{"id":"https://openalex.org/W7204702546","doi":"https://doi.org/10.61280/tjpls.v13i4.306","title":"Traditional Knowledge and Molecular Evidence of Medicinal Plants for Multi-Target Dengue Therapy: A Review","display_name":"Traditional Knowledge and Molecular Evidence of Medicinal Plants for Multi-Target Dengue Therapy: A Review","publication_year":2026,"publication_date":"2026-08-30","ids":{"openalex":"https://openalex.org/W7204702546","doi":"https://doi.org/10.61280/tjpls.v13i4.306"},"language":"en","primary_location":{"id":"doi:10.61280/tjpls.v13i4.306","doi":"https://doi.org/10.61280/tjpls.v13i4.306","is_oa":true,"landing_page_url":"https://doi.org/10.61280/tjpls.v13i4.306","pdf_url":null,"source":{"id":"https://openalex.org/S4387997668","display_name":"Tropical Journal of Pharmaceutical and Life Sciences","issn_l":"2349-9818","issn":["2349-9818"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tropical Journal of Pharmaceutical and Life Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.61280/tjpls.v13i4.306","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5144403557","display_name":"Mohammed Anas","orcid":"https://orcid.org/0009-0004-2275-0029","observed_orcids":["https://orcid.org/0009-0004-2275-0029"]},"institutions":[{"id":"https://openalex.org/I4210118921","display_name":"Institute of Life Sciences","ror":"https://ror.org/02927dx12","country_code":"IN","type":"education","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210118921","https://openalex.org/I4210134808"]},{"id":"https://openalex.org/I4210139271","display_name":"GIET University","ror":"https://ror.org/051f2wp73","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210139271"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Mohammed Anas","raw_affiliation_strings":["Department of Biotechnology, Gandhi Institute of Engineering and Technology University, Gunupur, Odisha-765022, India AND BRIC-Institute of Life Sciences (ILS), Bhubaneswar, Odisha, India"],"raw_orcid":"https://orcid.org/0009-0004-2275-0029","affiliations":[{"raw_affiliation_string":"Department of Biotechnology, Gandhi Institute of Engineering and Technology University, Gunupur, Odisha-765022, India AND BRIC-Institute of Life Sciences (ILS), Bhubaneswar, Odisha, India","institution_ids":["https://openalex.org/I4210118921","https://openalex.org/I4210139271"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5137997562","display_name":"Farhat Jahan","orcid":"https://orcid.org/0009-0005-3164-8453","observed_orcids":["https://orcid.org/0009-0005-3164-8453"]},"institutions":[{"id":"https://openalex.org/I6013171","display_name":"Ravenshaw University","ror":"https://ror.org/014ecgm61","country_code":"IN","type":"education","lineage":["https://openalex.org/I6013171"]},{"id":"https://openalex.org/I77541275","display_name":"Central Rice Research Institute","ror":"https://ror.org/029zb5621","country_code":"IN","type":"facility","lineage":["https://openalex.org/I179420787","https://openalex.org/I77541275"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Farhat Jahan","raw_affiliation_strings":["ICAR-Central Rice Research Institute (ICAR-CRRI), Cuttack-753006, Odisha, India  AND Department of Botany, Ravenshaw University, Cuttack-753003, Odisha, India"],"raw_orcid":"https://orcid.org/0009-0005-3164-8453","affiliations":[{"raw_affiliation_string":"ICAR-Central Rice Research Institute (ICAR-CRRI), Cuttack-753006, Odisha, India  AND Department of Botany, Ravenshaw University, Cuttack-753003, Odisha, India","institution_ids":["https://openalex.org/I6013171","https://openalex.org/I77541275"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"13","issue":"4","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10166","display_name":"Mosquito-borne diseases and control","score":0.5,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10166","display_name":"Mosquito-borne diseases and control","score":0.5,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.26030001044273376,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14478","display_name":"Papaya Research and Applications","score":0.16359999775886536,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dengue","display_name":"dengue","score":0.9179999828338623},{"id":"https://openalex.org/keywords/medicinal-plants","display_name":"medicinal plants","score":0.9520000219345093},{"id":"https://openalex.org/keywords/traditional-knowledge","display_name":"traditional knowledge","score":0.7419999837875366},{"id":"https://openalex.org/keywords/ns2b-ns3-protease","display_name":"NS2B-NS3 protease","score":0.8740000128746033},{"id":"https://openalex.org/keywords/ns5-rna-dependent-rna-polymerase","display_name":"NS5 RNA-dependent RNA polymerase","score":0.9980000257492065},{"id":"https://openalex.org/keywords/carica-papaya","display_name":"Carica papaya","score":0.8199999928474426},{"id":"https://openalex.org/keywords/andrographis-paniculata","display_name":"Andrographis paniculata","score":1.0},{"id":"https://openalex.org/keywords/tinospora-cordifolia","display_name":"Tinospora cordifolia","score":1.0},{"id":"https://openalex.org/keywords/flavonoids","display_name":"flavonoids","score":0.8489999771118164},{"id":"https://openalex.org/keywords/alkaloids","display_name":"alkaloids","score":0.796999990940094},{"id":"https://openalex.org/keywords/polyphenols","display_name":"polyphenols","score":0.7480000257492065},{"id":"https://openalex.org/keywords/phytochemicals","display_name":"phytochemicals","score":0.7269999980926514},{"id":"https://openalex.org/keywords/network-pharmacology","display_name":"network pharmacology","score":0.7139999866485596},{"id":"https://openalex.org/keywords/molecular-docking","display_name":"molecular docking","score":0.9089999794960022},{"id":"https://openalex.org/keywords/plant-conservation","display_name":"plant conservation","score":0.3959999978542328},{"id":"https://openalex.org/keywords/dengue-vector-control","display_name":"dengue vector control","score":0.7099999785423279},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7289999723434448},{"id":"https://openalex.org/keywords/platelet-recovery","display_name":"platelet recovery","score":0.7110000252723694}],"concepts":[{"id":"https://openalex.org/C533803919","wikidata":"https://www.wikidata.org/wiki/Q30953","display_name":"Dengue fever","level":2,"score":0.8263000249862671},{"id":"https://openalex.org/C2779635636","wikidata":"https://www.wikidata.org/wiki/Q476209","display_name":"Dengue virus","level":3,"score":0.6704000234603882},{"id":"https://openalex.org/C2777970627","wikidata":"https://www.wikidata.org/wiki/Q1551608","display_name":"Andrographis paniculata","level":3,"score":0.5285999774932861},{"id":"https://openalex.org/C2779158651","wikidata":"https://www.wikidata.org/wiki/Q188840","display_name":"Medicinal plants","level":2,"score":0.4875999987125397},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.48089998960494995},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.36739999055862427},{"id":"https://openalex.org/C10679952","wikidata":"https://www.wikidata.org/wiki/Q5308937","display_name":"Druggability","level":3,"score":0.3668999969959259},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.3522999882698059},{"id":"https://openalex.org/C46578552","wikidata":"https://www.wikidata.org/wiki/Q2725393","display_name":"Global health","level":3,"score":0.3407999873161316},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33329999446868896},{"id":"https://openalex.org/C92087593","wikidata":"https://www.wikidata.org/wiki/Q427389","display_name":"Vector (molecular biology)","level":4,"score":0.3208000063896179},{"id":"https://openalex.org/C52384281","wikidata":"https://www.wikidata.org/wiki/Q864713","display_name":"Biosafety","level":2,"score":0.3179999887943268},{"id":"https://openalex.org/C189708586","wikidata":"https://www.wikidata.org/wiki/Q1504425","display_name":"Systematic review","level":3,"score":0.30219998955726624},{"id":"https://openalex.org/C2779308166","wikidata":"https://www.wikidata.org/wiki/Q18388297","display_name":"Dengue vaccine","level":4,"score":0.2919999957084656},{"id":"https://openalex.org/C195475562","wikidata":"https://www.wikidata.org/wiki/Q1639139","display_name":"Phytochemical","level":2,"score":0.27219998836517334},{"id":"https://openalex.org/C66204764","wikidata":"https://www.wikidata.org/wiki/Q219416","display_name":"Sustainability","level":2,"score":0.2721000015735626},{"id":"https://openalex.org/C138816342","wikidata":"https://www.wikidata.org/wiki/Q189603","display_name":"Public health","level":2,"score":0.271699994802475},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.27090001106262207},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.26510000228881836},{"id":"https://openalex.org/C2777648638","wikidata":"https://www.wikidata.org/wiki/Q57751738","display_name":"Coronavirus","level":5,"score":0.26339998841285706},{"id":"https://openalex.org/C132379496","wikidata":"https://www.wikidata.org/wiki/Q83141645","display_name":"NS3","level":4,"score":0.25760000944137573}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.61280/tjpls.v13i4.306","doi":"https://doi.org/10.61280/tjpls.v13i4.306","is_oa":true,"landing_page_url":"https://doi.org/10.61280/tjpls.v13i4.306","pdf_url":null,"source":{"id":"https://openalex.org/S4387997668","display_name":"Tropical Journal of Pharmaceutical and Life Sciences","issn_l":"2349-9818","issn":["2349-9818"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tropical Journal of Pharmaceutical and Life Sciences","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.61280/tjpls.v13i4.306","doi":"https://doi.org/10.61280/tjpls.v13i4.306","is_oa":true,"landing_page_url":"https://doi.org/10.61280/tjpls.v13i4.306","pdf_url":null,"source":{"id":"https://openalex.org/S4387997668","display_name":"Tropical Journal of Pharmaceutical and Life Sciences","issn_l":"2349-9818","issn":["2349-9818"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tropical Journal of Pharmaceutical and Life Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":56,"referenced_works":["https://openalex.org/W1560224947","https://openalex.org/W1864178764","https://openalex.org/W1963677403","https://openalex.org/W1969353645","https://openalex.org/W2006539971","https://openalex.org/W2018750823","https://openalex.org/W2025312990","https://openalex.org/W2064558921","https://openalex.org/W2092998256","https://openalex.org/W2096108215","https://openalex.org/W2103800735","https://openalex.org/W2109578658","https://openalex.org/W2110628545","https://openalex.org/W2117662898","https://openalex.org/W2126789944","https://openalex.org/W2127359303","https://openalex.org/W2131222241","https://openalex.org/W2142180323","https://openalex.org/W2149682742","https://openalex.org/W2158337490","https://openalex.org/W2159415883","https://openalex.org/W2163412375","https://openalex.org/W2190260506","https://openalex.org/W2294320672","https://openalex.org/W2338936985","https://openalex.org/W2439821830","https://openalex.org/W2492658137","https://openalex.org/W2545070700","https://openalex.org/W2734465900","https://openalex.org/W2735055777","https://openalex.org/W2741552212","https://openalex.org/W2766187423","https://openalex.org/W2952094509","https://openalex.org/W2953761312","https://openalex.org/W2980775634","https://openalex.org/W2999742093","https://openalex.org/W3023251337","https://openalex.org/W3110712541","https://openalex.org/W3113676870","https://openalex.org/W3136190261","https://openalex.org/W3158098673","https://openalex.org/W3200612848","https://openalex.org/W4207035544","https://openalex.org/W4211248568","https://openalex.org/W4225136927","https://openalex.org/W4324311351","https://openalex.org/W4386156935","https://openalex.org/W4388023161","https://openalex.org/W4395684877","https://openalex.org/W4402236149","https://openalex.org/W4403502581","https://openalex.org/W4405330697","https://openalex.org/W4406562456","https://openalex.org/W4407115602","https://openalex.org/W4408162398","https://openalex.org/W4408414210"],"related_works":["https://openalex.org/W4403716336","https://openalex.org/W7223444142","https://openalex.org/W7202077297","https://openalex.org/W4400785887","https://openalex.org/W7161587325","https://openalex.org/W4286247376","https://openalex.org/W4404353714","https://openalex.org/W3115098502","https://openalex.org/W7223073826","https://openalex.org/W7133137599"],"abstract_inverted_index":{"Dengue":[0],"fever":[1],"continues":[2],"to":[3,68,88,197,228],"intensify":[4],"as":[5,96,214],"a":[6,26,34,44,223],"major":[7],"global":[8,232],"public":[9],"health":[10],"challenge,":[11],"driven":[12],"by":[13,168],"climate":[14],"change,":[15],"rapid":[16],"urbanization,":[17],"and":[18,29,66,82,99,109,121,136,148,155,161,176,193,225],"expanding":[19],"vector":[20,69],"habitats,":[21],"while":[22,104],"the":[23,199,230],"absence":[24],"of":[25,49,74,113,141,170,202],"universally":[27],"safe":[28],"effective":[30],"antiviral":[31],"therapy":[32],"remains":[33,166],"critical":[35],"limitation.":[36],"Unlike":[37],"conventional":[38],"single-target":[39],"antivirals,":[40],"plant-based":[41],"interventions":[42],"offer":[43],"multi-target":[45,216],"therapeutic":[46,153,200],"strategy":[47],"capable":[48],"simultaneously":[50],"inhibiting":[51],"viral":[52,93],"replication,":[53],"modulating":[54],"immune":[55],"dysregulation,":[56],"reducing":[57],"oxidative":[58],"stress,":[59],"stabilizing":[60],"endothelial":[61],"function,":[62],"enhancing":[63],"platelet":[64],"recovery,":[65],"contributing":[67],"control.":[70],"A":[71],"wide":[72],"range":[73],"phytochemicals,":[75],"including":[76],"flavonoids,":[77],"alkaloids,":[78],"tannins,":[79],"polyphenols,":[80],"polysaccharides,":[81],"bioactive":[83],"enzymes,":[84],"have":[85],"been":[86],"reported":[87],"interact":[89],"with":[90,116],"key":[91],"dengue":[92,187,206,220,233],"proteins":[94],"such":[95],"NS2B-NS3":[97],"protease":[98],"NS5":[100],"RNA-dependent":[101],"RNA":[102],"polymerase,":[103],"also":[105],"regulating":[106],"host":[107],"inflammatory":[108],"immunological":[110],"pathways.":[111],"Integration":[112],"ethnopharmacological":[114],"data":[115],"molecular":[117,195],"docking,":[118],"network":[119],"pharmacology,":[120],"preclinical":[122],"studies":[123],"provides":[124],"mechanistic":[125],"validation":[126],"for":[127,218],"traditionally":[128],"used":[129],"plants,":[130],"particularly":[131],"Carica":[132],"papaya,":[133],"Andrographis":[134],"paniculata,":[135],"Tinospora":[137],"cordifolia.":[138],"Additionally,":[139],"analysis":[140],"plant":[142],"diversity,":[143],"parts":[144],"used,":[145],"phytochemical":[146],"classes,":[147],"conservation":[149],"status":[150],"highlights":[151],"both":[152],"promise":[154],"sustainability":[156],"concerns.":[157],"Despite":[158],"promising":[159],"in-vitro":[160],"in-silico":[162],"evidence,":[163],"clinical":[164,179],"translation":[165],"constrained":[167],"lack":[169],"standardized":[171],"formulations,":[172],"limited":[173],"in-vivo":[174],"validation,":[175],"insufficient":[177],"large-scale":[178],"trials.":[180],"This":[181],"review":[182,210],"comprehensively":[183],"integrates":[184],"epidemiological":[185],"trends,":[186],"virus":[188],"biology,":[189],"pathogenesis,":[190],"traditional":[191],"knowledge,":[192],"modern":[194],"evidence":[196],"evaluate":[198],"potential":[201],"medicinal":[203,212],"plants":[204,213],"in":[205],"management.":[207],"Overall,":[208],"this":[209],"underscores":[211],"evidence-based,":[215],"candidates":[217],"next-generation":[219],"therapeutics,":[221],"offering":[222],"sustainable":[224],"affordable":[226],"pathway":[227],"mitigate":[229],"escalating":[231],"burden.":[234]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2026-08-31T00:00:00"}
