{"id":"https://openalex.org/W7204753415","doi":"https://doi.org/10.5281/zenodo.22208376","title":"Optimized Used Of Solvents In Active Pharmaceutical Ingredients Production by Angelini Eternal Case Study 2","display_name":"Optimized Used Of Solvents In Active Pharmaceutical Ingredients Production by Angelini Eternal Case Study 2","publication_year":2026,"publication_date":"2026-07-01","ids":{"openalex":"https://openalex.org/W7204753415","doi":"https://doi.org/10.5281/zenodo.22208376"},"language":"en","primary_location":{"id":"doi:10.5281/zenodo.22208376","doi":"https://doi.org/10.5281/zenodo.22208376","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.22208376","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.5281/zenodo.22208376","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023487930","display_name":"Tommaso Iacoangeli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210159862","display_name":"Angelini Pharma (Italy)","ror":"https://ror.org/05bz49965","country_code":"IT","type":"company","lineage":["https://openalex.org/I4210159862"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Iacoangeli, Tommaso","raw_affiliation_strings":["Angelini Pharma (Italy)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Angelini Pharma (Italy)","institution_ids":["https://openalex.org/I4210159862"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003199589","display_name":"Andrea Taffuri","orcid":"https://orcid.org/0009-0008-7605-911X","observed_orcids":["https://orcid.org/0009-0008-7605-911X"]},"institutions":[{"id":"https://openalex.org/I4210159862","display_name":"Angelini Pharma (Italy)","ror":"https://ror.org/05bz49965","country_code":"IT","type":"company","lineage":["https://openalex.org/I4210159862"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Taffuri, Andrea","raw_affiliation_strings":["Angelini Pharma (Italy)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Angelini Pharma (Italy)","institution_ids":["https://openalex.org/I4210159862"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210159862"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11053","display_name":"Process Optimization and Integration","score":0.6420999765396118,"subfield":{"id":"https://openalex.org/subfields/2207","display_name":"Control and Systems Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11053","display_name":"Process Optimization and Integration","score":0.6420999765396118,"subfield":{"id":"https://openalex.org/subfields/2207","display_name":"Control and Systems Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13180","display_name":"Chemistry and Chemical Engineering","score":0.3540000021457672,"subfield":{"id":"https://openalex.org/subfields/2304","display_name":"Environmental Chemistry"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10402","display_name":"Phase Equilibria and Thermodynamics","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/1606","display_name":"Physical and Theoretical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/active-pharmaceutical-ingredients","display_name":"active pharmaceutical ingredients","score":0.8659999966621399},{"id":"https://openalex.org/keywords/solvent-recovery","display_name":"solvent recovery","score":0.5789999961853027},{"id":"https://openalex.org/keywords/distillation","display_name":"distillation","score":0.7799999713897705},{"id":"https://openalex.org/keywords/green-solvents","display_name":"green solvents","score":0.9919999837875366},{"id":"https://openalex.org/keywords/bio-based-solvents","display_name":"bio-based solvents","score":0.9959999918937683},{"id":"https://openalex.org/keywords/waste-products","display_name":"waste products","score":0.5070000290870667},{"id":"https://openalex.org/keywords/pharmaceutical-manufacturing","display_name":"pharmaceutical manufacturing","score":0.5479999780654907}],"concepts":[{"id":"https://openalex.org/C45904493","wikidata":"https://www.wikidata.org/wiki/Q912807","display_name":"Active ingredient","level":2,"score":0.6802999973297119},{"id":"https://openalex.org/C2778348673","wikidata":"https://www.wikidata.org/wiki/Q739302","display_name":"Production (economics)","level":2,"score":0.4742000102996826},{"id":"https://openalex.org/C21880701","wikidata":"https://www.wikidata.org/wiki/Q2144042","display_name":"Process engineering","level":1,"score":0.47040000557899475},{"id":"https://openalex.org/C204030448","wikidata":"https://www.wikidata.org/wiki/Q101017","display_name":"Distillation","level":2,"score":0.4239000082015991},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.4237000048160553},{"id":"https://openalex.org/C2780471494","wikidata":"https://www.wikidata.org/wiki/Q146505","display_name":"Solvent","level":2,"score":0.41749998927116394},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.412200003862381},{"id":"https://openalex.org/C18762648","wikidata":"https://www.wikidata.org/wiki/Q42213","display_name":"Work (physics)","level":2,"score":0.3797999918460846},{"id":"https://openalex.org/C2992805683","wikidata":"https://www.wikidata.org/wiki/Q866399","display_name":"Solvent extraction","level":3,"score":0.3425000011920929},{"id":"https://openalex.org/C134121241","wikidata":"https://www.wikidata.org/wiki/Q899301","display_name":"Yield (engineering)","level":2,"score":0.328900009393692},{"id":"https://openalex.org/C2780615140","wikidata":"https://www.wikidata.org/wiki/Q920419","display_name":"Upgrade","level":2,"score":0.3255999982357025},{"id":"https://openalex.org/C2909937950","wikidata":"https://www.wikidata.org/wiki/Q426809","display_name":"Chlorinated solvents","level":3,"score":0.31779998540878296},{"id":"https://openalex.org/C2779652045","wikidata":"https://www.wikidata.org/wiki/Q507443","display_name":"Pharmaceutical industry","level":2,"score":0.3082999885082245},{"id":"https://openalex.org/C548081761","wikidata":"https://www.wikidata.org/wiki/Q180388","display_name":"Waste management","level":1,"score":0.298799991607666},{"id":"https://openalex.org/C19924549","wikidata":"https://www.wikidata.org/wiki/Q1385210","display_name":"Extractive distillation","level":3,"score":0.29499998688697815},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.29339998960494995},{"id":"https://openalex.org/C528095902","wikidata":"https://www.wikidata.org/wiki/Q2283886","display_name":"Pulp and paper industry","level":1,"score":0.26930001378059387}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.5281/zenodo.22208376","doi":"https://doi.org/10.5281/zenodo.22208376","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.22208376","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},{"id":"doi:10.5281/zenodo.22208377","doi":"https://doi.org/10.5281/zenodo.22208377","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.22208377","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.5281/zenodo.22208376","doi":"https://doi.org/10.5281/zenodo.22208376","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.22208376","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},"sustainable_development_goals":[{"score":1.0,"display_name":"Responsible consumption and production","id":"https://metadata.un.org/sdg/12"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8974677380","display_name":"Boosting the reduction of the environmental impact of pharmaceutical products throughout their entire life cycle.","funder_award_id":"101057668","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W6930855381","https://openalex.org/W2782190210","https://openalex.org/W2029217986","https://openalex.org/W2969014465","https://openalex.org/W6987880668","https://openalex.org/W3040511084","https://openalex.org/W2948717248","https://openalex.org/W2136695463","https://openalex.org/W6252130","https://openalex.org/W2609354632"],"abstract_inverted_index":{"As":[0],"part":[1],"of":[2,18,42,75],"the":[3,12,19,40,73,76,84],"Horizon":[4],"Europe":[5],"ETERNAL":[6],"project,":[7],"Angelini":[8],"Pharma":[9],"has":[10],"investigated":[11],"possibility":[13],"to":[14,22,64],"upgrade":[15],"in":[16,51,83],"capability":[17],"distillation":[20],"used":[21],"achieve":[23],"a":[24,34],"challenging":[25],"mixed":[26],"solvent":[27,46],"separation":[28],"and":[29,67],"recovery":[30],"duty":[31],"associated":[32],"with":[33],"current":[35],"commercial":[36],"process,":[37],"while":[38],"studying":[39],"opportunity":[41],"substituting":[43],"green,":[44],"bio-based":[45],"alternatives":[47],"for":[48],"conventional":[49],"solvents":[50],"Active":[52],"Pharmaceutical":[53],"Ingredients":[54],"(APIs)":[55],"manufacture":[56],"whilst":[57],"work":[58],"continues.":[59],"The":[60],"main":[61],"objective":[62],"was":[63],"capture":[65],"impurities":[66],"unreacted":[68],"formulation":[69],"components":[70],"generated":[71],"during":[72],"production":[74],"chemical,":[77],"as":[78,80],"well":[79],"those":[81],"present":[82],"waste":[85],"products.":[86]},"counts_by_year":[],"updated_date":"2026-10-07T09:51:55.459714","created_date":"2026-09-01T00:00:00"}