{"id":"https://openalex.org/W7204733838","doi":"https://doi.org/10.1016/s2152-2650(26)02225-1","title":"MDS-515: Durable Complete Remission Following HMA Therapy in Higher-Risk MDS Is Not Fully Determined by Baseline Disease Biology","display_name":"MDS-515: Durable Complete Remission Following HMA Therapy in Higher-Risk MDS Is Not Fully Determined by Baseline Disease Biology","publication_year":2026,"publication_date":"2026-08-01","ids":{"openalex":"https://openalex.org/W7204733838","doi":"https://doi.org/10.1016/s2152-2650(26)02225-1"},"language":"en","primary_location":{"id":"doi:10.1016/s2152-2650(26)02225-1","doi":"https://doi.org/10.1016/s2152-2650(26)02225-1","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s2152-2650(26)02225-1","pdf_url":null,"source":{"id":"https://openalex.org/S186546955","display_name":"Clinical Lymphoma Myeloma & Leukemia","issn_l":"2152-2650","issn":["2152-2650","2152-2669"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Lymphoma Myeloma and Leukemia","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050756854","display_name":"Julie S. Braish","orcid":"https://orcid.org/0009-0005-4527-0500","observed_orcids":["https://orcid.org/0009-0005-4527-0500"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julie Braish","raw_affiliation_strings":["Moffitt Cancer Center, Tampa, FL, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Moffitt Cancer Center, Tampa, FL, United States of America","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061883803","display_name":"Najla E. Al Ali","orcid":"https://orcid.org/0009-0002-1509-6319","observed_orcids":["https://orcid.org/0009-0002-1509-6319"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Najla Al Ali","raw_affiliation_strings":["Moffitt Cancer Center, Tampa, FL, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Moffitt Cancer Center, Tampa, FL, United States of America","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148650384","display_name":"Zena Komrokji RA","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zena Komrokji RA","raw_affiliation_strings":["Moffitt Cancer Center, Tampa, FL, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Moffitt Cancer Center, Tampa, FL, United States of America","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048791112","display_name":"Zhuoer Xie","orcid":"https://orcid.org/0000-0003-1266-9804","observed_orcids":["https://orcid.org/0000-0003-1266-9804"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhuoer Xie","raw_affiliation_strings":["Moffitt Cancer Center, Tampa, FL, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Moffitt Cancer Center, Tampa, FL, United States of America","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073057060","display_name":"Onyee Chan","orcid":"https://orcid.org/0000-0003-2872-1961","observed_orcids":["https://orcid.org/0000-0003-2872-1961"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Onyee Chan","raw_affiliation_strings":["Moffitt Cancer Center, Tampa, FL, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Moffitt Cancer Center, Tampa, FL, United States of America","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148741558","display_name":"Andrew T Kuykendall","orcid":"https://orcid.org/0000-0002-9040-7415","observed_orcids":["https://orcid.org/0000-0002-9040-7415"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew T Kuykendall","raw_affiliation_strings":["Moffitt Cancer Center, Tampa, FL, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Moffitt Cancer Center, Tampa, FL, United States of America","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011096418","display_name":"Seongseok Yun","orcid":"https://orcid.org/0000-0001-7343-1635","observed_orcids":["https://orcid.org/0000-0001-7343-1635"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Seongseok Yun","raw_affiliation_strings":["Moffitt Cancer Center, Tampa, FL, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Moffitt Cancer Center, Tampa, FL, United States of America","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091021372","display_name":"Rory Michael Shallis","orcid":"https://orcid.org/0000-0002-8542-2944","observed_orcids":["https://orcid.org/0000-0002-8542-2944"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rory M Shallis","raw_affiliation_strings":["Moffitt Cancer Center, Tampa, FL, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Moffitt Cancer Center, Tampa, FL, United States of America","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5130805602","display_name":"Sam B Reynolds","orcid":"https://orcid.org/0000-0002-8652-183X","observed_orcids":["https://orcid.org/0000-0002-8652-183X"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sam B Reynolds","raw_affiliation_strings":["Moffitt Cancer Center, Tampa, FL, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Moffitt Cancer Center, Tampa, FL, United States of America","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104111186","display_name":"Alison R. Walker","orcid":"https://orcid.org/0009-0003-8236-3381","observed_orcids":["https://orcid.org/0009-0003-8236-3381"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alison R Walker","raw_affiliation_strings":["Moffitt Cancer Center, Tampa, FL, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Moffitt Cancer Center, Tampa, FL, United States of America","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041443589","display_name":"Jeffrey E. Lancet","orcid":"https://orcid.org/0000-0002-7751-7310","observed_orcids":["https://orcid.org/0000-0002-7751-7310"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey E Lancet","raw_affiliation_strings":["Moffitt Cancer Center, Tampa, FL, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Moffitt Cancer Center, Tampa, FL, United States of America","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041754278","display_name":"Eric Padron","orcid":"https://orcid.org/0000-0002-4707-7916","observed_orcids":["https://orcid.org/0000-0002-4707-7916"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric Padron","raw_affiliation_strings":["Moffitt Cancer Center, Tampa, FL, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Moffitt Cancer Center, Tampa, FL, United States of America","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029369362","display_name":"David Andrew Sallman","orcid":"https://orcid.org/0000-0003-0504-8233","observed_orcids":["https://orcid.org/0000-0003-0504-8233"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David A Sallman","raw_affiliation_strings":["Moffitt Cancer Center, Tampa, FL, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Moffitt Cancer Center, Tampa, FL, United States of America","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010075752","display_name":"Rami S. Komrokji","orcid":"https://orcid.org/0000-0002-1876-5269","observed_orcids":["https://orcid.org/0000-0002-1876-5269"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rami S Komrokji","raw_affiliation_strings":["Moffitt Cancer Center, Tampa, FL, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Moffitt Cancer Center, Tampa, FL, United States of America","institution_ids":["https://openalex.org/I3019308854"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I3019308854"],"apc_list":{"value":3890,"currency":"USD","value_usd":3890},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"26","issue":null,"first_page":"S710","last_page":"S711"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/myelodysplastic-syndrome","display_name":"myelodysplastic syndrome","score":0.9200000166893005},{"id":"https://openalex.org/keywords/higher-risk-mds","display_name":"high-risk MDS","score":0.8059999942779541},{"id":"https://openalex.org/keywords/complete-remission","display_name":"complete remission","score":0.7910000085830688},{"id":"https://openalex.org/keywords/sustained-remission","display_name":"sustained remission","score":0.8410000205039978},{"id":"https://openalex.org/keywords/hypomethylating-agents","display_name":"hypomethylating agents","score":0.9869999885559082},{"id":"https://openalex.org/keywords/venetoclax","display_name":"venetoclax","score":0.9100000262260437},{"id":"https://openalex.org/keywords/tp53-mutation","display_name":"TP53 mutation","score":0.7409999966621399},{"id":"https://openalex.org/keywords/asxl1","display_name":"ASXL1","score":0.656000018119812},{"id":"https://openalex.org/keywords/runx1","display_name":"RUNX1","score":0.906000018119812},{"id":"https://openalex.org/keywords/ezh2","display_name":"EZH2","score":0.9049999713897705},{"id":"https://openalex.org/keywords/sf3b1","display_name":"SF3B1","score":0.9819999933242798},{"id":"https://openalex.org/keywords/spliceosome-mutations","display_name":"spliceosome mutations","score":0.7680000066757202},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7250000238418579},{"id":"https://openalex.org/keywords/baseline-hemoglobin","display_name":"baseline hemoglobin","score":0.6449999809265137},{"id":"https://openalex.org/keywords/first-line-treatment","display_name":"first-line therapy","score":0.5680000185966492},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.4230000078678131}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9495999813079834},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6769000291824341},{"id":"https://openalex.org/C3018657049","wikidata":"https://www.wikidata.org/wiki/Q1595418","display_name":"Complete remission","level":3,"score":0.5866000056266785},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.541700005531311},{"id":"https://openalex.org/C12725497","wikidata":"https://www.wikidata.org/wiki/Q810247","display_name":"Baseline (sea)","level":2,"score":0.46889999508857727},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4122999906539917},{"id":"https://openalex.org/C3019096185","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Complete response","level":3,"score":0.275299996137619},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.257999986410141},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.2549999952316284},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.24379999935626984}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/s2152-2650(26)02225-1","doi":"https://doi.org/10.1016/s2152-2650(26)02225-1","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s2152-2650(26)02225-1","pdf_url":null,"source":{"id":"https://openalex.org/S186546955","display_name":"Clinical Lymphoma Myeloma & Leukemia","issn_l":"2152-2650","issn":["2152-2650","2152-2669"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Lymphoma Myeloma and Leukemia","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9907000064849854,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4417010215","https://openalex.org/W4417007372","https://openalex.org/W2780282110","https://openalex.org/W3211725549","https://openalex.org/W4309192456","https://openalex.org/W3213293394","https://openalex.org/W3212821481","https://openalex.org/W2521778672","https://openalex.org/W4296468421","https://openalex.org/W2195661473"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2026-08-31T00:00:00"}