{"id":"https://openalex.org/W7204745305","doi":"https://doi.org/10.4103/jcecho.jcecho_180_25","title":"Phenotypic Heterogeneity in Mitral Valve Prolapse: Insights from a Case Series","display_name":"Phenotypic Heterogeneity in Mitral Valve Prolapse: Insights from a Case Series","publication_year":2026,"publication_date":"2026-07-01","ids":{"openalex":"https://openalex.org/W7204745305","doi":"https://doi.org/10.4103/jcecho.jcecho_180_25","pmid":"https://pubmed.ncbi.nlm.nih.gov/42781164","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13600639"},"language":"en","primary_location":{"id":"doi:10.4103/jcecho.jcecho_180_25","doi":"https://doi.org/10.4103/jcecho.jcecho_180_25","is_oa":true,"landing_page_url":"https://doi.org/10.4103/jcecho.jcecho_180_25","pdf_url":null,"source":{"id":"https://openalex.org/S2764677956","display_name":"Journal of Cardiovascular Echography","issn_l":"2211-4122","issn":["2211-4122","2347-193X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","ki-jl-1","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cardiovascular Echography","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.4103/jcecho.jcecho_180_25","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047909246","display_name":"Irene Cecilia Landi","orcid":"https://orcid.org/0000-0003-1263-1718","observed_orcids":["https://orcid.org/0000-0003-1263-1718"]},"institutions":[{"id":"https://openalex.org/I4405265950","display_name":"Ospedale Michele e Pietro Ferrero - Verduno","ror":"https://ror.org/02bnhae06","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210141322","https://openalex.org/I4405265950"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Irene Landi","raw_affiliation_strings":["Department of Emergency Medicine, Michele and Pietro Ferrero Hospital, Verduno, Cuneo, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency Medicine, Michele and Pietro Ferrero Hospital, Verduno, Cuneo, Italy","institution_ids":["https://openalex.org/I4405265950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5138401167","display_name":"L Favarato","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Luca Favarato","raw_affiliation_strings":["Department of Radiology, San Daniele Hospital, San Daniele del Friuli, Udine, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, San Daniele Hospital, San Daniele del Friuli, Udine, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051504344","display_name":"Paolo Toritto","orcid":"https://orcid.org/0009-0008-8724-3852","observed_orcids":["https://orcid.org/0009-0008-8724-3852"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paolo Toritto","raw_affiliation_strings":["Department of Internal Medicine, Sant\u2019Antonio Hospital, San Daniele del Friuli, Udine, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Sant\u2019Antonio Hospital, San Daniele del Friuli, Udine, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5138452121","display_name":"E Iengo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Enrico Iengo","raw_affiliation_strings":["Department of Radiology, San Daniele Hospital, San Daniele del Friuli, Udine, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, San Daniele Hospital, San Daniele del Friuli, Udine, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093059688","display_name":"Lorenzo Zuliani","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lorenzo Zuliani","raw_affiliation_strings":["Department of Cardiology, Sant\u2019Antonio Hospital, San Daniele del Friuli, Udine, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Sant\u2019Antonio Hospital, San Daniele del Friuli, Udine, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072182592","display_name":"Stefano Martina","orcid":"https://orcid.org/0000-0003-3877-1671","observed_orcids":["https://orcid.org/0000-0003-3877-1671"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stefano Martina","raw_affiliation_strings":["Department of Cardiology, Sant\u2019Antonio Hospital, San Daniele del Friuli, Udine, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Sant\u2019Antonio Hospital, San Daniele del Friuli, Udine, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060960078","display_name":"Tommaso della Giustina","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tommaso Della Giustina","raw_affiliation_strings":["Department of Cardiology, Sant\u2019Antonio Hospital, San Daniele del Friuli, Udine, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Sant\u2019Antonio Hospital, San Daniele del Friuli, Udine, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064489118","display_name":"A. Abdelkader","orcid":"https://orcid.org/0009-0006-2851-2835","observed_orcids":["https://orcid.org/0009-0006-2851-2835"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abdalla Eltayeb Abdelkader","raw_affiliation_strings":["Division of Cardiovascular Medicine, University of Florida, Gainesville, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiovascular Medicine, University of Florida, Gainesville, FL, USA","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030979202","display_name":"Olga Vriz","orcid":"https://orcid.org/0000-0001-8212-8646","observed_orcids":["https://orcid.org/0000-0001-8212-8646"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Olga Vriz","raw_affiliation_strings":["Department of Cardiology, Sant\u2019Antonio Hospital, San Daniele del Friuli, Udine, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Sant\u2019Antonio Hospital, San Daniele del Friuli, Udine, Italy","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5030979202"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"36","issue":"4","first_page":"453","last_page":"459"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10172","display_name":"Cardiac Valve Diseases and Treatments","score":0.9477999806404114,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10172","display_name":"Cardiac Valve Diseases and Treatments","score":0.9477999806404114,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.021400000900030136,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11922","display_name":"Cardiovascular Effects of Exercise","score":0.013100000098347664,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mitral-valve-prolapse","display_name":"mitral valve prolapse","score":1.0},{"id":"https://openalex.org/keywords/phenotypic-heterogeneity","display_name":"phenotypic heterogeneity","score":0.9359999895095825},{"id":"https://openalex.org/keywords/bileaflet-mitral-valve-prolapse","display_name":"bileaflet mitral valve prolapse","score":0.8579999804496765},{"id":"https://openalex.org/keywords/mitral-annular-disjunction","display_name":"mitral annular disjunction","score":0.9139999747276306},{"id":"https://openalex.org/keywords/left-ventricular-dilation","display_name":"left ventricular dilatation","score":0.8050000071525574},{"id":"https://openalex.org/keywords/late-gadolinium-enhancement","display_name":"late gadolinium enhancement","score":0.875},{"id":"https://openalex.org/keywords/ventricular-arrhythmias","display_name":"ventricular arrhythmias","score":0.8009999990463257},{"id":"https://openalex.org/keywords/nonsustained-ventricular-tachycardia","display_name":"non-sustained ventricular tachycardia","score":0.9739999771118164},{"id":"https://openalex.org/keywords/sudden-cardiac-death","display_name":"sudden cardiac death","score":0.7720000147819519},{"id":"https://openalex.org/keywords/risk-stratification","display_name":"risk stratification","score":0.7900000214576721},{"id":"https://openalex.org/keywords/myocardial-fibrosis","display_name":"myocardial fibrosis","score":0.7120000123977661},{"id":"https://openalex.org/keywords/mitral-regurgitation","display_name":"mitral regurgitation","score":0.8600000143051147}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8547000288963318},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.8030999898910522},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7717000246047974},{"id":"https://openalex.org/C2776331378","wikidata":"https://www.wikidata.org/wiki/Q56002","display_name":"Ventricular tachycardia","level":2,"score":0.6791999936103821},{"id":"https://openalex.org/C2777910003","wikidata":"https://www.wikidata.org/wiki/Q1707292","display_name":"Asymptomatic","level":2,"score":0.6674000024795532},{"id":"https://openalex.org/C2993373945","wikidata":"https://www.wikidata.org/wiki/Q268292","display_name":"Mitral regurgitation","level":2,"score":0.6498000025749207},{"id":"https://openalex.org/C2781030672","wikidata":"https://www.wikidata.org/wiki/Q735652","display_name":"Mitral valve prolapse","level":3,"score":0.5932999849319458},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.5371000170707703},{"id":"https://openalex.org/C2775935837","wikidata":"https://www.wikidata.org/wiki/Q202837","display_name":"Sudden cardiac death","level":2,"score":0.5083000063896179},{"id":"https://openalex.org/C2776008845","wikidata":"https://www.wikidata.org/wiki/Q5038325","display_name":"Cardiac magnetic resonance imaging","level":3,"score":0.4846999943256378},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.43389999866485596},{"id":"https://openalex.org/C2777543888","wikidata":"https://www.wikidata.org/wiki/Q369939","display_name":"Mitral valve","level":2,"score":0.40529999136924744},{"id":"https://openalex.org/C64618202","wikidata":"https://www.wikidata.org/wiki/Q3733697","display_name":"Genetic heterogeneity","level":4,"score":0.366100013256073},{"id":"https://openalex.org/C2780040984","wikidata":"https://www.wikidata.org/wiki/Q79785","display_name":"Electrocardiography","level":2,"score":0.3587000072002411},{"id":"https://openalex.org/C2775854548","wikidata":"https://www.wikidata.org/wiki/Q6882369","display_name":"Mitral valve replacement","level":3,"score":0.35190001130104065},{"id":"https://openalex.org/C2778024521","wikidata":"https://www.wikidata.org/wiki/Q55639806","display_name":"Basal (medicine)","level":3,"score":0.33079999685287476},{"id":"https://openalex.org/C2987145844","wikidata":"https://www.wikidata.org/wiki/Q5038325","display_name":"Cardiac magnetic resonance","level":3,"score":0.3292999863624573},{"id":"https://openalex.org/C3020646490","wikidata":"https://www.wikidata.org/wiki/Q25203551","display_name":"Clinical phenotype","level":4,"score":0.3012999892234802},{"id":"https://openalex.org/C2780875844","wikidata":"https://www.wikidata.org/wiki/Q186235","display_name":"Myocarditis","level":2,"score":0.298799991607666},{"id":"https://openalex.org/C2993353509","wikidata":"https://www.wikidata.org/wiki/Q411867","display_name":"Sudden death","level":2,"score":0.2946000099182129},{"id":"https://openalex.org/C2776127602","wikidata":"https://www.wikidata.org/wiki/Q5038319","display_name":"Cardiac imaging","level":2,"score":0.28690001368522644},{"id":"https://openalex.org/C2777892804","wikidata":"https://www.wikidata.org/wiki/Q2555727","display_name":"Arrhythmogenic right ventricular dysplasia","level":4,"score":0.27900001406669617},{"id":"https://openalex.org/C2780283014","wikidata":"https://www.wikidata.org/wiki/Q209583","display_name":"Tachycardia","level":2,"score":0.2736999988555908},{"id":"https://openalex.org/C2908909779","wikidata":"https://www.wikidata.org/wiki/Q186235","display_name":"Acute myocarditis","level":3,"score":0.26260000467300415}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.4103/jcecho.jcecho_180_25","doi":"https://doi.org/10.4103/jcecho.jcecho_180_25","is_oa":true,"landing_page_url":"https://doi.org/10.4103/jcecho.jcecho_180_25","pdf_url":null,"source":{"id":"https://openalex.org/S2764677956","display_name":"Journal of Cardiovascular Echography","issn_l":"2211-4122","issn":["2211-4122","2347-193X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","ki-jl-1","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cardiovascular Echography","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13600639","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13600639/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13600639/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Cardiovasc Echogr","raw_type":"Text"},{"id":"pmid:42781164","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42781164","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cardiovascular echography","raw_type":"Case Reports"}],"best_oa_location":{"id":"doi:10.4103/jcecho.jcecho_180_25","doi":"https://doi.org/10.4103/jcecho.jcecho_180_25","is_oa":true,"landing_page_url":"https://doi.org/10.4103/jcecho.jcecho_180_25","pdf_url":null,"source":{"id":"https://openalex.org/S2764677956","display_name":"Journal of Cardiovascular Echography","issn_l":"2211-4122","issn":["2211-4122","2347-193X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","ki-jl-1","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cardiovascular Echography","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204745305.pdf","grobid_xml":"https://content.openalex.org/works/W7204745305.grobid-xml"},"referenced_works_count":23,"referenced_works":["https://openalex.org/W2121275465","https://openalex.org/W2160641761","https://openalex.org/W2323812521","https://openalex.org/W2513684962","https://openalex.org/W2563865207","https://openalex.org/W2891096905","https://openalex.org/W2897972502","https://openalex.org/W2902167867","https://openalex.org/W2903194993","https://openalex.org/W2934633751","https://openalex.org/W2972606115","https://openalex.org/W3010994366","https://openalex.org/W3047063238","https://openalex.org/W3139452641","https://openalex.org/W3195842247","https://openalex.org/W4291020000","https://openalex.org/W4293217392","https://openalex.org/W4295358301","https://openalex.org/W4391617665","https://openalex.org/W4399874680","https://openalex.org/W4403283028","https://openalex.org/W4407607629","https://openalex.org/W4415965330"],"related_works":["https://openalex.org/W7125876574","https://openalex.org/W4410699643","https://openalex.org/W4388594744","https://openalex.org/W4391617665","https://openalex.org/W4417076220","https://openalex.org/W7164823560","https://openalex.org/W7166473971","https://openalex.org/W6939888618","https://openalex.org/W7165932042","https://openalex.org/W4206834875"],"abstract_inverted_index":{"Mitral":[0],"valve":[1],"prolapse":[2],"(MVP)":[3],"is":[4],"the":[5,91,125,174,182],"most":[6],"common":[7],"valvular":[8],"heart":[9],"disorder":[10],"and":[11,34,50,72,83,111,139,166,180,192,197,226],"shows":[12],"marked":[13,108],"phenotypic":[14,176],"heterogeneity,":[15],"ranging":[16],"from":[17],"benign":[18],"forms":[19],"to":[20,79,100,157,200],"malignant":[21],"variants":[22],"associated":[23],"with":[24,47,119,143],"ventricular":[25,105,117,121],"arrhythmias":[26],"(VA),":[27],"mitral":[28,52],"annular":[29],"disjunction":[30],"(MAD),":[31],"myocardial":[32],"fibrosis,":[33],"sudden":[35],"cardiac":[36,73],"death":[37],"(SCD).":[38],"We":[39],"present":[40],"a":[41,60,112,150],"case":[42],"series":[43],"of":[44,115,127,153,178,207],"three":[45,92],"patients":[46],"bileaflet":[48],"MVP":[49,179],"mild":[51,135],"regurgitation":[53],"(MR),":[54],"followed":[55],"longitudinally":[56],"for":[57,216],"more":[58],"than":[59],"decade.":[61],"Clinical":[62],"assessment,":[63],"electrocardiography,":[64],"advanced":[65],"echocardiography,":[66],"24-h":[67],"Holter":[68],"monitoring,":[69],"exercise":[70],"testing,":[71],"magnetic":[74],"resonance":[75],"imaging":[76,211],"were":[77],"used":[78],"characterize":[80],"structural,":[81],"mechanical,":[82],"electrical":[84,227],"features.":[85],"Phenotypic":[86],"variability":[87],"was":[88],"evident":[89],"across":[90],"patients.":[93],"Case":[94,132,147],"1":[95],"showed":[96,155],"progressive":[97],"MAD":[98],"(5.4":[99],"11.3":[101],"mm),":[102],"significant":[103],"left":[104],"(LV)":[106],"dilatation,":[107,137],"systolic":[109],"curling,":[110,138,163,196],"high":[113],"burden":[114],"premature":[116],"contractions":[118],"non-sustained":[120],"tachycardia":[122],"(NSVT),":[123],"despite":[124,149],"absence":[126],"late":[128],"gadolinium":[129],"enhancement":[130],"(LGE).":[131],"2":[133],"developed":[134],"LV":[136],"basal":[140],"inferolateral":[141],"LGE,":[142,165],"exercise-induced":[144],"NSVT,":[145],"whereas":[146],"3,":[148],"family":[151],"history":[152],"SCD,":[154],"progression":[156],"moderate":[158],"MR":[159],"but":[160,203],"no":[161],"MAD,":[162,195],"or":[164],"only":[167],"limited":[168],"arrhythmic":[169,208],"activity.":[170],"These":[171],"cases":[172],"illustrate":[173],"broad":[175],"spectrum":[177],"support":[181],"concept":[183],"that":[184],"this":[185],"condition":[186],"may":[187,212],"involve":[188],"valvular,":[189],"annular,":[190],"myocardial,":[191],"electrophysiological":[193],"abnormalities.":[194],"LGE":[198],"appear":[199],"represent":[201],"overlapping":[202],"potentially":[204],"independent":[205],"markers":[206],"risk.":[209],"Multimodality":[210],"therefore":[213],"be":[214],"valuable":[215],"comprehensive":[217],"risk":[218],"stratification,":[219],"even":[220],"in":[221],"asymptomatic":[222],"patients,":[223],"as":[224],"structural":[225],"features":[228],"can":[229],"evolve":[230],"over":[231],"time.":[232]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-09-01T00:00:00"}