{"id":"https://openalex.org/W7204682299","doi":"https://doi.org/10.1002/advs.77227","title":"WTAP Transcriptional Suppression by KLF9 Drives Osteoclastogenesis via M 6 A\u2010Mediated Regulation of CSF1R Signaling in Estrogen\u2010Deficient Osteoporosis","display_name":"WTAP Transcriptional Suppression by KLF9 Drives Osteoclastogenesis via M 6 A\u2010Mediated Regulation of CSF1R Signaling in Estrogen\u2010Deficient Osteoporosis","publication_year":2026,"publication_date":"2026-08-30","ids":{"openalex":"https://openalex.org/W7204682299","doi":"https://doi.org/10.1002/advs.77227","pmid":"https://pubmed.ncbi.nlm.nih.gov/42669152","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13526421"},"language":"en","primary_location":{"id":"doi:10.1002/advs.77227","doi":"https://doi.org/10.1002/advs.77227","is_oa":true,"landing_page_url":"https://doi.org/10.1002/advs.77227","pdf_url":null,"source":{"id":"https://openalex.org/S2737737698","display_name":"Advanced Science","issn_l":"2198-3844","issn":["2198-3844"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1002/advs.77227","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100678059","display_name":"Chen Shen","orcid":"https://orcid.org/0000-0001-8640-4492","observed_orcids":["https://orcid.org/0000-0001-8640-4492"]},"institutions":[{"id":"https://openalex.org/I4210153519","display_name":"First Affiliated Hospital of Soochow University","ror":"https://ror.org/051jg5p78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153519"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chen Shen","raw_affiliation_strings":["Department of Orthopedics The First Affiliated Hospital of Soochow University  Suzhou Jiangsu China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics The First Affiliated Hospital of Soochow University  Suzhou Jiangsu China","institution_ids":["https://openalex.org/I4210153519"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059479150","display_name":"Xin Liu","orcid":"https://orcid.org/0000-0002-8681-5096","observed_orcids":["https://orcid.org/0000-0002-8681-5096"]},"institutions":[{"id":"https://openalex.org/I4210153519","display_name":"First Affiliated Hospital of Soochow University","ror":"https://ror.org/051jg5p78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153519"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xin Liu","raw_affiliation_strings":["Department of Orthopedics The First Affiliated Hospital of Soochow University  Suzhou Jiangsu China"],"raw_orcid":"https://orcid.org/0000-0002-8681-5096","affiliations":[{"raw_affiliation_string":"Department of Orthopedics The First Affiliated Hospital of Soochow University  Suzhou Jiangsu China","institution_ids":["https://openalex.org/I4210153519"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029422969","display_name":"Gaoran Ge","orcid":"https://orcid.org/0000-0002-5535-7483","observed_orcids":["https://orcid.org/0000-0002-5535-7483","https://orcid.org/0000-0001-9290-9470"]},"institutions":[{"id":"https://openalex.org/I4210153519","display_name":"First Affiliated Hospital of Soochow University","ror":"https://ror.org/051jg5p78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153519"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Gaoran Ge","raw_affiliation_strings":["Department of Orthopedics The First Affiliated Hospital of Soochow University  Suzhou Jiangsu China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics The First Affiliated Hospital of Soochow University  Suzhou Jiangsu China","institution_ids":["https://openalex.org/I4210153519"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100860628","display_name":"Li Xu","orcid":"https://orcid.org/0000-0003-2529-2954","observed_orcids":["https://orcid.org/0000-0003-2529-2954"]},"institutions":[{"id":"https://openalex.org/I4210153519","display_name":"First Affiliated Hospital of Soochow University","ror":"https://ror.org/051jg5p78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153519"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li Xu","raw_affiliation_strings":["Department of Orthopedics The First Affiliated Hospital of Soochow University  Suzhou Jiangsu China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics The First Affiliated Hospital of Soochow University  Suzhou Jiangsu China","institution_ids":["https://openalex.org/I4210153519"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100706049","display_name":"Ziyu Zhang","orcid":"https://orcid.org/0000-0002-1982-112X","observed_orcids":["https://orcid.org/0000-0002-1982-112X","https://orcid.org/0009-0008-4182-5662"]},"institutions":[{"id":"https://openalex.org/I4210153519","display_name":"First Affiliated Hospital of Soochow University","ror":"https://ror.org/051jg5p78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153519"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ziyu Zhang","raw_affiliation_strings":["Department of Orthopedics The First Affiliated Hospital of Soochow University  Suzhou Jiangsu China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics The First Affiliated Hospital of Soochow University  Suzhou Jiangsu China","institution_ids":["https://openalex.org/I4210153519"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5143531813","display_name":"Chang Lv","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210153519","display_name":"First Affiliated Hospital of Soochow University","ror":"https://ror.org/051jg5p78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153519"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chang Lv","raw_affiliation_strings":["Department of Orthopedics The First Affiliated Hospital of Soochow University  Suzhou Jiangsu China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics The First Affiliated Hospital of Soochow University  Suzhou Jiangsu China","institution_ids":["https://openalex.org/I4210153519"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083340325","display_name":"Hao Xu","orcid":"https://orcid.org/0000-0002-2169-115X","observed_orcids":["https://orcid.org/0000-0002-2169-115X"]},"institutions":[{"id":"https://openalex.org/I4210153519","display_name":"First Affiliated Hospital of Soochow University","ror":"https://ror.org/051jg5p78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153519"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hao Xu","raw_affiliation_strings":["Department of Orthopedics The First Affiliated Hospital of Soochow University  Suzhou Jiangsu China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics The First Affiliated Hospital of Soochow University  Suzhou Jiangsu China","institution_ids":["https://openalex.org/I4210153519"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124395073","display_name":"Wenhao Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210153519","display_name":"First Affiliated Hospital of Soochow University","ror":"https://ror.org/051jg5p78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153519"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenhao Li","raw_affiliation_strings":["Department of Orthopedics The First Affiliated Hospital of Soochow University  Suzhou Jiangsu China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics The First Affiliated Hospital of Soochow University  Suzhou Jiangsu China","institution_ids":["https://openalex.org/I4210153519"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028883261","display_name":"Yi Qin","orcid":"https://orcid.org/0000-0001-8706-5007","observed_orcids":["https://orcid.org/0000-0001-8706-5007"]},"institutions":[{"id":"https://openalex.org/I4210153519","display_name":"First Affiliated Hospital of Soochow University","ror":"https://ror.org/051jg5p78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153519"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yi Qin","raw_affiliation_strings":["Department of Orthopedics The First Affiliated Hospital of Soochow University  Suzhou Jiangsu China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics The First Affiliated Hospital of Soochow University  Suzhou Jiangsu China","institution_ids":["https://openalex.org/I4210153519"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007564352","display_name":"Qifeng Sheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210153519","display_name":"First Affiliated Hospital of Soochow University","ror":"https://ror.org/051jg5p78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153519"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qifeng Sheng","raw_affiliation_strings":["Department of Orthopedics The First Affiliated Hospital of Soochow University  Suzhou Jiangsu China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics The First Affiliated Hospital of Soochow University  Suzhou Jiangsu China","institution_ids":["https://openalex.org/I4210153519"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057345322","display_name":"Qihan Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210153519","display_name":"First Affiliated Hospital of Soochow University","ror":"https://ror.org/051jg5p78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153519"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qihan Wang","raw_affiliation_strings":["Department of Orthopedics The First Affiliated Hospital of Soochow University  Suzhou Jiangsu China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics The First Affiliated Hospital of Soochow University  Suzhou Jiangsu China","institution_ids":["https://openalex.org/I4210153519"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Hongxia Li","orcid":"https://orcid.org/0000-0002-1440-1345","observed_orcids":["https://orcid.org/0000-0002-1440-1345"]},"institutions":[{"id":"https://openalex.org/I4210153519","display_name":"First Affiliated Hospital of Soochow University","ror":"https://ror.org/051jg5p78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153519"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Hongxia Li","raw_affiliation_strings":["Department of Cardiology The First Affiliated Hospital of Soochow University  Suzhou Jiangsu China"],"raw_orcid":"https://orcid.org/0000-0002-1440-1345","affiliations":[{"raw_affiliation_string":"Department of Cardiology The First Affiliated Hospital of Soochow University  Suzhou Jiangsu China","institution_ids":["https://openalex.org/I4210153519"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148743929","display_name":"Jun Zhou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210153519","display_name":"First Affiliated Hospital of Soochow University","ror":"https://ror.org/051jg5p78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153519"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jun Zhou","raw_affiliation_strings":["Department of Orthopedics The First Affiliated Hospital of Soochow University  Suzhou Jiangsu China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics The First Affiliated Hospital of Soochow University  Suzhou Jiangsu China","institution_ids":["https://openalex.org/I4210153519"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042318166","display_name":"Huilin Yang","orcid":"https://orcid.org/0000-0002-9459-7981","observed_orcids":["https://orcid.org/0000-0002-9459-7981"]},"institutions":[{"id":"https://openalex.org/I4210153519","display_name":"First Affiliated Hospital of Soochow University","ror":"https://ror.org/051jg5p78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153519"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Huilin Yang","raw_affiliation_strings":["Department of Orthopedics The First Affiliated Hospital of Soochow University  Suzhou Jiangsu China"],"raw_orcid":"https://orcid.org/0000-0002-9459-7981","affiliations":[{"raw_affiliation_string":"Department of Orthopedics The First Affiliated Hospital of Soochow University  Suzhou Jiangsu China","institution_ids":["https://openalex.org/I4210153519"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049167024","display_name":"Dechun Geng","orcid":"https://orcid.org/0000-0003-4375-2803","observed_orcids":["https://orcid.org/0000-0003-4375-2803","https://orcid.org/0000-0003-1425-2535"]},"institutions":[{"id":"https://openalex.org/I4210153519","display_name":"First Affiliated Hospital of Soochow University","ror":"https://ror.org/051jg5p78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153519"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Dechun Geng","raw_affiliation_strings":["Department of Orthopedics The First Affiliated Hospital of Soochow University  Suzhou Jiangsu China"],"raw_orcid":"https://orcid.org/0000-0003-4375-2803","affiliations":[{"raw_affiliation_string":"Department of Orthopedics The First Affiliated Hospital of Soochow University  Suzhou Jiangsu China","institution_ids":["https://openalex.org/I4210153519"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5042318166","https://openalex.org/A5049167024","https://openalex.org/A5148743929"],"corresponding_institution_ids":["https://openalex.org/I4210153519"],"apc_list":{"value":6730,"currency":"USD","value_usd":6730},"apc_paid":{"value":6730,"currency":"USD","value_usd":6730},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"13","issue":"60","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.9779999852180481,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.9779999852180481,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.01269999984651804,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/wtap","display_name":"WTAP","score":0.8830000162124634},{"id":"https://openalex.org/keywords/klf9","display_name":"KLF9","score":0.968999981880188},{"id":"https://openalex.org/keywords/m6a-methylation","display_name":"m6A RNA methylation","score":0.8140000104904175},{"id":"https://openalex.org/keywords/csf1r-signaling","display_name":"CSF1R signaling","score":0.8339999914169312},{"id":"https://openalex.org/keywords/osteoclastogenesis","display_name":"osteoclastogenesis","score":0.9359999895095825},{"id":"https://openalex.org/keywords/ythdf2","display_name":"YTHDF2","score":0.9380000233650208},{"id":"https://openalex.org/keywords/epitranscriptomics","display_name":"epitranscriptomics","score":0.7400000095367432},{"id":"https://openalex.org/keywords/transcriptional-repression","display_name":"transcriptional repression","score":0.8429999947547913},{"id":"https://openalex.org/keywords/bone-resorption","display_name":"bone resorption","score":0.9290000200271606},{"id":"https://openalex.org/keywords/pexidartinib","display_name":"pexidartinib","score":0.8259999752044678},{"id":"https://openalex.org/keywords/csf1r-inhibition","display_name":"CSF1R inhibition","score":0.7919999957084656},{"id":"https://openalex.org/keywords/myeloid-specific-knockout-mice","display_name":"myeloid-specific knockout","score":0.6470000147819519},{"id":"https://openalex.org/keywords/aav-gene-therapy","display_name":"AAV gene therapy","score":0.6169999837875366}],"concepts":[{"id":"https://openalex.org/C2776033226","wikidata":"https://www.wikidata.org/wiki/Q828410","display_name":"Osteoclast","level":3,"score":0.862500011920929},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.7239000201225281},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6383000016212463},{"id":"https://openalex.org/C673006","wikidata":"https://www.wikidata.org/wiki/Q4941581","display_name":"Bone resorption","level":2,"score":0.5810999870300293},{"id":"https://openalex.org/C170033053","wikidata":"https://www.wikidata.org/wiki/Q952019","display_name":"Bone remodeling","level":2,"score":0.5382000207901001},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.492900013923645},{"id":"https://openalex.org/C164659718","wikidata":"https://www.wikidata.org/wiki/Q5159266","display_name":"Conditional gene knockout","level":4,"score":0.484499990940094},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4733999967575073},{"id":"https://openalex.org/C2778260815","wikidata":"https://www.wikidata.org/wiki/Q917177","display_name":"Osteoblast","level":3,"score":0.4422999918460846},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4011000096797943},{"id":"https://openalex.org/C182704531","wikidata":"https://www.wikidata.org/wiki/Q1364740","display_name":"Knockout mouse","level":3,"score":0.390500009059906},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3903000056743622},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.3885999917984009},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.3862999975681305},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.383899986743927},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.37380000948905945},{"id":"https://openalex.org/C2993291840","wikidata":"https://www.wikidata.org/wiki/Q1121544","display_name":"Bone formation","level":2,"score":0.37279999256134033},{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.36660000681877136},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.35359999537467957},{"id":"https://openalex.org/C133605539","wikidata":"https://www.wikidata.org/wiki/Q913236","display_name":"Bone cell","level":2,"score":0.3221000134944916},{"id":"https://openalex.org/C27153228","wikidata":"https://www.wikidata.org/wiki/Q3787274","display_name":"Transcriptional regulation","level":4,"score":0.3142000138759613},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.313400000333786},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.30640000104904175},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.3025999963283539},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.29919999837875366},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.2939999997615814},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.29089999198913574},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.28290000557899475},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.2775000035762787},{"id":"https://openalex.org/C2911223091","wikidata":"https://www.wikidata.org/wiki/Q2304401","display_name":"Bone Density Conservation Agents","level":4,"score":0.2718000113964081},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.2621999979019165},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.25369998812675476}],"mesh":[{"descriptor_ui":"D000072260","descriptor_name":"RNA Splicing Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000072260","descriptor_name":"RNA Splicing Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004967","descriptor_name":"Estrogens","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":true},{"descriptor_ui":"D004967","descriptor_name":"Estrogens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010010","descriptor_name":"Osteoclasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010012","descriptor_name":"Osteogenesis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010024","descriptor_name":"Osteoporosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010024","descriptor_name":"Osteoporosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051741","descriptor_name":"Kruppel-Like Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051741","descriptor_name":"Kruppel-Like Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1002/advs.77227","doi":"https://doi.org/10.1002/advs.77227","is_oa":true,"landing_page_url":"https://doi.org/10.1002/advs.77227","pdf_url":null,"source":{"id":"https://openalex.org/S2737737698","display_name":"Advanced Science","issn_l":"2198-3844","issn":["2198-3844"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Science","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13526421","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13526421/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13526421/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Adv Sci (Weinh)","raw_type":"Text"},{"id":"pmid:42669152","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42669152","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced science (Weinheim, Baden-Wurttemberg, Germany)","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:25c76de50dbf4ef4bf71448d7d0bc4d6","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/25c76de50dbf4ef4bf71448d7d0bc4d6","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Advanced Science, Vol 13, Iss 60, Pp n/a-n/a (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1002/advs.77227","doi":"https://doi.org/10.1002/advs.77227","is_oa":true,"landing_page_url":"https://doi.org/10.1002/advs.77227","pdf_url":null,"source":{"id":"https://openalex.org/S2737737698","display_name":"Advanced Science","issn_l":"2198-3844","issn":["2198-3844"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Science","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4445967077","display_name":null,"funder_award_id":"82470272","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G55627397","display_name":null,"funder_award_id":"82502941","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G563474033","display_name":null,"funder_award_id":"82272567","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7875848636","display_name":null,"funder_award_id":"82472525","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320327518","display_name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204682299.pdf","grobid_xml":"https://content.openalex.org/works/W7204682299.grobid-xml"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W2069811152","https://openalex.org/W2091235283","https://openalex.org/W2093252878","https://openalex.org/W2096503607","https://openalex.org/W2115736737","https://openalex.org/W2472887612","https://openalex.org/W2942199823","https://openalex.org/W2943460751","https://openalex.org/W2972933339","https://openalex.org/W3009468546","https://openalex.org/W3028187297","https://openalex.org/W3133117790","https://openalex.org/W3166873110","https://openalex.org/W3168546979","https://openalex.org/W4220661589","https://openalex.org/W4303045401","https://openalex.org/W4307658486","https://openalex.org/W4309351898","https://openalex.org/W4309734382","https://openalex.org/W4315649130","https://openalex.org/W4316813181","https://openalex.org/W4318269971","https://openalex.org/W4362505906","https://openalex.org/W4365814655","https://openalex.org/W4367298955","https://openalex.org/W4378219864","https://openalex.org/W4385617446","https://openalex.org/W4387815001","https://openalex.org/W4388631070","https://openalex.org/W4390919689","https://openalex.org/W4391673148","https://openalex.org/W4391848764","https://openalex.org/W4392906060","https://openalex.org/W4393233061","https://openalex.org/W4395693675","https://openalex.org/W4396980200","https://openalex.org/W4401158079","https://openalex.org/W4401930315","https://openalex.org/W4403317762","https://openalex.org/W4403775053","https://openalex.org/W4404768535","https://openalex.org/W4405632850","https://openalex.org/W4407357280","https://openalex.org/W4408612773","https://openalex.org/W4410531678","https://openalex.org/W4412520497","https://openalex.org/W4413120055","https://openalex.org/W4414072914","https://openalex.org/W4414142524","https://openalex.org/W4415551839","https://openalex.org/W4416295902","https://openalex.org/W4417068338"],"related_works":["https://openalex.org/W4280514014","https://openalex.org/W4415759465","https://openalex.org/W4362505906","https://openalex.org/W4316813181","https://openalex.org/W4385617446","https://openalex.org/W2973345649","https://openalex.org/W2950163711","https://openalex.org/W7163926806","https://openalex.org/W2791389210","https://openalex.org/W2054720114"],"abstract_inverted_index":{"ABSTRACT":[0],"Osteoporosis,":[1],"characterized":[2],"by":[3,9,127],"imbalanced":[4],"bone":[5,12,55,85,124,144,162,184],"homeostasis,":[6],"is":[7],"driven":[8,126],"excessive":[10],"osteoclast\u2010mediated":[11],"resorption,":[13],"yet":[14],"the":[15,32,70,101,121],"epitranscriptomic":[16,173],"regulation":[17],"via":[18,69,150],"m":[19,33,60,72],"6":[20,34,61,73,135],"A":[21,35,62,74],"modification":[22],"remains":[23],"unclear.":[24],"Here,":[25],"we":[26],"identify":[27],"WTAP,":[28],"a":[29,39,139,170],"component":[30],"of":[31,43,115],"methyltransferase":[36],"complex,":[37],"as":[38],"critical":[40],"negative":[41],"regulator":[42],"osteoclastogenesis.":[44],"Myeloid\u2010specific":[45],"Wtap":[46,106,129,152],"knockout":[47,114],"in":[48,87,117,131,164],"mice":[49],"exacerbates":[50],"osteoclast":[51,97,118],"formation":[52],"and":[53,77,84,177],"osteoporotic":[54,123,165],"loss.":[56],"Mechanistically,":[57],"WTAP":[58],"mediates":[59],"deposition":[63],"on":[64],"Csflr":[65],"mRNA,":[66],"promoting":[67],"degradation":[68],"key":[71],"reader":[75],"YTHDF2":[76],"downregulating":[78],"CSF1R":[79,156],"expression,":[80],"thereby":[81],"enhancing":[82],"osteoclastogenesis":[83,176],"loss":[86,125,163],"estrogen\u2010deficient":[88],"osteoporosis.":[89],"We":[90],"further":[91],"discover":[92],"that":[93],"KLF9,":[94],"induced":[95],"during":[96],"differentiation,":[98],"translocates":[99],"to":[100,103],"nucleus":[102],"directly":[104],"repress":[105],"transcription,":[107],"initiating":[108],"this":[109,148],"pathological":[110,183],"process.":[111],"Concurrent":[112],"conditional":[113],"KLF9":[116],"precursors":[119],"rescues":[120],"exacerbated":[122],"myeloid\u2010specific":[128],"deficiency":[130],"vivo.":[132],"This":[133],"KLF9/WTAP/YTHDF2/m":[134],"A/CSF1R":[136],"axis":[137,149],"establishes":[138],"novel":[140],"epigenetic":[141],"circuit":[142],"regulating":[143],"resorption.":[145,185],"Therapeutically,":[146],"targeting":[147],"AAV\u2010mediated":[151],"overexpression":[153],"or":[154],"pharmacological":[155],"inhibition":[157],"with":[158],"pexidartinib":[159],"effectively":[160],"ameliorates":[161],"mice.":[166],"Our":[167],"findings":[168],"elucidate":[169],"previously":[171],"unrecognized":[172],"mechanism":[174],"controlling":[175],"highlight":[178],"its":[179],"therapeutic":[180],"potential":[181],"for":[182]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-08-31T00:00:00"}
