{"id":"https://openalex.org/W7204689766","doi":"https://doi.org/10.2174/0118715303483446260804045231","title":"Multi-omics Mendelian Randomization Prioritizes Neutrophil Extracellular Trap-related Genes Associated with Atrial Fibrillation Risk","display_name":"Multi-omics Mendelian Randomization Prioritizes Neutrophil Extracellular Trap-related Genes Associated with Atrial Fibrillation Risk","publication_year":2026,"publication_date":"2026-08-21","ids":{"openalex":"https://openalex.org/W7204689766","doi":"https://doi.org/10.2174/0118715303483446260804045231","pmid":"https://pubmed.ncbi.nlm.nih.gov/42693724"},"language":"en","primary_location":{"id":"doi:10.2174/0118715303483446260804045231","doi":"https://doi.org/10.2174/0118715303483446260804045231","is_oa":false,"landing_page_url":"https://doi.org/10.2174/0118715303483446260804045231","pdf_url":null,"source":{"id":"https://openalex.org/S4210179974","display_name":"Endocrine Metabolic & Immune Disorders - Drug Targets","issn_l":"1871-5303","issn":["1871-5303","2212-3873"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrine, Metabolic & Immune Disorders - Drug Targets","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5148632611","display_name":"Ruya Zhou","orcid":"https://orcid.org/0009-0008-2253-8289","observed_orcids":["https://orcid.org/0009-0008-2253-8289"]},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]},{"id":"https://openalex.org/I3129496460","display_name":"Lishui University","ror":"https://ror.org/0418kp584","country_code":"CN","type":"education","lineage":["https://openalex.org/I3129496460"]},{"id":"https://openalex.org/I4210125219","display_name":"Lishui City People's Hospital","ror":"https://ror.org/028yz2737","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210125219"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ruya Zhou","raw_affiliation_strings":["Department of Cardiology, Lishui Hospital of Wenzhou Medical University, The First Affiliated Hospital of LishuiUniversity, Lishui People's Hospital, Lishui, Zhejiang, China"],"raw_orcid":"https://orcid.org/0009-0008-2253-8289","affiliations":[{"raw_affiliation_string":"Department of Cardiology, Lishui Hospital of Wenzhou Medical University, The First Affiliated Hospital of LishuiUniversity, Lishui People's Hospital, Lishui, Zhejiang, China","institution_ids":["https://openalex.org/I27781120","https://openalex.org/I3129496460","https://openalex.org/I4210125219"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059242574","display_name":"Pengzhao Zhang","orcid":"https://orcid.org/0009-0007-8082-1974","observed_orcids":["https://orcid.org/0009-0007-8082-1974"]},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]},{"id":"https://openalex.org/I3129496460","display_name":"Lishui University","ror":"https://ror.org/0418kp584","country_code":"CN","type":"education","lineage":["https://openalex.org/I3129496460"]},{"id":"https://openalex.org/I4210125219","display_name":"Lishui City People's Hospital","ror":"https://ror.org/028yz2737","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210125219"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Pengzhao Zhang","raw_affiliation_strings":["Department of Interventional Medicine, Lishui Hospitalof Wenzhou Medical University, The First Affiliated Hospital of Lishui University, Lishui People's Hospital, Lishui,Zhejiang, China"],"raw_orcid":"https://orcid.org/0009-0007-8082-1974","affiliations":[{"raw_affiliation_string":"Department of Interventional Medicine, Lishui Hospitalof Wenzhou Medical University, The First Affiliated Hospital of Lishui University, Lishui People's Hospital, Lishui,Zhejiang, China","institution_ids":["https://openalex.org/I27781120","https://openalex.org/I3129496460","https://openalex.org/I4210125219"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101124710","display_name":"Feiyu Zhu","orcid":"https://orcid.org/0009-0007-0232-6601","observed_orcids":["https://orcid.org/0009-0007-0232-6601","https://orcid.org/0009-0006-3136-0406"]},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]},{"id":"https://openalex.org/I3129496460","display_name":"Lishui University","ror":"https://ror.org/0418kp584","country_code":"CN","type":"education","lineage":["https://openalex.org/I3129496460"]},{"id":"https://openalex.org/I4210125219","display_name":"Lishui City People's Hospital","ror":"https://ror.org/028yz2737","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210125219"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Feiyu Zhu","raw_affiliation_strings":["Department of Cardiology, Lishui Hospital of Wenzhou Medical University, The First Affiliated Hospital of LishuiUniversity, Lishui People's Hospital, Lishui, Zhejiang, China"],"raw_orcid":"https://orcid.org/0009-0006-3136-0406","affiliations":[{"raw_affiliation_string":"Department of Cardiology, Lishui Hospital of Wenzhou Medical University, The First Affiliated Hospital of LishuiUniversity, Lishui People's Hospital, Lishui, Zhejiang, China","institution_ids":["https://openalex.org/I27781120","https://openalex.org/I3129496460","https://openalex.org/I4210125219"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148641077","display_name":"Tingting Lian","orcid":"https://orcid.org/0009-0002-1814-622X","observed_orcids":["https://orcid.org/0009-0002-1814-622X"]},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]},{"id":"https://openalex.org/I3129496460","display_name":"Lishui University","ror":"https://ror.org/0418kp584","country_code":"CN","type":"education","lineage":["https://openalex.org/I3129496460"]},{"id":"https://openalex.org/I4210125219","display_name":"Lishui City People's Hospital","ror":"https://ror.org/028yz2737","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210125219"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tingting Lian","raw_affiliation_strings":["Department of Cardiology, Lishui Hospital of Wenzhou Medical University, The First Affiliated Hospital of LishuiUniversity, Lishui People's Hospital, Lishui, Zhejiang, China"],"raw_orcid":"https://orcid.org/0009-0002-1814-622X","affiliations":[{"raw_affiliation_string":"Department of Cardiology, Lishui Hospital of Wenzhou Medical University, The First Affiliated Hospital of LishuiUniversity, Lishui People's Hospital, Lishui, Zhejiang, China","institution_ids":["https://openalex.org/I27781120","https://openalex.org/I3129496460","https://openalex.org/I4210125219"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101704167","display_name":"Xianjun Wu","orcid":"https://orcid.org/0000-0002-9637-7181","observed_orcids":["https://orcid.org/0000-0002-9637-7181"]},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]},{"id":"https://openalex.org/I3129496460","display_name":"Lishui University","ror":"https://ror.org/0418kp584","country_code":"CN","type":"education","lineage":["https://openalex.org/I3129496460"]},{"id":"https://openalex.org/I4210125219","display_name":"Lishui City People's Hospital","ror":"https://ror.org/028yz2737","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210125219"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xianjun Wu","raw_affiliation_strings":["Department of Cardiology, Lishui Hospital of Wenzhou Medical University, The First Affiliated Hospital of LishuiUniversity, Lishui People's Hospital, Lishui, Zhejiang, China"],"raw_orcid":"https://orcid.org/0000-0002-9637-7181","affiliations":[{"raw_affiliation_string":"Department of Cardiology, Lishui Hospital of Wenzhou Medical University, The First Affiliated Hospital of LishuiUniversity, Lishui People's Hospital, Lishui, Zhejiang, China","institution_ids":["https://openalex.org/I27781120","https://openalex.org/I3129496460","https://openalex.org/I4210125219"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5101704167"],"corresponding_institution_ids":["https://openalex.org/I27781120","https://openalex.org/I3129496460","https://openalex.org/I4210125219"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"26","issue":null,"first_page":"e18715303483446","last_page":"e18715303483446"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.8730000257492065,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.8730000257492065,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10065","display_name":"Atrial Fibrillation Management and Outcomes","score":0.026200000196695328,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.014100000262260437,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neutrophil-extracellular-traps","display_name":"neutrophil extracellular traps","score":0.8999999761581421},{"id":"https://openalex.org/keywords/atrial-fibrillation","display_name":"atrial fibrillation","score":0.8790000081062317},{"id":"https://openalex.org/keywords/mendelian-randomization","display_name":"Mendelian randomization","score":0.8119999766349792},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.6949999928474426},{"id":"https://openalex.org/keywords/expression-quantitative-trait-loci","display_name":"expression quantitative trait loci","score":0.8989999890327454},{"id":"https://openalex.org/keywords/protein-quantitative-trait-loci","display_name":"protein quantitative trait loci","score":0.9980000257492065},{"id":"https://openalex.org/keywords/complement-c3","display_name":"complement C3","score":0.7200000286102295},{"id":"https://openalex.org/keywords/complement-activation","display_name":"complement activation","score":0.8159999847412109},{"id":"https://openalex.org/keywords/erk1","display_name":"ERK1","score":0.9929999709129333},{"id":"https://openalex.org/keywords/stat3","display_name":"STAT3","score":1.0},{"id":"https://openalex.org/keywords/colocalization","display_name":"colocalization","score":0.6909999847412109},{"id":"https://openalex.org/keywords/european-ancestry","display_name":"European ancestry","score":0.503000020980835}],"concepts":[{"id":"https://openalex.org/C2779901538","wikidata":"https://www.wikidata.org/wiki/Q6816584","display_name":"Mendelian randomization","level":5,"score":0.9092000126838684},{"id":"https://openalex.org/C2779161974","wikidata":"https://www.wikidata.org/wiki/Q815819","display_name":"Atrial fibrillation","level":2,"score":0.6025000214576721},{"id":"https://openalex.org/C81941488","wikidata":"https://www.wikidata.org/wiki/Q853421","display_name":"Quantitative trait locus","level":3,"score":0.5913000106811523},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5813000202178955},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5473999977111816},{"id":"https://openalex.org/C175783326","wikidata":"https://www.wikidata.org/wiki/Q185055","display_name":"Mendelian inheritance","level":3,"score":0.4763000011444092},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.44269999861717224},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.4228000044822693},{"id":"https://openalex.org/C168393362","wikidata":"https://www.wikidata.org/wiki/Q5421706","display_name":"Expression quantitative trait loci","level":5,"score":0.42260000109672546},{"id":"https://openalex.org/C140173407","wikidata":"https://www.wikidata.org/wiki/Q1138358","display_name":"CpG site","level":5,"score":0.40130001306533813},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38019999861717224},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.36880001425743103},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.35589998960494995},{"id":"https://openalex.org/C69991583","wikidata":"https://www.wikidata.org/wiki/Q1423575","display_name":"Candidate gene","level":3,"score":0.3483000099658966},{"id":"https://openalex.org/C106934330","wikidata":"https://www.wikidata.org/wiki/Q1971873","display_name":"Trait","level":2,"score":0.3167000114917755},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.3102000057697296},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3095000088214874},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.30889999866485596},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.29339998960494995},{"id":"https://openalex.org/C204243189","wikidata":"https://www.wikidata.org/wiki/Q1363085","display_name":"Randomization","level":3,"score":0.2922999858856201},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.29019999504089355},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.26429998874664307},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.263700008392334},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.25189998745918274}],"mesh":[{"descriptor_ui":"D000095028","descriptor_name":"Multiomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D001281","descriptor_name":"Atrial Fibrillation","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D001281","descriptor_name":"Atrial Fibrillation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001281","descriptor_name":"Atrial Fibrillation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001281","descriptor_name":"Atrial Fibrillation","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D040641","descriptor_name":"Quantitative Trait Loci","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D057182","descriptor_name":"Mendelian Randomization Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D065206","descriptor_name":"Extracellular Traps","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D065206","descriptor_name":"Extracellular Traps","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.2174/0118715303483446260804045231","doi":"https://doi.org/10.2174/0118715303483446260804045231","is_oa":false,"landing_page_url":"https://doi.org/10.2174/0118715303483446260804045231","pdf_url":null,"source":{"id":"https://openalex.org/S4210179974","display_name":"Endocrine Metabolic & Immune Disorders - Drug Targets","issn_l":"1871-5303","issn":["1871-5303","2212-3873"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrine, Metabolic & Immune Disorders - Drug Targets","raw_type":"journal-article"},{"id":"pmid:42693724","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42693724","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrine, metabolic & immune disorders drug targets","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4200432413","https://openalex.org/W4402576877","https://openalex.org/W7124832612","https://openalex.org/W4410883536","https://openalex.org/W7168254791","https://openalex.org/W7167023473","https://openalex.org/W4214768777","https://openalex.org/W4401102177","https://openalex.org/W4385723833","https://openalex.org/W7127201862"],"abstract_inverted_index":{"INTRODUCTION:":[0],"Neutrophil":[1],"extracellular":[2],"traps":[3],"(NETs)":[4],"participate":[5],"in":[6,85,240,326],"thrombosis,":[7],"inflammation,":[8],"and":[9,45,65,106,125,147,176,184,190,211,227,236,263,279,299,320],"cardiovascular":[10],"remodeling,":[11],"yet":[12],"whether":[13],"NET-related":[14,306,324],"genes":[15,141,193,307],"(NRGs)":[16],"are":[17],"associated":[18,308],"with":[19,82,204,231,309],"atrial":[20],"fibrillation":[21],"(AF)":[22],"risk":[23],"across":[24,139],"multiple":[25,205],"molecular":[26],"layers":[27],"remains":[28],"unclear.":[29],"This":[30],"study":[31],"used":[32],"a":[33,120,273,315],"multiomics":[34],"Mendelian":[35,78],"randomization":[36,79],"framework":[37,316],"to":[38,71],"prioritize":[39],"NRGs":[40],"supported":[41,305],"by":[42],"methylation,":[43],"expression,":[44],"protein":[46,67],"quantitative":[47],"trait":[48],"loci":[49],"(QTL)":[50],"data.":[51],"METHODS:":[52],")":[53],"were":[54,117],"obtained":[55,118],"for":[56,317],"90":[57],"methylation":[58,134],"QTLs":[59,63,68],"(mQTLs),":[60],"100":[61],"expression":[62],"(eQTLs),":[64],"38":[66],"(pQTLs)":[69],"mapped":[70],"137":[72],"literature-":[73],"curated":[74],"NRG":[75],"entries.":[76],"Summary-data-based":[77],"(SMR)":[80],"coupled":[81],"the":[83,133,244,260,264,268,280,302],"heterogeneity":[84,258],"dependent":[86],"instruments":[87],"(HEIDI)":[88],"test":[89],"was":[90],"applied":[91],"using":[92],"whole-blood":[93],"mQTL":[94],"data":[95,102,110,116],"(n":[96,103,111],"=":[97,104,112],"1,980),":[98],"eQTLGen":[99],"blood":[100],"eQTL":[101],"31,684),":[105],"deCODE":[107],"plasma":[108],"pQTL":[109,284],"35,559).":[113],"AF":[114,241,310],"outcome":[115],"from":[119],"meta-analysis":[121],"including":[122],"60,620":[123],"cases":[124],"970,216":[126],"controls":[127],"of":[128,267,283,323],"European":[129],"ancestry.":[130],"RESULTS:":[131],"At":[132],"level,":[135],"21":[136],"CpG-feature":[137],"associations":[138,202],"13":[140],"remained":[142],"significant":[143,157,165,206],"after":[144],"HEIDI":[145],"filtering":[146],"false":[148],"discovery":[149],"rate":[150],"(FDR)":[151],"correction.":[152],"Expression-level":[153],"analysis":[154,162],"identified":[155,163],"eight":[156],"gene-AF":[158],"associations,":[159],"whereas":[160,209],"protein-level":[161,201],"seven":[164],"features":[166],"representing":[167],"five":[168],"unique":[169],"proteins.":[170],"Cross-omics":[171],"integration":[172],"prioritized":[173],"C3,":[174,225,297],"MAPK3,":[175,226,298],"STAT3":[177,212,228,300],"as":[178,186,194,249,301],"Tier":[179,187,195],"1":[180],"genes,":[181,189],"CTSC,":[182],"LPAR3,":[183],"THBD":[185],"2":[188],"fourteen":[191],"additional":[192],"3":[196],"candidates.":[197],"C3":[198,261],"showed":[199,213],"risk-increasing":[200],"together":[203],"CpG":[207],"signals,":[208],"MAPK3":[210],"directionally":[214],"protective":[215],"expression/protein":[216],"or":[217],"methylation/protein":[218],"patterns.":[219],"DISCUSSION:":[220],"The":[221],"cross-omics":[222],"convergence":[223],"on":[224],"is":[229],"consistent":[230],"complement":[232],"activation,":[233],"immune-fibrotic":[234],"signaling,":[235],"cytokine-regulatory":[237],"pathways":[238,325],"implicated":[239],"biology,":[242],"but":[243],"findings":[245,313],"should":[246],"be":[247],"interpreted":[248],"genetic":[250],"prioritization":[251],"rather":[252],"than":[253],"definitive":[254],"intervention-ready":[255],"causality.":[256],"CpG-level":[257],"at":[259],"locus":[262],"blood/plasma":[265],"origin":[266],"QTL":[269],"resources":[270],"further":[271,287],"support":[272,278,288],"cautious":[274],"interpretation.":[275,292],"Modest":[276],"colocalization":[277],"unresolved":[281],"possibility":[282],"sample":[285],"overlap":[286],"this":[289],"cautious,":[290],"hypothesis-generating":[291],"CONCLUSION:":[293],"Multi-omics":[294],"SMR":[295],"prioritizes":[296],"most":[303],"consistently":[304],"risk.":[311],"These":[312],"provide":[314],"atrialtissue":[318],"replication":[319],"mechanistic":[321],"validation":[322],"AF.":[327]},"counts_by_year":[],"updated_date":"2026-09-24T07:57:37.273135","created_date":"2026-08-31T00:00:00"}