{"id":"https://openalex.org/W7204708010","doi":"https://doi.org/10.1016/s2152-2650(26)02042-2","title":"CLL-429: Daybreak CLL-201: A Study of Bexobrutideg (NX-5948), a Bruton Tyrosine Kinase Degrader, in Patients With Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma Previously Treated With a Covalent BTK Inhibitor, a Noncovalent BTK Inhibitor, and a BCL2 Inhibitor","display_name":"CLL-429: Daybreak CLL-201: A Study of Bexobrutideg (NX-5948), a Bruton Tyrosine Kinase Degrader, in Patients With Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma Previously Treated With a Covalent BTK Inhibitor, a Noncovalent BTK Inhibitor, and a BCL2 Inhibitor","publication_year":2026,"publication_date":"2026-08-01","ids":{"openalex":"https://openalex.org/W7204708010","doi":"https://doi.org/10.1016/s2152-2650(26)02042-2"},"language":"en","primary_location":{"id":"doi:10.1016/s2152-2650(26)02042-2","doi":"https://doi.org/10.1016/s2152-2650(26)02042-2","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s2152-2650(26)02042-2","pdf_url":null,"source":{"id":"https://openalex.org/S186546955","display_name":"Clinical Lymphoma Myeloma & Leukemia","issn_l":"2152-2650","issn":["2152-2650","2152-2669"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Lymphoma Myeloma and Leukemia","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5140204249","display_name":"Michael Tees","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210134093","display_name":"Colorado Blood Cancer Institute","ror":"https://ror.org/040pncp85","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210134093"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Tees","raw_affiliation_strings":["Colorado Blood Cancer Institute and Sarah Cannon Research Institute, Denver, CO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Colorado Blood Cancer Institute and Sarah Cannon Research Institute, Denver, CO, USA","institution_ids":["https://openalex.org/I4210134093"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087770514","display_name":"Paolo Ghia","orcid":"https://orcid.org/0000-0003-3750-7342","observed_orcids":["https://orcid.org/0000-0003-3750-7342"]},"institutions":[{"id":"https://openalex.org/I154387261","display_name":"Vita-Salute San Raffaele University","ror":"https://ror.org/01gmqr298","country_code":"IT","type":"education","lineage":["https://openalex.org/I154387261"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Paolo Ghia","raw_affiliation_strings":["Universit\u00e0 Vita-Salute San Raffaele di Milano, Milano, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e0 Vita-Salute San Raffaele di Milano, Milano, Italy","institution_ids":["https://openalex.org/I154387261"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080864734","display_name":"Dima El\u2010Sharkawi","orcid":"https://orcid.org/0000-0002-2752-5814","observed_orcids":["https://orcid.org/0000-0002-2752-5814"]},"institutions":[{"id":"https://openalex.org/I1325846038","display_name":"Royal Marsden NHS Foundation Trust","ror":"https://ror.org/0008wzh48","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1325846038"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Dima El-Sharkawi","raw_affiliation_strings":["Royal Marsden NHS Foundation Trust, Sutton, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Royal Marsden NHS Foundation Trust, Sutton, United Kingdom","institution_ids":["https://openalex.org/I1325846038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148624000","display_name":"Michal Kwiatek","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michal Kwiatek","raw_affiliation_strings":["AidPort Hospital, Sk\u00f3rzewo (Poznan), Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AidPort Hospital, Sk\u00f3rzewo (Poznan), Poland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148671101","display_name":"Sebastien Grosicki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I166182418","display_name":"Medical University of Silesia","ror":"https://ror.org/005k7hp45","country_code":"PL","type":"education","lineage":["https://openalex.org/I166182418"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Sebastien Grosicki","raw_affiliation_strings":["Medical University of Silesia, Katowice, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical University of Silesia, Katowice, Poland","institution_ids":["https://openalex.org/I166182418"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085813390","display_name":"Anne Lok","orcid":"https://orcid.org/0000-0001-8340-0963","observed_orcids":["https://orcid.org/0000-0001-8340-0963"]},"institutions":[{"id":"https://openalex.org/I3019204325","display_name":"Centre Hospitalier Universitaire de Nantes","ror":"https://ror.org/05c1qsg97","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019204325"]},{"id":"https://openalex.org/I97188460","display_name":"Nantes Universit\u00e9","ror":"https://ror.org/03gnr7b55","country_code":"FR","type":"education","lineage":["https://openalex.org/I97188460"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Anne Lok","raw_affiliation_strings":["Centre Hospitalier Universitaire de Nantes, Nantes, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre Hospitalier Universitaire de Nantes, Nantes, France","institution_ids":["https://openalex.org/I3019204325","https://openalex.org/I97188460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111162935","display_name":"Jane D. Robertson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210131968","display_name":"The Christie Hospital","ror":"https://ror.org/03nd63441","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210131968","https://openalex.org/I4210133995"]},{"id":"https://openalex.org/I4392738304","display_name":"Cancer Research UK Manchester Centre","ror":"https://ror.org/033svsm10","country_code":null,"type":"facility","lineage":["https://openalex.org/I2801316944","https://openalex.org/I28407311","https://openalex.org/I4210133995","https://openalex.org/I4392738304"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jane Robertson","raw_affiliation_strings":["The Christie Hospital and Manchester Cancer Research Centre, Division of Cancer Sciences, Manchester, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Christie Hospital and Manchester Cancer Research Centre, Division of Cancer Sciences, Manchester, United Kingdom","institution_ids":["https://openalex.org/I4210131968","https://openalex.org/I4392738304"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124879273","display_name":"Krish Patel","orcid":"https://orcid.org/0000-0002-2446-098X","observed_orcids":["https://orcid.org/0000-0002-2446-098X"]},"institutions":[{"id":"https://openalex.org/I4210100810","display_name":"Sarah Cannon","ror":"https://ror.org/014t21j89","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210100810"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Krish Patel","raw_affiliation_strings":["Sarah Cannon Research Institute, Nashville, TN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sarah Cannon Research Institute, Nashville, TN, USA","institution_ids":["https://openalex.org/I4210100810"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057017325","display_name":"Iwona Hus","orcid":"https://orcid.org/0000-0002-6096-4093","observed_orcids":["https://orcid.org/0000-0002-6096-4093"]},"institutions":[{"id":"https://openalex.org/I121032520","display_name":"Medical University of Lublin","ror":"https://ror.org/016f61126","country_code":"PL","type":"education","lineage":["https://openalex.org/I121032520"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Iwona Hus","raw_affiliation_strings":["Medical University of Lublin, Lublin, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical University of Lublin, Lublin, Poland","institution_ids":["https://openalex.org/I121032520"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148714610","display_name":"Lucy Yan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lucy Yan","raw_affiliation_strings":["Nurix Therapeutics, Inc, Brisbane, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nurix Therapeutics, Inc, Brisbane, CA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012624184","display_name":"Srinand Nandakumar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Srinand Nandakumar","raw_affiliation_strings":["Nurix Therapeutics, Inc, Brisbane, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nurix Therapeutics, Inc, Brisbane, CA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148746853","display_name":"Kelly O'Brien","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kelly O'Brien","raw_affiliation_strings":["Nurix Therapeutics, Inc, Brisbane, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nurix Therapeutics, Inc, Brisbane, CA, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5148694245","display_name":"Wojciech Jurczak","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210150880","display_name":"The Maria Sklodowska-Curie National Research Institute of Oncology","ror":"https://ror.org/04qcjsm24","country_code":"PL","type":"healthcare","lineage":["https://openalex.org/I4210150880"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Wojciech Jurczak","raw_affiliation_strings":["Maria Sklodowska-Curie National Research Institute of Oncology, Krak\u00f3w, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Maria Sklodowska-Curie National Research Institute of Oncology, Krak\u00f3w, Poland","institution_ids":["https://openalex.org/I4210150880"]}]}],"institutions":[],"countries_distinct_count":5,"institutions_distinct_count":11,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3890,"currency":"USD","value_usd":3890},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"26","issue":null,"first_page":"S607","last_page":"S607"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12534","display_name":"Protein Degradation and Inhibitors","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-lymphocytic-leukemia","display_name":"chronic lymphocytic leukemia","score":0.9729999899864197},{"id":"https://openalex.org/keywords/small-lymphocytic-lymphoma","display_name":"small lymphocytic lymphoma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/relapsed-refractory-b-cell-malignancies","display_name":"relapsed/refractory B-cell malignancies","score":0.9459999799728394},{"id":"https://openalex.org/keywords/btk-inhibitor-resistance","display_name":"BTK inhibitor resistance","score":0.7110000252723694},{"id":"https://openalex.org/keywords/bcl2-inhibitors","display_name":"BCL-2 inhibitor","score":0.6439999938011169},{"id":"https://openalex.org/keywords/proteasomal-degradation","display_name":"proteasomal degradation","score":0.8809999823570251}],"concepts":[{"id":"https://openalex.org/C90059517","wikidata":"https://www.wikidata.org/wiki/Q423572","display_name":"Bruton's tyrosine kinase","level":4,"score":0.9657999873161316},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7957000136375427},{"id":"https://openalex.org/C2777938653","wikidata":"https://www.wikidata.org/wiki/Q1088156","display_name":"Chronic lymphocytic leukemia","level":3,"score":0.6668999791145325},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5734999775886536},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.5712000131607056},{"id":"https://openalex.org/C2779878957","wikidata":"https://www.wikidata.org/wiki/Q5984881","display_name":"Ibrutinib","level":4,"score":0.47540000081062317},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.4675000011920929},{"id":"https://openalex.org/C2908812692","wikidata":"https://www.wikidata.org/wiki/Q3269477","display_name":"Lymphocytic infiltration","level":2,"score":0.4244999885559082},{"id":"https://openalex.org/C180577832","wikidata":"https://www.wikidata.org/wiki/Q127920","display_name":"Covalent bond","level":2,"score":0.420199990272522},{"id":"https://openalex.org/C2778453870","wikidata":"https://www.wikidata.org/wiki/Q188930","display_name":"B cell","level":3,"score":0.3386000096797943},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.33730000257492065},{"id":"https://openalex.org/C2776165026","wikidata":"https://www.wikidata.org/wiki/Q188017","display_name":"Tyrosine","level":2,"score":0.2815999984741211},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.27900001406669617},{"id":"https://openalex.org/C2909867262","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Protein-Tyrosine Kinases","level":4,"score":0.26489999890327454},{"id":"https://openalex.org/C2778820342","wikidata":"https://www.wikidata.org/wiki/Q906415","display_name":"Tyrosine-kinase inhibitor","level":3,"score":0.2621000111103058}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/s2152-2650(26)02042-2","doi":"https://doi.org/10.1016/s2152-2650(26)02042-2","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s2152-2650(26)02042-2","pdf_url":null,"source":{"id":"https://openalex.org/S186546955","display_name":"Clinical Lymphoma Myeloma & Leukemia","issn_l":"2152-2650","issn":["2152-2650","2152-2669"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Lymphoma Myeloma and Leukemia","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2026-08-31T00:00:00"}
