{"id":"https://openalex.org/W7204678602","doi":"https://doi.org/10.17605/osf.io/9t7ru","title":"Real Cells, Uncertain Identities: Progenitor and Stem-Cell Identity in Cardiac Surgery Research A Scoping Review Protocol","display_name":"Real Cells, Uncertain Identities: Progenitor and Stem-Cell Identity in Cardiac Surgery Research A Scoping Review Protocol","publication_year":2026,"publication_date":"2026-08-27","ids":{"openalex":"https://openalex.org/W7204678602","doi":"https://doi.org/10.17605/osf.io/9t7ru"},"language":"en","primary_location":{"id":"pmh:doi:10.17605/osf.io/9t7ru","doi":null,"is_oa":true,"landing_page_url":"https://osf.io/9t7ru","pdf_url":null,"source":null,"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"StudyRegistration"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://osf.io/9t7ru","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5147255865","display_name":"Omar Farooq","orcid":"https://orcid.org/0009-0007-0891-2986","observed_orcids":["https://orcid.org/0009-0007-0891-2986"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Omar Farooq","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0007-0891-2986","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5148607082","display_name":"Mustafa Zakkar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mustafa Zakkar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.9520999789237976,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.9520999789237976,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.028200000524520874,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.003800000064074993,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cardiac-progenitor-cells","display_name":"cardiac progenitor cells","score":0.9179999828338623},{"id":"https://openalex.org/keywords/stem-cells","display_name":"stem cells","score":0.7839999794960022},{"id":"https://openalex.org/keywords/endothelial-progenitor-cells","display_name":"endothelial progenitor cells","score":0.875},{"id":"https://openalex.org/keywords/cell-identity","display_name":"cell identity","score":0.7620000243186951},{"id":"https://openalex.org/keywords/cell-lineage","display_name":"cell lineage","score":0.4230000078678131},{"id":"https://openalex.org/keywords/cardiac-regeneration","display_name":"cardiac regeneration","score":0.5440000295639038},{"id":"https://openalex.org/keywords/cardiac-surgery","display_name":"cardiac surgery","score":0.4959999918937683},{"id":"https://openalex.org/keywords/cell-therapy","display_name":"cell therapy","score":0.49399998784065247},{"id":"https://openalex.org/keywords/vascular-repair","display_name":"vascular repair","score":0.6949999928474426},{"id":"https://openalex.org/keywords/skeletal-myoblasts","display_name":"skeletal myoblasts","score":0.8460000157356262},{"id":"https://openalex.org/keywords/immunophenotyping","display_name":"immunophenotyping","score":0.8149999976158142},{"id":"https://openalex.org/keywords/lineage-tracing","display_name":"lineage tracing","score":0.8600000143051147},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7089999914169312}],"concepts":[{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.6453999876976013},{"id":"https://openalex.org/C2778355321","wikidata":"https://www.wikidata.org/wiki/Q17079427","display_name":"Identity (music)","level":2,"score":0.5778999924659729},{"id":"https://openalex.org/C70437156","wikidata":"https://www.wikidata.org/wiki/Q7228652","display_name":"Pooling","level":2,"score":0.5081999897956848},{"id":"https://openalex.org/C2780385302","wikidata":"https://www.wikidata.org/wiki/Q367158","display_name":"Protocol (science)","level":3,"score":0.4702000021934509},{"id":"https://openalex.org/C160798450","wikidata":"https://www.wikidata.org/wiki/Q4230870","display_name":"Concordance","level":2,"score":0.4666999876499176},{"id":"https://openalex.org/C15729860","wikidata":"https://www.wikidata.org/wiki/Q2329919","display_name":"Progenitor","level":4,"score":0.44679999351501465},{"id":"https://openalex.org/C2780152582","wikidata":"https://www.wikidata.org/wiki/Q1340830","display_name":"Endothelial progenitor cell","level":4,"score":0.4465999901294708},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.42340001463890076},{"id":"https://openalex.org/C199033989","wikidata":"https://www.wikidata.org/wiki/Q1318295","display_name":"Narrative","level":2,"score":0.33820000290870667},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3287000060081482},{"id":"https://openalex.org/C3020000205","wikidata":"https://www.wikidata.org/wiki/Q2412849","display_name":"Narrative review","level":2,"score":0.30570000410079956},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3041999936103821},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.29420000314712524},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.2849000096321106},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2791999876499176},{"id":"https://openalex.org/C2777565915","wikidata":"https://www.wikidata.org/wiki/Q4919218","display_name":"Bivalirudin","level":4,"score":0.27390000224113464},{"id":"https://openalex.org/C2778789114","wikidata":"https://www.wikidata.org/wiki/Q235007","display_name":"Cardiac surgery","level":2,"score":0.26759999990463257},{"id":"https://openalex.org/C154504017","wikidata":"https://www.wikidata.org/wiki/Q853614","display_name":"Identifier","level":2,"score":0.262800008058548},{"id":"https://openalex.org/C4438859","wikidata":"https://www.wikidata.org/wiki/Q186117","display_name":"Timeline","level":2,"score":0.25920000672340393},{"id":"https://openalex.org/C2777826928","wikidata":"https://www.wikidata.org/wiki/Q3745713","display_name":"Fingerprint (computing)","level":2,"score":0.258899986743927},{"id":"https://openalex.org/C43091099","wikidata":"https://www.wikidata.org/wiki/Q1067788","display_name":"Through-the-lens metering","level":3,"score":0.25870001316070557},{"id":"https://openalex.org/C2779318504","wikidata":"https://www.wikidata.org/wiki/Q1438035","display_name":"Research design","level":2,"score":0.2563999891281128}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:doi:10.17605/osf.io/9t7ru","doi":null,"is_oa":true,"landing_page_url":"https://osf.io/9t7ru","pdf_url":null,"source":null,"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"StudyRegistration"},{"id":"pmh:oai:share.osf.io:f7cd7c89-2b5f-49cb-a199-224132795dcf","doi":null,"is_oa":true,"landing_page_url":"https://osf.io/s3av9","pdf_url":null,"source":{"id":"https://openalex.org/S4306401127","display_name":"OSF Preprints (OSF Preprints)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2799848540","host_organization_name":"Center for Open Science","host_organization_lineage":["https://openalex.org/I2799848540"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Project"},{"id":"doi:10.17605/osf.io/9t7ru","doi":"https://doi.org/10.17605/osf.io/9t7ru","is_oa":true,"landing_page_url":"https://doi.org/10.17605/osf.io/9t7ru","pdf_url":null,"source":{"id":"https://openalex.org/S7407050956","display_name":"Open Science Framework","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2799848540","host_organization_name":"Center for Open Science","host_organization_lineage":["https://openalex.org/I2799848540"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"StudyRegistration"}],"best_oa_location":{"id":"pmh:doi:10.17605/osf.io/9t7ru","doi":null,"is_oa":true,"landing_page_url":"https://osf.io/9t7ru","pdf_url":null,"source":null,"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"StudyRegistration"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2138019470","https://openalex.org/W2080714387","https://openalex.org/W7096082953","https://openalex.org/W2771469921","https://openalex.org/W2023535740","https://openalex.org/W2252320136","https://openalex.org/W1418903811","https://openalex.org/W2780243236","https://openalex.org/W2081559723","https://openalex.org/W3095366206"],"abstract_inverted_index":{"This":[0],"project":[1],"is":[2,67,87],"a":[3,35,53,175,186,198,217],"scoping":[4],"review":[5,116,215],"mapping":[6],"how":[7,154,190],"progenitor":[8,55,105],"and":[9,37,106,133,138,183,197,203,210],"stem-cell":[10],"populations":[11,120],"have":[12],"actually":[13,122],"been":[14],"studied":[15,123],"in":[16,102],"cardiac":[17],"surgery":[18],"research,":[19],"across":[20,113,165,222],"three":[21,42,224],"distinct":[22,77],"literatures:":[23],"cells":[24,32,38,51],"measured":[25],"as":[26,34,142],"prognostic":[27],"biomarkers":[28],"of":[29,85,189,201],"vascular-repair":[30],"capacity,":[31],"administered":[33],"therapy,":[36],"characterised":[39],"molecularly.":[40],"All":[41],"literatures":[43,225],"share":[44],"an":[45,70],"untested":[46],"assumption":[47],"\u2014":[48,157,163],"that":[49,166],"the":[50,58,61,103,180],"carrying":[52],"given":[54],"label":[56,62],"are":[57],"regenerative":[59],"progenitors":[60],"names.":[63],"The":[64,97],"clearest":[65],"example":[66],"\"EPC,\"":[68],"historically":[69],"umbrella":[71],"term":[72],"covering":[73],"at":[74,91],"least":[75],"two":[76],"cell":[78,119],"lineages":[79],"with":[80],"very":[81],"different":[82],"biology,":[83],"one":[84],"which":[86],"not":[88],"truly":[89],"endothelial":[90],"all":[92,223],"by":[93],"current":[94,148],"consensus":[95],"nomenclature.":[96],"same":[98],"label-versus-lineage":[99],"gap":[100],"recurs":[101],"cardiac-resident":[104],"skeletal-myoblast":[107],"literatures.":[108],"Rather":[109],"than":[110],"pooling":[111],"outcomes":[112,192],"studies,":[114],"this":[115],"charts":[117],"what":[118],"were":[121],"under":[124],"each":[125,140],"label,":[126],"using":[127],"immunophenotyping,":[128],"culture/colony":[129],"assays,":[130,132],"potency":[131],"lineage-tracing":[134],"methods":[135],"where":[136],"reported,":[137],"classifies":[139],"study":[141],"concordant,":[143],"discordant,":[144],"or":[145],"indeterminate":[146],"against":[147],"lineage/nomenclature":[149],"standards.":[150,212],"It":[151],"then":[152],"maps":[153],"reported":[155,191],"findings":[156],"associations,":[158],"therapeutic":[159],"effects,":[160],"molecular":[161,184],"results":[162],"distribute":[164],"concordance":[167,177],"classification,":[168],"without":[169],"making":[170],"causal":[171],"claims.":[172],"Expected":[173],"outputs:":[174],"label-to-identity":[176],"matrix":[178],"spanning":[179],"prognostic,":[181],"therapeutic,":[182],"literatures;":[185],"descriptive":[187],"map":[188],"relate":[193],"to":[194,206],"identity":[195,220],"concordance;":[196],"narrative":[199],"account":[200],"definitional":[202],"methodological":[204],"gaps":[205],"inform":[207],"future":[208],"research":[209],"reporting":[211],"No":[213],"existing":[214],"applies":[216],"single":[218],"current-standards":[219],"lens":[221],"simultaneously.":[226]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2026-08-30T00:00:00"}