{"id":"https://openalex.org/W7204705237","doi":"https://doi.org/10.1016/s2152-2650(26)02050-1","title":"CLL-476: Real-World Comparative Analysis of Treatment Discontinuation With Covalent Bruton Tyrosine Kinase Inhibitors in First-Line Chronic Lymphocytic Leukemia","display_name":"CLL-476: Real-World Comparative Analysis of Treatment Discontinuation With Covalent Bruton Tyrosine Kinase Inhibitors in First-Line Chronic Lymphocytic Leukemia","publication_year":2026,"publication_date":"2026-08-01","ids":{"openalex":"https://openalex.org/W7204705237","doi":"https://doi.org/10.1016/s2152-2650(26)02050-1"},"language":"en","primary_location":{"id":"doi:10.1016/s2152-2650(26)02050-1","doi":"https://doi.org/10.1016/s2152-2650(26)02050-1","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s2152-2650(26)02050-1","pdf_url":null,"source":{"id":"https://openalex.org/S186546955","display_name":"Clinical Lymphoma Myeloma & Leukemia","issn_l":"2152-2650","issn":["2152-2650","2152-2669"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Lymphoma Myeloma and Leukemia","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5148730044","display_name":"Nakhle Saba","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1303964898","display_name":"Our Lady of the Lake Regional Medical Center","ror":"https://ror.org/01y9s4r06","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1303964898"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nakhle Saba","raw_affiliation_strings":["Our Lady of the Lake Cancer Institute, Baton Rouge, LA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Our Lady of the Lake Cancer Institute, Baton Rouge, LA, USA","institution_ids":["https://openalex.org/I1303964898"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005778778","display_name":"Erin C. Mulvey","orcid":"https://orcid.org/0000-0002-4042-8875","observed_orcids":["https://orcid.org/0000-0002-4042-8875"]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erin Mulvey","raw_affiliation_strings":["Weill Cornell Medicine, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Weill Cornell Medicine, New York, NY, USA","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148658585","display_name":"Mei Xue","orcid":"https://orcid.org/0009-0008-8087-1143","observed_orcids":["https://orcid.org/0009-0008-8087-1143"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mei Xue","raw_affiliation_strings":["BeOne Medicines Ltd, San Carlos, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BeOne Medicines Ltd, San Carlos, CA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065477373","display_name":"Keri Yang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Keri Yang","raw_affiliation_strings":["BeOne Medicines Ltd, San Carlos, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BeOne Medicines Ltd, San Carlos, CA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004151035","display_name":"Qianhong Fu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Qianhong Fu","raw_affiliation_strings":["BeOne Medicines Ltd, San Carlos, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BeOne Medicines Ltd, San Carlos, CA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148699462","display_name":"Dong Yuan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dong Yuan","raw_affiliation_strings":["BeOne Medicines Ltd, San Carlos, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BeOne Medicines Ltd, San Carlos, CA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148755314","display_name":"Derrick van Beuge","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Derrick van Beuge","raw_affiliation_strings":["BeOne Medicines Ltd, San Carlos, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BeOne Medicines Ltd, San Carlos, CA, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044589378","display_name":"Sikander Ailawadhi","orcid":"https://orcid.org/0000-0002-8377-8111","observed_orcids":["https://orcid.org/0000-0002-8377-8111"]},"institutions":[{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sikander Ailawadhi","raw_affiliation_strings":["Mayo Clinic, Jacksonville, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Jacksonville, FL, USA","institution_ids":["https://openalex.org/I4210146710"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3890,"currency":"USD","value_usd":3890},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"26","issue":null,"first_page":"S611","last_page":"S612"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-lymphocytic-leukemia","display_name":"chronic lymphocytic leukemia","score":0.8960000276565552},{"id":"https://openalex.org/keywords/small-lymphocytic-leukemia","display_name":"small lymphocytic leukemia","score":0.925000011920929},{"id":"https://openalex.org/keywords/ibrutinib","display_name":"ibrutinib","score":0.9139999747276306},{"id":"https://openalex.org/keywords/acalabrutinib","display_name":"acalabrutinib","score":0.9940000176429749},{"id":"https://openalex.org/keywords/zanubrutinib","display_name":"zanubrutinib","score":1.0},{"id":"https://openalex.org/keywords/first-line-treatment","display_name":"first-line therapy","score":0.7260000109672546},{"id":"https://openalex.org/keywords/treatment-discontinuation","display_name":"treatment discontinuation","score":0.996999979019165},{"id":"https://openalex.org/keywords/medication-persistence","display_name":"treatment persistence","score":0.5699999928474426},{"id":"https://openalex.org/keywords/time-to-treatment-discontinuation","display_name":"time to treatment discontinuation","score":0.8379999995231628},{"id":"https://openalex.org/keywords/real-world-data","display_name":"real-world data","score":0.6480000019073486},{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.6439999938011169},{"id":"https://openalex.org/keywords/treatment-patterns","display_name":"treatment patterns","score":0.4339999854564667},{"id":"https://openalex.org/keywords/comparative-effectiveness","display_name":"comparative effectiveness","score":0.49900001287460327}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9235000014305115},{"id":"https://openalex.org/C90059517","wikidata":"https://www.wikidata.org/wiki/Q423572","display_name":"Bruton's tyrosine kinase","level":4,"score":0.6906999945640564},{"id":"https://openalex.org/C2777938653","wikidata":"https://www.wikidata.org/wiki/Q1088156","display_name":"Chronic lymphocytic leukemia","level":3,"score":0.6384999752044678},{"id":"https://openalex.org/C2778715236","wikidata":"https://www.wikidata.org/wiki/Q55622662","display_name":"Discontinuation","level":2,"score":0.6089000105857849},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5947999954223633},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.5281000137329102},{"id":"https://openalex.org/C41650920","wikidata":"https://www.wikidata.org/wiki/Q14912399","display_name":"CD135","level":4,"score":0.4180000126361847},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4138000011444092},{"id":"https://openalex.org/C2779878957","wikidata":"https://www.wikidata.org/wiki/Q5984881","display_name":"Ibrutinib","level":4,"score":0.36649999022483826},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.33059999346733093},{"id":"https://openalex.org/C2778820342","wikidata":"https://www.wikidata.org/wiki/Q906415","display_name":"Tyrosine-kinase inhibitor","level":3,"score":0.3158000111579895},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.29339998960494995},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.2542000114917755},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.2515999972820282}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/s2152-2650(26)02050-1","doi":"https://doi.org/10.1016/s2152-2650(26)02050-1","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s2152-2650(26)02050-1","pdf_url":null,"source":{"id":"https://openalex.org/S186546955","display_name":"Clinical Lymphoma Myeloma & Leukemia","issn_l":"2152-2650","issn":["2152-2650","2152-2669"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Lymphoma Myeloma and Leukemia","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2026-08-31T00:00:00"}
