{"id":"https://openalex.org/W7204750122","doi":"https://doi.org/10.2174/0115748855467673260804080328","title":"Multi-Omics and Molecular Simulations Identify Orthosiphon aristatus Phytochemicals with Predicted Activity Against Tuberculosis via SRC Kinase Modulation as Host-Directed Therapy","display_name":"Multi-Omics and Molecular Simulations Identify Orthosiphon aristatus Phytochemicals with Predicted Activity Against Tuberculosis via SRC Kinase Modulation as Host-Directed Therapy","publication_year":2026,"publication_date":"2026-08-21","ids":{"openalex":"https://openalex.org/W7204750122","doi":"https://doi.org/10.2174/0115748855467673260804080328"},"language":"en","primary_location":{"id":"doi:10.2174/0115748855467673260804080328","doi":"https://doi.org/10.2174/0115748855467673260804080328","is_oa":false,"landing_page_url":"https://doi.org/10.2174/0115748855467673260804080328","pdf_url":null,"source":{"id":"https://openalex.org/S184965954","display_name":"Current Drug Therapy","issn_l":"1574-8855","issn":["1574-8855","2212-3903"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Drug Therapy","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W7204750122"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034549032","display_name":"Fahrauk Faramayuda","orcid":"https://orcid.org/0000-0002-4411-5550","observed_orcids":["https://orcid.org/0000-0002-4411-5550"]},"institutions":[{"id":"https://openalex.org/I4210119108","display_name":"Universitas Jenderal Achmad Yani","ror":"https://ror.org/02k1der83","country_code":"ID","type":"education","lineage":["https://openalex.org/I4210119108"]}],"countries":["ID"],"is_corresponding":true,"raw_author_name":"Fahrauk Faramayuda","raw_affiliation_strings":["Faculty of Pharmacy, Universitas Jenderal Achmad Yani, Jl. Terusan Jenderal Sudirman, Cimahi, West Java, 40531, Indonesia"],"raw_orcid":"https://orcid.org/0000-0002-4411-5550","affiliations":[{"raw_affiliation_string":"Faculty of Pharmacy, Universitas Jenderal Achmad Yani, Jl. Terusan Jenderal Sudirman, Cimahi, West Java, 40531, Indonesia","institution_ids":["https://openalex.org/I4210119108"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041304678","display_name":"Ari Sri Windyaswari","orcid":"https://orcid.org/0009-0009-6185-6447","observed_orcids":["https://orcid.org/0009-0009-6185-6447"]},"institutions":[{"id":"https://openalex.org/I4210119108","display_name":"Universitas Jenderal Achmad Yani","ror":"https://ror.org/02k1der83","country_code":"ID","type":"education","lineage":["https://openalex.org/I4210119108"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Ari Sri Windyaswari","raw_affiliation_strings":["Faculty of Pharmacy, Universitas Jenderal Achmad Yani, Jl. Terusan Jenderal Sudirman, Cimahi, West Java, 40531, Indonesia"],"raw_orcid":"https://orcid.org/0009-0009-6185-6447","affiliations":[{"raw_affiliation_string":"Faculty of Pharmacy, Universitas Jenderal Achmad Yani, Jl. Terusan Jenderal Sudirman, Cimahi, West Java, 40531, Indonesia","institution_ids":["https://openalex.org/I4210119108"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101239680","display_name":"Nursafira Khairunnisa Ismail","orcid":"https://orcid.org/0009-0003-0387-1880","observed_orcids":["https://orcid.org/0009-0003-0387-1880"]},"institutions":[{"id":"https://openalex.org/I4210119108","display_name":"Universitas Jenderal Achmad Yani","ror":"https://ror.org/02k1der83","country_code":"ID","type":"education","lineage":["https://openalex.org/I4210119108"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Nursafira Khairunnisa Ismail","raw_affiliation_strings":["Faculty of Pharmacy, Universitas Jenderal Achmad Yani, Jl. Terusan Jenderal Sudirman, Cimahi, West Java, 40531, Indonesia"],"raw_orcid":"https://orcid.org/0009-0003-0387-1880","affiliations":[{"raw_affiliation_string":"Faculty of Pharmacy, Universitas Jenderal Achmad Yani, Jl. Terusan Jenderal Sudirman, Cimahi, West Java, 40531, Indonesia","institution_ids":["https://openalex.org/I4210119108"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002797443","display_name":"Sartini Sartini","orcid":"https://orcid.org/0000-0001-8155-4467","observed_orcids":["https://orcid.org/0000-0001-8155-4467"]},"institutions":[{"id":"https://openalex.org/I98301867","display_name":"Hasanuddin University","ror":"https://ror.org/00da1gf19","country_code":"ID","type":"education","lineage":["https://openalex.org/I98301867"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Sartini Sartini","raw_affiliation_strings":["Faculty of Pharmacy, Universitas Hasanudin, Makasar, Jl. Perintis Kemerdekaan KM.10, Makasar, South Sulawesi 90245, Indonesia"],"raw_orcid":"https://orcid.org/0000-0001-8155-4467","affiliations":[{"raw_affiliation_string":"Faculty of Pharmacy, Universitas Hasanudin, Makasar, Jl. Perintis Kemerdekaan KM.10, Makasar, South Sulawesi 90245, Indonesia","institution_ids":["https://openalex.org/I98301867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010692232","display_name":"Herlina Rante","orcid":"https://orcid.org/0000-0003-4063-2208","observed_orcids":["https://orcid.org/0000-0003-4063-2208"]},"institutions":[{"id":"https://openalex.org/I98301867","display_name":"Hasanuddin University","ror":"https://ror.org/00da1gf19","country_code":"ID","type":"education","lineage":["https://openalex.org/I98301867"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Herlina Rante","raw_affiliation_strings":["Faculty of Pharmacy, Universitas Hasanudin, Makasar, Jl. Perintis Kemerdekaan KM.10, Makasar, South Sulawesi 90245, Indonesia"],"raw_orcid":"https://orcid.org/0000-0003-4063-2208","affiliations":[{"raw_affiliation_string":"Faculty of Pharmacy, Universitas Hasanudin, Makasar, Jl. Perintis Kemerdekaan KM.10, Makasar, South Sulawesi 90245, Indonesia","institution_ids":["https://openalex.org/I98301867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032477405","display_name":"Sukrasno Sukrasno","orcid":"https://orcid.org/0000-0002-9303-0852","observed_orcids":["https://orcid.org/0000-0002-9303-0852"]},"institutions":[{"id":"https://openalex.org/I134635517","display_name":"Bandung Institute of Technology","ror":"https://ror.org/00apj8t60","country_code":"ID","type":"education","lineage":["https://openalex.org/I134635517"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Sukrasno Sukrasno","raw_affiliation_strings":["School of Pharmacy, Institut Teknologi Bandung, Jl. Ganesa No.10, Bandung, West Java, 40132, Indonesia"],"raw_orcid":"https://orcid.org/0000-0002-9303-0852","affiliations":[{"raw_affiliation_string":"School of Pharmacy, Institut Teknologi Bandung, Jl. Ganesa No.10, Bandung, West Java, 40132, Indonesia","institution_ids":["https://openalex.org/I134635517"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042685663","display_name":"Ani Haerani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405275712","display_name":"Institut Kesehatan Rajawali","ror":"https://ror.org/045f7ep44","country_code":"ID","type":"education","lineage":["https://openalex.org/I4405275712"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Ani Haerani","raw_affiliation_strings":["Department of Pharmacy, Institut Kesehatan Rajawali, Jl. Cihanjuang No.303, Cimahi, West Java, 40559, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Institut Kesehatan Rajawali, Jl. Cihanjuang No.303, Cimahi, West Java, 40559, Indonesia","institution_ids":["https://openalex.org/I4405275712"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148765281","display_name":"Eva Kusumahati","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405275712","display_name":"Institut Kesehatan Rajawali","ror":"https://ror.org/045f7ep44","country_code":"ID","type":"education","lineage":["https://openalex.org/I4405275712"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Eva Kusumahati","raw_affiliation_strings":["Department of Pharmacy, Institut Kesehatan Rajawali, Jl. Cihanjuang No.303, Cimahi, West Java, 40559, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Institut Kesehatan Rajawali, Jl. Cihanjuang No.303, Cimahi, West Java, 40559, Indonesia","institution_ids":["https://openalex.org/I4405275712"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035787829","display_name":"Himaniarwati Himaniarwati","orcid":"https://orcid.org/0000-0002-1348-3553","observed_orcids":["https://orcid.org/0000-0002-1348-3553"]},"institutions":[{"id":"https://openalex.org/I4405276262","display_name":"Universitas Mandala Waluya","ror":"https://ror.org/053hbvk53","country_code":"ID","type":"education","lineage":["https://openalex.org/I4405276262"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Himaniarwati Himaniarwati","raw_affiliation_strings":["Department of Pharmacy, Faculty of Health, Universitas Mandala Waluya, Kendari, Jl. Jend. AH. Nasution, Kendari, Southeast Sulawesi 93561, Indonesia"],"raw_orcid":"https://orcid.org/0000-0002-1348-3553","affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Faculty of Health, Universitas Mandala Waluya, Kendari, Jl. Jend. AH. Nasution, Kendari, Southeast Sulawesi 93561, Indonesia","institution_ids":["https://openalex.org/I4405276262"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013074344","display_name":"Bertha Rusdi","orcid":"https://orcid.org/0000-0001-7082-0272","observed_orcids":["https://orcid.org/0000-0001-7082-0272","https://orcid.org/0000-0002-7109-5460"]},"institutions":[{"id":"https://openalex.org/I4210150439","display_name":"Bandung Islamic University","ror":"https://ror.org/04tp6pr14","country_code":"ID","type":"education","lineage":["https://openalex.org/I4210150439"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Bertha Rusdi","raw_affiliation_strings":["Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Universitas Islam Bandung, Jl. Ranggagading, Bandung, West Java, 40116, Indonesia"],"raw_orcid":"https://orcid.org/0000-0001-7082-0272","affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Universitas Islam Bandung, Jl. Ranggagading, Bandung, West Java, 40116, Indonesia","institution_ids":["https://openalex.org/I4210150439"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065569211","display_name":"Taufik Muhammad Fakih","orcid":"https://orcid.org/0000-0001-7155-4412","observed_orcids":["https://orcid.org/0000-0001-7155-4412"]},"institutions":[{"id":"https://openalex.org/I4210150439","display_name":"Bandung Islamic University","ror":"https://ror.org/04tp6pr14","country_code":"ID","type":"education","lineage":["https://openalex.org/I4210150439"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Taufik Muhammad Fakih","raw_affiliation_strings":["Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Universitas Islam Bandung, Jl. Ranggagading, Bandung, West Java, 40116, Indonesia"],"raw_orcid":"https://orcid.org/0000-0001-7155-4412","affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Universitas Islam Bandung, Jl. Ranggagading, Bandung, West Java, 40116, Indonesia","institution_ids":["https://openalex.org/I4210150439"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044603510","display_name":"Farhan Farhan","orcid":"https://orcid.org/0000-0003-4815-3738","observed_orcids":["https://orcid.org/0000-0003-4815-3738","https://orcid.org/0000-0002-9988-7523"]},"institutions":[{"id":"https://openalex.org/I4405272229","display_name":"Sekolah Tinggi Ilmu Kesehatan Holistik","ror":"https://ror.org/03t356073","country_code":"ID","type":"education","lineage":["https://openalex.org/I4405272229"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Farhan Farhan","raw_affiliation_strings":["Department of Pharmacy, Sekolah Tinggi Ilmu Kesehatan Holistik, Purwakarta, West Java, Indonesia","Holistic Bio Medicine, Jl. Terusan Kapten Halim KM.9 Pondoksalam, Purwakarta, West Java, Indonesia"],"raw_orcid":"https://orcid.org/0000-0002-9988-7523","affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Sekolah Tinggi Ilmu Kesehatan Holistik, Purwakarta, West Java, Indonesia","institution_ids":["https://openalex.org/I4405272229"]},{"raw_affiliation_string":"Holistic Bio Medicine, Jl. Terusan Kapten Halim KM.9 Pondoksalam, Purwakarta, West Java, Indonesia","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5034549032"],"corresponding_institution_ids":["https://openalex.org/I4210119108"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"21","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/orthosiphon-aristatus","display_name":"Orthosiphon aristatus","score":0.9909999966621399},{"id":"https://openalex.org/keywords/cat-s-whiskers","display_name":"cat's whiskers","score":0.9240000247955322},{"id":"https://openalex.org/keywords/tuberculosis","display_name":"tuberculosis","score":0.9570000171661377},{"id":"https://openalex.org/keywords/host-directed-therapy","display_name":"host-directed therapy","score":0.9900000095367432},{"id":"https://openalex.org/keywords/src-kinase","display_name":"Src kinase","score":0.9440000057220459},{"id":"https://openalex.org/keywords/phytochemicals","display_name":"phytochemicals","score":0.890999972820282},{"id":"https://openalex.org/keywords/solanidine","display_name":"solanidine","score":0.9039999842643738},{"id":"https://openalex.org/keywords/network-pharmacology","display_name":"network pharmacology","score":0.6150000095367432},{"id":"https://openalex.org/keywords/molecular-docking","display_name":"molecular docking","score":0.8080000281333923},{"id":"https://openalex.org/keywords/molecular-dynamics-simulation","display_name":"molecular dynamics simulation","score":0.7599999904632568},{"id":"https://openalex.org/keywords/mm-pbsa-binding-free-energy","display_name":"MM-PBSA binding free energy","score":0.843999981880188},{"id":"https://openalex.org/keywords/drug-resistant-tuberculosis","display_name":"drug-resistant tuberculosis","score":0.6700000166893005},{"id":"https://openalex.org/keywords/traditional-medicine","display_name":"traditional medicine","score":0.5609999895095825},{"id":"https://openalex.org/keywords/phenolic-acids","display_name":"phenolic acids","score":0.5540000200271606},{"id":"https://openalex.org/keywords/flavonoids","display_name":"flavonoids","score":0.9559999704360962},{"id":"https://openalex.org/keywords/triterpenoids","display_name":"triterpenoids","score":0.8370000123977661}],"concepts":[{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.699999988079071},{"id":"https://openalex.org/C2778771215","wikidata":"https://www.wikidata.org/wiki/Q50380051","display_name":"Rosmarinic acid","level":3,"score":0.6535000205039978},{"id":"https://openalex.org/C195475562","wikidata":"https://www.wikidata.org/wiki/Q1639139","display_name":"Phytochemical","level":2,"score":0.6330999732017517},{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.5324000120162964},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5058000087738037},{"id":"https://openalex.org/C2777975735","wikidata":"https://www.wikidata.org/wiki/Q130971","display_name":"Mycobacterium tuberculosis","level":3,"score":0.49219998717308044},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4758000075817108},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.46380001306533813},{"id":"https://openalex.org/C2777347573","wikidata":"https://www.wikidata.org/wiki/Q522244","display_name":"Secondary metabolite","level":3,"score":0.43160000443458557},{"id":"https://openalex.org/C108636557","wikidata":"https://www.wikidata.org/wiki/Q21109354","display_name":"Proto-oncogene tyrosine-protein kinase Src","level":3,"score":0.4262000024318695},{"id":"https://openalex.org/C41685203","wikidata":"https://www.wikidata.org/wiki/Q1974042","display_name":"Docking (animal)","level":2,"score":0.39660000801086426},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.36739999055862427},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.35010001063346863},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.33809998631477356},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33399999141693115},{"id":"https://openalex.org/C2776080593","wikidata":"https://www.wikidata.org/wiki/Q415011","display_name":"Luteolin","level":4,"score":0.328000009059906},{"id":"https://openalex.org/C121587506","wikidata":"https://www.wikidata.org/wiki/Q6888113","display_name":"Mode of action","level":2,"score":0.320499986410141},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.31310001015663147},{"id":"https://openalex.org/C2776120743","wikidata":"https://www.wikidata.org/wiki/Q3271540","display_name":"Mechanism of action","level":3,"score":0.2879999876022339},{"id":"https://openalex.org/C2776967927","wikidata":"https://www.wikidata.org/wiki/Q423169","display_name":"Isoniazid","level":3,"score":0.28540000319480896},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.2847000062465668},{"id":"https://openalex.org/C103697762","wikidata":"https://www.wikidata.org/wiki/Q4112105","display_name":"Virtual screening","level":3,"score":0.2612000107765198},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.251800000667572}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.2174/0115748855467673260804080328","doi":"https://doi.org/10.2174/0115748855467673260804080328","is_oa":false,"landing_page_url":"https://doi.org/10.2174/0115748855467673260804080328","pdf_url":null,"source":{"id":"https://openalex.org/S184965954","display_name":"Current Drug Therapy","issn_l":"1574-8855","issn":["1574-8855","2212-3903"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Drug Therapy","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4410570729","https://openalex.org/W4409792354","https://openalex.org/W4414420710","https://openalex.org/W4406978326","https://openalex.org/W4407766599","https://openalex.org/W4411532453","https://openalex.org/W4210254005","https://openalex.org/W7155714889","https://openalex.org/W4415069205","https://openalex.org/W3204597400"],"abstract_inverted_index":{"Introduction:":[0],"Tuberculosis":[1],"(TB)":[2],"remains":[3],"a":[4,28,58,169,217,343,379,386,417],"leading":[5,368],"global":[6],"health":[7],"emergency,":[8],"exacerbated":[9],"by":[10,80,110,149,351],"the":[11,18,144,223,390,407],"rise":[12],"of":[13,20,99,204,314,393,410],"drug-resistant":[14,427],"strains":[15],"that":[16,35,347],"reduce":[17],"efficacy":[19],"conventional":[21],"treatments.":[22],"Amid":[23],"these":[24,411,414],"challenges,":[25],"there":[26],"is":[27,49],"critical":[29],"need":[30],"for":[31,272,285,319,325,332,389,420],"plant-derived":[32,422],"host-directed":[33,345],"therapies":[34,424],"can":[36],"serve":[37],"as":[38,46,222,342,367,378],"adjuvants":[39],"to":[40,88,116,133,158,405,425],"current":[41],"regimens.":[42],"Orthosiphon":[43,373],"aristatus,":[44],"known":[45],"cat\u2019s":[47],"whiskers,":[48],"widely":[50],"used":[51],"in":[52,92,337],"Indonesian":[53],"traditional":[54],"medicine":[55],"and":[56,84,95,153,162,180,200,208,215,256,287,303,327,359,365,375,401],"offers":[57],"rich":[59],"phytochemical":[60],"repertoire":[61],"with":[62,127,220,236,276,282,311],"unexplored":[63],"therapeutic":[64,408],"potential.":[65],"However,":[66],"its":[67,118],"specific":[68],"molecular":[69,85,139,150,266,360],"targets":[70,124,207,211],"against":[71,101,143,231],"TB":[72],"remain":[73],"uncharacterized.":[74],"This":[75,356],"study":[76,339,362],"addresses":[77],"this":[78],"gap":[79],"employing":[81],"integrated":[82,126],"multi-omics":[83,358],"simulation":[86,361],"approaches":[87],"identify":[89,117],"bioactive":[90],"phytochemicals":[91],"O.":[93,352],"aristatus":[94,353,374],"predict":[96],"their":[97],"mechanisms":[98],"action":[100],"tuberculosis.":[102,428],"Methods:":[103],"An":[104],"aqueous":[105],"leaf":[106],"extract":[107],"was":[108,141],"analyzed":[109],"Liquid":[111],"Chromatography-Tandem":[112],"Mass":[113],"Spectrometry":[114],"(LC-MS/MS)":[115],"metabolite":[119,123,171,210],"compounds.":[120,412],"The":[121,335],"predicted":[122,209],"were":[125],"tuberculosis-related":[128],"genes":[129],"using":[130],"network":[131],"pharmacology":[132],"pinpoint":[134],"key":[135,344],"regulatory":[136],"hubs.":[137],"Structure-based":[138,229],"docking":[140,230],"performed":[142],"prioritized":[145,216],"target":[146,346],"SRC,":[147],"followed":[148],"dynamics":[151,267],"simulations":[152,268],"MM/PBSA":[154,306],"binding":[155,310],"free-energy":[156],"assessments":[157],"evaluate":[159],"complex":[160],"stability":[161],"interaction":[163],"details.":[164],"Results:":[165],"LC-MS/MS":[166],"analysis":[167],"revealed":[168],"diverse":[170],"profile":[172],"comprising":[173],"phenolic":[174],"acids,":[175,179],"flavonoids,":[176],"alkaloids,":[177],"fatty":[178],"triterpenoids;":[181],"representative":[182],"signals":[183],"included":[184],"tartaric":[185],"acid,":[186,190,194,199],"adenosine,":[187],"cyanidin-3-glucoside,":[188],"chlorogenic":[189],"ethyl":[191],"gallate,":[192],"rosmarinic":[193],"acacetin,":[195],"tetrahydropalmatine,":[196],"solanidine,":[197,320],"16-hydroxyhexadecanoic":[198],"dammarenediol.":[201],"Network":[202],"integration":[203],"tuberculosis":[205],"disease":[206],"yielded":[212],"194":[213],"overlaps":[214],"kinase-centered":[218],"module,":[219],"SRC":[221,232,341],"highest-ranked":[224],"hub,":[225],"motivating":[226],"receptor-focused":[227],"screening.":[228],"highlighted":[233],"three":[234,274],"candidates":[235,371],"sub-micromolar":[237],"predictions,":[238],"namely":[239],"solanidine":[240,364],"(\u0394G":[241,249,258],"\u22129.69":[242],"kcal/mol;":[243,251,260],"Ki":[244,252,261],"\u2248":[245,253,262],"79.43":[246],"nM),":[247,255],"dammarenediol":[248,366],"\u22129.13":[250],"204.32":[254],"rubijervine":[257,377],"\u22129.00":[259],"251.71":[263],"nM).":[264],"One-hundred-nanosecond":[265],"supported":[269],"stable":[270],"complexes":[271],"all":[273],"ligands":[275],"native-like":[277],"backbone":[278],"deviation,":[279],"compactness":[280],"consistent":[281],"deep":[283],"burial":[284],"dammarenediol,":[286,326],"balanced":[288],"solvation":[289],"around":[290],"rubijervine.":[291,333],"Hydrogen-bond":[292],"occupancy":[293],"mapped":[294],"recurring":[295],"anchoring":[296],"residues":[297],"at":[298],"MET344,":[299],"LYS298,":[300],"THR341,":[301],"GLU342,":[302],"ASP407,":[304],"while":[305],"decomposition":[307],"indicated":[308],"dispersion-driven":[309],"total":[312],"energies":[313],"\u221271.866":[315],"\u00b1":[316,322,329],"48.633":[317],"kJ/mol":[318,324,331],"\u221269.077":[321],"77.772":[323],"\u221220.188":[328],"56.455":[330],"Discussion:":[334],"integrative":[336,357],"silico":[338],"highlights":[340],"may":[348],"be":[349],"modulated":[350],"phytochemicals.":[354],"Conclusion:":[355],"identifies":[363],"SRC-targeted":[369],"antituberculosis":[370],"from":[372],"designates":[376],"distinct":[380],"hinge-stabilizing":[381],"scaffold.":[382],"These":[383],"findings":[384,415],"establish":[385],"mechanistic":[387],"foundation":[388],"next":[391],"phase":[392],"development,":[394],"which":[395],"will":[396],"use":[397],"enzymatic":[398],"inhibition":[399],"assays":[400],"macrophage":[402],"infection":[403],"models":[404],"validate":[406],"index":[409],"Ultimately,":[413],"represent":[416],"promising":[418],"pathway":[419],"developing":[421],"adjunct":[423],"combat":[426]},"counts_by_year":[],"updated_date":"2026-09-24T07:57:37.273135","created_date":"2026-09-01T00:00:00"}
