{"id":"https://openalex.org/W7204736070","doi":"https://doi.org/10.1016/s2152-2650(26)02738-2","title":"IBCL-1525: Efficacy of BRAF Inhibitors Plus Rituximab in Relapsed or Refractory Hairy Cell Leukemia: A Systematic Review and Meta-Analysis","display_name":"IBCL-1525: Efficacy of BRAF Inhibitors Plus Rituximab in Relapsed or Refractory Hairy Cell Leukemia: A Systematic Review and Meta-Analysis","publication_year":2026,"publication_date":"2026-08-01","ids":{"openalex":"https://openalex.org/W7204736070","doi":"https://doi.org/10.1016/s2152-2650(26)02738-2"},"language":"en","primary_location":{"id":"doi:10.1016/s2152-2650(26)02738-2","doi":"https://doi.org/10.1016/s2152-2650(26)02738-2","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s2152-2650(26)02738-2","pdf_url":null,"source":{"id":"https://openalex.org/S186546955","display_name":"Clinical Lymphoma Myeloma & Leukemia","issn_l":"2152-2650","issn":["2152-2650","2152-2669"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Lymphoma Myeloma and Leukemia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5120098555","display_name":"M.S. Vibhav","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I876098953","display_name":"Bangalore Medical College and Research Institute","ror":"https://ror.org/05qmk4a18","country_code":"IN","type":"education","lineage":["https://openalex.org/I286135121","https://openalex.org/I876098953"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"MS Vibhav","raw_affiliation_strings":["Bangalore Medical College and Research Institute, Bangalore, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bangalore Medical College and Research Institute, Bangalore, India","institution_ids":["https://openalex.org/I876098953"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009475221","display_name":"Tooba Shaukat Butt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799648416","display_name":"AdventHealth Orlando","ror":"https://ror.org/02n1cyj49","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799648416"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tooba Shaukat Butt","raw_affiliation_strings":["AdventHealth, Orlando, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AdventHealth, Orlando, FL, USA","institution_ids":["https://openalex.org/I2799648416"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5116843391","display_name":"Deepika Reddy Aluru","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I876098953","display_name":"Bangalore Medical College and Research Institute","ror":"https://ror.org/05qmk4a18","country_code":"IN","type":"education","lineage":["https://openalex.org/I286135121","https://openalex.org/I876098953"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Deepika Reddy Aluru","raw_affiliation_strings":["Bangalore Medical College and Research Institute, Bangalore, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bangalore Medical College and Research Institute, Bangalore, India","institution_ids":["https://openalex.org/I876098953"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114391913","display_name":"Vinay Chandramouli Bellur","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210134671","display_name":"M.S. Ramaiah Medical College","ror":"https://ror.org/03j554d90","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210134671"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Vinay C Bellur","raw_affiliation_strings":["MS Ramaiah Medical College, Bangalore, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MS Ramaiah Medical College, Bangalore, India","institution_ids":["https://openalex.org/I4210134671"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5130763489","display_name":"Ranjan Krupesh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I876098953","display_name":"Bangalore Medical College and Research Institute","ror":"https://ror.org/05qmk4a18","country_code":"IN","type":"education","lineage":["https://openalex.org/I286135121","https://openalex.org/I876098953"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Ranjan Krupesh","raw_affiliation_strings":["Bangalore Medical College and Research Institute, Bangalore, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bangalore Medical College and Research Institute, Bangalore, India","institution_ids":["https://openalex.org/I876098953"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Roshan Agarwal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I876098953","display_name":"Bangalore Medical College and Research Institute","ror":"https://ror.org/05qmk4a18","country_code":"IN","type":"education","lineage":["https://openalex.org/I286135121","https://openalex.org/I876098953"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Roshan Agarwal","raw_affiliation_strings":["Bangalore Medical College and Research Institute, Bangalore, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bangalore Medical College and Research Institute, Bangalore, India","institution_ids":["https://openalex.org/I876098953"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148634104","display_name":"Aditya Singh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I876098953","display_name":"Bangalore Medical College and Research Institute","ror":"https://ror.org/05qmk4a18","country_code":"IN","type":"education","lineage":["https://openalex.org/I286135121","https://openalex.org/I876098953"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Aditya Singh","raw_affiliation_strings":["Bangalore Medical College and Research Institute, Bangalore, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bangalore Medical College and Research Institute, Bangalore, India","institution_ids":["https://openalex.org/I876098953"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148729589","display_name":"Naithik Jain","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I876098953","display_name":"Bangalore Medical College and Research Institute","ror":"https://ror.org/05qmk4a18","country_code":"IN","type":"education","lineage":["https://openalex.org/I286135121","https://openalex.org/I876098953"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Naithik Jain","raw_affiliation_strings":["Bangalore Medical College and Research Institute, Bangalore, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bangalore Medical College and Research Institute, Bangalore, India","institution_ids":["https://openalex.org/I876098953"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148718814","display_name":"Suhana Banerjee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I876098953","display_name":"Bangalore Medical College and Research Institute","ror":"https://ror.org/05qmk4a18","country_code":"IN","type":"education","lineage":["https://openalex.org/I286135121","https://openalex.org/I876098953"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Suhana Banerjee","raw_affiliation_strings":["Bangalore Medical College and Research Institute, Bangalore, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bangalore Medical College and Research Institute, Bangalore, India","institution_ids":["https://openalex.org/I876098953"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148754153","display_name":"Druvadeep Srinivas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1323219464","display_name":"Rajarajeswari Medical College and Hospital","ror":"https://ror.org/00gn6h668","country_code":"IN","type":"education","lineage":["https://openalex.org/I1323219464"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Druvadeep Srinivas","raw_affiliation_strings":["RajaRajeswari Medical College & Hospital, Bengaluru, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RajaRajeswari Medical College & Hospital, Bengaluru, India","institution_ids":["https://openalex.org/I1323219464"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114391912","display_name":"Deepak B. Shivananda","orcid":"https://orcid.org/0009-0009-3601-3886","observed_orcids":["https://orcid.org/0009-0009-3601-3886"]},"institutions":[{"id":"https://openalex.org/I876098953","display_name":"Bangalore Medical College and Research Institute","ror":"https://ror.org/05qmk4a18","country_code":"IN","type":"education","lineage":["https://openalex.org/I286135121","https://openalex.org/I876098953"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Deepak B Shivananda","raw_affiliation_strings":["Bangalore Medical College and Research Institute, Bangalore, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bangalore Medical College and Research Institute, Bangalore, India","institution_ids":["https://openalex.org/I876098953"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5117728078","display_name":"Rishikesh R. Magaji","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210150676","display_name":"BGS Global Hospital","ror":"https://ror.org/058qp7v13","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I4210150676"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Rishikesh R Magaji","raw_affiliation_strings":["BGS Global Institute of Medical Sciences, Bengaluru, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BGS Global Institute of Medical Sciences, Bengaluru, India","institution_ids":["https://openalex.org/I4210150676"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108762245","display_name":"Trisha Chandra Mohan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210150676","display_name":"BGS Global Hospital","ror":"https://ror.org/058qp7v13","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I4210150676"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Trisha Chandra Mohan","raw_affiliation_strings":["BGS Global Institute of Medical Sciences, Bengaluru, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BGS Global Institute of Medical Sciences, Bengaluru, India","institution_ids":["https://openalex.org/I4210150676"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148751543","display_name":"Adithya SathyanarayanaMBBS","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210134671","display_name":"M.S. Ramaiah Medical College","ror":"https://ror.org/03j554d90","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210134671"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Adithya SathyanarayanaMBBS","raw_affiliation_strings":["MS Ramaiah Medical College, Bangalore, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MS Ramaiah Medical College, Bangalore, India","institution_ids":["https://openalex.org/I4210134671"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5107067237","display_name":"Gaurav Jayadev","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405286997","display_name":"Basaveshwara Medical College & Hospital","ror":"https://ror.org/03scnre95","country_code":"IN","type":"education","lineage":["https://openalex.org/I4405286997"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Gaurav Jayadev","raw_affiliation_strings":["Basaveshwara Medical College & Hospital, Chitradurga, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Basaveshwara Medical College & Hospital, Chitradurga, India","institution_ids":["https://openalex.org/I4405286997"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3890,"currency":"USD","value_usd":3890},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.63846323,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"26","issue":null,"first_page":"S1004","last_page":"S1005"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11811","display_name":"Cutaneous lymphoproliferative disorders research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hairy-cell-leukemia","display_name":"hairy cell leukemia","score":0.9959999918937683},{"id":"https://openalex.org/keywords/relapsed-refractory-disease","display_name":"relapsed/refractory disease","score":0.9079999923706055},{"id":"https://openalex.org/keywords/braf-inhibitors","display_name":"BRAF inhibitors","score":0.9829999804496765},{"id":"https://openalex.org/keywords/braf-v600e-mutation","display_name":"BRAF V600E mutation","score":0.9089999794960022},{"id":"https://openalex.org/keywords/rituximab","display_name":"rituximab","score":0.984000027179718},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.9449999928474426},{"id":"https://openalex.org/keywords/complete-response-rate","display_name":"complete response rate","score":0.9520000219345093},{"id":"https://openalex.org/keywords/minimal-residual-disease-negativity","display_name":"minimal residual disease negativity","score":0.8889999985694885},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9340000152587891},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.9990000128746033},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.9100000262260437},{"id":"https://openalex.org/keywords/myelosuppression","display_name":"myelosuppression","score":0.7799999713897705},{"id":"https://openalex.org/keywords/purine-analogs","display_name":"purine analogues","score":0.6809999942779541},{"id":"https://openalex.org/keywords/b-cell-malignancies","display_name":"B-cell malignancies","score":0.6539999842643738},{"id":"https://openalex.org/keywords/treatment-efficacy-and-safety","display_name":"treatment efficacy and safety","score":0.5649999976158142},{"id":"https://openalex.org/keywords/mortality-rates","display_name":"mortality rates","score":0.40799999237060547}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9688000082969666},{"id":"https://openalex.org/C2780653079","wikidata":"https://www.wikidata.org/wiki/Q412323","display_name":"Rituximab","level":3,"score":0.7441999912261963},{"id":"https://openalex.org/C142424586","wikidata":"https://www.wikidata.org/wiki/Q7307572","display_name":"Refractory (planetary science)","level":2,"score":0.6288999915122986},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5080999732017517},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4772000014781952},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3878999948501587},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.35910001397132874},{"id":"https://openalex.org/C169382597","wikidata":"https://www.wikidata.org/wiki/Q21208025","display_name":"Programmed cell death 1","level":5,"score":0.3368000090122223},{"id":"https://openalex.org/C163864487","wikidata":"https://www.wikidata.org/wiki/Q6901461","display_name":"Monoclonal","level":4,"score":0.3296000063419342},{"id":"https://openalex.org/C2776131300","wikidata":"https://www.wikidata.org/wiki/Q423111","display_name":"Vemurafenib","level":4,"score":0.3208000063896179},{"id":"https://openalex.org/C2780483514","wikidata":"https://www.wikidata.org/wiki/Q201299","display_name":"Hairy cell leukemia","level":3,"score":0.2994999885559082},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.27469998598098755},{"id":"https://openalex.org/C2994294914","wikidata":"https://www.wikidata.org/wiki/Q1645075","display_name":"Acquired resistance","level":3,"score":0.2599000036716461}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/s2152-2650(26)02738-2","doi":"https://doi.org/10.1016/s2152-2650(26)02738-2","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s2152-2650(26)02738-2","pdf_url":null,"source":{"id":"https://openalex.org/S186546955","display_name":"Clinical Lymphoma Myeloma & Leukemia","issn_l":"2152-2650","issn":["2152-2650","2152-2669"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Lymphoma Myeloma and Leukemia","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"},{"id":"https://openalex.org/study-designs/meta-analysis","display_name":"Meta-Analysis"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4389244479","https://openalex.org/W3160538443","https://openalex.org/W7204697379","https://openalex.org/W4415665060","https://openalex.org/W4393321453","https://openalex.org/W2950364027","https://openalex.org/W4389233650","https://openalex.org/W2949766968","https://openalex.org/W2980816621","https://openalex.org/W2900990181"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-24T09:50:30.924529","created_date":"2026-08-31T00:00:00"}