{"id":"https://openalex.org/W7204729209","doi":"https://doi.org/10.7554/elife.113238","title":"Single-Molecule Nanopore Profiling of p53-TAD\u2019s Conformational Dynamics, Interactions, and Inhibition","display_name":"Single-Molecule Nanopore Profiling of p53-TAD\u2019s Conformational Dynamics, Interactions, and Inhibition","publication_year":2026,"publication_date":"2026-08-29","ids":{"openalex":"https://openalex.org/W7204729209","doi":"https://doi.org/10.7554/elife.113238"},"language":"en","primary_location":{"id":"doi:10.7554/elife.113238","doi":"https://doi.org/10.7554/elife.113238","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.113238","pdf_url":"https://elifesciences.org/reviewed-preprints/113238.pdf","source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"eLife","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://elifesciences.org/reviewed-preprints/113238.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5116256474","display_name":"David DeCoeur","orcid":"https://orcid.org/0009-0008-4552-2343","observed_orcids":["https://orcid.org/0009-0008-4552-2343"]},"institutions":[{"id":"https://openalex.org/I24603500","display_name":"University of Massachusetts Amherst","ror":"https://ror.org/0072zz521","country_code":"US","type":"education","lineage":["https://openalex.org/I24603500"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David DeCoeur","raw_affiliation_strings":["Molecular and Cellular Biology Program, University of Massachusetts, Amherst, MA 01003, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular and Cellular Biology Program, University of Massachusetts, Amherst, MA 01003, USA","institution_ids":["https://openalex.org/I24603500"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157339418","display_name":"Samantha Schultz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24603500","display_name":"University of Massachusetts Amherst","ror":"https://ror.org/0072zz521","country_code":"US","type":"education","lineage":["https://openalex.org/I24603500"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samantha Schultz","raw_affiliation_strings":["Molecular and Cellular Biology Program, University of Massachusetts, Amherst, MA 01003, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular and Cellular Biology Program, University of Massachusetts, Amherst, MA 01003, USA","institution_ids":["https://openalex.org/I24603500"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032839759","display_name":"Jianhan Chen","orcid":"https://orcid.org/0000-0002-5281-1150","observed_orcids":["https://orcid.org/0000-0002-5281-1150"]},"institutions":[{"id":"https://openalex.org/I24603500","display_name":"University of Massachusetts Amherst","ror":"https://ror.org/0072zz521","country_code":"US","type":"education","lineage":["https://openalex.org/I24603500"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jianhan Chen","raw_affiliation_strings":["Department of Chemistry, University of Massachusetts, Amherst, MA 01003, USA","Molecular and Cellular Biology Program, University of Massachusetts, Amherst, MA 01003, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Massachusetts, Amherst, MA 01003, USA","institution_ids":["https://openalex.org/I24603500"]},{"raw_affiliation_string":"Molecular and Cellular Biology Program, University of Massachusetts, Amherst, MA 01003, USA","institution_ids":["https://openalex.org/I24603500"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100337242","display_name":"Min Chen","orcid":"https://orcid.org/0000-0002-7572-0761","observed_orcids":["https://orcid.org/0000-0002-7572-0761"]},"institutions":[{"id":"https://openalex.org/I24603500","display_name":"University of Massachusetts Amherst","ror":"https://ror.org/0072zz521","country_code":"US","type":"education","lineage":["https://openalex.org/I24603500"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Min Chen","raw_affiliation_strings":["Department of Chemistry, University of Massachusetts, Amherst, MA 01003, USA","Molecular and Cellular Biology Program, University of Massachusetts, Amherst, MA 01003, USA"],"raw_orcid":"https://orcid.org/0000-0002-7572-0761","affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Massachusetts, Amherst, MA 01003, USA","institution_ids":["https://openalex.org/I24603500"]},{"raw_affiliation_string":"Molecular and Cellular Biology Program, University of Massachusetts, Amherst, MA 01003, USA","institution_ids":["https://openalex.org/I24603500"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5100337242"],"corresponding_institution_ids":["https://openalex.org/I24603500"],"apc_list":{"value":3000,"currency":"USD","value_usd":2500},"apc_paid":{"value":3000,"currency":"USD","value_usd":2500},"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11582","display_name":"Nanopore and Nanochannel Transport Studies","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11582","display_name":"Nanopore and Nanochannel Transport Studies","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.006399999838322401,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10923","display_name":"Force Microscopy Techniques and Applications","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/3107","display_name":"Atomic and Molecular Physics, and Optics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/p53-transactivation-domain","display_name":"p53 transactivation domain","score":0.9539999961853027},{"id":"https://openalex.org/keywords/intrinsically-disordered-proteins","display_name":"intrinsically disordered proteins","score":0.9909999966621399},{"id":"https://openalex.org/keywords/conformational-dynamics","display_name":"conformational dynamics","score":0.8820000290870667},{"id":"https://openalex.org/keywords/epigallocatechin-gallate","display_name":"epigallocatechin gallate","score":0.9639999866485596},{"id":"https://openalex.org/keywords/protein-protein-interaction-inhibition","display_name":"protein-protein interaction inhibition","score":0.5730000138282776},{"id":"https://openalex.org/keywords/steered-molecular-dynamics","display_name":"steered molecular dynamics","score":0.7789999842643738}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6711000204086304},{"id":"https://openalex.org/C141795571","wikidata":"https://www.wikidata.org/wiki/Q580942","display_name":"Nanopore","level":2,"score":0.6510999798774719},{"id":"https://openalex.org/C2778815515","wikidata":"https://www.wikidata.org/wiki/Q3408242","display_name":"Intrinsically disordered proteins","level":2,"score":0.6446999907493591},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.6431999802589417},{"id":"https://openalex.org/C2777339483","wikidata":"https://www.wikidata.org/wiki/Q647203","display_name":"Conformational change","level":2,"score":0.5458999872207642},{"id":"https://openalex.org/C59593255","wikidata":"https://www.wikidata.org/wiki/Q901663","display_name":"Molecular dynamics","level":2,"score":0.5181999802589417},{"id":"https://openalex.org/C2777936996","wikidata":"https://www.wikidata.org/wiki/Q17148461","display_name":"Conformational ensembles","level":3,"score":0.4984999895095825},{"id":"https://openalex.org/C134459356","wikidata":"https://www.wikidata.org/wiki/Q4274835","display_name":"Ubiquitin ligase","level":4,"score":0.4803999960422516},{"id":"https://openalex.org/C1292079","wikidata":"https://www.wikidata.org/wiki/Q3817769","display_name":"Transactivation","level":4,"score":0.4564000070095062},{"id":"https://openalex.org/C11804247","wikidata":"https://www.wikidata.org/wiki/Q896177","display_name":"Protein\u2013protein interaction","level":2,"score":0.4097000062465668},{"id":"https://openalex.org/C179185449","wikidata":"https://www.wikidata.org/wiki/Q219699","display_name":"Suppressor","level":3,"score":0.3953000009059906},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.3901999890804291},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.3828999996185303},{"id":"https://openalex.org/C51639874","wikidata":"https://www.wikidata.org/wiki/Q167149","display_name":"Plasma protein binding","level":2,"score":0.37549999356269836},{"id":"https://openalex.org/C166342909","wikidata":"https://www.wikidata.org/wiki/Q845326","display_name":"Allosteric regulation","level":3,"score":0.3677000105381012},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.30720001459121704},{"id":"https://openalex.org/C204491159","wikidata":"https://www.wikidata.org/wiki/Q24726881","display_name":"WW domain","level":3,"score":0.29280000925064087},{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.2921999990940094},{"id":"https://openalex.org/C2986374874","wikidata":"https://www.wikidata.org/wiki/Q8054","display_name":"Protein function","level":3,"score":0.2888000011444092},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.288100004196167},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.28459998965263367},{"id":"https://openalex.org/C145912823","wikidata":"https://www.wikidata.org/wiki/Q113558","display_name":"Dynamics (music)","level":2,"score":0.2816999852657318},{"id":"https://openalex.org/C2776192174","wikidata":"https://www.wikidata.org/wiki/Q18028978","display_name":"Mdm2","level":3,"score":0.2711000144481659},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.26579999923706055},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.26330000162124634},{"id":"https://openalex.org/C30095370","wikidata":"https://www.wikidata.org/wiki/Q899488","display_name":"Protonation","level":3,"score":0.2621000111103058},{"id":"https://openalex.org/C144292202","wikidata":"https://www.wikidata.org/wiki/Q898273","display_name":"Protein domain","level":3,"score":0.2612999975681305},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.2603999972343445},{"id":"https://openalex.org/C174510640","wikidata":"https://www.wikidata.org/wiki/Q489618","display_name":"HEK 293 cells","level":3,"score":0.25209999084472656}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.7554/elife.113238","doi":"https://doi.org/10.7554/elife.113238","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.113238","pdf_url":"https://elifesciences.org/reviewed-preprints/113238.pdf","source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"eLife","raw_type":"posted-content"},{"id":"doi:10.7554/elife.113238.1","doi":"https://doi.org/10.7554/elife.113238.1","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.113238.1","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"eLife","raw_type":"posted-content"},{"id":"doi:10.64898/2026.08.28.747917","doi":"https://doi.org/10.64898/2026.08.28.747917","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.28.747917","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/08/29/2026.08.28.747917.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.7554/elife.113238","doi":"https://doi.org/10.7554/elife.113238","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.113238","pdf_url":"https://elifesciences.org/reviewed-preprints/113238.pdf","source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"eLife","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.46810001134872437,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7259822537","display_name":null,"funder_award_id":"T32 GM139789","funder_id":"https://openalex.org/F4320332749","funder_display_name":"University of Massachusetts Amherst"},{"id":"https://openalex.org/G9000878374","display_name":"Developing a Nanopore Tweezer Toolkit for Analyzing Kinase Structural Dynamics and Screening Allosteric Inhibitors","funder_award_id":"1r01gm159415-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000894425","display_name":"Disordered Proteins and Dynamic Interactions in Biology and Diseases.","funder_award_id":"R35GM144045","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000895330","display_name":"Chemistry-Biology Interface Predoctoral Training Grant","funder_award_id":"T32GM139789","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000896895","display_name":"Probing Functional States and Inhibition of Flaviviral Proteases Using Nanopore Tweezers","funder_award_id":"R01AI156187","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332749","display_name":"University of Massachusetts Amherst","ror":"https://ror.org/0072zz521"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204729209.pdf","grobid_xml":"https://content.openalex.org/works/W7204729209.grobid-xml"},"referenced_works_count":71,"referenced_works":["https://openalex.org/W1966717195","https://openalex.org/W1972376083","https://openalex.org/W1974425511","https://openalex.org/W1974623964","https://openalex.org/W1976261939","https://openalex.org/W1976873804","https://openalex.org/W1996560714","https://openalex.org/W1997760180","https://openalex.org/W2006192061","https://openalex.org/W2015117663","https://openalex.org/W2016170088","https://openalex.org/W2019595592","https://openalex.org/W2023486531","https://openalex.org/W2025722611","https://openalex.org/W2042316019","https://openalex.org/W2042484101","https://openalex.org/W2055644676","https://openalex.org/W2066158357","https://openalex.org/W2066962978","https://openalex.org/W2071626756","https://openalex.org/W2081184407","https://openalex.org/W2083627679","https://openalex.org/W2085656056","https://openalex.org/W2097933346","https://openalex.org/W2099459640","https://openalex.org/W2113370608","https://openalex.org/W2118608964","https://openalex.org/W2120881407","https://openalex.org/W2126099124","https://openalex.org/W2127929745","https://openalex.org/W2128944252","https://openalex.org/W2129938424","https://openalex.org/W2133959309","https://openalex.org/W2149472608","https://openalex.org/W2166269098","https://openalex.org/W2170146374","https://openalex.org/W2334130133","https://openalex.org/W2345839951","https://openalex.org/W2522129328","https://openalex.org/W2752942423","https://openalex.org/W2768740024","https://openalex.org/W2802596480","https://openalex.org/W2805364376","https://openalex.org/W2889972211","https://openalex.org/W2971678516","https://openalex.org/W3008920080","https://openalex.org/W3014450044","https://openalex.org/W3021765302","https://openalex.org/W3126550244","https://openalex.org/W3145012116","https://openalex.org/W3158082151","https://openalex.org/W3163638763","https://openalex.org/W4205435879","https://openalex.org/W4224214254","https://openalex.org/W4226117864","https://openalex.org/W4297243252","https://openalex.org/W4307777362","https://openalex.org/W4362560719","https://openalex.org/W4386161523","https://openalex.org/W4390016576","https://openalex.org/W4396721167","https://openalex.org/W4400987989","https://openalex.org/W4402534399","https://openalex.org/W4404578963","https://openalex.org/W4404636581","https://openalex.org/W4410253781","https://openalex.org/W4411134946","https://openalex.org/W4414569518","https://openalex.org/W4417168362","https://openalex.org/W7154252873","https://openalex.org/W7165894845"],"related_works":["https://openalex.org/W4407493848","https://openalex.org/W6940085792","https://openalex.org/W2989910233","https://openalex.org/W3163638763","https://openalex.org/W3145012116","https://openalex.org/W1989553458","https://openalex.org/W4402534399","https://openalex.org/W4410762274","https://openalex.org/W2889972211","https://openalex.org/W2965266033"],"abstract_inverted_index":{"Abstract":[0],"Investigating":[1],"the":[2,36,44,52,64,98,117,134,165,183,186],"conformational":[3,37,92,121,194],"dynamics":[4,38,112],"of":[5,41,57,63,100,140,164,185,192],"intrinsically":[6,53],"disordered":[7,54],"proteins":[8,66],"(IDPs)":[9],"is":[10,152],"essential":[11],"to":[12,25,81,145],"understanding":[13],"how":[14,21,149],"their":[15,22],"structural":[16],"heterogeneity":[17],"underlies":[18],"function":[19],"and":[20,39,78,147,198],"dysregulation":[23],"contributes":[24],"diseases.":[26],"Here,":[27],"we":[28,114],"utilized":[29],"an":[30],"MspA":[31,73,135],"nanopore-based":[32],"approach":[33],"for":[34,175,189],"studying":[35],"interactions":[40],"IDPs":[42],"at":[43,200],"single-molecule":[45,201],"level.":[46],"The":[47,94],"platform":[48,136,188],"was":[49],"demonstrated":[50],"using":[51],"transactivation":[55],"domain":[56],"tumor":[58],"suppressor":[59],"p53":[60],"(p53-TAD),":[61],"one":[62,163],"important":[65],"in":[67],"cancer":[68],"biology.":[69],"We":[70],"showed":[71,115],"that":[72,116],"can":[74],"stably":[75],"capture":[76],"p53-TAD":[77,146],"resolve":[79],"up":[80],"six":[82,166],"distinct":[83],"current":[84],"states":[85,122,167],"with":[86,109,129],"frequent":[87],"interconversions,":[88],"revealing":[89],"a":[90,101,172],"rich":[91],"landscape.":[93],"nanopore":[95,187],"also":[96],"detected":[97],"effect":[99],"cancer-associated":[102],"double":[103],"mutational":[104],"variant,":[105],"N29K/N30D.":[106],"Combining":[107],"experiments":[108],"steered":[110],"molecular":[111],"simulations,":[113],"mutant":[118],"sampled":[119,168],"compact":[120],"more":[123],"frequently":[124],"than":[125],"wild":[126],"type,":[127],"consistent":[128],"previous":[130],"NMR":[131],"studies.":[132],"Importantly,":[133],"enabled":[137],"direct":[138],"monitoring":[139,191],"E3":[141],"ligase":[142],"MDM2":[143],"binding":[144,197],"resolved":[148],"this":[150],"interaction":[151],"inhibited":[153],"by":[154,169],"anti-cancer":[155],"compound":[156],"epigallocatechin":[157],"gallate":[158],"(EGCG).":[159],"Notably,":[160],"EGCG":[161],"stabilizes":[162],"p53-TAD,":[170],"providing":[171],"mechanistic":[173],"explanation":[174],"its":[176],"inhibitory":[177],"effect.":[178],"Together,":[179],"these":[180],"findings":[181],"demonstrate":[182],"promise":[184],"label-free":[190],"IDP":[193],"dynamics,":[195],"modulation,":[196],"inhibition":[199],"resolution.":[202]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-08-31T00:00:00"}
