{"id":"https://openalex.org/W7204686431","doi":"https://doi.org/10.6913/nr64bg13","title":"Trends in osteoarthritis burden and the role of body mass index among older U.S. adults, 1999\u20132023: a NHANES and GBD analysis","display_name":"Trends in osteoarthritis burden and the role of body mass index among older U.S. adults, 1999\u20132023: a NHANES and GBD analysis","publication_year":2026,"publication_date":"2026-08-31","ids":{"openalex":"https://openalex.org/W7204686431","doi":"https://doi.org/10.6913/nr64bg13"},"language":"en","primary_location":{"id":"doi:10.6913/nr64bg13","doi":"https://doi.org/10.6913/nr64bg13","is_oa":true,"landing_page_url":"https://doi.org/10.6913/nr64bg13","pdf_url":"https://mrhk.cc/mrhk/article/view/175/140","source":{"id":"https://openalex.org/S4210198916","display_name":"Medical Research","issn_l":"2664-0333","issn":["2664-0333","2664-0341"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://mrhk.cc/mrhk/article/view/175/140","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5114214985","display_name":"Rongxiang Sun","orcid":"https://orcid.org/0000-0003-0993-2640","observed_orcids":["https://orcid.org/0000-0003-0993-2640"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210096354","display_name":"The Seventh Affiliated Hospital of Sun Yat-sen University","ror":"https://ror.org/00rfd5b88","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210096354"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rongxiang Sun","raw_affiliation_strings":["Department of Emergency and Disaster Medicine Center , The Seventh Affiliated Hospital , Sun Yat-sen University , Shenzhen 518107 , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency and Disaster Medicine Center , The Seventh Affiliated Hospital , Sun Yat-sen University , Shenzhen 518107 , China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210096354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108046050","display_name":"Zhifeng Mo","orcid":"https://orcid.org/0000-0001-9238-2242","observed_orcids":["https://orcid.org/0000-0001-9238-2242"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210096354","display_name":"The Seventh Affiliated Hospital of Sun Yat-sen University","ror":"https://ror.org/00rfd5b88","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210096354"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhifeng Mo","raw_affiliation_strings":["Department of Emergency and Disaster Medicine Center , The Seventh Affiliated Hospital , Sun Yat-sen University , Shenzhen 518107 , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency and Disaster Medicine Center , The Seventh Affiliated Hospital , Sun Yat-sen University , Shenzhen 518107 , China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210096354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004393117","display_name":"Maolin LIU","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210096354","display_name":"The Seventh Affiliated Hospital of Sun Yat-sen University","ror":"https://ror.org/00rfd5b88","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210096354"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Maolin Liu","raw_affiliation_strings":["Department of Emergency and Disaster Medicine Center , The Seventh Affiliated Hospital , Sun Yat-sen University , Shenzhen 518107 , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency and Disaster Medicine Center , The Seventh Affiliated Hospital , Sun Yat-sen University , Shenzhen 518107 , China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210096354"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5148737518","display_name":"Qinglong Jian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210096354","display_name":"The Seventh Affiliated Hospital of Sun Yat-sen University","ror":"https://ror.org/00rfd5b88","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210096354"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qinglong Jian","raw_affiliation_strings":["Department of Emergency and Disaster Medicine Center , The Seventh Affiliated Hospital , Sun Yat-sen University , Shenzhen 518107 , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency and Disaster Medicine Center , The Seventh Affiliated Hospital , Sun Yat-sen University , Shenzhen 518107 , China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210096354"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.62856003,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"8","issue":"3","first_page":"6","last_page":"25"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.6029999852180481,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.6029999852180481,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10084","display_name":"Musculoskeletal pain and rehabilitation","score":0.2766000032424927,"subfield":{"id":"https://openalex.org/subfields/3612","display_name":"Physical Therapy, Sports Therapy and Rehabilitation"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10010","display_name":"Obesity, Physical Activity, Diet","score":0.019300000742077827,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/osteoarthritis","display_name":"osteoarthritis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/body-mass-index","display_name":"body mass index","score":0.9990000128746033},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.9950000047683716},{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.699999988079071},{"id":"https://openalex.org/keywords/temporal-trends","display_name":"temporal trends","score":0.7229999899864197},{"id":"https://openalex.org/keywords/disability-adjusted-life-years","display_name":"disability-adjusted life years","score":0.9110000133514404},{"id":"https://openalex.org/keywords/incidence","display_name":"incidence","score":0.39100000262260437},{"id":"https://openalex.org/keywords/prevalence","display_name":"prevalence","score":0.8169999718666077},{"id":"https://openalex.org/keywords/burden-projections","display_name":"burden projections","score":0.6380000114440918},{"id":"https://openalex.org/keywords/population-aging","display_name":"population aging","score":0.7179999947547913},{"id":"https://openalex.org/keywords/regional-variation","display_name":"regional variation","score":0.6639999747276306},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.7789999842643738},{"id":"https://openalex.org/keywords/dose-response-relationship","display_name":"dose-response relationship","score":0.6919999718666077},{"id":"https://openalex.org/keywords/nhanes","display_name":"NHANES","score":0.7170000076293945},{"id":"https://openalex.org/keywords/global-burden-of-disease","display_name":"global burden of disease","score":0.9259999990463257}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7904999852180481},{"id":"https://openalex.org/C2780221984","wikidata":"https://www.wikidata.org/wiki/Q131191","display_name":"Body mass index","level":2,"score":0.7698000073432922},{"id":"https://openalex.org/C2779874844","wikidata":"https://www.wikidata.org/wiki/Q1967281","display_name":"National Health and Nutrition Examination Survey","level":3,"score":0.7332000136375427},{"id":"https://openalex.org/C143095724","wikidata":"https://www.wikidata.org/wiki/Q515895","display_name":"Odds","level":3,"score":0.6485999822616577},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.6470000147819519},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.6367999911308289},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.5188000202178955},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.49070000648498535},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.48399999737739563},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.4814000129699707},{"id":"https://openalex.org/C2780586474","wikidata":"https://www.wikidata.org/wiki/Q332428","display_name":"Overweight","level":3,"score":0.4410000145435333},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.40400001406669617},{"id":"https://openalex.org/C107130276","wikidata":"https://www.wikidata.org/wiki/Q133805","display_name":"Epidemiology","level":2,"score":0.396699994802475},{"id":"https://openalex.org/C13774568","wikidata":"https://www.wikidata.org/wiki/Q439112","display_name":"Population ageing","level":3,"score":0.36959999799728394},{"id":"https://openalex.org/C127142870","wikidata":"https://www.wikidata.org/wiki/Q7838279","display_name":"Trend analysis","level":2,"score":0.311599999666214},{"id":"https://openalex.org/C2780128664","wikidata":"https://www.wikidata.org/wiki/Q6973004","display_name":"National Health Interview Survey","level":3,"score":0.3077999949455261},{"id":"https://openalex.org/C142052008","wikidata":"https://www.wikidata.org/wiki/Q954027","display_name":"Cross-sectional study","level":2,"score":0.30379998683929443},{"id":"https://openalex.org/C138816342","wikidata":"https://www.wikidata.org/wiki/Q189603","display_name":"Public health","level":2,"score":0.29679998755455017},{"id":"https://openalex.org/C205545832","wikidata":"https://www.wikidata.org/wiki/Q17156455","display_name":"Young adult","level":2,"score":0.2793999910354614},{"id":"https://openalex.org/C2778149918","wikidata":"https://www.wikidata.org/wiki/Q3291156","display_name":"Population health","level":3,"score":0.2703999876976013},{"id":"https://openalex.org/C2776319399","wikidata":"https://www.wikidata.org/wiki/Q7070517","display_name":"Nutrition transition","level":4,"score":0.2651999890804291},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.25769999623298645}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.6913/nr64bg13","doi":"https://doi.org/10.6913/nr64bg13","is_oa":true,"landing_page_url":"https://doi.org/10.6913/nr64bg13","pdf_url":"https://mrhk.cc/mrhk/article/view/175/140","source":{"id":"https://openalex.org/S4210198916","display_name":"Medical Research","issn_l":"2664-0333","issn":["2664-0333","2664-0341"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Research","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.6913/nr64bg13","doi":"https://doi.org/10.6913/nr64bg13","is_oa":true,"landing_page_url":"https://doi.org/10.6913/nr64bg13","pdf_url":"https://mrhk.cc/mrhk/article/view/175/140","source":{"id":"https://openalex.org/S4210198916","display_name":"Medical Research","issn_l":"2664-0333","issn":["2664-0333","2664-0341"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Research","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321160","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204686431.pdf","grobid_xml":"https://content.openalex.org/works/W7204686431.grobid-xml"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W2076963888","https://openalex.org/W2113670619","https://openalex.org/W2264990363","https://openalex.org/W2292049380","https://openalex.org/W2793436565","https://openalex.org/W2898741363","https://openalex.org/W2947430334","https://openalex.org/W4223581588","https://openalex.org/W4300688852","https://openalex.org/W4377564835","https://openalex.org/W4384926080","https://openalex.org/W4385798749","https://openalex.org/W4386042200","https://openalex.org/W4386252907","https://openalex.org/W4392361382","https://openalex.org/W4395954663","https://openalex.org/W4401386598","https://openalex.org/W4401760070","https://openalex.org/W4402697865","https://openalex.org/W4406065270","https://openalex.org/W4407425556","https://openalex.org/W4408130003","https://openalex.org/W4408507353","https://openalex.org/W4409205401","https://openalex.org/W4409745621","https://openalex.org/W4410396535","https://openalex.org/W4410481426","https://openalex.org/W4410879242","https://openalex.org/W4411394625","https://openalex.org/W4411462429","https://openalex.org/W4413100858","https://openalex.org/W4414084155","https://openalex.org/W4414162896","https://openalex.org/W4414193467","https://openalex.org/W4414243547","https://openalex.org/W4414554356","https://openalex.org/W4415091769","https://openalex.org/W4415214775","https://openalex.org/W4415741618","https://openalex.org/W7119516695","https://openalex.org/W7161825860","https://openalex.org/W7163037566"],"related_works":["https://openalex.org/W7143286799","https://openalex.org/W7204084951","https://openalex.org/W4205738388","https://openalex.org/W4411394625","https://openalex.org/W4410481426","https://openalex.org/W4409864456","https://openalex.org/W7166710617","https://openalex.org/W4300688852","https://openalex.org/W4395954663","https://openalex.org/W7162944964"],"abstract_inverted_index":{"Objective:":[0],"To":[1],"examine":[2],"the":[3,210],"association":[4],"between":[5],"body":[6],"mass":[7],"index":[8],"(BMI)":[9],"and":[10,19,27,38,50,59,84,124,163,193,201,226],"osteoarthritis":[11],"(OA)":[12],"among":[13,120],"U.S.":[14],"adults":[15],"aged":[16],"\u226555":[17],"years":[18],"to":[20,70,137,157],"characterize":[21],"national":[22],"temporal":[23,55,128],"trends,":[24],"geographic":[25,80],"patterns,":[26],"future":[28,221],"burden":[29,173],"projections.":[30],"Methods:":[31],"This":[32],"multi-source":[33],"study":[34],"integrated":[35],"NHANES":[36,53,127,192],"(1999\u20132023)":[37],"GBD":[39,66,148,194],"data.":[40],"Multivariable":[41],"logistic":[42],"regression":[43],"assessed":[44],"BMI\u2013OA":[45],"associations":[46,117],"with":[47,104,113,147,182,187],"sex-stratified,":[48],"subgroup,":[49],"interaction":[51],"analyses.":[52],"survey-weighted":[54],"trends":[56,129],"in":[57,99,212],"obesity":[58,132,217],"OA":[60,72,109,141,151,213],"prevalence":[61,133,142],"were":[62,68,118],"examined":[63],"across":[64],"cycles.":[65],"estimates":[67],"used":[69],"evaluate":[71],"incidence,":[73],"prevalence,":[74],"disability-adjusted":[75],"life":[76],"years,":[77],"age-standardized":[78,165],"rates,":[79],"variation,":[81],"decomposition":[82],"analyses,":[83],"projections":[85],"through":[86,174],"2040.":[87,175],"Results:":[88],"Among":[89],"7,857":[90],"participants,":[91],"1,054":[92],"had":[93],"OA.":[94],"Each":[95],"1":[96],"kg/m\u00b2":[97],"increase":[98,211],"BMI":[100,178],"was":[101,179],"independently":[102,180],"associated":[103,181],"5%":[105],"higher":[106],"odds":[107,184],"of":[108,185],"after":[110],"full":[111],"adjustment,":[112],"a":[114,188],"dose\u2013response":[115,190],"gradient;":[116],"stronger":[119],"women,":[121],"older":[122],"adults,":[123],"lower-income":[125],"participants.":[126],"showed":[130,197],"that":[131,198],"rose":[134],"from":[135,155],"29.3%":[136],"41.8%":[138],"(2011\u20132020)":[139],"while":[140,215],"remained":[143],"stable":[144],"(27.8\u201332.3%),":[145],"consistent":[146],"findings.":[149],"Incident":[150],"cases":[152],"increased":[153,183],"substantially":[154],"1999":[156],"2023,":[158],"driven":[159,209],"by":[160],"population":[161,199],"growth":[162,200],"ageing;":[164],"rates":[166],"changed":[167],"modestly.":[168],"Projections":[169],"indicate":[170],"persistently":[171],"high":[172],"Conclusion:":[176],"Higher":[177],"OA,":[186],"clear":[189],"gradient.":[191],"data":[195],"consistently":[196],"ageing,":[202],"rather":[203],"than":[204],"rising":[205,216],"age-specific":[206],"risk,":[207],"have":[208],"burden,":[214],"may":[218],"portend":[219],"additional":[220],"burden.":[222],"Targeted":[223],"weight":[224],"management":[225],"risk-stratified":[227],"prevention":[228],"are":[229],"warranted":[230],"for":[231],"ageing":[232],"populations.":[233]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-08-31T00:00:00"}