"study":[228],"provides":[229],"validated":[230],"candidate":[234],"establishing":[236],"foundation":[239],"future":[241],"functional":[242],"studies":[243],"development":[247],"transmission-blocking":[249],"strategies.":[250]},"counts_by_year":[],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2026-09-01T00:00:00"}
